GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Ptprs | affects methylation | ISO | PTPRS (Homo sapiens) | 6480464 | CTD | Benzo(a)pyrene affects the methylation of PTPRS 5' UTR; Benzo(a)pyrene affects the methylation of PTPRS intron | PMID:27901495 PMID:30157460 | Ptprs | decreases expression | ISO | Ptprs (Mus musculus) | 6480464 | CTD | Benzo(a)pyrene results in decreased expression of PTPRS mRNA | PMID:19770486 | Ptprs | decreases methylation | ISO | Ptprs (Mus musculus) | 6480464 | CTD | Benzo(a)pyrene results in decreased methylation of PTPRS exon; Benzo(a)pyrene results in decreased methylation of PTPRS intron | PMID:27901495 | Ptprs | increases expression | ISO | Ptprs (Mus musculus) | 6480464 | CTD | Benzo(a)pyrene results in increased expression of PTPRS mRNA | PMID:22228805 | Ptprs | multiple interactions | ISO | Ptprs (Mus musculus) | 6480464 | CTD | Benzo(a)pyrene promotes the reaction [AHR protein binds to PTPRS promoter] | PMID:19654925 | |
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