Symbol:
Tomm20
Name:
translocase of outer mitochondrial membrane 20
Description:
Exhibits mitochondrion targeting sequence binding activity. Predicted to contribute to protein transmembrane transporter activity. Involved in protein targeting to mitochondrion; response to 3,3',5-triiodo-L-thyronine; and response to muscle activity. Localizes to the mitochondrial outer membrane. Biomarker of muscular atrophy. Orthologous to human TOMM20 (translocase of outer mitochondrial membrane 20); PARTICIPATES IN beta-barrel pathway of mitochondrial protein import; carrier pathway of mitochondrial protein import.; presequence pathway of mitochondrial protein import; INTERACTS WITH 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type:
protein-coding
RefSeq Status:
PROVISIONAL
Also known as:
LOC266601; MGC93136; mitochondrial 20 kDa outer membrane protein; mitochondrial import receptor subunit TOM20 homolog; outer mitochondrial membrane receptor rTOM20; outer mitochondrial membrane receptor Tom20; translocase of outer mitochondrial membrane 20 homolog; translocase of outer mitochondrial membrane 20 homolog (yeast)
Orthologs:
Species
Gene symbol and name
Data Source
Assertion derived from
less info ...
Orthologs 1
Homo sapiens (human):
TOMM20 (translocase of outer mitochondrial membrane 20) HGNC
EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):
Tomm20 (translocase of outer mitochondrial membrane 20) HGNC
Treefam, EggNOG, NCBI, OMA, HomoloGene, Inparanoid, Panther, PhylomeDB, OrthoDB, Ensembl
Chinchilla lanigera (long-tailed chinchilla):
Tomm20 (translocase of outer mitochondrial membrane 20) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):
TOMM20 (translocase of outer mitochondrial membrane 20) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Canis lupus familiaris (dog):
TOMM20 (translocase of outer mitochondrial membrane 20) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):
Tomm20 (translocase of outer mitochondrial membrane 20) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Sus scrofa (pig):
TOMM20 (translocase of outer mitochondrial membrane 20) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Alliance orthologs 3
Mus musculus (house mouse):
Tomm20 (translocase of outer mitochondrial membrane 20)
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, TreeFam)
Homo sapiens (human):
TOMM20 (translocase of outer mitochondrial membrane 20)
Alliance
DIOPT (Ensembl Compara, HGNC, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, TreeFam)
Danio rerio (zebrafish):
tomm20b (translocase of outer mitochondrial membrane 20b)
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, TreeFam)
Danio rerio (zebrafish):
tomm20a (translocase of outer mitochondrial membrane 20)
Alliance
DIOPT (Ensembl Compara, OMA, OrthoFinder, PhylomeDB)
Caenorhabditis elegans (roundworm):
F32B4.2
Alliance
DIOPT (OrthoFinder, PANTHER, TreeFam)
Saccharomyces cerevisiae (baker's yeast):
TOM20
Alliance
DIOPT (Hieranoid, InParanoid, OMA, OrthoFinder, PANTHER, PhylomeDB, TreeFam)
Drosophila melanogaster (fruit fly):
Tom20
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, TreeFam)
Drosophila melanogaster (fruit fly):
tomboy20
Alliance
DIOPT (Ensembl Compara, OrthoFinder, PANTHER, PhylomeDB, TreeFam)
Caenorhabditis elegans (roundworm):
tomm-20
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB)
Latest Assembly:
Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl Rnor_6.0 19 59,863,421 - 59,873,411 (-) NCBI Rnor6.0 Rnor_6.0 rn6 Rnor6.0 Rnor_6.0 Ensembl 19 59,863,421 - 59,873,411 (-) Ensembl Rnor_5.0 19 70,530,583 - 70,540,402 (-) NCBI Rnor5.0 Rnor_5.0 rn5 Rnor5.0 RGSC_v3.4 19 56,850,851 - 56,863,167 (-) NCBI RGSC3.4 rn4 RGSC3.4 RGSC_v3.1 19 56,855,910 - 56,868,227 (-) NCBI Celera 19 54,265,379 - 54,274,601 (-) NCBI Celera Cytogenetic Map 19 q12 NCBI
JBrowse:
View Region in Genome Browser (JBrowse)
Model
(-)-epigallocatechin 3-gallate multiple interactions ISO RGD:735635 6480464 [potassium chromate(VI) co-treated with epigallocatechin gallate] results in increased expression of TOMM20 mRNA CTD PMID:22079256 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane increases expression EXP 6480464 o, p'-DDT results in increased expression of TOMM20 mRNA CTD PMID:24096037 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane increases expression ISO RGD:733127 6480464 o, p'-DDT results in increased expression of TOMM20 mRNA CTD PMID:24096037 17alpha-ethynylestradiol increases expression EXP 6480464 Ethinyl Estradiol results in increased expression of TOMM20 mRNA CTD PMID:24096037 17alpha-ethynylestradiol increases expression ISO RGD:733127 6480464 Ethinyl Estradiol results in increased expression of TOMM20 mRNA CTD PMID:24096037 2,3,7,8-tetrachlorodibenzodioxine decreases expression ISO RGD:735635 6480464 Tetrachlorodibenzodioxin results in decreased expression of TOMM20 mRNA CTD PMID:20106945 , PMID:21632981 2,3,7,8-tetrachlorodibenzodioxine increases expression EXP 6480464 Tetrachlorodibenzodioxin results in increased expression of TOMM20 mRNA CTD PMID:26232522 2,4-dinitrotoluene affects expression EXP 6480464 2, 4-dinitrotoluene affects the expression of TOMM20 mRNA CTD PMID:21346803 2,6-dinitrotoluene affects expression EXP 6480464 2, 6-dinitrotoluene affects the expression of TOMM20 mRNA CTD PMID:21346803 3-methyladenine multiple interactions ISO RGD:735635 6480464 3-methyladenine inhibits the reaction [Doxorubicin results in decreased expression of TOMM20 protein] CTD PMID:31226464 3H-1,2-dithiole-3-thione decreases expression EXP 6480464 1, 2-dithiol-3-thione results in decreased expression of TOMM20 mRNA CTD PMID:19162173 4,4'-diaminodiphenylmethane increases expression ISO RGD:733127 6480464 4, 4'-diaminodiphenylmethane results in increased expression of TOMM20 mRNA CTD PMID:18648102 4-hydroxyphenyl retinamide increases expression ISO RGD:733127 6480464 Fenretinide results in increased expression of TOMM20 mRNA CTD PMID:28973697 aflatoxin B1 decreases expression ISO RGD:733127 6480464 Aflatoxin B1 results in decreased expression of TOMM20 mRNA CTD PMID:19770486 aflatoxin B1 decreases methylation ISO RGD:735635 6480464 Aflatoxin B1 results in decreased methylation of TOMM20 intron CTD PMID:30157460 aflatoxin B2 decreases methylation ISO RGD:735635 6480464 aflatoxin B2 results in decreased methylation of TOMM20 intron CTD PMID:30157460 ammonium chloride affects expression EXP 6480464 Ammonium Chloride affects the expression of TOMM20 mRNA CTD PMID:16483693 atorvastatin calcium multiple interactions ISO RGD:733127 6480464 [PPARGC1B protein affects the susceptibility to Atorvastatin] which affects the expression of TOMM20 protein CTD PMID:30511338 atorvastatin calcium increases expression ISO RGD:733127 6480464 Atorvastatin results in increased expression of TOMM20 protein CTD PMID:30511338 atrazine decreases expression ISO RGD:735635 6480464 Atrazine results in decreased expression of TOMM20 mRNA CTD PMID:22378314 benzo[a]pyrene affects methylation ISO RGD:735635 6480464 Benzo(a)pyrene affects the methylation of TOMM20 intron CTD PMID:30157460 benzo[e]pyrene decreases methylation ISO RGD:735635 6480464 benzo(e)pyrene results in decreased methylation of TOMM20 intron CTD PMID:30157460 bis(2-chloroethyl) sulfide increases expression ISO RGD:735635 6480464 Mustard Gas results in increased expression of TOMM20 mRNA CTD PMID:12884408 bisphenol A decreases expression ISO RGD:735635 6480464 bisphenol A results in decreased expression of TOMM20 mRNA CTD PMID:22576693 bisphenol A affects expression ISO RGD:735635 6480464 bisphenol A affects the expression of TOMM20 mRNA CTD PMID:30903817 bisphenol A decreases expression EXP 6480464 bisphenol A results in decreased expression of TOMM20 protein CTD PMID:26139607 bisphenol A increases expression EXP 6480464 bisphenol A results in increased expression of TOMM20 mRNA CTD PMID:25181051 bisphenol A increases methylation ISO RGD:735635 6480464 bisphenol A results in increased methylation of TOMM20 gene CTD PMID:22576693 carbamazepine affects expression ISO RGD:735635 6480464 Carbamazepine affects the expression of TOMM20 mRNA CTD PMID:25979313 carbon nanotube increases expression ISO RGD:733127 6480464 Nanotubes, Carbon analog results in increased expression of TOMM20 mRNA, Nanotubes, Carbon results in increased expression of TOMM20 mRNA CTD PMID:25554681 , PMID:25620056 chloropicrin increases expression ISO RGD:735635 6480464 chloropicrin results in increased expression of TOMM20 mRNA CTD PMID:26352163 choline multiple interactions ISO RGD:733127 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of TOMM20 mRNA CTD PMID:20938992 chromium(6+) affects expression ISO RGD:733127 6480464 chromium hexavalent ion affects the expression of TOMM20 mRNA CTD PMID:28472532 clofibrate increases expression EXP 6480464 Clofibrate results in increased expression of TOMM20 mRNA CTD PMID:12851107 clofibric acid affects expression EXP 6480464 Clofibric Acid affects the expression of TOMM20 mRNA CTD PMID:17602206 copper(II) sulfate decreases expression ISO RGD:735635 6480464 Copper Sulfate results in decreased expression of TOMM20 mRNA CTD PMID:19549813 cyclosporin A decreases expression ISO RGD:733127 6480464 Cyclosporine results in decreased expression of TOMM20 mRNA CTD PMID:19770486 cyclosporin A decreases expression ISO RGD:735635 6480464 Cyclosporine results in decreased expression of TOMM20 mRNA CTD PMID:25562108 dibutyl phthalate increases expression EXP 6480464 Dibutyl Phthalate results in increased expression of TOMM20 mRNA CTD PMID:21266533 dibutyl phthalate decreases expression ISO RGD:733127 6480464 Dibutyl Phthalate results in decreased expression of TOMM20 mRNA CTD PMID:17361019 doxorubicin decreases response to substance ISO RGD:735635 6480464 TOMM20 mRNA results in decreased susceptibility to Doxorubicin CTD PMID:16322897 doxorubicin increases expression ISO RGD:735635 6480464 Doxorubicin results in increased expression of TOMM20 mRNA CTD PMID:29803840 doxorubicin decreases expression ISO RGD:735635 6480464 Doxorubicin results in decreased expression of TOMM20 protein CTD PMID:31226464 doxorubicin multiple interactions ISO RGD:735635 6480464 3-methyladenine inhibits the reaction [Doxorubicin results in decreased expression of TOMM20 protein] more ... CTD PMID:31226464 enalapril decreases expression EXP 6480464 Enalapril results in decreased expression of TOMM20 mRNA CTD PMID:18765277 ethanol affects splicing ISO RGD:733127 6480464 Ethanol affects the splicing of TOMM20 mRNA CTD PMID:30319688 flutamide increases expression EXP 6480464 Flutamide results in increased expression of TOMM20 mRNA CTD PMID:24136188 folic acid multiple interactions ISO RGD:733127 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of TOMM20 mRNA CTD PMID:20938992 gentamycin increases expression EXP 6480464 Gentamicins results in increased expression of TOMM20 mRNA CTD PMID:22061828 hydralazine multiple interactions ISO RGD:735635 6480464 [Hydralazine co-treated with Valproic Acid] results in increased expression of TOMM20 mRNA CTD PMID:17183730 L-methionine multiple interactions ISO RGD:733127 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of TOMM20 mRNA CTD PMID:20938992 lactacystin affects localization ISO RGD:735635 6480464 lactacystin affects the localization of TOMM20 protein CTD PMID:11161710 losartan decreases expression EXP 6480464 Losartan results in decreased expression of TOMM20 mRNA CTD PMID:18765277 methapyrilene decreases methylation ISO RGD:735635 6480464 Methapyrilene results in decreased methylation of TOMM20 intron CTD PMID:30157460 methyl methanesulfonate decreases expression ISO RGD:735635 6480464 Methyl Methanesulfonate results in decreased expression of TOMM20 mRNA CTD PMID:23649840 N-nitrosodiethylamine multiple interactions EXP 6480464 [Diethylnitrosamine co-treated with Phenobarbital] results in increased expression of TOMM20 mRNA, [Diethylnitrosamine co-treated with Phenobarbital] results in increased methylation of TOMM20 promoter CTD PMID:25374375 nefazodone increases expression EXP 6480464 nefazodone results in increased expression of TOMM20 mRNA CTD PMID:24136188 nimesulide increases expression EXP 6480464 nimesulide results in increased expression of TOMM20 mRNA CTD PMID:24136188 paracetamol affects expression ISO RGD:733127 6480464 Acetaminophen affects the expression of TOMM20 mRNA CTD PMID:17562736 paracetamol increases expression ISO RGD:733127 6480464 Acetaminophen results in increased expression of TOMM20 protein CTD PMID:28827156 paracetamol decreases expression ISO RGD:735635 6480464 Acetaminophen results in decreased expression of TOMM20 mRNA CTD PMID:25704631 Pepstatin multiple interactions ISO RGD:735635 6480464 pepstatin inhibits the reaction [Doxorubicin results in decreased expression of TOMM20 protein] CTD PMID:31226464 perfluorooctanoic acid increases expression EXP 6480464 perfluorooctanoic acid results in increased expression of TOMM20 mRNA CTD PMID:19162173 phenobarbital multiple interactions EXP 6480464 [Diethylnitrosamine co-treated with Phenobarbital] results in increased expression of TOMM20 mRNA, [Diethylnitrosamine co-treated with Phenobarbital] results in increased methylation of TOMM20 promoter CTD PMID:25374375 pirinixic acid increases expression ISO RGD:733127 6480464 pirinixic acid results in increased expression of TOMM20 mRNA CTD PMID:18445702 , PMID:23811191 potassium chromate increases expression ISO RGD:735635 6480464 potassium chromate(VI) results in increased expression of TOMM20 mRNA CTD PMID:22079256 potassium chromate multiple interactions ISO RGD:735635 6480464 [potassium chromate(VI) co-treated with epigallocatechin gallate] results in increased expression of TOMM20 mRNA CTD PMID:22079256 propiconazole increases expression ISO RGD:733127 6480464 propiconazole results in increased expression of TOMM20 mRNA CTD PMID:21278054 pyrroloquinoline quinone multiple interactions ISO RGD:735635 6480464 PQQ Cofactor inhibits the reaction [Doxorubicin results in decreased expression of TOMM20 protein] CTD PMID:31226464 Soman increases expression EXP 6480464 Soman results in increased expression of TOMM20 mRNA CTD PMID:19281266 tetrachloromethane increases expression EXP 6480464 Carbon Tetrachloride results in increased expression of TOMM20 mRNA CTD PMID:31150632 titanium dioxide decreases expression ISO RGD:733127 6480464 titanium dioxide results in decreased expression of TOMM20 mRNA CTD PMID:29264374 tolcapone affects binding EXP 6480464 tolcapone binds to TOMM20 protein CTD PMID:19783845 trimellitic anhydride increases expression ISO RGD:733127 6480464 trimellitic anhydride results in increased expression of TOMM20 mRNA CTD PMID:19042947 troglitazone increases expression ISO RGD:733127 6480464 troglitazone results in increased expression of TOMM20 mRNA CTD PMID:28973697 tungsten increases expression ISO RGD:733127 6480464 Tungsten results in increased expression of TOMM20 mRNA CTD PMID:30912803 uranium atom affects expression ISO RGD:735635 6480464 Uranium affects the expression of TOMM20 mRNA CTD PMID:15672453 valproic acid multiple interactions ISO RGD:735635 6480464 [Hydralazine co-treated with Valproic Acid] results in increased expression of TOMM20 mRNA CTD PMID:17183730 valproic acid affects expression ISO RGD:733127 6480464 Valproic Acid affects the expression of TOMM20 mRNA CTD PMID:17292431 , PMID:17963808 valproic acid decreases expression ISO RGD:735635 6480464 Valproic Acid results in decreased expression of TOMM20 mRNA CTD PMID:23179753 valproic acid affects expression ISO RGD:735635 6480464 Valproic Acid affects the expression of TOMM20 mRNA CTD PMID:25979313 
Gene-Chemical Interaction Annotations
