Tpi1 (triosephosphate isomerase 1) - Rat Genome Database

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Gene: Tpi1 (triosephosphate isomerase 1) Rattus norvegicus
Analyze
Symbol: Tpi1
Name: triosephosphate isomerase 1
RGD ID: 3896
Description: Exhibits triose-phosphate isomerase activity. Involved in carbohydrate metabolic process. Localizes to cytosol and nucleus. Biomarker of ocular hypertension. Human ortholog(s) of this gene implicated in carbohydrate metabolic disorder and triosephosphate isomerase deficiency. Orthologous to human TPI1 (triosephosphate isomerase 1); PARTICIPATES IN Fanconi syndrome pathway; fructose and mannose metabolic pathway; fructose-1,6-bisphosphatase deficiency pathway; INTERACTS WITH (+)-schisandrin B; 1,2,4-trimethylbenzene; 1,3-dinitrobenzene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: LOC100911515; methylglyoxal synthase; MGC156639; TIM; Tpi; triose-phosphate isomerase; triosephosphate isomerase; triosephosphate isomerase-like
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Related Pseudogenes: LOC681129  
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.24157,615,283 - 157,618,813 (-)NCBI
Rnor_6.0 Ensembl4157,328,379 - 157,331,905 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0 Ensembl920,213,588 - 20,217,176 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.04157,328,375 - 157,331,905 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.04224,345,971 - 224,349,501 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44160,933,341 - 160,936,871 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.14161,178,382 - 161,181,807 (-)NCBI
Celera4146,353,273 - 146,356,791 (-)NCBICelera
Cytogenetic Map4q42NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
1,2,4-trimethylbenzene  (EXP)
1,2-dimethylhydrazine  (ISO)
1,3-dinitrobenzene  (EXP)
1-bromopropane  (EXP)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (EXP)
2,4-dinitrotoluene  (EXP)
2,5-hexanedione  (EXP)
3-chloropropane-1,2-diol  (EXP)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-fluorouracil  (ISO)
acrolein  (ISO)
acrylamide  (EXP)
all-trans-retinoic acid  (ISO)
all-trans-retinol  (EXP)
alpha-naphthoflavone  (ISO)
alpha-pinene  (ISO)
ammonium chloride  (EXP)
amphetamine  (EXP)
aristolochic acid  (ISO)
arsane  (EXP)
arsenic atom  (EXP)
arsenous acid  (ISO)
Azaspiracid  (ISO)
benzalkonium chloride  (ISO)
benzo[a]pyrene  (ISO)
bis(2-chloroethyl) sulfide  (EXP)
bisphenol A  (EXP,ISO)
bortezomib  (ISO)
bromobenzene  (EXP)
bucladesine  (ISO)
bufalin  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
capsaicin  (ISO)
captan  (ISO)
carbamazepine  (ISO)
carbon dioxide  (EXP)
carbon nanotube  (ISO)
casticin  (ISO)
ceruletide  (EXP)
chloropicrin  (ISO)
cisplatin  (ISO)
clobetasol  (ISO)
clofibrate  (EXP)
clozapine  (EXP)
cobalt dichloride  (EXP)
copper(II) sulfate  (ISO)
coumestrol  (ISO)
cyclosporin A  (ISO)
desferrioxamine B  (EXP)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (EXP,ISO)
dihydroartemisinin  (ISO)
dihydroxyacetone phosphate  (EXP)
dinophysistoxin 1  (ISO)
dioxygen  (ISO)
dipotassium bis[mu-tartrato(4-)]diantimonate(2-) trihydrate  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
Enterolactone  (ISO)
enzyme inhibitor  (ISO)
ethanol  (EXP,ISO)
etoposide  (ISO)
flutamide  (EXP)
folic acid  (ISO)
folpet  (ISO)
furan  (EXP)
genistein  (EXP)
haloperidol  (EXP)
hydralazine  (ISO)
ibuprofen  (ISO)
lithium atom  (EXP)
lithium hydride  (EXP)
mancozeb  (ISO)
medroxyprogesterone acetate  (ISO)
methamphetamine  (EXP)
methotrexate  (ISO)
methylisothiazolinone  (ISO)
methylmercury chloride  (ISO)
microcystin  (EXP)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodiethylamine  (ISO)
nickel dichloride  (EXP,ISO)
nickel subsulfide  (EXP,ISO)
niclosamide  (ISO)
nimesulide  (EXP)
olomoucine  (ISO)
ouabain  (ISO)
ozone  (EXP,ISO)
p-menthan-3-ol  (ISO)
p-toluidine  (EXP)
paracetamol  (EXP,ISO)
phenylpropanolamine  (ISO)
pioglitazone  (ISO)
pirinixic acid  (EXP)
quartz  (ISO)
quercetin  (ISO)
resveratrol  (ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (EXP)
sarin  (EXP)
SB 431542  (ISO)
selenium atom  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (ISO)
sodium fluoride  (ISO)
T-2 toxin  (EXP)
tamoxifen  (ISO)
tetrachloromethane  (EXP,ISO)
thapsigargin  (ISO)
thimerosal  (ISO)
trichloroethene  (EXP)
trimellitic anhydride  (ISO)
trovafloxacin  (EXP)
tunicamycin  (ISO)
undecane  (EXP)
valproic acid  (ISO)
vincristine  (ISO)
vitamin E  (ISO)
vorinostat  (ISO)
Yessotoxin  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytosol  (IBA,IDA)
nucleus  (IDA)

Molecular Function

References

Additional References at PubMed
PMID:204065   PMID:566475   PMID:566476   PMID:2693209   PMID:3796661   PMID:6434534   PMID:8417789   PMID:15155459   PMID:15489334   PMID:15632090   PMID:16502470   PMID:16854843  
PMID:17023274   PMID:18562316   PMID:19056867   PMID:19182904   PMID:19725078   PMID:21630459   PMID:22420779   PMID:22664934   PMID:22871113   PMID:23376485   PMID:23533145   PMID:23580065  
PMID:26316108   PMID:26945066   PMID:29476059  


Genomics

Comparative Map Data
Tpi1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.24157,615,283 - 157,618,813 (-)NCBI
Rnor_6.0 Ensembl4157,328,379 - 157,331,905 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0 Ensembl920,213,588 - 20,217,176 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.04157,328,375 - 157,331,905 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.04224,345,971 - 224,349,501 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44160,933,341 - 160,936,871 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.14161,178,382 - 161,181,807 (-)NCBI
Celera4146,353,273 - 146,356,791 (-)NCBICelera
Cytogenetic Map4q42NCBI
TPI1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl126,867,119 - 6,870,948 (+)EnsemblGRCh38hg38GRCh38
GRCh38126,866,834 - 6,870,948 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37126,976,584 - 6,980,112 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36126,846,967 - 6,850,253 (+)NCBINCBI36hg18NCBI36
Build 34126,846,966 - 6,850,253NCBI
Celera128,593,870 - 8,597,397 (+)NCBI
Cytogenetic Map12p13.31NCBI
HuRef126,830,312 - 6,833,839 (+)NCBIHuRef
CHM1_1126,975,582 - 6,979,109 (+)NCBICHM1_1
Tpi1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm396124,787,549 - 124,791,121 (-)NCBIGRCm39mm39
GRCm39 Ensembl6124,787,549 - 124,791,259 (-)Ensembl
GRCm386124,810,586 - 124,814,158 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl6124,810,586 - 124,814,296 (-)EnsemblGRCm38mm10GRCm38
MGSCv376124,760,610 - 124,764,314 (-)NCBIGRCm37mm9NCBIm37
MGSCv366124,776,334 - 124,780,031 (-)NCBImm8
Celera6126,486,721 - 126,490,425 (-)NCBICelera
Cytogenetic Map6F2NCBI
cM Map659.17NCBI
Tpi1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554134,467,566 - 4,471,177 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554134,467,615 - 4,471,594 (+)NCBIChiLan1.0ChiLan1.0
TPI1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1126,910,819 - 6,914,056 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl126,910,813 - 6,913,612 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0126,999,275 - 7,002,678 (+)NCBIMhudiblu_PPA_v0panPan3
TPI1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12738,154,519 - 38,157,900 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2738,154,519 - 38,158,137 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha278,458,847 - 8,462,228 (+)NCBI
ROS_Cfam_1.02738,507,407 - 38,510,797 (-)NCBI
UMICH_Zoey_3.12738,381,481 - 38,384,861 (-)NCBI
UNSW_CanFamBas_1.02738,422,508 - 38,425,888 (-)NCBI
UU_Cfam_GSD_1.0277,937,580 - 7,940,961 (+)NCBI
Tpi1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404945102,280,602 - 102,283,888 (-)NCBI
SpeTri2.0NW_004936709948,151 - 951,430 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TPI1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl563,837,506 - 63,843,137 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1563,839,473 - 63,842,853 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2566,274,980 - 66,278,361 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TPI1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1116,900,762 - 6,904,188 (+)NCBI
ChlSab1.1 Ensembl116,900,787 - 6,906,787 (+)Ensembl
Vero_WHO_p1.0NW_0236660631,319,371 - 1,323,379 (-)NCBI
Tpi1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248603,533,226 - 3,536,786 (+)NCBI

Position Markers
RH94523  
Rat AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map4q42UniSTS
RH129184  
Rat AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map4q42UniSTS
AI411387  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24157,619,843 - 157,620,056 (-)MAPPER
mRatBN7.24157,619,843 - 157,620,056 (+)MAPPER
Rnor_6.04157,332,936 - 157,333,148NCBIRnor6.0
Rnor_6.0920,212,509 - 20,212,721NCBIRnor6.0
Rnor_5.04224,350,532 - 224,350,744UniSTSRnor5.0
Rnor_5.0919,088,485 - 19,088,697UniSTSRnor5.0
RGSC_v3.44160,937,902 - 160,938,114UniSTSRGSC3.4
Celera4146,357,822 - 146,358,034UniSTS
RH 3.4 Map41005.8UniSTS
Cytogenetic Map4q42UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61451Ciaa4CIA Autoantibody QTL 43.1blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)4125884464168047091Rat
724535Cm18Cardiac mass QTL 182.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)4117926139162926139Rat
724558Plsm2Polydactyly-luxate syndrome (PLS) morphotypes QTL 20.0003hindlimb integrity trait (VT:0010563)hind foot phalanges count (CMO:0001949)4131834282176834282Rat
1331738Bp209Blood pressure QTL 2092.979arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)4136351734180689124Rat
1331759Hrtrt13Heart rate QTL 133.54628heart pumping trait (VT:2000009)heart rate (CMO:0000002)4108876717169215811Rat
737821Hcar9Hepatocarcinoma resistance QTL 93.7liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)4105971071168047091Rat
631683Bp116Blood pressure QTL 1160.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)4123111827168111827Rat
737978Pia23Pristane induced arthritis QTL 235.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4131532269168047091Rat
1582237Kidm34Kidney mass QTL 3440.0001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)4146942075168998263Rat
1298524Oia8Oil induced arthritis QTL 8joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4136351734174694858Rat
631511Pia7Pristane induced arthritis QTL 74.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4131532269168047091Rat
1581574Eae20Experimental allergic encephalomyelitis QTL 207.8nervous system integrity trait (VT:0010566)percentage of study population developing experimental autoimmune encephalomyelitis during a period of time (CMO:0001047)4152482121158564471Rat
2293659Bmd35Bone mineral density QTL 354.50.0001femur strength trait (VT:0010010)femoral neck ultimate force (CMO:0001703)4136908430182878540Rat
634335Anxrr16Anxiety related response QTL 167.22locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)494893247168046938Rat
634342Cia24Collagen induced arthritis QTL 244.5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4145373934176509907Rat
634347Hcar8Hepatocarcinoma resistance QTL 85.8liver integrity trait (VT:0010547)liver tumorous lesion area to total liver area ratio (CMO:0001075)4123478354168478354Rat
1576316Ept5Estrogen-induced pituitary tumorigenesis QTL 53.8pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)484475257178931073Rat
1578674Bmd12Bone mineral density QTL 123.8femur mineral mass (VT:0010011)cortical volumetric bone mineral density (CMO:0001730)4137171018182171018Rat
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)47850904182171018Rat
1358364Sradr4Stress Responsive Adrenal Weight QTL 44.92adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)4128602727173602727Rat
1358202Gluco11Glucose level QTL 112.40.02adipocyte glucose uptake trait (VT:0004185)absolute change in adipocyte glucose uptake (CMO:0000873)486438317168047091Rat
2303623Vencon2Ventilatory control QTL 23.8respiration trait (VT:0001943)minute ventilation (CMO:0000132)4134917642179917642Rat
1549827Scl46Serum cholesterol level QTL 463.5blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)4131864442176864442Rat
61362Oia2Oil induced arthritis QTL 20.001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4136351734174694858Rat
61422Cia13Collagen induced arthritis QTL 134.5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4132455408168047091Rat
6478718Anxrr34Anxiety related response QTL 340.00896locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4145547014184226339Rat
6478720Alc23Alcohol consumption QTL 230.00509drinking behavior trait (VT:0001422)ethanol drink intake rate to body weight ratio (CMO:0001616)4155386197184226339Rat
6478728Anxrr36Anxiety related response QTL 360.01061locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4155386197184226339Rat
6478733Anxrr37Anxiety related response QTL 370.00095locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4155386197184226339Rat
6478737Anxrr38Anxiety related response QTL 380.00159locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4155386197184226339Rat
6478748Anxrr42Anxiety related response QTL 420.28008locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4145547014184226339Rat
6478754Anxrr43Anxiety related response QTL 430.14035locomotor behavior trait (VT:0001392)distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)4145547014184226339Rat
6478757Anxrr44Anxiety related response QTL 440.01087locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4155386197184226339Rat
6478778Anxrr51Anxiety related response QTL 510.25384locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)4123587009168587009Rat
6478782Anxrr52Anxiety related response QTL 520.02091locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4155386197184226339Rat
6478785Anxrr53Anxiety related response QTL 530.01397locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4155386197184226339Rat
6478693Anxrr32Anxiety related response QTL 320.00092locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)4145547014184226339Rat
6478700Anxrr33Anxiety related response QTL 330.00896locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4145547014184226339Rat
7411558Bw133Body weight QTL 13313.840.001body mass (VT:0001259)body weight gain (CMO:0000420)4124442168169442168Rat
10053718Scort25Serum corticosterone level QTL 252.150.0097blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)4156855449184226339Rat
10401796Kidm48Kidney mass QTL 48kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)4146497452184226339Rat
10755501Bp390Blood pressure QTL 3902.5arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)423850384169318094Rat
12798519Anxrr54Anxiety related response QTL 542.540.05locomotor behavior trait (VT:0001392)distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)4112807675157807675Rat
12798525Anxrr57Anxiety related response QTL 573.210.05locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4146086918168047091Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:135
Count of miRNA genes:107
Interacting mature miRNAs:114
Transcripts:ENSRNOT00000020647
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 7
Low 4 42 47 34 10 34 16 19 114 36 36 4 16
Below cutoff 2 44 58 43 24 43 33 34 34 17

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_022922 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC115420 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC061781 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC126087 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473964 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ212675 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ214607 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ214670 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ214759 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ214880 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ215018 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ215213 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ215529 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ215606 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ215810 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ215834 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ215973 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ216226 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ216307 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ216332 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ216584 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ216804 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ223237 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ224880 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ224920 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ224970 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JACYVU010000150 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L36250 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000020647   ⟹   ENSRNOP00000020647
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl4157,328,379 - 157,331,905 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000071439   ⟹   ENSRNOP00000067409
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl920,213,776 - 20,216,608 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000089341   ⟹   ENSRNOP00000069904
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl920,213,588 - 20,217,176 (+)Ensembl
RefSeq Acc Id: NM_022922   ⟹   NP_075211
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.24157,615,283 - 157,618,813 (-)NCBI
Rnor_6.04157,328,375 - 157,331,905 (-)NCBI
Rnor_5.04224,345,971 - 224,349,501 (-)NCBI
RGSC_v3.44160,933,341 - 160,936,871 (-)RGD
Celera4146,353,273 - 146,356,791 (-)RGD
Sequence:
Reference Sequences
RefSeq Acc Id: NP_075211   ⟸   NM_022922
- UniProtKB: P48500 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000020647   ⟸   ENSRNOT00000020647
RefSeq Acc Id: ENSRNOP00000067409   ⟸   ENSRNOT00000071439
RefSeq Acc Id: ENSRNOP00000069904   ⟸   ENSRNOT00000089341

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13693390
Promoter ID:EPDNEW_R3915
Type:multiple initiation site
Name:Tpi1_1
Description:triosephosphate isomerase 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.04157,331,917 - 157,331,977EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3896 AgrOrtholog
  RGD:6492323 AgrOrtholog
Ensembl Genes ENSRNOG00000015290 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOG00000050669 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000020647 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOP00000067409 UniProtKB/Swiss-Prot
  ENSRNOP00000069904 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000020647 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOT00000071439 UniProtKB/Swiss-Prot
  ENSRNOT00000089341 UniProtKB/TrEMBL
Gene3D-CATH 3.20.20.70 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:5623367 IMAGE-MGC_LOAD
  IMAGE:8368624 IMAGE-MGC_LOAD
InterPro Aldolase_TIM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TIM_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TrioseP_Isoase_bac/euk UniProtKB/Swiss-Prot
  Triosephosphate_isomerase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Triosephosphate_isomerase_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:24849 UniProtKB/Swiss-Prot
MGC_CLONE MGC:156639 IMAGE-MGC_LOAD
  MGC:72436 IMAGE-MGC_LOAD
NCBI Gene 24849 ENTREZGENE
PANTHER PTHR21139 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam TIM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Tpi1 PhenoGen
PROSITE TIM_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TIM_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF51351 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGRFAMs tim UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2JWJ4_RAT UniProtKB/TrEMBL
  P48500 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary A0JN18 UniProtKB/Swiss-Prot
  Q6P793 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Tpi1  triosephosphate isomerase 1  LOC100911515  triosephosphate isomerase-like  Data Merged 737654 PROVISIONAL
2012-07-05 LOC100911515  triosephosphate isomerase-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2003-04-09 Tpi1  triosephosphate isomerase 1    Triosephosphate isomerase 1  Name updated 629478 APPROVED
2002-06-10 Tpi1  Triosephosphate isomerase 1      Symbol and Name status set to approved 70586 APPROVED