RGD Reference Report - Neurexin and Neuroligin-based adhesion complexes drive axonal arborisation growth independent of synaptic activity. - Rat Genome Database

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Neurexin and Neuroligin-based adhesion complexes drive axonal arborisation growth independent of synaptic activity.

Authors: Constance, William D  Mukherjee, Amrita  Fisher, Yvette E  Pop, Sinziana  Blanc, Eric  Toyama, Yusuke  Williams, Darren W 
Citation: Constance WD, etal., Elife. 2018 Mar 5;7. pii: 31659. doi: 10.7554/eLife.31659.
RGD ID: 151356619
Pubmed: PMID:29504935   (View Abstract at PubMed)
PMCID: PMC5869020   (View Article at PubMed Central)
DOI: DOI:10.7554/eLife.31659   (Journal Full-text)

Building arborisations of the right size and shape is fundamental for neural network function. Live imaging in vertebrate brains strongly suggests that nascent synapses are critical for branch growth during development. The molecular mechanisms underlying this are largely unknown. Here we present a novel system in Drosophila for studying the development of complex arborisations live, in vivo during metamorphosis. In growing arborisations we see branch dynamics and localisations of presynaptic proteins very similar to the 'synaptotropic growth' described in fish/frogs. These accumulations of presynaptic proteins do not appear to be presynaptic release sites and are not paired with neurotransmitter receptors. Knockdowns of either evoked or spontaneous neurotransmission do not impact arbor growth. Instead, we find that axonal branch growth is regulated by dynamic, focal localisations of Neurexin and Neuroligin. These adhesion complexes provide stability for filopodia by a 'stick-and-grow' based mechanism wholly independent of synaptic activity.

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
maintenance of synapse structure involved_inNAS 151356619; 151356619PMID:29504935ComplexPortal 
neuron projection morphogenesis involved_inNAS 151356619; 151356619PMID:29504935ComplexPortal 
positive regulation of neuron projection development involved_inNAS 151356619; 151356619PMID:29504935ComplexPortal 

Objects Annotated

Genes (Rattus norvegicus)
Nlgn1  (neuroligin 1)
Nrxn1  (neurexin 1)


Additional Information