Bdkrb2 (bradykinin receptor B2) - Rat Genome Database

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Gene: Bdkrb2 (bradykinin receptor B2) Rattus norvegicus
Analyze
Symbol: Bdkrb2
Name: bradykinin receptor B2
RGD ID: 2201
Description: Enables beta-2 adrenergic receptor binding activity and bradykinin receptor activity. Involved in several processes, including acute inflammatory response to antigenic stimulus; cellular response to hypoxia; and maintenance of blood-brain barrier. Located in plasma membrane. Used to study several diseases, including asthma; pancreatitis; pleurisy; portal hypertension; and pulmonary hypertension. Biomarker of high grade glioma; hypertension; myocardial infarction; and sciatic neuropathy. Human ortholog(s) of this gene implicated in asthma; chronic obstructive pulmonary disease; hypertension; and rhinitis. Orthologous to human BDKRB2 (bradykinin receptor B2); PARTICIPATES IN G protein mediated signaling pathway via Galphai family; G protein mediated signaling pathway via Galphaq family; kallikrein-kinin cascade pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3',5'-cyclic GMP; 4-amino-2,6-dinitrotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: B2 bradykinin receptor; B2BKR; B2BRA; B2R; BK-2 receptor; bradykinin receptor, beta 2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: Bdkrb2m1Mcwi   Bdkrb2m2Mcwi  
Genetic Models: FHH-Bdkrb2m1Mcwi SS-Bdkrb2m2Mcwi
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.26124,472,317 - 124,502,497 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl6124,472,566 - 124,502,497 (+)Ensembl
Rnor_6.06129,399,468 - 129,429,676 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6129,399,468 - 129,429,676 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06138,615,812 - 138,622,272 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.46129,744,781 - 129,748,851 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.16129,748,527 - 129,752,598 (+)NCBI
Celera6122,039,524 - 122,069,422 (+)NCBICelera
RH 3.4 Map6815.41RGD
Cytogenetic Map6q32NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (ISO)
(R)-noradrenaline  (ISO)
1,2-dichloroethane  (ISO)
15-acetyldeoxynivalenol  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
3',5'-cyclic GMP  (EXP)
3,3',5,5'-tetrabromobisphenol A  (ISO)
4-amino-2,6-dinitrotoluene  (EXP)
4-hydroxycyclophosphamide  (EXP)
5-fluorouracil  (ISO)
6-oxoprostaglandin F1alpha  (EXP,ISO)
8-Br-cAMP  (ISO)
afimoxifene  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
allyl isothiocyanate  (ISO)
amlodipine  (ISO)
aristolochic acid  (ISO)
atenolol  (ISO)
atropine  (ISO)
benazepril  (EXP,ISO)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP)
calcium atom  (ISO)
calcium(0)  (ISO)
candesartan  (EXP)
capsaicin  (EXP,ISO)
captopril  (ISO)
carbon nanotube  (ISO)
ceruletide  (ISO)
chondroitin sulfate  (EXP)
cisplatin  (ISO)
copper(II) sulfate  (ISO)
cyclophosphamide  (EXP)
dextran sulfate  (ISO)
dibutyl phthalate  (EXP)
dichlorine  (EXP)
dioxygen  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
enalapril  (EXP)
fenvalerate  (EXP)
fonofos  (ISO)
formaldehyde  (ISO)
genistein  (EXP)
Hexamethonium  (ISO)
icatibant  (EXP,ISO)
irbesartan  (ISO)
manganese(II) chloride  (EXP)
methoxychlor  (EXP)
N-methyl-4-phenylpyridinium  (ISO)
N-Nitrosopyrrolidine  (ISO)
nickel atom  (ISO)
nitric oxide  (EXP)
nitroprusside  (ISO)
O-methyleugenol  (ISO)
ozone  (EXP)
paracetamol  (ISO)
parathion  (ISO)
PD123319  (ISO)
perindopril  (EXP)
phenobarbital  (ISO)
phenylephrine  (EXP,ISO)
potassium dichromate  (ISO)
Pranoprofen  (ISO)
propranolol  (ISO)
ramiprilat  (ISO)
resveratrol  (ISO)
rotenone  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
streptozocin  (EXP,ISO)
sulforaphane  (ISO)
terbufos  (ISO)
tetrachloromethane  (EXP,ISO)
titanium dioxide  (ISO)
trichloroethene  (ISO)
triclosan  (ISO)
tropan-3alpha-yl 3-hydroxy-2-phenylpropanoate  (ISO)
valproic acid  (ISO)
valsartan  (EXP)
vincristine  (EXP)
zinc atom  (EXP)
zinc(0)  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
1. Abadir PM, etal., Hypertension. 2006 Aug;48(2):316-22. Epub 2006 Jun 5.
2. Abdouh M, etal., Br J Pharmacol. 2008 May;154(1):136-43. Epub 2008 Mar 3.
3. Akbary AM, etal., Immunopharmacology. 1996 Jun;33(1-3):238-42.
4. Becker KG, etal., Nat Genet. 2004 May;36(5):431-2.
5. Bertram CM, etal., J Leukoc Biol. 2009 Mar;85(3):544-52. Epub 2008 Nov 26.
6. Bujalska M and Makulska-Nowak H, Neuro Endocrinol Lett. 2009 Mar;30(1):144-52.
7. Campos MM, etal., Synapse. 2005 Dec 1;58(3):184-92.
8. Chen CT, etal., Hepatogastroenterology. 2009 Sep-Oct;56(94-95):1261-7.
9. Chopra B, etal., J Physiol. 2005 Feb 1;562(Pt 3):859-71. Epub 2004 Dec 2.
10. Cloutier F, etal., Br J Pharmacol. 2002 Apr;135(7):1641-54.
11. Cote J, etal., Neuropeptides. 2010 Apr;44(2):177-85. Epub 2010 Jan 18.
12. Dabek J, etal., Scand Cardiovasc J. 2007 Dec;41(6):391-6.
13. Duchene J, etal., Biochem Biophys Res Commun. 2005 Jan 28;326(4):894-900.
14. Duchene J, etal., J Biol Chem. 2002 Oct 25;277(43):40375-83. Epub 2002 Aug 12.
15. Duka A, etal., Am J Physiol Endocrinol Metab. 2006 Aug;291(2):E268-74. Epub 2006 Feb 28.
16. Ellis KM, etal., Naunyn Schmiedebergs Arch Pharmacol. 2004 Feb;369(2):166-78. Epub 2004 Jan 15.
17. Feletou M, etal., J Pharmacol Exp Ther. 1995 Jun;273(3):1078-84.
18. Fischer LG, etal., Anesth Analg. 2000 Mar;90(3):625-31.
19. Gama Landgraf R, etal., Inflamm Res. 2004 Feb;53(2):78-83. Epub 2004 Jan 26.
20. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
21. GOA data from the GO Consortium
22. Grilo A, etal., Pharmacogenet Genomics. 2011 Jan;21(1):10-7.
23. Haack KK, etal., J Biomol Screen. 2010 Mar;15(3):251-60. doi: 10.1177/1087057109360254. Epub 2010 Feb 11.
24. Hopkinson NS, etal., Am J Clin Nutr. 2006 Apr;83(4):912-7.
25. Imai C, etal., Clin Exp Hypertens 2005 Jan;27(1):59-69.
26. Kakoki M, etal., Proc Natl Acad Sci U S A. 2010 Jun 1;107(22):10190-5. doi: 10.1073/pnas.1005144107. Epub 2010 May 17.
27. Kusser B, etal., Biol Chem. 2001 May;382(5):885-9.
28. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
29. Lee YJ and Tsai JC, Metabolism. 2001 Nov;50(11):1346-50.
30. Leeb-Lundberg LM, etal., Pharmacol Rev. 2005 Mar;57(1):27-77.
31. Liesmaa I, etal., J Cell Physiol. 2009 Nov;221(2):359-66.
32. Majima M, etal., Br J Pharmacol. 1997 Jun;121(4):723-30.
33. McEachern AE, etal., Proc Natl Acad Sci U S A 1991 Sep 1;88(17):7724-8.
34. MGD data from the GO Consortium
35. Moreau ME, etal., J Pharmacol Sci. 2005 Sep;99(1):6-38.
36. Mukae S, etal., Hypertension. 2000 Jul;36(1):127-31.
37. Mukae S, etal., J Hum Hypertens. 2002 Dec;16(12):857-63.
38. NCBI rat LocusLink and RefSeq merged data July 26, 2002
39. Ongali B, etal., J Comp Neurol 2003 Jul 7;461(4):506-19.
40. Pesquero JB, etal., J Biol Chem 1994 Oct 28;269(43):26920-5.
41. Petcu M, etal., Int Immunopharmacol. 2008 Feb;8(2):188-96. Epub 2007 Sep 29.
42. Pipeline to import KEGG annotations from KEGG into RGD
43. Poole S, etal., Br J Pharmacol. 1999 Feb;126(3):649-56.
44. Qadri F, etal., Can J Physiol Pharmacol 2002 Apr;80(4):258-63.
45. Rajakulasingam K, etal., J Physiol. 1991 Jun;437:577-87.
46. Rastelli VM, etal., Peptides. 2008 Mar;29(3):404-11. Epub 2007 Dec 7.
47. RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
48. RGD automated import pipeline for gene-chemical interactions
49. Silva AR, etal., Br J Pharmacol. 1999 May;127(2):569-75.
50. Spillmann F, etal., Int Immunopharmacol 2002 Dec;2(13-14):1823-32.
51. Tan Y, etal., Am J Physiol Renal Physiol. 2007 Oct;293(4):F1026-35. Epub 2007 Jun 27.
52. Taraseviciene-Stewart L, etal., Peptides. 2005 Aug;26(8):1292-300.
53. Turner P, etal., J Allergy Clin Immunol. 2001 Jan;107(1):105-13.
54. Wang DZ, etal., Hypertension. 1997 Jan;29(1 Pt 2):488-93.
55. Woo SW, etal., J Clin Pharm Ther. 2009 Oct;34(5):561-7.
56. Yuhki K, etal., J Pharmacol Exp Ther. 2004 Dec;311(3):1218-24. Epub 2004 Aug 17.
Additional References at PubMed
PMID:8086459   PMID:8394991   PMID:8652530   PMID:10085087   PMID:10993080   PMID:11282893   PMID:11686492   PMID:12025970   PMID:12435802   PMID:12444060   PMID:12558524   PMID:12558526  
PMID:12623134   PMID:12639805   PMID:12694402   PMID:12791684   PMID:12923406   PMID:14753436   PMID:14766673   PMID:14766794   PMID:15001555   PMID:15708952   PMID:16513137   PMID:16571598  
PMID:17077303   PMID:18264983   PMID:18302192   PMID:18632797   PMID:19017652   PMID:19027830   PMID:19544046   PMID:19889854   PMID:19954757   PMID:20198577   PMID:20345876   PMID:20531238  
PMID:20637711   PMID:20883789   PMID:21232147   PMID:21986469   PMID:22739815   PMID:22862305   PMID:22877648   PMID:23132855   PMID:23306173   PMID:23417862   PMID:23735753   PMID:23846981  
PMID:23982204   PMID:24025224   PMID:24724708   PMID:25713410   PMID:25955317   PMID:26256678   PMID:26565562   PMID:27628189   PMID:27923787   PMID:30580020   PMID:31086419   PMID:33687297  


Genomics

Comparative Map Data
Bdkrb2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.26124,472,317 - 124,502,497 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl6124,472,566 - 124,502,497 (+)Ensembl
Rnor_6.06129,399,468 - 129,429,676 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6129,399,468 - 129,429,676 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06138,615,812 - 138,622,272 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.46129,744,781 - 129,748,851 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.16129,748,527 - 129,752,598 (+)NCBI
Celera6122,039,524 - 122,069,422 (+)NCBICelera
RH 3.4 Map6815.41RGD
Cytogenetic Map6q32NCBI
BDKRB2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1496,204,679 - 96,244,166 (+)EnsemblGRCh38hg38GRCh38
GRCh381496,204,839 - 96,244,164 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371496,671,176 - 96,710,501 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361495,740,950 - 95,780,542 (+)NCBINCBI36hg18NCBI36
Build 341495,740,949 - 95,780,536NCBI
Celera1476,726,862 - 76,766,386 (+)NCBI
Cytogenetic Map14q32.2NCBI
HuRef1476,856,277 - 76,895,774 (+)NCBIHuRef
CHM1_11496,610,085 - 96,649,595 (+)NCBICHM1_1
Bdkrb2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3912105,529,431 - 105,561,503 (+)NCBIGRCm39mm39
GRCm39 Ensembl12105,529,485 - 105,561,496 (+)Ensembl
GRCm3812105,563,172 - 105,595,244 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl12105,563,226 - 105,595,237 (+)EnsemblGRCm38mm10GRCm38
MGSCv3712106,801,382 - 106,831,281 (+)NCBIGRCm37mm9NCBIm37
MGSCv3612105,964,222 - 105,994,121 (+)NCBImm8
Celera12106,797,782 - 106,827,683 (+)NCBICelera
Cytogenetic Map12ENCBI
cM Map1255.76NCBI
Bdkrb2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543816,511,759 - 16,537,172 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495543816,514,300 - 16,537,160 (-)NCBIChiLan1.0ChiLan1.0
BDKRB2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11496,157,122 - 96,196,253 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1496,156,494 - 96,196,253 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01476,832,833 - 76,873,860 (+)NCBIMhudiblu_PPA_v0panPan3
BDKRB2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1864,974,588 - 65,005,682 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl864,974,997 - 65,003,407 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha864,490,876 - 64,519,295 (+)NCBI
ROS_Cfam_1.0865,246,390 - 65,277,067 (+)NCBI
UMICH_Zoey_3.1864,919,488 - 64,947,871 (+)NCBI
UNSW_CanFamBas_1.0864,980,727 - 65,009,155 (+)NCBI
UU_Cfam_GSD_1.0865,304,383 - 65,332,835 (+)NCBI
Bdkrb2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244086409,528,206 - 9,533,778 (-)NCBI
SpeTri2.0NW_004936604548,844 - 551,031 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
BDKRB2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl7117,438,543 - 117,472,003 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.17117,438,622 - 117,472,005 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
BDKRB2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12474,084,907 - 74,125,604 (+)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl2474,118,210 - 74,122,909 (+)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366605361,236,289 - 61,276,664 (+)NCBIVero_WHO_p1.0
Bdkrb2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247348,513,601 - 8,538,838 (+)NCBIHetGla_female_1.0hetGla2

Position Markers
PMC150944P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.26124,498,937 - 124,499,509 (+)MAPPERmRatBN7.2
Rnor_6.06129,426,117 - 129,426,688NCBIRnor6.0
Rnor_5.06138,618,713 - 138,619,284UniSTSRnor5.0
RGSC_v3.46129,747,682 - 129,748,253UniSTSRGSC3.4
Celera6122,065,863 - 122,066,434UniSTS
Cytogenetic Map6q32UniSTS
L27595  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.26124,499,992 - 124,500,146 (+)MAPPERmRatBN7.2
Rnor_6.06129,427,172 - 129,427,325NCBIRnor6.0
Rnor_5.06138,619,768 - 138,619,921UniSTSRnor5.0
RGSC_v3.46129,748,737 - 129,748,890UniSTSRGSC3.4
Celera6122,066,918 - 122,067,071UniSTS
Cytogenetic Map6q32UniSTS
PMC126639P3  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.26124,500,590 - 124,500,832 (+)MAPPERmRatBN7.2
Rnor_6.06129,427,770 - 129,428,011NCBIRnor6.0
Rnor_5.06138,620,366 - 138,620,607UniSTSRnor5.0
RGSC_v3.46129,749,335 - 129,749,576UniSTSRGSC3.4
Celera6122,067,516 - 122,067,757UniSTS
Cytogenetic Map6q32UniSTS
RH94464  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.26124,501,455 - 124,501,608 (+)MAPPERmRatBN7.2
Rnor_6.06129,428,635 - 129,428,787NCBIRnor6.0
Rnor_5.06138,621,231 - 138,621,383UniSTSRnor5.0
RGSC_v3.46129,750,200 - 129,750,352UniSTSRGSC3.4
Celera6122,068,381 - 122,068,533UniSTS
RH 3.4 Map6815.41UniSTS
Cytogenetic Map6q32UniSTS


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
731173Uae22Urinary albumin excretion QTL 2210.1urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)665531555140994061Rat
2290393Uae37Urinary albumin excretion QTL 370.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)665531555140994061Rat
724536Uae7Urinary albumin excretion QTL 73.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)672202632130729475Rat
1331799Bp211Blood pressure QTL 2113.66407arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)672202632130919985Rat
1581550Pur8Proteinuria QTL 8total urine protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)672227641130729205Rat
1581563Uae33Urinary albumin excretion QTL 33urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)672227641130729205Rat
738034Anxrr5Anxiety related response QTL 55.9exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)684130881129130881Rat
10054138Gmadr3Adrenal mass QTL 33.680.00045adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)685140138130140138Rat
10054123Srcrt6Stress Responsive Cort QTL 62.50.0043blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)685140138130140138Rat
724513Uae14Urinary albumin excretion QTL 146.5urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)685311061133478515Rat
1300076Glom8Glomerulus QTL 870.000000009kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli directly contacting the kidney surface (CMO:0001001)686894788131894788Rat
2303624Vencon5Ventilatory control QTL 54.45respiration trait (VT:0001943)minute ventilation (CMO:0000132)688047916133047916Rat
1331725Bp212Blood pressure QTL 2123.52475arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)693701310128713626Rat
61414Pia3Pristane induced arthritis QTL 34.5joint integrity trait (VT:0010548)post-insult time to onset of experimental arthritis (CMO:0001450)694968928137848904Rat
12801411Schws8Schwannoma susceptibility QTL 8nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)694968928139968928Rat
8552796Vie3Viral induced encephalitis QTL 32.6brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)696833997140994061Rat
1358355Srcrt4Stress Responsive Cort QTL 46.39blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)6100364669140994061Rat
2313399Anxrr28Anxiety related response QTL 28aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)6100671796132340886Rat
1331797Bp213Blood pressure QTL 2133.291arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)6104085867128713626Rat
71111Iddm8Insulin dependent diabetes mellitus QTL 81.90.002blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)6105156861140994061Rat
4145118Mcs26Mammary carcinoma susceptibility QTL 260.0001mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)6106752656132339866Rat
737976Pia24Pristane induced arthritis QTL 24joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)6112636280140994061Rat
1298087Iddm18Insulin dependent diabetes mellitus QTL 180.0001urine glucose amount (VT:0001758)percentage of study population developing diabetes mellitus during a period of time (CMO:0001114)6116506292130245370Rat
1641917Colcr5Colorectal carcinoma resistance QTL 53.180.0009intestine integrity trait (VT:0010554)benign colorectal tumor number (CMO:0001795)6122549046137801795Rat
2293085Iddm29Insulin dependent diabetes mellitus QTL 297.66blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)6122549046140286318Rat
61329Eae9Experimental allergic encephalomyelitis QTL 93.7body mass (VT:0001259)change in body weight (CMO:0002045)6122549046140994061Rat


Genetic Models
This gene Bdkrb2 is modified in the following models/strains
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:352
Count of miRNA genes:134
Interacting mature miRNAs:152
Transcripts:ENSRNOT00000071735, ENSRNOT00000074621
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 15
Low 3 39 16 17 8 11 63 35 19 11 8
Below cutoff 4 26 26 2 26 11 7

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000071735   ⟹   ENSRNOP00000064715
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl6124,472,566 - 124,502,497 (+)Ensembl
Rnor_6.0 Ensembl6129,399,468 - 129,429,676 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000074621   ⟹   ENSRNOP00000064990
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl6124,472,625 - 124,502,497 (+)Ensembl
Rnor_6.0 Ensembl6129,399,505 - 129,429,676 (+)Ensembl
RefSeq Acc Id: NM_001270713   ⟹   NP_001257642
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.26124,472,631 - 124,502,497 (+)NCBI
Rnor_6.06129,399,526 - 129,429,676 (+)NCBI
Rnor_5.06138,615,812 - 138,622,272 (+)NCBI
Celera6122,039,584 - 122,069,422 (+)NCBI
Sequence:
RefSeq Acc Id: NM_173100   ⟹   NP_775123
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.26124,472,566 - 124,502,497 (+)NCBI
Rnor_6.06129,399,468 - 129,429,676 (+)NCBI
Rnor_5.06138,615,812 - 138,622,272 (+)NCBI
RGSC_v3.46129,744,781 - 129,748,851 (+)RGD
Celera6122,039,524 - 122,069,422 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039111800   ⟹   XP_038967728
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.26124,472,317 - 124,502,497 (+)NCBI
RefSeq Acc Id: XM_039111801   ⟹   XP_038967729
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.26124,472,342 - 124,502,497 (+)NCBI
Reference Sequences
RefSeq Acc Id: NP_775123   ⟸   NM_173100
- Peptide Label: isoform 2
- UniProtKB: P25023 (UniProtKB/Swiss-Prot),   A0A0H2UI29 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001257642   ⟸   NM_001270713
- Peptide Label: isoform 1
- UniProtKB: G3V942 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000064715   ⟸   ENSRNOT00000071735
RefSeq Acc Id: ENSRNOP00000064990   ⟸   ENSRNOT00000074621
RefSeq Acc Id: XP_038967728   ⟸   XM_039111800
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038967729   ⟸   XM_039111801
- Peptide Label: isoform X2
Protein Domains
G_PROTEIN_RECEP_F1_2

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13694815
Promoter ID:EPDNEW_R5336
Type:single initiation site
Name:Bdkrb2_1
Description:bradykinin receptor B2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.06129,399,450 - 129,399,510EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (2019)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
ACI/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (2020)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
ACI/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN-Lx/CubMcwi (2019)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2019)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2020)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/SsN (2020)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/SsN (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BUF/N (2020)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH2/CubMcwi (2020)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH3/CubMcwi (2020)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
Buf/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
DA/OlaHsd (2019)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/DuCrl (2019)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/N (2020)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/NCrl (2019)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
F344/Stm (2019)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FHH/EurMcwi (2019)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FHH/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FXLE16/Stm (2020)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE18/Stm (2020)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
GH/OmrMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/FarMcwi (2019)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
GK/Ox (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
HXB10/IpcvMcwi (2019)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB2/IpcvMcwi (2019)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB20/IpcvMcwi (2020)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB31/IpcvMcwi (2019)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB4/IpcvMcwi (2020)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LE/Stm (2019)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LE/Stm (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (2019)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEW/Crl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEXF10A/StmMcwi (2020)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF11/Stm (2020)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1A/Stm (2019)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1C/Stm (2019)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF2B/Stm (2019)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF3/Stm (2020)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF4/Stm (2020)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LH/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrcAek (2020)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LL/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrcAek (2020)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LN/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrcAek (2020)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/N (2020)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
M520/NRrrcMcwi (2019)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MHS/Gib (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (2020)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MR/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MWF/Hsd (2019)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
PVG/Seac (2019)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SBH/Ygl (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/OlalpcvMcwi (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHRSP/A3NCrl (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHRSP/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SR/JrHsd (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SS/JrHsdMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/RijCrl (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WN/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2201 AgrOrtholog
Ensembl Genes ENSRNOG00000047300 Ensembl, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000064715 UniProtKB/TrEMBL
  ENSRNOP00000064990 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000071735 UniProtKB/TrEMBL
  ENSRNOT00000074621 UniProtKB/TrEMBL
InterPro Brdyknn_2_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Brdyknn_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25245 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 25245 ENTREZGENE
Pfam 7tm_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB BDKRB2 RGD
PhenoGen Bdkrb2 PhenoGen
PRINTS BRADYKININR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  BRADYKINNB2R UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCRRHODOPSN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0H2UI29 ENTREZGENE, UniProtKB/TrEMBL
  BKRB2_RAT UniProtKB/Swiss-Prot
  G3V942 ENTREZGENE, UniProtKB/TrEMBL
  P25023 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-09-25 Bdkrb2  bradykinin receptor B2  Bdkrb2  bradykinin receptor, beta 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Bdkrb2  bradykinin receptor, beta 2    bradykinin receptor b2  Name updated 1299863 APPROVED
2002-06-10 Bdkrb2  Bradykinin receptor B2      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in uterus, vas deferens, kidney, lung, heart, ileum, testis, and brain 631709
gene_function receptor 631709
gene_process involved in pain response 631709
gene_product member of seven transmembrane G protein-coupled superfamily of receptors 631709
gene_regulation expression is higher in unstimulated, cultured cardiac fibroblasts from adult SHR rats than in those from WKY rats. After exposure of cells to IL-1 beta, expression is enhanced in cells of both strains to equivalent levels. 1358958
gene_transcript mRNA exists in two splicing variants 631790