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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 61797
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Prkn
Name: parkin RBR E3 ubiquitin protein ligase
Acc ID: CHEBI:75142
Term: N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal
Definition: A tripeptide that is L-leucyl-L-leucyl-L-leucine in which the C-terminal carboxy group has been reduced to the corresponding aldehyde and the N-terminal amino group is protected as its benzyloxycarbonyl derivative.
Chemical ID: MESH:C072553
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Prkndecreases expressionEXP 6480464CTDbenzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of PRKN mRNAPMID:18586549
Prknaffects expressionISOPRKN (Homo sapiens)6480464CTDbenzyloxycarbonylleucyl-leucyl-leucine aldehyde affects the expression of PRKN protein alternative formPMID:28688199
Prkndecreases expressionISOPRKN (Homo sapiens)6480464CTDbenzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of PRKN proteinPMID:28688199
Prknmultiple interactionsISOPRKN (Homo sapiens)6480464CTDbenzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [[Sorafenib co-treated with PRKN protein] results in decreased expression of MCL1 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [PRKN protein results in decreased expression of SLC11A2 protein alternative form]; Tretinoin affects the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde affects the expression of PRKN protein alternative form]PMID:20089134 PMID:28673964 PMID:28688199
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