RGD Reference Report - Neurexin mediates the assembly of presynaptic terminals. - Rat Genome Database

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Neurexin mediates the assembly of presynaptic terminals.

Authors: Dean, Camin  Scholl, Francisco G  Choih, Jenny  DeMaria, Shannon  Berger, James  Isacoff, Ehud  Scheiffele, Peter 
Citation: Dean C, etal., Nat Neurosci. 2003 Jul;6(7):708-16. doi: 10.1038/nn1074.
RGD ID: 13702298
Pubmed: PMID:12796785   (View Abstract at PubMed)
PMCID: PMC1646425   (View Article at PubMed Central)
DOI: DOI:10.1038/nn1074   (Journal Full-text)

Neurexins are a large family of proteins that act as neuronal cell-surface receptors. The function and localization of the various neurexins, however, have not yet been clarified. Beta-neurexins are candidate receptors for neuroligin-1, a postsynaptic membrane protein that can trigger synapse formation at axon contacts. Here we report that neurexins are concentrated at synapses and that purified neuroligin is sufficient to cluster neurexin and to induce presynaptic differentiation. Oligomerization of neuroligin is required for its function, and we find that beta-neurexin clustering is sufficient to trigger the recruitment of synaptic vesicles through interactions that require the cytoplasmic domain of neurexin. We propose a two-step model in which postsynaptic neuroligin multimers initially cluster axonal neurexins. In response to this clustering, neurexins nucleate the assembly of a cytoplasmic scaffold to which the exocytotic apparatus is recruited.



Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Nrxn1Ratpresynapse assembly involved_inEXP PMID:12796785SynGO 
Nrxn1Ratpresynapse assembly involved_inIDA PMID:12796785SynGO 
Nrxn1Ratpresynapse assembly involved_inIMP PMID:12796785SynGO 

Objects Annotated

Genes (Rattus norvegicus)
Nrxn1  (neurexin 1)


Additional Information