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Gene: Idh2 (isocitrate dehydrogenase (NADP(+)) 2, mitochondrial) Rattus norvegicus
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Symbol: Idh2
Name: isocitrate dehydrogenase (NADP(+)) 2, mitochondrial
Description: Exhibits isocitrate dehydrogenase (NADP+) activity. Involved in NADP biosynthetic process; negative regulation of gliogenesis; and negative regulation of matrix metallopeptidase secretion. Predicted to localize to the cytosol; mitochondrion; and peroxisome. Human ortholog(s) of this gene implicated in D-2-hydroxyglutaric aciduria and acute myeloid leukemia. Orthologous to human IDH2 (isocitrate dehydrogenase (NADP(+)) 2, mitochondrial); PARTICIPATES IN citric acid cycle pathway; glutathione metabolic pathway; INTERACTS WITH (R)-adrenaline; 17alpha-ethynylestradiol; 17beta-estradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: ICD-M; IDH; IDP; isocitrate dehydrogenase 2 (NADP+), mitochondrial; isocitrate dehydrogenase [NADP], mitochondrial; LOC361596; NADP(+)-specific ICDH; oxalosuccinate decarboxylase; similar to NADP+-specific isocitrate dehydrogenase
Orthologs:
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01141,874,354 - 141,893,674 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01142,830,040 - 142,849,360 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41135,876,052 - 135,895,373 (-)NCBIRGSC3.4rn4RGSC3.4
Celera1126,099,085 - 126,118,402 (-)NCBICelera
Cytogenetic Map1q31NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated
RGD Disease Portals

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 5.0)

Additional Information

External Database Links
Nomenclature History
 
More on Idh2
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1597139
Created: 2006-11-20
Species: Rattus norvegicus
Last Modified: 2019-05-07
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.