Ptprs (protein tyrosine phosphatase, receptor type, S) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Gene: Ptprs (protein tyrosine phosphatase, receptor type, S) Rattus norvegicus
Analyze
Symbol: Ptprs
Name: protein tyrosine phosphatase, receptor type, S
RGD ID: 3452
Description: Enables protein tyrosine phosphatase activity. Involved in presynapse assembly; regulation of postsynaptic density assembly; and synaptic membrane adhesion. Located in postsynaptic density membrane and synaptic vesicle membrane. Is active in glutamatergic synapse and presynaptic membrane. Orthologous to human PTPRS (protein tyrosine phosphatase receptor type S); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-diaminodiphenylmethane; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LAR-PTP2; Larptp2; leukocyte common antigen-related protein-tyrosine phosphatase 2; leukocyte common antigen-related proten-tyrosine phosphatase 2; MGC124537; protein tyrosine phosphatase, receptor type, D; Ptprd; Ptpsigma; Ptpsigma.; R-PTP-S; R-PTP-sigma; receptor-type tyrosine-protein phosphatase S; receptor-type tyrosine-protein phosphatase sigma; Rptpd
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr891,332,558 - 1,394,161 (-)NCBIGRCr8
mRatBN7.291,245,408 - 1,307,015 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl91,245,410 - 1,306,947 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx91,691,696 - 1,752,582 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.097,039,698 - 7,100,595 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.095,996,746 - 6,057,635 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0910,585,360 - 10,646,205 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl910,603,813 - 10,645,939 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.099,578,004 - 9,637,940 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera97,203,284 - 7,264,120 (+)NCBICelera
Cytogenetic Map9q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-butoxyethanol  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
acrylamide  (EXP)
aflatoxin B1  (EXP,ISO)
Aflatoxin B2 alpha  (ISO)
all-trans-retinoic acid  (ISO)
allethrin  (EXP)
amitrole  (EXP)
amphetamine  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
atrazine  (EXP)
benzo[a]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chlordecone  (ISO)
chloroprene  (EXP)
chlorpyrifos  (ISO)
choline  (ISO)
clobetasol  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
cyhalothrin  (EXP)
cypermethrin  (EXP)
DDE  (ISO)
dibutyl phthalate  (EXP,ISO)
dicrotophos  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
ethanol  (ISO)
fenvalerate  (EXP)
folic acid  (ISO)
FR900359  (ISO)
fulvestrant  (ISO)
glutathione  (EXP)
glyphosate  (ISO)
indole-3-methanol  (EXP)
L-methionine  (ISO)
methamphetamine  (ISO)
methapyrilene  (EXP)
methimazole  (EXP)
methoxychlor  (EXP)
miconazole  (ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (ISO)
N-nitrosodiethylamine  (EXP)
ozone  (ISO)
paraquat  (EXP)
PCB138  (ISO)
perfluorohexanesulfonic acid  (ISO)
phenylmercury acetate  (ISO)
piperonyl butoxide  (EXP)
pirinixic acid  (ISO)
potassium dichromate  (ISO)
propanal  (ISO)
pyrethrins  (EXP)
rotenone  (EXP)
SB 431542  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP)
sodium fluoride  (ISO)
tamoxifen  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
trichloroethene  (ISO)
trichostatin A  (ISO)
triphenyl phosphate  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. SALM5 trans-synaptically interacts with LAR-RPTPs in a splicing-dependent manner to regulate synapse development. Choi Y, etal., Sci Rep. 2016 May 26;6:26676. doi: 10.1038/srep26676.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Receptor protein tyrosine phosphatase sigma regulates synapse structure, function and plasticity. Horn KE, etal., J Neurochem. 2012 Jul;122(1):147-61. doi: 10.1111/j.1471-4159.2012.07762.x. Epub 2012 May 17.
5. Trans-synaptic adhesions between netrin-G ligand-3 (NGL-3) and receptor tyrosine phosphatases LAR, protein-tyrosine phosphatase delta (PTPdelta), and PTPsigma via specific domains regulate excitatory synapse formation. Kwon SK, etal., J Biol Chem. 2010 Apr 30;285(18):13966-78. doi: 10.1074/jbc.M109.061127. Epub 2010 Feb 6.
6. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
7. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
8. Cloning and expression of two structurally distinct receptor-linked protein-tyrosine phosphatases generated by RNA processing from a single gene. Pan MG, etal., J Biol Chem 1993 Sep 15;268(26):19284-91.
9. GOA pipeline RGD automated data pipeline
10. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
11. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
12. Postsynaptic TrkC and presynaptic PTPs function as a bidirectional excitatory synaptic organizing complex. Takahashi H, etal., Neuron. 2011 Jan 27;69(2):287-303. doi: 10.1016/j.neuron.2010.12.024.
13. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
14. A novel receptor-type protein tyrosine phosphatase is expressed during neurogenesis in the olfactory neuroepithelium. Walton KM, etal., Neuron 1993 Aug;11(2):387-400.
15. Molecular cloning and expression of a unique receptor-like protein-tyrosine-phosphatase in the leucocyte-common-antigen-related phosphate family. Zhang WR, etal., Biochem J 1994 Aug 15;302 ( Pt 1):39-47.
Additional References at PubMed
PMID:7529177   PMID:8229209   PMID:8524829   PMID:12110683   PMID:12477932   PMID:15750591   PMID:15842738   PMID:19780196   PMID:22406547   PMID:23345436   PMID:23376485   PMID:23533145  
PMID:23718120   PMID:24385580   PMID:25470046   PMID:25624497   PMID:26231120   PMID:26464223   PMID:28752900   PMID:33662380  


Genomics

Comparative Map Data
Ptprs
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr891,332,558 - 1,394,161 (-)NCBIGRCr8
mRatBN7.291,245,408 - 1,307,015 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl91,245,410 - 1,306,947 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx91,691,696 - 1,752,582 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.097,039,698 - 7,100,595 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.095,996,746 - 6,057,635 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0910,585,360 - 10,646,205 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl910,603,813 - 10,645,939 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.099,578,004 - 9,637,940 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera97,203,284 - 7,264,120 (+)NCBICelera
Cytogenetic Map9q11NCBI
PTPRS
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38195,205,508 - 5,340,812 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl195,158,495 - 5,340,812 (-)EnsemblGRCh38hg38GRCh38
GRCh37195,205,519 - 5,340,823 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36195,156,519 - 5,291,814 (-)NCBINCBI36Build 36hg18NCBI36
Build 34195,157,380 - 5,237,399NCBI
Celera195,143,031 - 5,278,326 (-)NCBICelera
Cytogenetic Map19p13.3NCBI
HuRef194,967,302 - 5,101,977 (-)NCBIHuRef
CHM1_1195,205,046 - 5,340,693 (-)NCBICHM1_1
T2T-CHM13v2.0195,192,102 - 5,327,425 (-)NCBIT2T-CHM13v2.0
Ptprs
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391756,719,426 - 56,783,480 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1756,719,426 - 56,783,483 (-)EnsemblGRCm39 Ensembl
GRCm381756,412,426 - 56,476,561 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1756,412,426 - 56,476,483 (-)EnsemblGRCm38mm10GRCm38
MGSCv371756,551,849 - 56,615,903 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361756,046,141 - 56,110,077 (-)NCBIMGSCv36mm8
Celera1760,758,165 - 60,822,309 (-)NCBICelera
Cytogenetic Map17DNCBI
cM Map1729.32NCBI
Ptprs
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554953,943,170 - 3,990,927 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554953,943,075 - 3,991,361 (+)NCBIChiLan1.0ChiLan1.0
PTPRS
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2209,606,261 - 9,741,280 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1198,832,498 - 8,967,414 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0194,227,038 - 4,361,958 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1195,167,338 - 5,254,343 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl195,168,599 - 5,247,778 (-)Ensemblpanpan1.1panPan2
PTPRS
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12054,575,853 - 54,672,141 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2054,575,895 - 54,672,068 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2054,301,762 - 54,397,754 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02055,231,459 - 55,327,738 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2055,231,447 - 55,326,993 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12054,293,104 - 54,389,219 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02054,773,757 - 54,869,877 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02054,971,421 - 55,067,624 (+)NCBIUU_Cfam_GSD_1.0
Ptprs
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118214,761,700 - 214,813,370 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365883,022,321 - 3,072,993 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365883,021,418 - 3,073,080 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PTPRS
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl273,574,854 - 73,680,686 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1273,607,815 - 73,680,685 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2274,545,303 - 74,550,135 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PTPRS
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.164,880,942 - 5,019,654 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl64,882,223 - 4,964,919 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660813,106,747 - 3,243,187 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ptprs
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248284,716,249 - 4,764,614 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248284,688,555 - 4,764,805 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Ptprs
77 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1091
Count of miRNA genes:257
Interacting mature miRNAs:312
Transcripts:ENSRNOT00000073991, ENSRNOT00000074469
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70226Eae4Experimental allergic encephalomyelitis QTL 4nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)9125661317Rat
10054141Gmadr4Adrenal mass QTL 42.450.0074adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)9114209783Rat
9589158Gluco65Glucose level QTL 656.820.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)9137999212Rat
10054125Srcrt7Stress Responsive Cort QTL 73.330.0011blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)9187073594Rat
2303559Gluco54Glucose level QTL 542blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)9125408446254084Rat
7411592Foco8Food consumption QTL 87.40.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)9137999212Rat
1331757Cdexp1CD45RC expression in CD8 T cells QTL 14.3CD8-positive T cell quantity (VT:0008077)blood CD45RC(high) CD8 T cell count to CD45RC(low) CD8 T cell count ratio (CMO:0001990)9102453767509080Rat
1298088Edpm11Estrogen-dependent pituitary mass QTL 112.5pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)9143718459Rat
9589055Scfw5Subcutaneous fat weight QTL 55.550.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)9137999212Rat
1641911Alcrsp13Alcohol response QTL 13response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)9143718459Rat
1354650Despr5Despair related QTL 54.010.0017locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)9125408446254084Rat
1300124Cm4Cardiac mass QTL 43.55heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)9140594091Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 42 45 29 18 29 4 7 74 22 41 11 4
Low 3 1 12 12 1 12 4 4 13 4
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_019140 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039083058 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039083059 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039083066 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039083067 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039083068 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063266697 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063266698 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063266699 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063266701 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063266702 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063266703 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063266704 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide BC105753 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH474092 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000009 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L12329 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L19180 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L19181 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L19933 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U03273 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000073991   ⟹   ENSRNOP00000065227
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl91,246,039 - 1,306,947 (-)Ensembl
Rnor_6.0 Ensembl910,603,813 - 10,645,939 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000074469   ⟹   ENSRNOP00000066443
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl91,245,998 - 1,285,600 (-)Ensembl
Rnor_6.0 Ensembl910,603,813 - 10,645,939 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000079999   ⟹   ENSRNOP00000071910
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl91,246,039 - 1,306,947 (-)Ensembl
Rnor_6.0 Ensembl910,603,813 - 10,645,939 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000099559   ⟹   ENSRNOP00000084660
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl91,245,998 - 1,285,600 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000103214   ⟹   ENSRNOP00000084874
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl91,245,410 - 1,292,680 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000104893   ⟹   ENSRNOP00000084417
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl91,245,410 - 1,292,680 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000111910   ⟹   ENSRNOP00000093127
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl91,245,410 - 1,285,600 (-)Ensembl
RefSeq Acc Id: NM_019140   ⟹   NP_062013
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr891,333,188 - 1,394,091 (-)NCBI
mRatBN7.291,246,039 - 1,306,945 (-)NCBI
Rnor_6.0910,585,360 - 10,646,205 (+)NCBI
Rnor_5.099,578,004 - 9,637,940 (+)NCBI
Celera97,203,284 - 7,264,120 (+)RGD
Sequence:
RefSeq Acc Id: XM_039083058   ⟹   XP_038938986
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr891,332,558 - 1,394,161 (-)NCBI
mRatBN7.291,245,408 - 1,307,015 (-)NCBI
RefSeq Acc Id: XM_039083059   ⟹   XP_038938987
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr891,332,558 - 1,379,833 (-)NCBI
mRatBN7.291,245,409 - 1,292,680 (-)NCBI
RefSeq Acc Id: XM_039083066   ⟹   XP_038938994
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr891,332,558 - 1,394,160 (-)NCBI
mRatBN7.291,246,037 - 1,306,945 (-)NCBI
RefSeq Acc Id: XM_039083067   ⟹   XP_038938995
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr891,332,558 - 1,394,160 (-)NCBI
mRatBN7.291,245,408 - 1,307,015 (-)NCBI
RefSeq Acc Id: XM_039083068   ⟹   XP_038938996
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr891,332,558 - 1,354,472 (-)NCBI
mRatBN7.291,245,408 - 1,267,584 (-)NCBI
RefSeq Acc Id: XM_063266697   ⟹   XP_063122767
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr891,332,558 - 1,379,833 (-)NCBI
RefSeq Acc Id: XM_063266698   ⟹   XP_063122768
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr891,332,558 - 1,379,266 (-)NCBI
RefSeq Acc Id: XM_063266699   ⟹   XP_063122769
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr891,332,558 - 1,394,161 (-)NCBI
RefSeq Acc Id: XM_063266701   ⟹   XP_063122771
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr891,332,558 - 1,394,161 (-)NCBI
RefSeq Acc Id: XM_063266702   ⟹   XP_063122772
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr891,332,558 - 1,379,833 (-)NCBI
RefSeq Acc Id: XM_063266703   ⟹   XP_063122773
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr891,332,558 - 1,394,161 (-)NCBI
RefSeq Acc Id: XM_063266704   ⟹   XP_063122774
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr891,332,558 - 1,394,161 (-)NCBI
Protein Sequences
Protein RefSeqs NP_062013 (Get FASTA)   NCBI Sequence Viewer  
  XP_038938986 (Get FASTA)   NCBI Sequence Viewer  
  XP_038938987 (Get FASTA)   NCBI Sequence Viewer  
  XP_038938994 (Get FASTA)   NCBI Sequence Viewer  
  XP_038938995 (Get FASTA)   NCBI Sequence Viewer  
  XP_038938996 (Get FASTA)   NCBI Sequence Viewer  
  XP_063122767 (Get FASTA)   NCBI Sequence Viewer  
  XP_063122768 (Get FASTA)   NCBI Sequence Viewer  
  XP_063122769 (Get FASTA)   NCBI Sequence Viewer  
  XP_063122771 (Get FASTA)   NCBI Sequence Viewer  
  XP_063122772 (Get FASTA)   NCBI Sequence Viewer  
  XP_063122773 (Get FASTA)   NCBI Sequence Viewer  
  XP_063122774 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA42309 (Get FASTA)   NCBI Sequence Viewer  
  AAA50568 (Get FASTA)   NCBI Sequence Viewer  
  AAA75407 (Get FASTA)   NCBI Sequence Viewer  
  AAC37657 (Get FASTA)   NCBI Sequence Viewer  
  AAC52124 (Get FASTA)   NCBI Sequence Viewer  
  AAI05754 (Get FASTA)   NCBI Sequence Viewer  
  EDL83634 (Get FASTA)   NCBI Sequence Viewer  
  EDL83635 (Get FASTA)   NCBI Sequence Viewer  
  EDL83636 (Get FASTA)   NCBI Sequence Viewer  
  EDL83637 (Get FASTA)   NCBI Sequence Viewer  
  EDL83638 (Get FASTA)   NCBI Sequence Viewer  
  EDL83639 (Get FASTA)   NCBI Sequence Viewer  
  EDL83640 (Get FASTA)   NCBI Sequence Viewer  
  EDL83641 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000065227
  ENSRNOP00000065227.3
  ENSRNOP00000066443.3
  ENSRNOP00000071910.2
  ENSRNOP00000084417.1
  ENSRNOP00000084660.1
  ENSRNOP00000084874.1
  ENSRNOP00000093127.1
  ENSRNOP00055021755
  ENSRNOP00060030636
  ENSRNOP00065016959
GenBank Protein Q64605 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_062013   ⟸   NM_019140
- Peptide Label: precursor
- UniProtKB: M0R711 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000071910   ⟸   ENSRNOT00000079999
Ensembl Acc Id: ENSRNOP00000065227   ⟸   ENSRNOT00000073991
Ensembl Acc Id: ENSRNOP00000066443   ⟸   ENSRNOT00000074469
RefSeq Acc Id: XP_038938995   ⟸   XM_039083067
- Peptide Label: isoform X8
- UniProtKB: Q4JFL8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038938986   ⟸   XM_039083058
- Peptide Label: isoform X1
- UniProtKB: A0A8I5ZXU5 (UniProtKB/TrEMBL),   M0R711 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038938996   ⟸   XM_039083068
- Peptide Label: isoform X9
RefSeq Acc Id: XP_038938987   ⟸   XM_039083059
- Peptide Label: isoform X3
- UniProtKB: Q64621 (UniProtKB/Swiss-Prot),   Q64605 (UniProtKB/Swiss-Prot),   Q3KRE9 (UniProtKB/Swiss-Prot),   Q07808 (UniProtKB/Swiss-Prot),   Q64675 (UniProtKB/Swiss-Prot),   M0R711 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038938994   ⟸   XM_039083066
- Peptide Label: isoform X7
- UniProtKB: Q4JFL8 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000084874   ⟸   ENSRNOT00000103214
Ensembl Acc Id: ENSRNOP00000084417   ⟸   ENSRNOT00000104893
Ensembl Acc Id: ENSRNOP00000084660   ⟸   ENSRNOT00000099559
Ensembl Acc Id: ENSRNOP00000093127   ⟸   ENSRNOT00000111910
RefSeq Acc Id: XP_063122774   ⟸   XM_063266704
- Peptide Label: isoform X6
- UniProtKB: A0A8I6AF78 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063122773   ⟸   XM_063266703
- Peptide Label: isoform X5
- UniProtKB: M0R711 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063122771   ⟸   XM_063266701
- Peptide Label: isoform X4
- UniProtKB: A0A8I6AF78 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063122769   ⟸   XM_063266699
- Peptide Label: isoform X2
- UniProtKB: A0A8I6AF78 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063122772   ⟸   XM_063266702
- Peptide Label: isoform X4
- UniProtKB: A0A8I6AF78 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063122767   ⟸   XM_063266697
- Peptide Label: isoform X1
- UniProtKB: M0R711 (UniProtKB/TrEMBL),   A0A8I5ZXU5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063122768   ⟸   XM_063266698
- Peptide Label: isoform X1
- UniProtKB: M0R711 (UniProtKB/TrEMBL),   A0A8I5ZXU5 (UniProtKB/TrEMBL)
Protein Domains
Fibronectin type-III   Ig-like   Ig-like C2-type   Tyrosine specific protein phosphatases   Tyrosine-protein phosphatase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q64605-F1-model_v2 AlphaFold Q64605 1-1907 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3452 AgrOrtholog
BioCyc Gene G2FUF-28531 BioCyc
Ensembl Genes ENSRNOG00000047247 Ensembl, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055015334 UniProtKB/Swiss-Prot
  ENSRNOG00060019713 UniProtKB/Swiss-Prot
  ENSRNOG00065013010 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000073991 UniProtKB/TrEMBL
  ENSRNOT00000073991.4 UniProtKB/Swiss-Prot
  ENSRNOT00000074469.3 UniProtKB/TrEMBL
  ENSRNOT00000079999.2 UniProtKB/TrEMBL
  ENSRNOT00000099559.1 UniProtKB/TrEMBL
  ENSRNOT00000103214.1 UniProtKB/Swiss-Prot
  ENSRNOT00000104893.1 UniProtKB/TrEMBL
  ENSRNOT00000111910.1 UniProtKB/TrEMBL
  ENSRNOT00055026900 UniProtKB/Swiss-Prot
  ENSRNOT00060037142 UniProtKB/Swiss-Prot
  ENSRNOT00065021883 UniProtKB/Swiss-Prot
Gene3D-CATH 2.60.40.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.90.190.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:5599711 IMAGE-MGC_LOAD
InterPro FN3_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FN3_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig_I-set UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig_sub UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig_sub2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot-tyrosine_phosphatase-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTPase_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tyr_Pase_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tyr_Pase_cat UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TYR_PHOSPHATASE_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25529 UniProtKB/Swiss-Prot
MGC_CLONE MGC:124537 IMAGE-MGC_LOAD
NCBI Gene 25529 ENTREZGENE
PANTHER CYTOKINE RECEPTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN TYROSINE PHOSPHATASE RECEPTOR TYPE S UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam fn3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  I-set UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Y_phosphatase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Ptprs PhenoGen
PRINTS FNTYPEIII UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PRTYPHPHTASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE FN3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IG_LIKE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TYR_PHOSPHATASE_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TYR_PHOSPHATASE_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TYR_PHOSPHATASE_PTP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000047247 RatGTEx
  ENSRNOG00055015334 RatGTEx
  ENSRNOG00060019713 RatGTEx
  ENSRNOG00065013010 RatGTEx
SMART FN3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IGc2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTPc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTPc_motif UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SM00409 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF48726 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF49265 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF52799 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC228239
UniProt A0A0G2K1N1_RAT UniProtKB/TrEMBL
  A0A8I5ZXQ0_RAT UniProtKB/TrEMBL
  A0A8I5ZXU5 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AF78 ENTREZGENE, UniProtKB/TrEMBL
  M0R711 ENTREZGENE, UniProtKB/TrEMBL
  M0RA99_RAT UniProtKB/TrEMBL
  PTPRS_RAT UniProtKB/Swiss-Prot
  Q07808 ENTREZGENE
  Q3KRE9 ENTREZGENE
  Q4JFL8 ENTREZGENE, UniProtKB/TrEMBL
  Q64605 ENTREZGENE
  Q64621 ENTREZGENE
  Q64675 ENTREZGENE
UniProt Secondary Q07808 UniProtKB/Swiss-Prot
  Q3KRE9 UniProtKB/Swiss-Prot
  Q64621 UniProtKB/Swiss-Prot
  Q64675 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2009-04-29 Ptprs  protein tyrosine phosphatase, receptor type, S  Ptprd  protein tyrosine phosphatase, receptor type, D  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Ptprd  protein tyrosine phosphatase, receptor type, D      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_product member of a family of protein tyrosine phosphatases related to human leukocyte common antigen-related PTPase 69951