(+)-schisandrin B multiple interactions EXP 6480464 schizandrin B inhibits the reaction [Carbon Tetrachloride results in decreased expression of IDH2 mRNA] CTD PMID:31150632 (N(omega)-L-arginino)succinic acid decreases abundance ISO RGD:1557355 6480464 IDH2 protein mutant form results in decreased abundance of Argininosuccinic Acid CTD PMID:27469509 (N(omega)-L-arginino)succinic acid multiple interactions ISO RGD:1557355 6480464 Triazines inhibits the reaction [IDH2 protein mutant form results in decreased abundance of Argininosuccinic Acid] CTD PMID:27469509 (R)-adrenaline decreases expression EXP 6480464 Epinephrine results in decreased expression of IDH2 protein CTD PMID:19464573 (R)-adrenaline multiple interactions EXP 6480464 [Epinephrine co-treated with Xanthine co-treated with XDH] results in decreased expression of IDH2 protein CTD PMID:19464573 (R)-carnitine increases abundance ISO RGD:1557355 6480464 IDH2 protein mutant form results in increased abundance of Carnitine CTD PMID:27469509 (R)-carnitine multiple interactions ISO RGD:1557355 6480464 Triazines inhibits the reaction [IDH2 protein mutant form results in increased abundance of Carnitine] CTD PMID:27469509 (R)-pantothenic acid increases abundance ISO RGD:1557355 6480464 IDH2 protein mutant form results in increased abundance of Pantothenic Acid CTD PMID:27469509 (R)-pantothenic acid multiple interactions ISO RGD:1557355 6480464 Triazines inhibits the reaction [IDH2 protein mutant form results in increased abundance of Pantothenic Acid] CTD PMID:27469509 1,2-dimethylhydrazine multiple interactions ISO RGD:1557355 6480464 [1, 2-Dimethylhydrazine co-treated with Folic Acid] results in increased expression of IDH2 mRNA CTD PMID:22206623 1,2-dimethylhydrazine increases expression ISO RGD:1557355 6480464 1, 2-Dimethylhydrazine results in increased expression of IDH2 mRNA CTD PMID:22206623 17alpha-ethynylestradiol affects expression EXP 6480464 Ethinyl Estradiol affects the expression of IDH2 mRNA CTD PMID:16079270 17alpha-ethynylestradiol decreases expression EXP 6480464 Ethinyl Estradiol results in decreased expression of IDH2 mRNA CTD PMID:17557909 17beta-estradiol multiple interactions EXP 6480464 [bisphenol A co-treated with Estradiol] results in decreased expression of IDH2 mRNA CTD PMID:26496021 2'-deoxycytosine 5'-monophosphate multiple interactions ISO RGD:1557355 6480464 Triazines inhibits the reaction [IDH2 protein mutant form results in increased abundance of Deoxycytidine Monophosphate] CTD PMID:27469509 2'-deoxycytosine 5'-monophosphate increases abundance ISO RGD:1557355 6480464 IDH2 protein mutant form results in increased abundance of Deoxycytidine Monophosphate CTD PMID:27469509 2'-deoxyguanosine 5'-monophosphate multiple interactions ISO RGD:1557355 6480464 Triazines inhibits the reaction [IDH2 protein mutant form results in increased abundance of 2'-deoxyguanosine 5'-phosphate] CTD PMID:27469509 2'-deoxyguanosine 5'-monophosphate increases abundance ISO RGD:1557355 6480464 IDH2 protein mutant form results in increased abundance of 2'-deoxyguanosine 5'-phosphate CTD PMID:27469509 2,2',4,4',5,5'-hexachlorobiphenyl multiple interactions EXP 6480464 [3 more ... CTD PMID:16984957 2,2',4,4'-Tetrabromodiphenyl ether affects expression ISO RGD:1557355 6480464 2 more ... CTD PMID:30294300 2,3,7,8-tetrachlorodibenzodioxine decreases expression ISO RGD:1557355 6480464 Tetrachlorodibenzodioxin results in decreased expression of IDH2 mRNA CTD PMID:19770486 2,3,7,8-tetrachlorodibenzodioxine affects expression EXP 6480464 Tetrachlorodibenzodioxin affects the expression of IDH2 mRNA CTD PMID:34747641 2,3,7,8-tetrachlorodibenzodioxine increases expression ISO RGD:1313391 6480464 Tetrachlorodibenzodioxin results in increased expression of IDH2 mRNA CTD PMID:20106945 , PMID:21632981 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO RGD:1557355 6480464 Tetrachlorodibenzodioxin affects the expression of IDH2 mRNA CTD PMID:21570461 2,3,7,8-tetrachlorodibenzodioxine decreases expression EXP 6480464 Tetrachlorodibenzodioxin results in decreased expression of IDH2 mRNA CTD PMID:21215274 2-amino-2-deoxy-D-glucopyranose 6-phosphate increases abundance ISO RGD:1557355 6480464 IDH2 protein mutant form results in increased abundance of glucosamine 6-phosphate CTD PMID:27469509 2-amino-2-deoxy-D-glucopyranose 6-phosphate multiple interactions ISO RGD:1557355 6480464 Triazines inhibits the reaction [IDH2 protein mutant form results in increased abundance of glucosamine 6-phosphate] CTD PMID:27469509 2-hydroxyglutaric acid multiple interactions ISO RGD:1557355 6480464 Triazines inhibits the reaction [IDH2 protein mutant form results in increased abundance of alpha-hydroxyglutarate] CTD PMID:27469509 2-hydroxyglutaric acid increases abundance ISO RGD:1557355 6480464 IDH2 protein mutant form results in increased abundance of alpha-hydroxyglutarate CTD PMID:27469509 2-hydroxypropanoic acid increases abundance ISO RGD:1557355 6480464 IDH2 protein mutant form results in increased abundance of Lactic Acid CTD PMID:27469509 2-hydroxypropanoic acid multiple interactions ISO RGD:1557355 6480464 Triazines inhibits the reaction [IDH2 protein mutant form results in increased abundance of Lactic Acid] CTD PMID:27469509 3',5'-cyclic AMP multiple interactions ISO RGD:1557355 6480464 Triazines inhibits the reaction [IDH2 protein mutant form results in increased abundance of Cyclic AMP] CTD PMID:27469509 3',5'-cyclic AMP increases abundance ISO RGD:1557355 6480464 IDH2 protein mutant form results in increased abundance of Cyclic AMP CTD PMID:27469509 3,3',4,4',5-pentachlorobiphenyl decreases expression EXP 6480464 3 more ... CTD PMID:16984957 3,3',4,4',5-pentachlorobiphenyl multiple interactions EXP 6480464 [3 more ... CTD PMID:16984957 3,4-methylenedioxymethamphetamine increases expression ISO RGD:1557355 6480464 N-Methyl-3, 4-methylenedioxyamphetamine results in increased expression of IDH2 mRNA CTD PMID:20188158 3-dehydrocarnitine multiple interactions ISO RGD:1557355 6480464 Triazines inhibits the reaction [IDH2 protein mutant form results in increased abundance of 3-dehydrocarnitine] CTD PMID:27469509 3-dehydrocarnitine increases abundance ISO RGD:1557355 6480464 IDH2 protein mutant form results in increased abundance of 3-dehydrocarnitine CTD PMID:27469509 3-methylcholanthrene multiple interactions ISO RGD:1313391 6480464 Methylcholanthrene promotes the reaction [AHR protein binds to IDH2 promoter] CTD PMID:20348232 3-phosphoglyceric acid increases abundance ISO RGD:1557355 6480464 IDH2 protein mutant form results in increased abundance of 3-phosphoglycerate CTD PMID:27469509 3-phosphoglyceric acid multiple interactions ISO RGD:1557355 6480464 Triazines inhibits the reaction [IDH2 protein mutant form results in increased abundance of 3-phosphoglycerate] CTD PMID:27469509 3H-1,2-dithiole-3-thione increases expression EXP 6480464 1, 2-dithiol-3-thione results in increased expression of IDH2 mRNA CTD PMID:19162173 4,4'-sulfonyldiphenol increases expression ISO RGD:1313391 6480464 bis(4-hydroxyphenyl)sulfone results in increased expression of IDH2 mRNA, bis(4-hydroxyphenyl)sulfone results in increased expression of IDH2 protein CTD PMID:31121516 , PMID:34186270 4-(trimethylammonio)butanoate multiple interactions ISO RGD:1557355 6480464 Triazines inhibits the reaction [IDH2 protein mutant form results in increased abundance of gamma-butyrobetaine] CTD PMID:27469509 4-(trimethylammonio)butanoate increases abundance ISO RGD:1557355 6480464 IDH2 protein mutant form results in increased abundance of gamma-butyrobetaine CTD PMID:27469509 5'-S-methyl-5'-thioadenosine multiple interactions ISO RGD:1557355 6480464 Triazines inhibits the reaction [IDH2 protein mutant form results in increased abundance of 5'-methylthioadenosine] CTD PMID:27469509 5'-S-methyl-5'-thioadenosine increases abundance ISO RGD:1557355 6480464 IDH2 protein mutant form results in increased abundance of 5'-methylthioadenosine CTD PMID:27469509 5-(hydroxymethyl)cytosine decreases abundance ISO RGD:1557355 6480464 IDH2 protein mutant form results in decreased abundance of 5-hydroxymethylcytosine CTD PMID:27469509 7H-xanthine multiple interactions EXP 6480464 [Epinephrine co-treated with Xanthine co-treated with XDH] results in decreased expression of IDH2 protein, [Xanthine co-treated with XDH protein] results in decreased expression of IDH2 protein CTD PMID:19464573 8-Epidiosbulbin E acetate decreases expression ISO RGD:1557355 6480464 8-epidiosbulbin E acetate results in decreased expression of IDH2 mRNA CTD PMID:31626840 9H-xanthine multiple interactions EXP 6480464 [Epinephrine co-treated with Xanthine co-treated with XDH] results in decreased expression of IDH2 protein, [Xanthine co-treated with XDH protein] results in decreased expression of IDH2 protein CTD PMID:19464573 acetamide increases expression EXP 6480464 acetamide results in increased expression of IDH2 mRNA CTD PMID:31881176 aconitic acid increases abundance ISO RGD:1557355 6480464 IDH2 protein mutant form results in increased abundance of Aconitic Acid CTD PMID:27469509 aconitic acid multiple interactions ISO RGD:1557355 6480464 Triazines inhibits the reaction [IDH2 protein mutant form results in increased abundance of Aconitic Acid] CTD PMID:27469509 acrylamide decreases expression ISO RGD:1313391 6480464 Acrylamide results in decreased expression of IDH2 mRNA CTD PMID:32763439 adenosine increases abundance ISO RGD:1557355 6480464 IDH2 protein mutant form results in increased abundance of Adenosine CTD PMID:27469509 adenosine multiple interactions ISO RGD:1557355 6480464 Triazines inhibits the reaction [IDH2 protein mutant form results in increased abundance of Adenosine] CTD PMID:27469509 ADP multiple interactions ISO RGD:1557355 6480464 Triazines inhibits the reaction [IDH2 protein mutant form results in increased abundance of Adenosine Diphosphate] CTD PMID:27469509 ADP increases abundance ISO RGD:1557355 6480464 IDH2 protein mutant form results in increased abundance of Adenosine Diphosphate CTD PMID:27469509 aflatoxin B1 decreases expression ISO RGD:1557355 6480464 Aflatoxin B1 results in decreased expression of IDH2 mRNA CTD PMID:19770486 aflatoxin B1 decreases expression ISO RGD:1313391 6480464 Aflatoxin B1 results in decreased expression of IDH2 mRNA CTD PMID:27153756 aldehydo-D-glucosamine 6-phosphate multiple interactions ISO RGD:1557355 6480464 Triazines inhibits the reaction [IDH2 protein mutant form results in increased abundance of glucosamine 6-phosphate] CTD PMID:27469509 aldehydo-D-glucosamine 6-phosphate increases abundance ISO RGD:1557355 6480464 IDH2 protein mutant form results in increased abundance of glucosamine 6-phosphate CTD PMID:27469509 alendronic acid affects expression EXP 6480464 Alendronate affects the expression of IDH2 mRNA CTD PMID:16079270 all-trans-retinoic acid decreases expression ISO RGD:1313391 6480464 Tretinoin results in decreased expression of IDH2 mRNA CTD PMID:33167477 alpha-D-glucose 1-phosphate increases abundance ISO RGD:1557355 6480464 IDH2 protein mutant form results in increased abundance of glucose-1-phosphate CTD PMID:27469509 alpha-D-glucose 1-phosphate multiple interactions ISO RGD:1557355 6480464 Triazines inhibits the reaction [IDH2 protein mutant form results in increased abundance of glucose-1-phosphate] CTD PMID:27469509 aluminium atom decreases activity EXP 6480464 Aluminum results in decreased activity of IDH2 protein CTD PMID:15486972 aluminium(0) decreases activity EXP 6480464 Aluminum results in decreased activity of IDH2 protein CTD PMID:15486972 amiodarone increases expression ISO RGD:1557355 6480464 Amiodarone results in increased expression of IDH2 mRNA CTD PMID:24489787 aristolochic acid A increases expression ISO RGD:1557355 6480464 aristolochic acid I results in increased expression of IDH2 mRNA CTD PMID:31009690 arsane affects methylation ISO RGD:1313391 6480464 Arsenic affects the methylation of IDH2 gene CTD PMID:25304211 arsenic atom affects methylation ISO RGD:1313391 6480464 Arsenic affects the methylation of IDH2 gene CTD PMID:25304211 arsenite(3-) multiple interactions ISO RGD:1313391 6480464 arsenite inhibits the reaction [G3BP1 protein binds to IDH2 protein] CTD PMID:32406909 arsenous acid increases expression ISO RGD:1313391 6480464 Arsenic Trioxide results in increased expression of IDH2 protein CTD PMID:25419056 arsenous acid decreases expression EXP 6480464 Arsenic Trioxide results in decreased expression of IDH2 mRNA CTD PMID:29223816 aspartame multiple interactions ISO RGD:1557355 6480464 [Fats more ... CTD PMID:23783067 benzo[a]pyrene decreases expression ISO RGD:1557355 6480464 Benzo(a)pyrene results in decreased expression of IDH2 mRNA CTD PMID:19770486 benzo[a]pyrene increases expression ISO RGD:1557355 6480464 Benzo(a)pyrene results in increased expression of IDH2 mRNA CTD PMID:22228805 benzo[a]pyrene multiple interactions ISO RGD:1557355 6480464 AHR protein affects the reaction [Benzo(a)pyrene affects the expression of IDH2 mRNA] CTD PMID:22228805 benzo[a]pyrene diol epoxide I increases expression ISO RGD:1313391 6480464 7 more ... CTD PMID:19150397 beta-D-fructofuranose 1,6-bisphosphate increases abundance ISO RGD:1557355 6480464 IDH2 protein mutant form results in increased abundance of fructose-1, 6-diphosphate CTD PMID:27469509 beta-D-fructofuranose 1,6-bisphosphate multiple interactions ISO RGD:1557355 6480464 Triazines inhibits the reaction [IDH2 protein mutant form results in increased abundance of fructose-1, 6-diphosphate] CTD PMID:27469509 bilirubin IXalpha decreases expression ISO RGD:1313391 6480464 Bilirubin results in decreased expression of IDH2 mRNA CTD PMID:20196124 bis(2-ethylhexyl) phthalate increases expression ISO RGD:1557355 6480464 Diethylhexyl Phthalate results in increased expression of IDH2 mRNA CTD PMID:21318169 bisphenol A multiple interactions EXP 6480464 [bisphenol A co-treated with Estradiol] results in decreased expression of IDH2 mRNA CTD PMID:26496021 bisphenol A decreases expression ISO RGD:1313391 6480464 bisphenol A results in decreased expression of IDH2 protein CTD PMID:34186270 bisphenol A decreases expression EXP 6480464 bisphenol A results in decreased expression of IDH2 mRNA CTD PMID:34947998 bisphenol A affects expression ISO RGD:1313391 6480464 bisphenol A affects the expression of IDH2 mRNA CTD PMID:30903817 bisphenol A affects expression EXP 6480464 bisphenol A affects the expression of IDH2 mRNA CTD PMID:25181051 Bisphenol B increases expression ISO RGD:1313391 6480464 bisphenol B results in increased expression of IDH2 protein CTD PMID:34186270 bisphenol F increases expression ISO RGD:1313391 6480464 bisphenol F results in increased expression of IDH2 protein CTD PMID:34186270 bleomycin A2 decreases expression EXP 6480464 Bleomycin results in decreased expression of IDH2 protein CTD PMID:25933445 butan-1-ol multiple interactions ISO RGD:1313391 6480464 [[Gasoline co-treated with 1-Butanol] results in increased abundance of [Particulate Matter co-treated with Polycyclic Aromatic Hydrocarbons]] which results in increased expression of IDH2 mRNA CTD PMID:29432896 carbon nanotube decreases expression ISO RGD:1557355 6480464 Nanotubes, Carbon results in decreased expression of IDH2 mRNA CTD PMID:25620056 choline multiple interactions ISO RGD:1557355 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of IDH2 gene CTD PMID:20938992 chromium(6+) affects expression ISO RGD:1557355 6480464 chromium hexavalent ion affects the expression of IDH2 mRNA CTD PMID:28472532 cisplatin multiple interactions ISO RGD:1313391 6480464 [Cisplatin co-treated with jinfukang] results in increased expression of IDH2 mRNA CTD PMID:27392435 cisplatin increases expression ISO RGD:1313391 6480464 Cisplatin results in increased expression of IDH2 mRNA CTD PMID:27392435 , PMID:27594783 clobetasol increases expression ISO RGD:1557355 6480464 Clobetasol results in increased expression of IDH2 mRNA CTD PMID:27462272 clozapine multiple interactions ISO RGD:1313391 6480464 [Cuprizone co-treated with Clozapine] results in decreased expression of IDH2 protein CTD PMID:34122009 cobalt dichloride decreases expression ISO RGD:1313391 6480464 cobaltous chloride results in decreased expression of IDH2 mRNA CTD PMID:19320972 , PMID:19376846 copper(II) sulfate decreases expression ISO RGD:1313391 6480464 Copper Sulfate results in decreased expression of IDH2 mRNA CTD PMID:19549813 creatinine multiple interactions ISO RGD:1557355 6480464 Triazines inhibits the reaction [IDH2 protein mutant form results in increased abundance of Creatinine] CTD PMID:27469509 creatinine increases abundance ISO RGD:1557355 6480464 IDH2 protein mutant form results in increased abundance of Creatinine CTD PMID:27469509 Cuprizon multiple interactions ISO RGD:1313391 6480464 [Cuprizone co-treated with Clozapine] results in decreased expression of IDH2 protein CTD PMID:34122009 cyclosporin A decreases expression ISO RGD:1313391 6480464 Cyclosporine results in decreased expression of IDH2 mRNA CTD PMID:20106945 more ... cytidine multiple interactions ISO RGD:1557355 6480464 Triazines inhibits the reaction [IDH2 protein mutant form results in increased abundance of Cytidine] CTD PMID:27469509 cytidine increases abundance ISO RGD:1557355 6480464 IDH2 protein mutant form results in increased abundance of Cytidine CTD PMID:27469509 D-erythrose 4-phosphate multiple interactions ISO RGD:1557355 6480464 Triazines inhibits the reaction [IDH2 protein mutant form results in increased abundance of erythrose 4-phosphate] CTD PMID:27469509 D-erythrose 4-phosphate increases abundance ISO RGD:1557355 6480464 IDH2 protein mutant form results in increased abundance of erythrose 4-phosphate CTD PMID:27469509 D-fructofuranose 1,6-bisphosphate increases abundance ISO RGD:1557355 6480464 IDH2 protein mutant form results in increased abundance of fructose-1, 6-diphosphate CTD PMID:27469509 D-fructofuranose 1,6-bisphosphate multiple interactions ISO RGD:1557355 6480464 Triazines inhibits the reaction [IDH2 protein mutant form results in increased abundance of fructose-1, 6-diphosphate] CTD PMID:27469509 D-glyceric acid increases abundance ISO RGD:1557355 6480464 IDH2 protein mutant form results in increased abundance of glyceric acid CTD PMID:27469509 D-glyceric acid multiple interactions ISO RGD:1557355 6480464 Triazines inhibits the reaction [IDH2 protein mutant form results in increased abundance of glyceric acid] CTD PMID:27469509 diarsenic trioxide increases expression ISO RGD:1313391 6480464 Arsenic Trioxide results in increased expression of IDH2 protein CTD PMID:25419056 diarsenic trioxide decreases expression EXP 6480464 Arsenic Trioxide results in decreased expression of IDH2 mRNA CTD PMID:29223816 diclofenac decreases expression ISO RGD:1557355 6480464 Diclofenac results in decreased expression of IDH2 mRNA CTD PMID:26934552 dihydroxyacetone phosphate multiple interactions ISO RGD:1557355 6480464 Triazines inhibits the reaction [IDH2 protein mutant form results in increased abundance of Dihydroxyacetone Phosphate] CTD PMID:27469509 dihydroxyacetone phosphate increases abundance ISO RGD:1557355 6480464 IDH2 protein mutant form results in increased abundance of Dihydroxyacetone Phosphate CTD PMID:27469509 Diosbulbin B decreases expression ISO RGD:1557355 6480464 diosbulbin B results in decreased expression of IDH2 mRNA CTD PMID:32148032 diuron increases expression EXP 6480464 Diuron results in increased expression of IDH2 mRNA CTD PMID:21551480 doxorubicin multiple interactions ISO RGD:1557355 6480464 [docetaxel co-treated with Doxorubicin] results in decreased expression of IDH2 protein CTD PMID:20457137 doxorubicin increases expression ISO RGD:1313391 6480464 Doxorubicin results in increased expression of IDH2 mRNA CTD PMID:29803840 doxorubicin decreases expression ISO RGD:1557355 6480464 Doxorubicin results in decreased expression of IDH2 mRNA CTD PMID:26873546 dTMP increases abundance ISO RGD:1557355 6480464 IDH2 protein mutant form results in increased abundance of Thymidine Monophosphate CTD PMID:27469509 dTMP multiple interactions ISO RGD:1557355 6480464 Triazines inhibits the reaction [IDH2 protein mutant form results in increased abundance of Thymidine Monophosphate] CTD PMID:27469509 endosulfan decreases expression EXP 6480464 Endosulfan results in decreased expression of IDH2 mRNA CTD PMID:29391264 ethanol multiple interactions ISO RGD:1313391 6480464 [[Gasoline co-treated with Ethanol] results in increased abundance of [Particulate Matter co-treated with Polycyclic Aromatic Hydrocarbons]] which results in increased expression of IDH2 mRNA CTD PMID:29432896 ethanol increases expression ISO RGD:1557355 6480464 Ethanol results in increased expression of IDH2 mRNA CTD PMID:30319688 FMN multiple interactions ISO RGD:1557355 6480464 Triazines inhibits the reaction [IDH2 protein mutant form results in increased abundance of Flavin Mononucleotide] CTD PMID:27469509 FMN increases abundance ISO RGD:1557355 6480464 IDH2 protein mutant form results in increased abundance of Flavin Mononucleotide CTD PMID:27469509 folic acid multiple interactions ISO RGD:1557355 6480464 [1 more ... CTD PMID:20938992 , PMID:22206623 folic acid decreases expression ISO RGD:1313391 6480464 Folic Acid deficiency results in decreased expression of IDH2 protein CTD PMID:28639913 GDP-alpha-D-glucose multiple interactions ISO RGD:1557355 6480464 Triazines inhibits the reaction [IDH2 protein mutant form results in increased abundance of guanosine diphosphate glucose] CTD PMID:27469509 GDP-alpha-D-glucose increases abundance ISO RGD:1557355 6480464 IDH2 protein mutant form results in increased abundance of guanosine diphosphate glucose CTD PMID:27469509 glutathione increases abundance ISO RGD:1557355 6480464 IDH2 protein mutant form results in increased abundance of Glutathione CTD PMID:27469509 glutathione multiple interactions ISO RGD:1557355 6480464 Triazines inhibits the reaction [IDH2 protein mutant form results in increased abundance of Glutathione] CTD PMID:27469509 glyceric acid multiple interactions ISO RGD:1557355 6480464 Triazines inhibits the reaction [IDH2 protein mutant form results in increased abundance of glyceric acid] CTD PMID:27469509 glyceric acid increases abundance ISO RGD:1557355 6480464 IDH2 protein mutant form results in increased abundance of glyceric acid CTD PMID:27469509 glycerol 1-phosphate increases abundance ISO RGD:1557355 6480464 IDH2 protein mutant form results in increased abundance of alpha-glycerophosphoric acid CTD PMID:27469509 glycerol 1-phosphate multiple interactions ISO RGD:1557355 6480464 Triazines inhibits the reaction [IDH2 protein mutant form results in increased abundance of alpha-glycerophosphoric acid] CTD PMID:27469509 glycine betaine increases abundance ISO RGD:1557355 6480464 IDH2 protein mutant form results in increased abundance of Betaine CTD PMID:27469509 glycine betaine multiple interactions ISO RGD:1557355 6480464 Triazines inhibits the reaction [IDH2 protein mutant form results in increased abundance of Betaine] CTD PMID:27469509 guanine increases abundance ISO RGD:1557355 6480464 IDH2 protein mutant form results in increased abundance of Guanine CTD PMID:27469509 guanine multiple interactions ISO RGD:1557355 6480464 Triazines inhibits the reaction [IDH2 protein mutant form results in increased abundance of Guanine] CTD PMID:27469509 Honokiol multiple interactions EXP 6480464 honokiol inhibits the reaction [Thioacetamide results in decreased activity of IDH2 protein] CTD PMID:33522075 hyaluronic acid decreases expression EXP 6480464 Hyaluronic Acid analog results in decreased expression of IDH2 protein CTD PMID:23178681 hydrogen peroxide decreases expression EXP 6480464 Hydrogen Peroxide results in decreased expression of IDH2 protein CTD PMID:23178681 , PMID:30104959 hydrogen peroxide multiple interactions ISO RGD:1313391 6480464 [GYY 4137 results in increased abundance of Hydrogen Sulfide] inhibits the reaction [Hydrogen Peroxide results in decreased expression of IDH2 protein], SIRT3 protein affects the reaction [[GYY 4137 results in increased abundance of Hydrogen Sulfide] inhibits the reaction [Hydrogen Peroxide results in decreased expression of IDH2 protein]] CTD PMID:26422756 hydrogen peroxide decreases expression ISO RGD:1313391 6480464 Hydrogen Peroxide results in decreased expression of IDH2 protein CTD PMID:26422756 hydrogen peroxide decreases activity EXP 6480464 Hydrogen Peroxide results in decreased activity of IDH2 protein CTD PMID:30104959 hydrogen peroxide multiple interactions EXP 6480464 Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in decreased activity of IDH2 protein] more ... CTD PMID:30104959 hydrogen sulfide multiple interactions ISO RGD:1313391 6480464 [GYY 4137 results in increased abundance of Hydrogen Sulfide] inhibits the reaction [Hydrogen Peroxide results in decreased expression of IDH2 protein], SIRT3 protein affects the reaction [[GYY 4137 results in increased abundance of Hydrogen Sulfide] inhibits the reaction [Hydrogen Peroxide results in decreased expression of IDH2 protein]] CTD PMID:26422756 hydrogen sulfide multiple interactions EXP 6480464 [[sodium sulfide results in increased abundance of Hydrogen Sulfide] which co-treated with Paraquat] results in decreased expression of IDH2 protein, [sodium sulfide results in increased abundance of Hydrogen Sulfide] inhibits the reaction [Paraquat results in decreased expression of and results in decreased activity of IDH2 protein] CTD PMID:32064027 ivermectin decreases expression ISO RGD:1313391 6480464 Ivermectin results in decreased expression of IDH2 protein CTD PMID:32959892 keto-D-fructose 1,6-bisphosphate multiple interactions ISO RGD:1557355 6480464 Triazines inhibits the reaction [IDH2 protein mutant form results in increased abundance of fructose-1, 6-diphosphate] CTD PMID:27469509 keto-D-fructose 1,6-bisphosphate increases abundance ISO RGD:1557355 6480464 IDH2 protein mutant form results in increased abundance of fructose-1, 6-diphosphate CTD PMID:27469509 L-alanine decreases abundance ISO RGD:1557355 6480464 IDH2 protein mutant form results in decreased abundance of Alanine CTD PMID:27469509 L-alanine multiple interactions ISO RGD:1557355 6480464 Triazines inhibits the reaction [IDH2 protein mutant form results in decreased abundance of Alanine] CTD PMID:27469509 L-methionine multiple interactions ISO RGD:1557355 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of IDH2 gene CTD PMID:20938992 lamivudine multiple interactions ISO RGD:1557355 6480464 [Zidovudine co-treated with Lamivudine] results in increased expression of IDH2 mRNA CTD PMID:18313992 malic acid multiple interactions ISO RGD:1557355 6480464 Triazines inhibits the reaction [IDH2 protein mutant form results in decreased abundance of malic acid] CTD PMID:27469509 malic acid decreases abundance ISO RGD:1557355 6480464 IDH2 protein mutant form results in decreased abundance of malic acid CTD PMID:27469509 methapyrilene decreases expression EXP 6480464 Methapyrilene results in decreased expression of IDH2 mRNA CTD PMID:30467583 methylisothiazolinone decreases expression ISO RGD:1313391 6480464 2-methyl-4-isothiazolin-3-one results in decreased expression of IDH2 mRNA CTD PMID:31629900 monosodium L-glutamate multiple interactions ISO RGD:1557355 6480464 [Fats more ... CTD PMID:20111022 , PMID:23783067 N-acetyl-L-cysteine multiple interactions EXP 6480464 Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in decreased activity of IDH2 protein], Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in decreased expression of IDH2 protein] CTD PMID:30104959 N-methylnicotinamide increases abundance ISO RGD:1557355 6480464 IDH2 protein mutant form results in increased abundance of N-methylnicotinamide CTD PMID:27469509 N-methylnicotinamide multiple interactions ISO RGD:1557355 6480464 Triazines inhibits the reaction [IDH2 protein mutant form results in increased abundance of N-methylnicotinamide] CTD PMID:27469509 N-nitrosodiethylamine multiple interactions ISO RGD:1557355 6480464 RB1 protein inhibits the reaction [Diethylnitrosamine results in increased expression of IDH2 mRNA] CTD PMID:17854601 N-nitrosodiethylamine increases expression ISO RGD:1557355 6480464 Diethylnitrosamine results in increased expression of IDH2 mRNA CTD PMID:17854601 NAD zwitterion increases abundance ISO RGD:1557355 6480464 IDH2 protein mutant form results in increased abundance of NAD, IDH2 protein mutant form results in increased abundance of NAD metabolite CTD PMID:27469509 NAD zwitterion multiple interactions ISO RGD:1557355 6480464 Triazines inhibits the reaction [IDH2 protein mutant form results in increased abundance of NAD metabolite], Triazines inhibits the reaction [IDH2 protein mutant form results in increased abundance of NAD] CTD PMID:27469509 NAD(+) multiple interactions ISO RGD:1557355 6480464 Triazines inhibits the reaction [IDH2 protein mutant form results in increased abundance of NAD metabolite], Triazines inhibits the reaction [IDH2 protein mutant form results in increased abundance of NAD] CTD PMID:27469509 NAD(+) increases abundance ISO RGD:1557355 6480464 IDH2 protein mutant form results in increased abundance of NAD, IDH2 protein mutant form results in increased abundance of NAD metabolite CTD PMID:27469509 NADP zwitterion multiple interactions ISO RGD:1557355 6480464 Triazines inhibits the reaction [IDH2 protein mutant form results in increased abundance of NADP] CTD PMID:27469509 NADP zwitterion increases abundance ISO RGD:1557355 6480464 IDH2 protein mutant form results in increased abundance of NADP CTD PMID:27469509 NADP(+) multiple interactions ISO RGD:1557355 6480464 Triazines inhibits the reaction [IDH2 protein mutant form results in increased abundance of NADP] CTD PMID:27469509 NADP(+) increases abundance ISO RGD:1557355 6480464 IDH2 protein mutant form results in increased abundance of NADP CTD PMID:27469509 nickel dichloride increases activity ISO RGD:1313391 6480464 nickel chloride results in increased activity of IDH2 protein CTD PMID:17018869 O-acetyl-L-carnitine increases abundance ISO RGD:1557355 6480464 IDH2 protein mutant form results in increased abundance of Acetylcarnitine CTD PMID:27469509 O-acetyl-L-carnitine multiple interactions ISO RGD:1557355 6480464 Triazines inhibits the reaction [IDH2 protein mutant form results in increased abundance of Acetylcarnitine] CTD PMID:27469509 O-butanoyl-L-carnitine multiple interactions ISO RGD:1557355 6480464 Triazines inhibits the reaction [IDH2 protein mutant form results in increased abundance of butyrylcarnitine] CTD PMID:27469509 O-butanoyl-L-carnitine increases abundance ISO RGD:1557355 6480464 IDH2 protein mutant form results in increased abundance of butyrylcarnitine CTD PMID:27469509 oxybenzone decreases expression EXP 6480464 oxybenzone results in decreased expression of IDH2 mRNA CTD PMID:30316929 paclitaxel affects response to substance ISO RGD:1313391 6480464 IDH2 protein affects the susceptibility to Paclitaxel CTD PMID:16217747 paclitaxel decreases expression ISO RGD:1313391 6480464 Paclitaxel results in decreased expression of IDH2 mRNA CTD PMID:15000894 paracetamol increases expression ISO RGD:1313391 6480464 Acetaminophen results in increased expression of IDH2 mRNA CTD PMID:25704631 paraquat decreases expression EXP 6480464 Paraquat results in decreased expression of IDH2 protein CTD PMID:32064027 paraquat multiple interactions EXP 6480464 [[sodium sulfide results in increased abundance of Hydrogen Sulfide] which co-treated with Paraquat] results in decreased expression of IDH2 protein more ... CTD PMID:32064027 perfluorononanoic acid decreases expression ISO RGD:1313391 6480464 perfluoro-n-nonanoic acid results in decreased expression of IDH2 mRNA CTD PMID:32588087 perfluorooctanoic acid decreases expression EXP 6480464 perfluorooctanoic acid results in decreased expression of IDH2 mRNA CTD PMID:19162173 phenobarbital multiple interactions ISO RGD:1557355 6480464 NR1I3 protein affects the reaction [Phenobarbital results in increased expression of IDH2 mRNA] CTD PMID:19482888 phenobarbital affects expression ISO RGD:1313391 6480464 Phenobarbital affects the expression of IDH2 mRNA CTD PMID:19159669 phenobarbital increases expression EXP 6480464 Phenobarbital results in increased expression of IDH2 mRNA CTD PMID:19162173 phenobarbital increases expression ISO RGD:1557355 6480464 Phenobarbital results in increased expression of IDH2 mRNA CTD PMID:19482888 PhIP increases expression EXP 6480464 2-amino-1-methyl-6-phenylimidazo(4, 5-b)pyridine results in increased expression of IDH2 mRNA CTD PMID:33945839 phlorizin increases expression ISO RGD:1557355 6480464 Phlorhizin results in increased expression of IDH2 mRNA CTD PMID:22538082 pirinixic acid multiple interactions ISO RGD:1313391 6480464 [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of IDH2 mRNA CTD PMID:19710929 pirinixic acid multiple interactions ISO RGD:1557355 6480464 PPARA protein affects the reaction [pirinixic acid results in increased expression of IDH2 mRNA] CTD PMID:21318169 pirinixic acid increases expression ISO RGD:1557355 6480464 pirinixic acid results in increased expression of IDH2 mRNA CTD PMID:21318169 potassium chromate decreases expression ISO RGD:1313391 6480464 potassium chromate(VI) results in decreased expression of IDH2 mRNA CTD PMID:22714537 pregnenolone 16alpha-carbonitrile decreases expression ISO RGD:1557355 6480464 Pregnenolone Carbonitrile results in decreased expression of IDH2 mRNA CTD PMID:28903501 prostaglandin A1 increases metabolic processing ISO RGD:1557355 6480464 prostaglandin A1 analog results in increased metabolism of IDH2 protein CTD PMID:19800325 pyruvic acid multiple interactions ISO RGD:1557355 6480464 Triazines inhibits the reaction [IDH2 protein mutant form results in increased abundance of Pyruvic Acid] CTD PMID:27469509 pyruvic acid increases abundance ISO RGD:1557355 6480464 IDH2 protein mutant form results in increased abundance of Pyruvic Acid CTD PMID:27469509 rac-lactic acid increases abundance ISO RGD:1557355 6480464 IDH2 protein mutant form results in increased abundance of Lactic Acid CTD PMID:27469509 rac-lactic acid multiple interactions ISO RGD:1557355 6480464 Triazines inhibits the reaction [IDH2 protein mutant form results in increased abundance of Lactic Acid] CTD PMID:27469509 raloxifene affects expression EXP 6480464 Raloxifene Hydrochloride affects the expression of IDH2 mRNA CTD PMID:16079270 raloxifene affects expression ISO RGD:1313391 6480464 Raloxifene Hydrochloride affects the expression of IDH2 mRNA CTD PMID:14699072 raloxifene multiple interactions ISO RGD:1313391 6480464 [Raloxifene Hydrochloride co-treated with ESR1 protein] results in increased expression of IDH2 mRNA, ESR1 protein affects the reaction [Raloxifene Hydrochloride results in increased expression of IDH2 mRNA] CTD PMID:14699072 , PMID:19059307 resveratrol multiple interactions ISO RGD:1313391 6480464 resveratrol inhibits the reaction [tert-Butylhydroperoxide results in decreased activity of IDH2 protein], SIRT3 mutant form inhibits the reaction [resveratrol inhibits the reaction [tert-Butylhydroperoxide results in decreased activity of IDH2 protein]] CTD PMID:25522270 resveratrol increases expression EXP 6480464 resveratrol results in increased expression of IDH2 mRNA CTD PMID:25905778 resveratrol increases expression ISO RGD:1557355 6480464 resveratrol results in increased expression of IDH2 protein CTD PMID:25505154 rotenone increases expression EXP 6480464 Rotenone results in increased expression of IDH2 mRNA, Rotenone results in increased expression of IDH2 protein CTD PMID:28374803 , PMID:35544339 sedoheptulose 1,7-bisphosphate multiple interactions ISO RGD:1557355 6480464 Triazines inhibits the reaction [IDH2 protein mutant form results in increased abundance of sedoheptulose 1, 7-bisphosphate] CTD PMID:27469509 sedoheptulose 1,7-bisphosphate increases abundance ISO RGD:1557355 6480464 IDH2 protein mutant form results in increased abundance of sedoheptulose 1, 7-bisphosphate CTD PMID:27469509 silicon dioxide decreases expression ISO RGD:1313391 6480464 Silicon Dioxide analog results in decreased expression of IDH2 mRNA CTD PMID:25895662 sodium arsenite multiple interactions ISO RGD:1313391 6480464 sodium arsenite results in decreased expression of and affects the splicing of IDH2 mRNA CTD PMID:25879800 sodium arsenite increases expression ISO RGD:1313391 6480464 sodium arsenite results in increased expression of IDH2 mRNA CTD PMID:34032870 sodium fluoride decreases expression ISO RGD:1557355 6480464 Sodium Fluoride results in decreased expression of IDH2 mRNA, Sodium Fluoride results in decreased expression of IDH2 protein CTD PMID:27548804 , PMID:27862939 sodium fluoride multiple interactions ISO RGD:1557355 6480464 [Sodium Fluoride results in increased abundance of Fluorides] which results in decreased activity of IDH2 protein CTD PMID:34780879 sodium fluoride multiple interactions ISO RGD:1313391 6480464 [Sodium Fluoride results in increased abundance of Fluorides] which results in decreased activity of IDH2 protein, SIRT3 protein inhibits the reaction [[Sodium Fluoride results in increased abundance of Fluorides] which results in decreased activity of IDH2 protein] CTD PMID:34780879 sodium sulfide (anhydrous) multiple interactions EXP 6480464 [[sodium sulfide results in increased abundance of Hydrogen Sulfide] which co-treated with Paraquat] results in decreased expression of IDH2 protein, [sodium sulfide results in increased abundance of Hydrogen Sulfide] inhibits the reaction [Paraquat results in decreased expression of and results in decreased activity of IDH2 protein] CTD PMID:32064027 Soman decreases expression EXP 6480464 Soman results in decreased expression of IDH2 mRNA CTD PMID:19281266 spermine increases abundance ISO RGD:1557355 6480464 IDH2 protein mutant form results in increased abundance of Spermine CTD PMID:27469509 spermine multiple interactions ISO RGD:1557355 6480464 Triazines inhibits the reaction [IDH2 protein mutant form results in increased abundance of Spermine] CTD PMID:27469509 streptozocin affects expression ISO RGD:1557355 6480464 Streptozocin affects the expression of IDH2 mRNA CTD PMID:18583417 sunitinib decreases expression ISO RGD:1313391 6480464 Sunitinib results in decreased expression of IDH2 mRNA CTD PMID:31533062 tamoxifen affects expression ISO RGD:1313391 6480464 Tamoxifen affects the expression of IDH2 mRNA CTD PMID:14699072 tamoxifen multiple interactions ISO RGD:1313391 6480464 [Tamoxifen co-treated with ESR1 protein] results in increased expression of IDH2 mRNA CTD PMID:19059307 taurine increases abundance ISO RGD:1557355 6480464 IDH2 protein mutant form results in increased abundance of Taurine CTD PMID:27469509 taurine multiple interactions ISO RGD:1557355 6480464 Triazines inhibits the reaction [IDH2 protein mutant form results in increased abundance of Taurine] CTD PMID:27469509 temozolomide decreases expression ISO RGD:1313391 6480464 Temozolomide results in decreased expression of IDH2 mRNA CTD PMID:31758290 tert-butyl hydroperoxide decreases activity ISO RGD:1313391 6480464 tert-Butylhydroperoxide results in decreased activity of IDH2 protein CTD PMID:25522270 tert-butyl hydroperoxide multiple interactions ISO RGD:1313391 6480464 Resveratrol inhibits the reaction [tert-Butylhydroperoxide results in decreased activity of IDH2 protein], SIRT3 mutant form inhibits the reaction [Resveratrol inhibits the reaction [tert-Butylhydroperoxide results in decreased activity of IDH2 protein]] CTD PMID:25522270 tetrachloromethane multiple interactions EXP 6480464 schizandrin B inhibits the reaction [Carbon Tetrachloride results in decreased expression of IDH2 mRNA] CTD PMID:31150632 tetrachloromethane decreases expression ISO RGD:1557355 6480464 Carbon Tetrachloride results in decreased expression of IDH2 mRNA CTD PMID:31919559 tetrachloromethane decreases expression EXP 6480464 Carbon Tetrachloride results in decreased expression of IDH2 mRNA CTD PMID:31150632 thioacetamide multiple interactions EXP 6480464 honokiol inhibits the reaction [Thioacetamide results in decreased activity of IDH2 protein] CTD PMID:33522075 thioacetamide decreases expression EXP 6480464 Thioacetamide results in decreased expression of IDH2 mRNA CTD PMID:34492290 thioacetamide decreases activity EXP 6480464 Thioacetamide results in decreased activity of IDH2 protein CTD PMID:33522075 triazines multiple interactions ISO RGD:1557355 6480464 Triazines inhibits the reaction [IDH2 protein mutant form results in decreased abundance of Alanine] more ... CTD PMID:27469509 trilobatin multiple interactions EXP 6480464 trilobatin inhibits the reaction [Hydrogen Peroxide results in decreased activity of IDH2 protein], trilobatin inhibits the reaction [Hydrogen Peroxide results in decreased expression of IDH2 protein] CTD PMID:30104959 triptonide decreases expression ISO RGD:1557355 6480464 triptonide results in decreased expression of IDH2 mRNA CTD PMID:33045310 trovafloxacin decreases expression EXP 6480464 trovafloxacin results in decreased expression of IDH2 mRNA CTD PMID:24136188 trovafloxacin decreases expression ISO RGD:1557355 6480464 trovafloxacin results in decreased expression of IDH2 mRNA CTD PMID:35537566 tunicamycin decreases expression ISO RGD:1313391 6480464 Tunicamycin results in decreased expression of IDH2 mRNA CTD PMID:20196124 tunicamycin increases expression ISO RGD:1313391 6480464 Tunicamycin results in increased expression of IDH2 mRNA CTD PMID:29453283 UDP increases abundance ISO RGD:1557355 6480464 IDH2 protein mutant form results in increased abundance of Uridine Diphosphate CTD PMID:27469509 UDP multiple interactions ISO RGD:1557355 6480464 Triazines inhibits the reaction [IDH2 protein mutant form results in increased abundance of Uridine Diphosphate] CTD PMID:27469509 UDP-N-acetyl-alpha-D-glucosamine multiple interactions ISO RGD:1557355 6480464 Triazines inhibits the reaction [IDH2 protein mutant form results in increased abundance of Uridine Diphosphate N-Acetylglucosamine] CTD PMID:27469509 UDP-N-acetyl-alpha-D-glucosamine increases abundance ISO RGD:1557355 6480464 IDH2 protein mutant form results in increased abundance of Uridine Diphosphate N-Acetylglucosamine CTD PMID:27469509 uridine multiple interactions ISO RGD:1557355 6480464 Triazines inhibits the reaction [IDH2 protein mutant form results in increased abundance of Uridine] CTD PMID:27469509 uridine increases abundance ISO RGD:1557355 6480464 IDH2 protein mutant form results in increased abundance of Uridine CTD PMID:27469509 valproic acid decreases expression ISO RGD:1313391 6480464 Valproic Acid results in decreased expression of IDH2 mRNA CTD PMID:19101580 more ... valproic acid increases methylation ISO RGD:1313391 6480464 Valproic Acid results in increased methylation of IDH2 gene CTD PMID:29501571 valproic acid increases expression ISO RGD:1313391 6480464 Valproic Acid results in increased expression of IDH2 mRNA CTD PMID:24383497 vincaleukoblastine affects response to substance ISO RGD:1313391 6480464 IDH2 protein affects the susceptibility to Vinblastine CTD PMID:16217747 VX nerve agent decreases activity EXP 6480464 VX results in decreased activity of IDH2 protein CTD PMID:28267914 XL147 multiple interactions ISO RGD:1557355 6480464 XL147 inhibits the reaction [N-nitroso-tris-chloroethylurea results in increased expression of IDH2 mRNA] CTD PMID:29891994 zidovudine multiple interactions ISO RGD:1557355 6480464 [Zidovudine co-treated with Lamivudine] results in increased expression of IDH2 mRNA CTD PMID:18313992 zoledronic acid decreases expression ISO RGD:1313391 6480464 zoledronic acid results in decreased expression of IDH2 mRNA CTD PMID:24714768 zoledronic acid increases expression ISO RGD:1313391 6480464 zoledronic acid results in increased expression of IDH2 protein CTD PMID:28871336
