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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3452
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ptprs
Name: protein tyrosine phosphatase, receptor type, S
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
affects methylationISORGD:7343576480464CTDBenzo(a)pyrene affects the methylation of PTPRS intron

PMID:30157460
decreases expressionISORGD:7343586480464CTDBenzo(a)pyrene results in decreased expression of PTPRS mRNA

PMID:19770486
increases expressionISORGD:7343586480464CTDBenzo(a)pyrene results in increased expression of PTPRS mRNA

PMID:22228805
multiple interactionsISORGD:7343586480464CTDBenzo(a)pyrene promotes the reaction [AHR protein binds to PTPRS promoter]

PMID:19654925
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.