RGD Reference Report - CASK: a novel dlg/PSD95 homolog with an N-terminal calmodulin-dependent protein kinase domain identified by interaction with neurexins. - Rat Genome Database

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CASK: a novel dlg/PSD95 homolog with an N-terminal calmodulin-dependent protein kinase domain identified by interaction with neurexins.

Authors: Hata, Y  Butz, S  Sudhof, TC 
Citation: Hata Y, etal., J Neurosci 1996 Apr 15;16(8):2488-94.
RGD ID: 61546
Pubmed: PMID:8786425   (View Abstract at PubMed)
PMCID: PMC6578772   (View Article at PubMed Central)

Neurexins are neuronal cell surface proteins with hundreds of isoforms. In yeast two-hybrid screens for intracellular molecules interacting with different neurexins, we identified a single interacting protein called CASK. CASK is composed of an N-terminal Ca2+, calmodulin-dependent protein kinase sequence and a C-terminal region that is similar to the intercellular junction proteins dlg-A, PSD95/SAP90, SAP97, Z01, and Z02 and that contains DHR-, SH3-, and guanylate kinase domains. CASK is enriched in brain in synaptic plasma membranes but is also detectable at low levels in all tissues tested. The cytoplasmic domains of all three neurexins bind CASK in a salt-labile interaction. In neurexin I, this interaction is dependent on the C-terminal three residues. Thus, CASK is a membrane-associated protein that combines domains found in Ca2+ - activated protein kinases and in proteins specific for intercellular junctions, suggesting that it may be a signaling molecule operating at the plasma membrane, possibly in conjunction with neurexins.



Gene Ontology Annotations    Click to see Annotation Detail View

Cellular Component

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
CaskRatsynaptic membrane located_inIDA PMID:8786425BHF-UCL 
CaskRatsynaptic membrane part_ofIDA PMID:8786425CACAO 

Molecular Function

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
CaskRatneurexin family protein binding  IPINrxn1 (Rattus norvegicus) more ... RGD 

Objects Annotated

Genes (Rattus norvegicus)
Cask  (calcium/calmodulin dependent serine protein kinase)

Objects referenced in this article
Gene Nrxn1 neurexin 1 Rattus norvegicus
Gene Nrxn2 neurexin 2 Rattus norvegicus
Gene Nrxn3 neurexin 3 Rattus norvegicus

Additional Information