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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:S-(2,4-dinitrophenyl)glutathione
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Accession:CHEBI:8927 term browser browse the term
Definition:A glutathione conjugate in which the thiol hydrogen of glutathione has been replaced by a 2,4-dinitrophenyl group.
Synonyms:exact_synonym: L-gamma-glutamyl-S-(2,4-dinitrophenyl)-L-cysteinylglycine
 related_synonym: DNP-S-glutathione;   DNP-SG;   Formula=C16H19N5O10S;   InChI=1S/C16H19N5O10S/c17-9(16(26)27)2-4-13(22)19-10(15(25)18-6-14(23)24)7-32-12-3-1-8(20(28)29)5-11(12)21(30)31/h1,3,5,9-10H,2,4,6-7,17H2,(H,18,25)(H,19,22)(H,23,24)(H,26,27)/t9-,10-/m0/s1;   InChIKey=FXEUKVKGTKDDIQ-UWVGGRQHSA-N;   SMILES=C1(=C(C=C([N+](=O)[O-])C=C1)[N+](=O)[O-])SC[C@H](NC(CC[C@H](N)C(=O)O)=O)C(=O)NCC(=O)O;   dinitrophenyl-S-glutathione
 alt_id: CHEBI:42826
 xref: Beilstein:2033318;   CAS:26289-39-4;   KEGG:C11175
 xref_mesh: MESH:C030190
 xref: MetaCyc:S-24-DINITROPHENYLGLUTATHIONE;   PDBeChem:GDN;   PMID:10366541;   PMID:1484101;   PMID:19299525;   PMID:20719938;   PMID:20846144;   PMID:22453052;   PMID:22925079;   PMID:23272261;   PMID:2420897;   PMID:7581009;   Reaxys:2199791
 cyclic_relationship: is_conjugate_acid_of CHEBI:133977


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S-(2,4-dinitrophenyl)glutathione term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc1 ATP binding cassette subfamily C member 1 affects export
affects transport
increases export
multiple interactions
ISO ABCC1 protein affects the export of S-(2,4-dinitrophenyl)glutathione
ABCC1 protein affects the transport of S-(2,4-dinitrophenyl)glutathione
ABCC1 protein results in increased export of S-(2,4-dinitrophenyl)glutathione
flavone inhibits the reaction [ABCC1 protein affects the export of S-(2,4-dinitrophenyl)glutathione]; hesperetin inhibits the reaction [ABCC1 protein results in increased export of S-(2,4-dinitrophenyl)glutathione]; Mefloquine inhibits the reaction [ABCC1 protein affects the transport of S-(2,4-dinitrophenyl)glutathione]; naringenin inhibits the reaction [ABCC1 protein results in increased export of S-(2,4-dinitrophenyl)glutathione]; Quercetin inhibits the reaction [ABCC1 protein affects the export of S-(2,4-dinitrophenyl)glutathione]; Quercetin inhibits the reaction [ABCC1 protein results in increased export of S-(2,4-dinitrophenyl)glutathione]; resveratrol inhibits the reaction [ABCC1 protein results in increased export of S-(2,4-dinitrophenyl)glutathione]; Silymarin inhibits the reaction [ABCC1 protein results in increased export of S-(2,4-dinitrophenyl)glutathione]; taxifolin inhibits the reaction [ABCC1 protein affects the export of S-(2,4-dinitrophenyl)glutathione]; verlukast inhibits the reaction [ABCC1 protein affects the transport of S-(2,4-dinitrophenyl)glutathione]
CTD PMID:15041478 PMID:16004972 PMID:16156793 NCBI chr10:549,537...672,235
Ensembl chr10:549,883...672,196
JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 multiple interactions
increases transport
affects transport
increases export
EXP
ISO
[Benzbromarone results in decreased activity of ABCC2 protein] inhibits the reaction [Glucose results in increased secretion of S-(2,4-dinitrophenyl)glutathione]; [Furosemide results in increased activity of ABCC2 protein] promotes the reaction [Glucose results in increased secretion of S-(2,4-dinitrophenyl)glutathione]; [Spironolactone results in increased expression of ABCC2 protein] which results in increased transport of S-(2,4-dinitrophenyl)glutathione; [sulfanitran results in increased activity of ABCC2 protein] promotes the reaction [Glucose results in increased secretion of S-(2,4-dinitrophenyl)glutathione]; Acetaminophen promotes the reaction [ABCC2 protein results in increased transport of S-(2,4-dinitrophenyl)glutathione]; S-(2,4-dinitrophenyl)glutathione inhibits the reaction [ABCC2 protein results in increased transport of temocaprilat]; temocaprilat inhibits the reaction [ABCC2 protein results in increased transport of S-(2,4-dinitrophenyl)glutathione]; Ursodeoxycholic Acid promotes the reaction [ABCC2 protein results in increased export of S-(2,4-dinitrophenyl)glutathione]
ABCC2 protein affects the transport of S-(2,4-dinitrophenyl)glutathione
CTD PMID:9067317 PMID:9430713 PMID:9525973 PMID:15276087 PMID:15652244 PMID:15846474 PMID:15901347 PMID:19067394 PMID:19766108 PMID:19782883 NCBI chr 1:263,554,426...263,612,556
Ensembl chr 1:263,554,453...263,613,252
JBrowse link
G Abcc4 ATP binding cassette subfamily C member 4 multiple interactions ISO S-(2,4-dinitrophenyl)glutathione inhibits the reaction [ABCC4 protein results in increased transport of Methotrexate] CTD PMID:11856762 NCBI chr15:103,695,415...103,927,980
Ensembl chr15:103,696,557...103,927,592
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19853
    role 19804
      chemical role 19320
        antioxidant 14239
          glutathione 376
            S-(2,4-dinitrophenyl)glutathione 3
Path 2
Term Annotations click to browse term
  CHEBI ontology 19853
    subatomic particle 19851
      composite particle 19851
        hadron 19851
          baryon 19851
            nucleon 19851
              atomic nucleus 19851
                atom 19851
                  main group element atom 19744
                    p-block element atom 19744
                      carbon group element atom 19650
                        carbon atom 19639
                          organic molecular entity 19639
                            organic group 18550
                              organic divalent group 18541
                                organodiyl group 18541
                                  carbonyl group 18447
                                    carbonyl compound 18447
                                      carboxylic acid 18125
                                        carboacyl group 17383
                                          univalent carboacyl group 17383
                                            carbamoyl group 17166
                                              carboxamide 17166
                                                peptide 9400
                                                  oligopeptide 1204
                                                    tripeptide 887
                                                      glutathione 376
                                                        glutathione derivative 59
                                                          glutathione conjugate 4
                                                            S-(2,4-dinitrophenyl)glutathione 3
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