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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3452
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ptprs
Name: protein tyrosine phosphatase, receptor type, S
Acc ID: CHEBI:34687
Term: dibutyl phthalate
Definition: A phthalate ester that is the diester obtained by the formal condensation of the carboxy groups of phthalic acid with two molecules of butan-1-ol. Although used extensively as a plasticiser, it is a ubiquitous environmental contaminant that poses a risk to humans.
Chemical ID: MESH:D003993
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
multiple interactionsEXP 6480464CTD[bisphenol A co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate] affects the methylation of PTPRS promoter

PMID:23359474
decreases expressionISORGD:7343586480464CTDDibutyl Phthalate results in decreased expression of PTPRS mRNA

PMID:17361019
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.