RGD Reference Report - Expression of neurexin, neuroligin, and their cytoplasmic binding partners in the pancreatic beta-cells and the involvement of neuroligin in insulin secretion. - Rat Genome Database

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Expression of neurexin, neuroligin, and their cytoplasmic binding partners in the pancreatic beta-cells and the involvement of neuroligin in insulin secretion.

Authors: Suckow, AT  Comoletti, D  Waldrop, MA  Mosedale, M  Egodage, S  Taylor, P  Chessler, SD 
Citation: Suckow AT, etal., Endocrinology. 2008 Dec;149(12):6006-17. Epub 2008 Aug 28.
RGD ID: 2314456
Pubmed: PMID:18755801   (View Abstract at PubMed)
PMCID: PMC2613060   (View Article at PubMed Central)
DOI: DOI:10.1210/en.2008-0274   (Journal Full-text)

The composition of the beta-cell exocytic machinery is very similar to that of neuronal synapses, and the developmental pathway of beta-cells and neurons substantially overlap. beta-Cells secrete gamma-aminobutyric acid and express proteins that, in the brain, are specific markers of inhibitory synapses. Recently, neuronal coculture experiments have identified three families of synaptic cell-surface molecules (neurexins, neuroligins, and SynCAM) that drive synapse formation in vitro and that control the differentiation of nascent synapses into either excitatory or inhibitory fully mature nerve terminals. The inhibitory synapse-like character of the beta-cells led us to hypothesize that members of these families of synapse-inducing adhesion molecules would be expressed in beta-cells and that the pattern of expression would resemble that associated with neuronal inhibitory synaptogenesis. Here, we describe beta-cell expression of the neuroligins, neurexins, and SynCAM, and show that neuroligin expression affects insulin secretion in INS-1 beta-cells and rat islet cells. Our findings demonstrate that neuroligins and neurexins are expressed outside the central nervous system and help confer an inhibitory synaptic-like phenotype onto the beta-cell surface. Analogous to their role in synaptic neurotransmission, neurexin-neuroligin interactions may play a role in the formation of the submembrane insulin secretory apparatus.



Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Nlgn2Ratpositive regulation of insulin secretion  IMP  RGD 

Objects Annotated

Genes (Rattus norvegicus)
Nlgn2  (neuroligin 2)

Objects referenced in this article
Gene Nrxn1 neurexin 1 Rattus norvegicus

Additional Information