Bdkrb2 (bradykinin receptor B2) - Rat Genome Database

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Gene: Bdkrb2 (bradykinin receptor B2) Rattus norvegicus
Symbol: Bdkrb2
Name: bradykinin receptor B2
RGD ID: 2201
Description: Enables beta-2 adrenergic receptor binding activity and bradykinin receptor activity. Involved in several processes, including acute inflammatory response to antigenic stimulus; cellular response to hypoxia; and maintenance of blood-brain barrier. Predicted to be located in Golgi apparatus and endosome. Predicted to be active in plasma membrane. Used to study several diseases, including asthma; pancreatitis; pleurisy; portal hypertension; and pulmonary hypertension. Biomarker of high grade glioma; hypertension; myocardial infarction; and sciatic neuropathy. Human ortholog(s) of this gene implicated in asthma; chronic obstructive pulmonary disease; hypertension; and rhinitis. Orthologous to human BDKRB2 (bradykinin receptor B2); PARTICIPATES IN G protein mediated signaling pathway via Galphai family; G protein mediated signaling pathway via Galphaq family; kallikrein-kinin cascade pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3',5'-cyclic GMP; 4-amino-2,6-dinitrotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: B2 bradykinin receptor; B2BKR; B2BRA; B2R; BK-2 receptor; bradykinin receptor, beta 2
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: Bdkrb2m1Mcwi   Bdkrb2m2Mcwi  
Genetic Models: FHH-Bdkrb2m1Mcwi SS-Bdkrb2m2Mcwi
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.26124,472,317 - 124,502,497 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl6124,472,566 - 124,502,497 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx6124,593,665 - 124,623,640 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.06124,888,932 - 124,918,906 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.06124,250,138 - 124,280,235 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.06129,399,468 - 129,429,676 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6129,399,468 - 129,429,676 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06138,615,812 - 138,622,272 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.46129,744,781 - 129,748,851 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.16129,748,527 - 129,752,598 (+)NCBI
Celera6122,039,524 - 122,069,422 (+)NCBICelera
RH 3.4 Map6815.41RGD
Cytogenetic Map6q32NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (ISO)
(R)-noradrenaline  (ISO)
1,2-dichloroethane  (ISO)
15-acetyldeoxynivalenol  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
3',5'-cyclic GMP  (EXP)
3,3',5,5'-tetrabromobisphenol A  (ISO)
4-amino-2,6-dinitrotoluene  (EXP)
4-hydroxycyclophosphamide  (EXP)
5-fluorouracil  (ISO)
6-oxoprostaglandin F1alpha  (EXP,ISO)
8-Br-cAMP  (ISO)
afimoxifene  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
allyl isothiocyanate  (ISO)
amlodipine  (ISO)
aristolochic acid A  (ISO)
atenolol  (ISO)
atropine  (ISO)
benazepril  (EXP,ISO)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP)
calcium atom  (ISO)
calcium(0)  (ISO)
candesartan  (EXP)
capsaicin  (EXP,ISO)
captopril  (ISO)
carbon nanotube  (ISO)
ceruletide  (ISO)
CGP 52608  (ISO)
chondroitin sulfate  (EXP)
cisplatin  (ISO)
copper(II) sulfate  (ISO)
cyclophosphamide  (EXP)
dextran sulfate  (ISO)
diallyl trisulfide  (ISO)
dibutyl phthalate  (EXP)
dichlorine  (EXP)
dioxygen  (ISO)
diquat  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
enalapril  (EXP)
fenvalerate  (EXP)
fonofos  (ISO)
formaldehyde  (ISO)
genistein  (EXP)
gentamycin  (EXP)
Hexamethonium  (ISO)
icatibant  (EXP,ISO)
irbesartan  (ISO)
lipopolysaccharide  (ISO)
manganese(II) chloride  (EXP)
methoxychlor  (EXP)
microcystin-LR  (EXP)
N-methyl-4-phenylpyridinium  (ISO)
N-Nitrosopyrrolidine  (ISO)
nickel atom  (ISO)
nitric oxide  (EXP)
nitroprusside  (ISO)
O-methyleugenol  (ISO)
ozone  (EXP,ISO)
paracetamol  (EXP,ISO)
parathion  (ISO)
PD123319  (ISO)
perfluorohexanesulfonic acid  (ISO)
perindopril  (EXP)
phenobarbital  (ISO)
phenylephrine  (EXP,ISO)
potassium dichromate  (ISO)
Pranoprofen  (ISO)
propranolol  (ISO)
ramiprilat  (ISO)
resveratrol  (ISO)
rotenone  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
streptozocin  (EXP,ISO)
sulforaphane  (ISO)
terbufos  (ISO)
tetrachloromethane  (EXP,ISO)
titanium dioxide  (ISO)
trichloroethene  (ISO)
triclosan  (ISO)
tropan-3alpha-yl 3-hydroxy-2-phenylpropanoate  (ISO)
valproic acid  (ISO)
valsartan  (EXP)
vincristine  (EXP)
zinc atom  (EXP)
zinc(0)  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function


References - curated
# Reference Title Reference Citation
1. Angiotensin II type 2 receptor-bradykinin B2 receptor functional heterodimerization. Abadir PM, etal., Hypertension. 2006 Aug;48(2):316-22. Epub 2006 Jun 5.
2. Retinal plasma extravasation in streptozotocin-diabetic rats mediated by kinin B(1) and B(2) receptors. Abdouh M, etal., Br J Pharmacol. 2008 May;154(1):136-43. Epub 2008 Mar 3.
3. Efficacy and tolerability of Icatibant (Hoe 140) in patients with moderately severe chronic bronchial asthma. Akbary AM, etal., Immunopharmacology. 1996 Jun;33(1-3):238-42.
4. The genetic association database. Becker KG, etal., Nat Genet. 2004 May;36(5):431-2.
5. Expression of kinin receptors on eosinophils: comparison of asthmatic patients and healthy subjects. Bertram CM, etal., J Leukoc Biol. 2009 Mar;85(3):544-52. Epub 2008 Nov 26.
6. Bradykinin receptors antagonists and nitric oxide synthase inhibitors in vincristine and streptozotocin induced hyperalgesia in chemotherapy and diabetic neuropathy rat model. Bujalska M and Makulska-Nowak H, Neuro Endocrinol Lett. 2009 Mar;30(1):144-52.
7. Autoradiographic distribution and alterations of kinin B(2) receptors in the brain and spinal cord of streptozotocin-diabetic rats. Campos MM, etal., Synapse. 2005 Dec 1;58(3):184-92.
8. Splanchnic hyposensitivity to glypressin in a hemorrhage-transfused common bile duct-ligated rat model of portal hypertension: role of nitric oxide and bradykinin. Chen CT, etal., Hepatogastroenterology. 2009 Sep-Oct;56(94-95):1261-7.
9. Expression and function of bradykinin B1 and B2 receptors in normal and inflamed rat urinary bladder urothelium. Chopra B, etal., J Physiol. 2005 Feb 1;562(Pt 3):859-71. Epub 2004 Dec 2.
10. Pharmacologic and autoradiographic evidence for an up-regulation of kinin B(2) receptors in the spinal cord of spontaneously hypertensive rats. Cloutier F, etal., Br J Pharmacol. 2002 Apr;135(7):1641-54.
11. Selective tumor blood-brain barrier opening with the kinin B2 receptor agonist -BK in a F98 glioma rat model: an MRI study. Cote J, etal., Neuropeptides. 2010 Apr;44(2):177-85. Epub 2010 Jan 18.
12. Gene expression of kinin receptors B1 and B2 in PBMC from patients with cardiac syndrome X. Dabek J, etal., Scand Cardiovasc J. 2007 Dec;41(6):391-6.
13. Direct protein-protein interaction between PLCgamma1 and the bradykinin B2 receptor--importance of growth conditions. Duchene J, etal., Biochem Biophys Res Commun. 2005 Jan 28;326(4):894-900.
14. A novel protein-protein interaction between a G protein-coupled receptor and the phosphatase SHP-2 is involved in bradykinin-induced inhibition of cell proliferation. Duchene J, etal., J Biol Chem. 2002 Oct 25;277(43):40375-83. Epub 2002 Aug 12.
15. Role of bradykinin B1 and B2 receptors in normal blood pressure regulation. Duka A, etal., Am J Physiol Endocrinol Metab. 2006 Aug;291(2):E268-74. Epub 2006 Feb 28.
16. Airway hyperresponsiveness to bradykinin induced by allergen challenge in actively sensitised Brown Norway rats. Ellis KM, etal., Naunyn Schmiedebergs Arch Pharmacol. 2004 Feb;369(2):166-78. Epub 2004 Jan 15.
17. Effects of the bradykinin B2 receptor antagonist S 16118 (p-guanidobenzoyl-[Hyp3,Thi5,D-Tic7,Oic8]bradykinin) in different in vivo animal models of inflammation. Feletou M, etal., J Pharmacol Exp Ther. 1995 Jun;273(3):1078-84.
18. Cyclooxygenase inhibitors attenuate bradykinin-induced vasoconstriction in septic isolated rat lungs. Fischer LG, etal., Anesth Analg. 2000 Mar;90(3):625-31.
19. Modulation of allergic and immune complex-induced lung inflammation by bradykinin receptor antagonists. Gama Landgraf R, etal., Inflamm Res. 2004 Feb;53(2):78-83. Epub 2004 Jan 26.
20. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
21. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
22. Identification of genetic factors associated with susceptibility to angiotensin-converting enzyme inhibitors-induced cough. Grilo A, etal., Pharmacogenet Genomics. 2011 Jan;21(1):10-7.
23. A novel bioassay for detecting GPCR heterodimerization: transactivation of beta 2 adrenergic receptor by bradykinin receptor. Haack KK, etal., J Biomol Screen. 2010 Mar;15(3):251-60. doi: 10.1177/1087057109360254. Epub 2010 Feb 11.
24. +9/+9 Homozygosity of the bradykinin receptor gene polymorphism is associated with reduced fat-free mass in chronic obstructive pulmonary disease. Hopkinson NS, etal., Am J Clin Nutr. 2006 Apr;83(4):912-7.
25. Interleukin-1beta enhanced action of kinins on extracellular matrix of spontaneous hypertensive rat cardiac fibroblasts. Imai C, etal., Clin Exp Hypertens 2005 Jan;27(1):59-69.
26. Lack of both bradykinin B1 and B2 receptors enhances nephropathy, neuropathy, and bone mineral loss in Akita diabetic mice. Kakoki M, etal., Proc Natl Acad Sci U S A. 2010 Jun 1;107(22):10190-5. doi: 10.1073/pnas.1005144107. Epub 2010 May 17.
27. Polymorphisms in the bradykinin B2 receptor gene and childhood asthma. Kusser B, etal., Biol Chem. 2001 May;382(5):885-9.
28. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
29. Angiotensin-converting enzyme gene insertion/deletion, not bradykinin B2 receptor -58T/C gene polymorphism, associated with angiotensin-converting enzyme inhibitor-related cough in Chinese female patients with non-insulin-dependent diabetes mellitus. Lee YJ and Tsai JC, Metabolism. 2001 Nov;50(11):1346-50.
30. International union of pharmacology. XLV. Classification of the kinin receptor family: from molecular mechanisms to pathophysiological consequences. Leeb-Lundberg LM, etal., Pharmacol Rev. 2005 Mar;57(1):27-77.
31. Hypoxia-induced expression of bradykinin type-2 receptors in endothelial cells triggers NO production, cell migration, and angiogenesis. Liesmaa I, etal., J Cell Physiol. 2009 Nov;221(2):359-66.
32. Effects of an orally active non-peptide bradykinin B2 receptor antagonist, FR173657, on plasma exudation in rat carrageenin-induced pleurisy. Majima M, etal., Br J Pharmacol. 1997 Jun;121(4):723-30.
33. Expression cloning of a rat B2 bradykinin receptor. McEachern AE, etal., Proc Natl Acad Sci U S A 1991 Sep 1;88(17):7724-8.
34. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
35. The kallikrein-kinin system: current and future pharmacological targets. Moreau ME, etal., J Pharmacol Sci. 2005 Sep;99(1):6-38.
36. Bradykinin B(2) receptor gene polymorphism is associated with angiotensin-converting enzyme inhibitor-related cough. Mukae S, etal., Hypertension. 2000 Jul;36(1):127-31.
37. Association of polymorphisms of the renin-angiotensin system and bradykinin B2 receptor with ACE-inhibitor-related cough. Mukae S, etal., J Hum Hypertens. 2002 Dec;16(12):857-63.
38. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
39. Autoradiographic analysis of rat brain kinin B1 and B2 receptors: normal distribution and alterations induced by epilepsy. Ongali B, etal., J Comp Neurol 2003 Jul 7;461(4):506-19.
40. Molecular structure and expression of rat bradykinin B2 receptor gene. Evidence for alternative splicing. Pesquero JB, etal., J Biol Chem 1994 Oct 28;269(43):26920-5.
41. Role of kinin B1 and B2 receptors in a rat model of neuropathic pain. Petcu M, etal., Int Immunopharmacol. 2008 Feb;8(2):188-96. Epub 2007 Sep 29.
42. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
43. Bradykinin B1 and B2 receptors, tumour necrosis factor alpha and inflammatory hyperalgesia. Poole S, etal., Br J Pharmacol. 1999 Feb;126(3):649-56.
44. Kinin B1 and B2 receptor mRNA expression in the hypothalamus of spontaneously hypertensive rats. Qadri F, etal., Can J Physiol Pharmacol 2002 Apr;80(4):258-63.
45. Comparative nasal effects of bradykinin, kallidin and [Des-Arg9]-bradykinin in atopic rhinitic and normal volunteers. Rajakulasingam K, etal., J Physiol. 1991 Jun;437:577-87.
46. Enalapril treatment corrects the reduced response to bradykinin in diabetes increasing the B2 protein expression. Rastelli VM, etal., Peptides. 2008 Mar;29(3):404-11. Epub 2007 Dec 7.
47. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
48. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
49. Bradykinin down-regulates LPS-induced eosinophil accumulation in the pleural cavity of mice through type 2-kinin receptor activation: a role for prostaglandins. Silva AR, etal., Br J Pharmacol. 1999 May;127(2):569-75.
50. Regulation of cardiac bradykinin B1- and B2-receptor mRNA in experimental ischemic, diabetic, and pressure-overload-induced cardiomyopathy. Spillmann F, etal., Int Immunopharmacol 2002 Dec;2(13-14):1823-32.
51. Targeted deletion of B2-kinin receptors protects against the development of diabetic nephropathy. Tan Y, etal., Am J Physiol Renal Physiol. 2007 Oct;293(4):F1026-35. Epub 2007 Jun 27.
52. Treatment of severe pulmonary hypertension: a bradykinin receptor 2 agonist B9972 causes reduction of pulmonary artery pressure and right ventricular hypertrophy. Taraseviciene-Stewart L, etal., Peptides. 2005 Aug;26(8):1292-300.
53. Role of kinins in seasonal allergic rhinitis: icatibant, a bradykinin B2 receptor antagonist, abolishes the hyperresponsiveness and nasal eosinophilia induced by antigen. Turner P, etal., J Allergy Clin Immunol. 2001 Jan;107(1):105-13.
54. Hypotension in transgenic mice overexpressing human bradykinin B2 receptor. Wang DZ, etal., Hypertension. 1997 Jan;29(1 Pt 2):488-93.
55. Lack of association between ACE and bradykinin B2 receptor gene polymorphisms and ACE inhibitor-induced coughing in hypertensive Koreans. Woo SW, etal., J Clin Pharm Ther. 2009 Oct;34(5):561-7.
56. Prostaglandin receptors EP2, EP3, and IP mediate exudate formation in carrageenin-induced mouse pleurisy. Yuhki K, etal., J Pharmacol Exp Ther. 2004 Dec;311(3):1218-24. Epub 2004 Aug 17.
Additional References at PubMed
PMID:8086459   PMID:8394991   PMID:8652530   PMID:10085087   PMID:10993080   PMID:11282893   PMID:11686492   PMID:12025970   PMID:12435802   PMID:12444060   PMID:12558524   PMID:12558526  
PMID:12623134   PMID:12639805   PMID:12694402   PMID:12791684   PMID:12923406   PMID:14753436   PMID:14766673   PMID:14766794   PMID:15001555   PMID:15708952   PMID:16513137   PMID:16571598  
PMID:17077303   PMID:18264983   PMID:18302192   PMID:18632797   PMID:19017652   PMID:19027830   PMID:19544046   PMID:19889854   PMID:19954757   PMID:20198577   PMID:20345876   PMID:20531238  
PMID:20637711   PMID:20883789   PMID:21232147   PMID:21986469   PMID:22739815   PMID:22862305   PMID:22877648   PMID:23132855   PMID:23306173   PMID:23417862   PMID:23735753   PMID:23846981  
PMID:23982204   PMID:24025224   PMID:24724708   PMID:25713410   PMID:25955317   PMID:26256678   PMID:26565562   PMID:27628189   PMID:27923787   PMID:30580020   PMID:31086419   PMID:33687297  


Comparative Map Data
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.26124,472,317 - 124,502,497 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl6124,472,566 - 124,502,497 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx6124,593,665 - 124,623,640 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.06124,888,932 - 124,918,906 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.06124,250,138 - 124,280,235 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.06129,399,468 - 129,429,676 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6129,399,468 - 129,429,676 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06138,615,812 - 138,622,272 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.46129,744,781 - 129,748,851 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.16129,748,527 - 129,752,598 (+)NCBI
Celera6122,039,524 - 122,069,422 (+)NCBICelera
RH 3.4 Map6815.41RGD
Cytogenetic Map6q32NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh381496,204,839 - 96,244,164 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1496,204,679 - 96,244,166 (+)EnsemblGRCh38hg38GRCh38
GRCh371496,671,176 - 96,710,501 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361495,740,950 - 95,780,542 (+)NCBINCBI36Build 36hg18NCBI36
Build 341495,740,949 - 95,780,536NCBI
Celera1476,726,862 - 76,766,386 (+)NCBICelera
Cytogenetic Map14q32.2NCBI
HuRef1476,856,277 - 76,895,774 (+)NCBIHuRef
CHM1_11496,610,085 - 96,649,595 (+)NCBICHM1_1
T2T-CHM13v2.01490,436,088 - 90,475,413 (+)NCBIT2T-CHM13v2.0
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm3912105,529,431 - 105,561,503 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl12105,529,485 - 105,561,496 (+)EnsemblGRCm39 Ensembl
GRCm3812105,563,172 - 105,595,244 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl12105,563,226 - 105,595,237 (+)EnsemblGRCm38mm10GRCm38
MGSCv3712106,801,382 - 106,831,281 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3612105,964,222 - 105,994,121 (+)NCBIMGSCv36mm8
Celera12106,797,782 - 106,827,683 (+)NCBICelera
Cytogenetic Map12ENCBI
cM Map1255.76NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_00495543816,511,759 - 16,537,172 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495543816,514,300 - 16,537,160 (-)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
NHGRI_mPanPan11496,579,702 - 96,620,931 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01476,832,833 - 76,873,860 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11496,157,122 - 96,196,253 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1496,156,494 - 96,196,253 (+)Ensemblpanpan1.1panPan2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.1864,974,588 - 65,005,682 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl864,974,997 - 65,003,407 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha864,490,876 - 64,519,295 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0865,246,390 - 65,277,067 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl865,246,390 - 65,274,792 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1864,919,488 - 64,947,871 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0864,980,727 - 65,009,155 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0865,304,383 - 65,332,835 (+)NCBIUU_Cfam_GSD_1.0
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_0244086409,528,206 - 9,533,778 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936604548,847 - 549,956 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936604548,844 - 551,031 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl7117,438,713 - 117,472,005 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.17117,438,622 - 117,472,005 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.12474,084,907 - 74,125,604 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2474,118,210 - 74,122,909 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605361,236,289 - 61,276,664 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla_female_1.0 EnsemblNW_0046247348,513,814 - 8,539,036 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247348,513,601 - 8,538,838 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Variants in Bdkrb2
269 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:352
Count of miRNA genes:134
Interacting mature miRNAs:152
Transcripts:ENSRNOT00000071735, ENSRNOT00000074621
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
731173Uae22Urinary albumin excretion QTL 2210.1urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)665531555140994061Rat
2290393Uae37Urinary albumin excretion QTL 370.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)665531555140994061Rat
724536Uae7Urinary albumin excretion QTL 73.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)672202632130729475Rat
1331799Bp211Blood pressure QTL 2113.66407arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)672202632130919985Rat
1581550Pur8Proteinuria QTL 8urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)672227641130729205Rat
1581563Uae33Urinary albumin excretion QTL 33urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)672227641130729205Rat
738034Anxrr5Anxiety related response QTL 55.9exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)684130881129130881Rat
10054138Gmadr3Adrenal mass QTL 33.680.00045adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)685140138130140138Rat
10054123Srcrt6Stress Responsive Cort QTL 62.50.0043blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)685140138130140138Rat
724513Uae14Urinary albumin excretion QTL 146.5urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)685311061133478515Rat
1300076Glom8Glomerulus QTL 870.000000009kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli directly contacting the kidney surface (CMO:0001001)686894788131894788Rat
2303624Vencon5Ventilatory control QTL 54.45respiration trait (VT:0001943)minute ventilation (CMO:0000132)688047916133047916Rat
1331725Bp212Blood pressure QTL 2123.52475arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)693701310128713626Rat
61414Pia3Pristane induced arthritis QTL 34.5joint integrity trait (VT:0010548)post-insult time to onset of experimental arthritis (CMO:0001450)694968928137848904Rat
12801411Schws8Schwannoma susceptibility QTL 8nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)694968928139968928Rat
8552796Vie3Viral induced encephalitis QTL 32.6brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)696833997140994061Rat
1358355Srcrt4Stress Responsive Cort QTL 46.39blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)6100364669140994061Rat
2313399Anxrr28Anxiety related response QTL 28aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)6100671796132340886Rat
1331797Bp213Blood pressure QTL 2133.291arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)6104085867128713626Rat
71111Iddm8Insulin dependent diabetes mellitus QTL 81.90.002blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)6105156861140994061Rat
4145118Mcs26Mammary carcinoma susceptibility QTL 260.0001mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)6106752656132339866Rat
737976Pia24Pristane induced arthritis QTL 24joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)6112636280140994061Rat
1298087Iddm18Insulin dependent diabetes mellitus QTL 180.0001urine glucose amount (VT:0001758)percentage of study population developing diabetes mellitus during a period of time (CMO:0001114)6116506292130245370Rat
1641917Colcr5Colorectal carcinoma resistance QTL 53.180.0009intestine integrity trait (VT:0010554)benign colorectal tumor number (CMO:0001795)6122549046137801795Rat
2293085Iddm29Insulin dependent diabetes mellitus QTL 297.66blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)6122549046140286318Rat
61329Eae9Experimental allergic encephalomyelitis QTL 93.7body mass (VT:0001259)change in body weight (CMO:0002045)6122549046140994061Rat

Markers in Region
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.26124,498,937 - 124,499,509 (+)MAPPERmRatBN7.2
Rnor_6.06129,426,117 - 129,426,688NCBIRnor6.0
Rnor_5.06138,618,713 - 138,619,284UniSTSRnor5.0
RGSC_v3.46129,747,682 - 129,748,253UniSTSRGSC3.4
Celera6122,065,863 - 122,066,434UniSTS
Cytogenetic Map6q32UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.26124,499,992 - 124,500,146 (+)MAPPERmRatBN7.2
Rnor_6.06129,427,172 - 129,427,325NCBIRnor6.0
Rnor_5.06138,619,768 - 138,619,921UniSTSRnor5.0
RGSC_v3.46129,748,737 - 129,748,890UniSTSRGSC3.4
Celera6122,066,918 - 122,067,071UniSTS
Cytogenetic Map6q32UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.26124,500,590 - 124,500,832 (+)MAPPERmRatBN7.2
Rnor_6.06129,427,770 - 129,428,011NCBIRnor6.0
Rnor_5.06138,620,366 - 138,620,607UniSTSRnor5.0
RGSC_v3.46129,749,335 - 129,749,576UniSTSRGSC3.4
Celera6122,067,516 - 122,067,757UniSTS
Cytogenetic Map6q32UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.26124,501,455 - 124,501,608 (+)MAPPERmRatBN7.2
Rnor_6.06129,428,635 - 129,428,787NCBIRnor6.0
Rnor_5.06138,621,231 - 138,621,383UniSTSRnor5.0
RGSC_v3.46129,750,200 - 129,750,352UniSTSRGSC3.4
Celera6122,068,381 - 122,068,533UniSTS
RH 3.4 Map6815.41UniSTS
Cytogenetic Map6q32UniSTS

Genetic Models
This gene Bdkrb2 is modified in the following models/strains:


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
Medium 15
Low 3 39 16 17 8 11 63 35 19 11 8
Below cutoff 4 26 26 2 26 11 7


RefSeq Acc Id: ENSRNOT00000071735   ⟹   ENSRNOP00000064715
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl6124,472,566 - 124,502,497 (+)Ensembl
Rnor_6.0 Ensembl6129,399,468 - 129,429,676 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000074621   ⟹   ENSRNOP00000064990
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl6124,472,625 - 124,502,497 (+)Ensembl
Rnor_6.0 Ensembl6129,399,505 - 129,429,676 (+)Ensembl
RefSeq Acc Id: NM_001270713   ⟹   NP_001257642
RefSeq Status: VALIDATED
Rat AssemblyChrPosition (strand)Source
mRatBN7.26124,472,631 - 124,502,497 (+)NCBI
Rnor_6.06129,399,526 - 129,429,676 (+)NCBI
Rnor_5.06138,615,812 - 138,622,272 (+)NCBI
Celera6122,039,584 - 122,069,422 (+)NCBI
RefSeq Acc Id: NM_173100   ⟹   NP_775123
RefSeq Status: VALIDATED
Rat AssemblyChrPosition (strand)Source
mRatBN7.26124,472,566 - 124,502,497 (+)NCBI
Rnor_6.06129,399,468 - 129,429,676 (+)NCBI
Rnor_5.06138,615,812 - 138,622,272 (+)NCBI
RGSC_v3.46129,744,781 - 129,748,851 (+)RGD
Celera6122,039,524 - 122,069,422 (+)NCBI
RefSeq Acc Id: XM_039111800   ⟹   XP_038967728
Rat AssemblyChrPosition (strand)Source
mRatBN7.26124,472,317 - 124,502,497 (+)NCBI
RefSeq Acc Id: XM_039111801   ⟹   XP_038967729
Rat AssemblyChrPosition (strand)Source
mRatBN7.26124,472,342 - 124,502,497 (+)NCBI
RefSeq Acc Id: NP_775123   ⟸   NM_173100
- Peptide Label: isoform 2
- UniProtKB: P25023 (UniProtKB/Swiss-Prot),   A0A0H2UI29 (UniProtKB/TrEMBL),   A6KBC4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001257642   ⟸   NM_001270713
- Peptide Label: isoform 1
- UniProtKB: P25023 (UniProtKB/Swiss-Prot),   G3V942 (UniProtKB/TrEMBL),   A6KBC5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000064715   ⟸   ENSRNOT00000071735
RefSeq Acc Id: ENSRNOP00000064990   ⟸   ENSRNOT00000074621
RefSeq Acc Id: XP_038967728   ⟸   XM_039111800
- Peptide Label: isoform X1
- UniProtKB: P25023 (UniProtKB/Swiss-Prot),   G3V942 (UniProtKB/TrEMBL),   A6KBC5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038967729   ⟸   XM_039111801
- Peptide Label: isoform X2
- UniProtKB: P25023 (UniProtKB/Swiss-Prot),   A0A0H2UI29 (UniProtKB/TrEMBL),   A6KBC4 (UniProtKB/TrEMBL)
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P25023-F1-model_v2 AlphaFold P25023 1-396 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13694815
Promoter ID:EPDNEW_R5336
Type:single initiation site
Description:bradykinin receptor B2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database,
Experiment Methods:Single-end sequencing.
Rat AssemblyChrPosition (strand)Source
Rnor_6.06129,399,450 - 129,399,510EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2201 AgrOrtholog
BioCyc Gene G2FUF-36337 BioCyc
Ensembl Genes ENSRNOG00000047300 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOG00065026514 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000071735 ENTREZGENE
  ENSRNOT00000071735.3 UniProtKB/TrEMBL
  ENSRNOT00000074621.3 UniProtKB/TrEMBL
  ENSRNOT00065045794 UniProtKB/Swiss-Prot
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Brdyknn_2_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Brdyknn_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25245 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam 7tm_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Bdkrb2 PhenoGen
  BRADYKINNB2R UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000047300 RatGTEx
  ENSRNOG00065026514 RatGTEx
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  BKRB2_RAT UniProtKB/Swiss-Prot

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-09-25 Bdkrb2  bradykinin receptor B2  Bdkrb2  bradykinin receptor, beta 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Bdkrb2  bradykinin receptor, beta 2    bradykinin receptor b2  Name updated 1299863 APPROVED
2002-06-10 Bdkrb2  Bradykinin receptor B2      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in uterus, vas deferens, kidney, lung, heart, ileum, testis, and brain 631709
gene_function receptor 631709
gene_process involved in pain response 631709
gene_product member of seven transmembrane G protein-coupled superfamily of receptors 631709
gene_regulation expression is higher in unstimulated, cultured cardiac fibroblasts from adult SHR rats than in those from WKY rats. After exposure of cells to IL-1 beta, expression is enhanced in cells of both strains to equivalent levels. 1358958
gene_transcript mRNA exists in two splicing variants 631790