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Gene: Nrxn1 (neurexin 1) Rattus norvegicus
Symbol: Nrxn1
Name: neurexin 1
RGD ID: 628659
Description: Exhibits several functions, including calcium ion binding activity; cell adhesion molecule binding activity; and neuroligin family protein binding activity. Involved in several processes, including cellular response to calcium ion; presynapse assembly; and vesicle docking involved in exocytosis. Localizes to cell surface; endocytic vesicle; and plasma membrane. Colocalizes with slit diaphragm. Used to study autism spectrum disorder. Biomarker of transient cerebral ischemia. Human ortholog(s) of this gene implicated in Pitt-Hopkins-like syndrome 2. Orthologous to human NRXN1 (neurexin 1); INTERACTS WITH 17alpha-ethynylestradiol; 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
Also known as: neurexin I-alpha; neurexin I-beta; neurexin-1; neurexin-1-alpha; neurexin-1-beta; non-processed neurexin I-alpha; Nrxn1b
Homo sapiens (human) : NRXN1 (neurexin 1)  HGNC  Alliance
Mus musculus (house mouse) : Nrxn1 (neurexin I)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Nrxn1 (neurexin 1)
Pan paniscus (bonobo/pygmy chimpanzee) : NRXN1 (neurexin 1)
Canis lupus familiaris (dog) : NRXN1 (neurexin 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Nrxn1 (neurexin 1)
Sus scrofa (pig) : NRXN1 (neurexin 1)
Chlorocebus sabaeus (African green monkey) : NRXN1 (neurexin 1)
Heterocephalus glaber (naked mole-rat) : Nrxn1 (neurexin 1)
more info ...
Allele / Splice: Nrxn1em1  
Genetic Models: SD-Nrxn1em1Sage
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
NCBI Annotation Information: Note: There is an assembly problem in the Rnor_6.0 reference genome assembly, and therefore, annotation of this gene is split across NW_007905831.1, NW_007905830.1, and NW_007905829.1 in NCBI's Rattus norvegicus Annotation Release 105. [17 Jun 2015]; Annotation category: partial on reference assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.0613,886,757 - 15,191,660 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl613,886,740 - 15,191,660 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0623,843,153 - 24,482,073 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.0624,704,937 - 25,145,167 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4614,050,929 - 15,354,069 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1615,245,705 - 15,354,069 (-)NCBI
Celera62,975,004 - 4,118,378 (+)NCBICelera
Cytogenetic Map6q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
Genetic Models
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Nrxn1
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 628659
Created: 2003-02-27
Species: Rattus norvegicus
Last Modified: 2020-08-20
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.