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Gene: PTPRS (protein tyrosine phosphatase receptor type S) Homo sapiens
Symbol: PTPRS
Name: protein tyrosine phosphatase receptor type S
Description: The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular region, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. The extracellular region of this protein is composed of multiple Ig-like and fibronectin type III-like domains. Studies of the similar gene in mice suggested that this PTP may be involved in cell-cell interaction, primary axonogenesis, and axon guidance during embryogenesis. This PTP has been also implicated in the molecular control of adult nerve repair. Four alternatively spliced transcript variants, which encode distinct proteins, have been reported. [provided by RefSeq, Jul 2008]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: protein tyrosine phosphatase PTPsigma; protein tyrosine phosphatase, receptor type, d; protein tyrosine phosphatase, receptor type, sigma; PTPSIGMA; R-PTP-S; R-PTP-sigma; receptor-type tyrosine-protein phosphatase S; receptor-type tyrosine-protein phosphatase sigma
Mus musculus (house mouse) : Ptprs (protein tyrosine phosphatase, receptor type, S)  MGI  Alliance
Rattus norvegicus (Norway rat) : Ptprs (protein tyrosine phosphatase, receptor type, S)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ptprs (protein tyrosine phosphatase receptor type S)
Pan paniscus (bonobo/pygmy chimpanzee) : PTPRS (protein tyrosine phosphatase receptor type S)
Canis lupus familiaris (dog) : PTPRS (protein tyrosine phosphatase receptor type S)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Ptprs (protein tyrosine phosphatase receptor type S)
Sus scrofa (pig) : PTPRS (protein tyrosine phosphatase receptor type S)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38195,205,503 - 5,340,812 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37195,205,514 - 5,340,814 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36195,156,519 - 5,291,814 (-)NCBINCBI36hg18NCBI36
Build 34195,157,380 - 5,237,399NCBI
Celera195,143,031 - 5,278,326 (-)NCBI
Cytogenetic Map19p13.3NCBI
HuRef194,967,302 - 5,101,977 (-)NCBIHuRef
CHM1_1195,205,046 - 5,340,693 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on PTPRS
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 734357
Created: 2004-01-12
Species: Homo sapiens
Last Modified: 2019-09-12
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.