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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 628659
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nrxn1
Name: neurexin 1
Acc ID: CHEBI:33216
Term: bisphenol A
Definition: A bisphenol that is 4,4'-methanediyldiphenol in which the methylene hydrogens are replaced by two methyl groups.
Chemical ID: MESH:C006780
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nrxn1decreases expressionEXP 6480464CTDbisphenol A results in decreased expression of NRXN1 mRNAPMID:25181051
Nrxn1increases expressionEXP 6480464CTDbisphenol A results in increased expression of NRXN1 mRNAPMID:29097150
Nrxn1increases methylationEXP 6480464CTDbisphenol A results in increased methylation of NRXN1 genePMID:28505145
Nrxn1multiple interactionsEXP 6480464CTD[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben co-treated with Androgen Antagonists co-treated with Acetaminophen] results in increased expression of NRXN1 mRNA; [bisphenol A co-treated with Genistein] results in increased methylation of NRXN1 genePMID:25607892 PMID:28505145
Nrxn1affects methylationISONRXN1 (Homo sapiens)6480464CTDbisphenol A affects the methylation of NRXN1 genePMID:31601247
Nrxn1decreases expressionISONrxn1 (Mus musculus)6480464CTDbisphenol A results in decreased expression of NRXN1 mRNAPMID:32156529
Nrxn1increases expressionISONrxn1 (Mus musculus)6480464CTDbisphenol A results in increased expression of NRXN1 mRNAPMID:25594700
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