RGD Reference Report - A splice code for trans-synaptic cell adhesion mediated by binding of neuroligin 1 to alpha- and beta-neurexins. - Rat Genome Database

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A splice code for trans-synaptic cell adhesion mediated by binding of neuroligin 1 to alpha- and beta-neurexins.

Authors: Boucard, Antony A  Chubykin, Alexander A  Comoletti, Davide  Taylor, Palmer  S├╝dhof, Thomas C 
Citation: Boucard AA, etal., Neuron. 2005 Oct 20;48(2):229-36. doi: 10.1016/j.neuron.2005.08.026.
RGD ID: 151356616
Pubmed: PMID:16242404   (View Abstract at PubMed)
DOI: DOI:10.1016/j.neuron.2005.08.026   (Journal Full-text)

Previous studies suggested that postsynaptic neuroligins form a trans-synaptic complex with presynaptic beta-neurexins, but not with presynaptic alpha-neurexins. Unexpectedly, we now find that neuroligins also bind alpha-neurexins and that alpha- and beta-neurexin binding by neuroligin 1 is regulated by alternative splicing of neuroligin 1 (at splice site B) and of neurexins (at splice site 4). In neuroligin 1, splice site B is a master switch that determines alpha-neurexin binding but leaves beta-neurexin binding largely unaffected, whereas alternative splicing of neurexins modulates neuroligin binding. Moreover, neuroligin 1 splice variants with distinct neurexin binding properties differentially regulate synaptogenesis: neuroligin 1 that binds only beta-neurexins potently stimulates synapse formation, whereas neuroligin 1 that binds to both alpha- and beta-neurexins more effectively promotes synapse expansion. These findings suggest that neuroligin binding to alpha- and beta-neurexins mediates trans-synaptic cell adhesion but has distinct effects on synapse formation, indicating that expression of different neuroligin and neurexin isoforms specifies a trans-synaptic signaling code.

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process

Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Nlgn1Ratcell-cell adhesion involved in synapse maturation involved_inNAS PMID:16242404ComplexPortal 
Nrxn1Ratcell-cell adhesion involved in synapse maturation involved_inNAS PMID:16242404ComplexPortal 
Nlgn1Ratneuron cell-cell adhesion involved_inNAS PMID:16242404ComplexPortal 
Nrxn1Ratneuron cell-cell adhesion involved_inNAS PMID:16242404ComplexPortal 
Nlgn1Ratsynapse assembly involved_inNAS PMID:16242404ComplexPortal 
Nrxn1Ratsynapse assembly involved_inNAS PMID:16242404ComplexPortal 
Nlgn1Ratsynapse maturation involved_inNAS PMID:16242404ComplexPortal 
Nrxn1Ratsynapse maturation involved_inNAS PMID:16242404ComplexPortal 

Cellular Component

Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Nlgn1Ratneuron to neuron synapse part_ofNAS PMID:16242404ComplexPortal 
Nrxn1Ratneuron to neuron synapse part_ofNAS PMID:16242404ComplexPortal 

Objects Annotated

Genes (Rattus norvegicus)
Nlgn1  (neuroligin 1)
Nrxn1  (neurexin 1)

Additional Information