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GENE - TERM ANNOTATION REPORT

RGD ID: 628659
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nrxn1
Name: neurexin 1
Acc ID: GO:0007268
Term: chemical synaptic transmission
Definition: The vesicular release of classical neurotransmitter molecules from a presynapse, across a chemical synapse, the subsequent activation of neurotransmitter receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse.
Definition Source(s): GOC:jl, MeSH:D009435
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nrxn1acts_upstream_of_or_withinISONrxn1 (Mus musculus)1624291RGDMGI:1096362 MGI:1096389 PMID:12827191

PMID:12827191
Nrxn1involved_inISSUniProtKB:Q9CS841600115BHF-UCLGO_REF:0000024

GO_REF:0000024
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