Slc22a7 (solute carrier family 22 member 7) - Rat Genome Database

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Gene: Slc22a7 (solute carrier family 22 member 7) Rattus norvegicus
Analyze
Symbol: Slc22a7
Name: solute carrier family 22 member 7
RGD ID: 621699
Description: Enables prostaglandin transmembrane transporter activity and sodium-independent organic anion transmembrane transporter activity. Involved in prostaglandin transport. Located in apical plasma membrane and basolateral plasma membrane. Orthologous to human SLC22A7 (solute carrier family 22 member 7); PARTICIPATES IN multispecific organic anion transporter mediated transport pathway; bile acid transport pathway; INTERACTS WITH (+)-schisandrin B; 17alpha-ethynylestradiol; 17beta-estradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Liver-specific transporter; Livtr; novel liver transporter; Oat2; organic anion transporter 2; rOAT2; solute carrier family 22 (organic anion transporter), member 7
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8922,044,672 - 22,052,051 (+)NCBIGRCr8
mRatBN7.2914,547,073 - 14,554,354 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl914,547,849 - 14,553,921 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx923,131,122 - 23,136,904 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0928,194,555 - 28,200,325 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0926,494,501 - 26,500,283 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0916,925,321 - 16,931,119 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl916,924,520 - 16,931,766 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0915,822,368 - 15,828,166 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.499,934,309 - 9,940,107 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.199,931,570 - 9,937,643 (+)NCBI
Celera912,295,095 - 12,300,893 (+)NCBICelera
Cytogenetic Map9q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(1->4)-beta-D-glucan  (ISO)
1,1-dichloroethene  (ISO)
1,2-dichloroethane  (ISO)
1-naphthyl isothiocyanate  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
2,2,3,3,4,4,5,5,6,6,7,7,8,8,9,9-hexadecafluorononanoic acid  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluoro-1-decanol  (EXP)
3-chloropropane-1,2-diol  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-aminobenzoic acid  (EXP,ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
acetylsalicylic acid  (ISO)
aflatoxin B1  (EXP,ISO)
aldehydo-D-glucose  (ISO)
allopurinol  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
amphotericin B  (ISO)
ampicillin  (ISO)
benzo[a]pyrene  (ISO)
benzoic acid  (EXP,ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bosentan  (ISO)
bromosulfophthalein  (ISO)
bumetanide  (ISO)
C60 fullerene  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
carbamazepine  (EXP)
carbon nanotube  (ISO)
cefoperazone  (ISO)
chenodeoxycholic acid  (ISO)
chloramphenicol  (ISO)
chlorpromazine  (ISO)
choline  (ISO)
cimetidine  (ISO)
cisplatin  (ISO)
clofibrate  (ISO)
cyclosporin A  (ISO)
D-glucose  (ISO)
dehydroepiandrosterone sulfate  (ISO)
deoxycholic acid  (ISO)
dexamethasone  (EXP)
dibenzofurans  (ISO)
dichloroacetic acid  (ISO)
diclofenac  (ISO)
diquat  (ISO)
enalapril  (ISO)
endosulfan  (ISO)
epoxiconazole  (ISO)
erythromycin A  (ISO)
estrone 3-sulfate  (ISO)
felbamate  (EXP)
flutamide  (EXP)
folic acid  (ISO)
fructose  (ISO)
furosemide  (ISO)
gabapentin  (EXP)
gamma-aminobutyric acid  (ISO)
glucose  (ISO)
glycidol  (ISO)
GW 501516  (ISO)
Heliotrine  (ISO)
ibuprofen  (ISO)
indocyanine green  (ISO)
indometacin  (ISO)
inulin  (ISO)
keto-phenylpyruvic acid  (ISO)
ketoprofen  (ISO)
L-ascorbic acid  (ISO)
L-methionine  (ISO)
mefenamic acid  (ISO)
methimazole  (EXP)
methotrexate  (ISO)
methylmercury(1+)  (EXP)
methyltestosterone  (ISO)
metronidazole  (ISO)
microcystin-LR  (ISO)
minocycline  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
N-Nitrosopyrrolidine  (ISO)
N1'-[2-[[5-[(dimethylamino)methyl]-2-furanyl]methylthio]ethyl]-N1-methyl-2-nitroethene-1,1-diamine  (ISO)
naproxen  (ISO)
nefazodone  (EXP)
neomycin  (ISO)
nicotinic acid  (EXP,ISO)
O-methyleugenol  (ISO)
ochratoxin A  (EXP,ISO)
oltipraz  (ISO)
orotic acid  (EXP,ISO)
oxytetracycline  (ISO)
p-aminohippuric acid  (ISO)
paclitaxel  (ISO)
paracetamol  (ISO)
parathion  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (EXP)
phenacetin  (ISO)
phenobarbital  (EXP,ISO)
phenylacetic acid  (EXP)
phenytoin  (EXP)
pirinixic acid  (ISO)
piroxicam  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
propiconazole  (ISO)
prostaglandin E2  (ISO)
prostaglandin F2alpha  (ISO)
ranitidine  (ISO)
resveratrol  (ISO)
rifampicin  (ISO)
rotenone  (EXP)
salicylic acid  (EXP,ISO)
senecionine  (ISO)
Senkirkine  (ISO)
sodium arsenite  (ISO)
soybean oil  (EXP)
sulfadimethoxine  (EXP)
sulfasalazine  (ISO)
sulindac  (ISO)
tamoxifen  (ISO)
tebuconazole  (ISO)
testosterone  (EXP)
tetrachloroethene  (ISO)
tetrachloromethane  (EXP,ISO)
tetracycline  (ISO)
thioacetamide  (EXP)
trans-cinnamic acid  (EXP,ISO)
triadimefon  (EXP)
trichloroethene  (EXP,ISO)
Triptolide  (EXP,ISO)
triptonide  (ISO)
troglitazone  (ISO)
urethane  (ISO)
valproic acid  (EXP,ISO)
vancomycin  (ISO)
zidovudine  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Molecular evidence of organic ion transporters in the rat adrenal cortex with adrenocorticotropin-regulated zonal expression. Beery E, etal., Endocrinology 2003 Oct;144(10):4519-26. Epub 2003 Jun 26.
2. Gender-specific and developmental influences on the expression of rat organic anion transporters. Buist SC, etal., J Pharmacol Exp Ther 2002 Apr;301(1):145-51.
3. OAT2 catalyses efflux of glutamate and uptake of orotic acid. Fork C, etal., Biochem J. 2011 Jun 1;436(2):305-12. doi: 10.1042/BJ20101904.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
6. Differential gene expression of organic anion transporters in male and female rats. Kobayashi Y, etal., Biochem Biophys Res Commun 2002 Jan 11;290(1):482-7.
7. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
8. Functional involvement of rat organic anion transporter 2 (Slc22a7) in the hepatic uptake of the nonsteroidal anti-inflammatory drug ketoprofen. Morita N, etal., Drug Metab Dispos. 2005 Aug;33(8):1151-7. doi: 10.1124/dmd.104.001552. Epub 2005 May 17.
9. Functional characterization of rat organic anion transporter 2 in LLC-PK1 cells. Morita N, etal., J Pharmacol Exp Ther. 2001 Sep;298(3):1179-84.
10. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
11. Identification of new SNPs associated with severe toxicity to capecitabine. Pellicer M, etal., Pharmacol Res. 2017 Jun;120:133-137. doi: 10.1016/j.phrs.2017.03.021. Epub 2017 Mar 27.
12. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
13. GOA pipeline RGD automated data pipeline
14. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
15. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
16. Identification of multispecific organic anion transporter 2 expressed predominantly in the liver. Sekine T, etal., FEBS Lett 1998 Jun 12;429(2):179-82.
17. Characterization of Organic Anion Transporter 2 (SLC22A7): A Highly Efficient Transporter for Creatinine and Species-Dependent Renal Tubular Expression. Shen H, etal., Drug Metab Dispos. 2015 Jul;43(7):984-93. doi: 10.1124/dmd.114.062364. Epub 2015 Apr 22.
18. Molecular cloning and characterization of a novel liver-specific transport protein. Simonson GD, etal., J Cell Sci 1994 Apr;107 ( Pt 4):1065-72.
Additional References at PubMed
PMID:7890171   PMID:12034823   PMID:16885152   PMID:17086191   PMID:17244698   PMID:25710042   PMID:27053689  


Genomics

Comparative Map Data
Slc22a7
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8922,044,672 - 22,052,051 (+)NCBIGRCr8
mRatBN7.2914,547,073 - 14,554,354 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl914,547,849 - 14,553,921 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx923,131,122 - 23,136,904 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0928,194,555 - 28,200,325 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0926,494,501 - 26,500,283 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0916,925,321 - 16,931,119 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl916,924,520 - 16,931,766 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0915,822,368 - 15,828,166 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.499,934,309 - 9,940,107 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.199,931,570 - 9,937,643 (+)NCBI
Celera912,295,095 - 12,300,893 (+)NCBICelera
Cytogenetic Map9q12NCBI
SLC22A7
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38643,295,714 - 43,305,538 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl643,295,694 - 43,305,538 (+)EnsemblGRCh38hg38GRCh38
GRCh37643,265,998 - 43,273,276 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36643,373,976 - 43,381,254 (+)NCBINCBI36Build 36hg18NCBI36
Build 34643,373,979 - 43,381,252NCBI
Celera644,817,758 - 44,825,036 (+)NCBICelera
Cytogenetic Map6p21.1NCBI
HuRef642,984,503 - 42,991,781 (+)NCBIHuRef
CHM1_1643,268,944 - 43,276,222 (+)NCBICHM1_1
T2T-CHM13v2.0643,127,200 - 43,134,478 (+)NCBIT2T-CHM13v2.0
Slc22a7
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391746,743,111 - 46,749,403 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1746,743,109 - 46,749,383 (-)EnsemblGRCm39 Ensembl
GRCm381746,432,185 - 46,438,477 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1746,432,183 - 46,438,457 (-)EnsemblGRCm38mm10GRCm38
MGSCv371746,569,134 - 46,575,426 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361745,895,372 - 45,901,620 (-)NCBIMGSCv36mm8
Celera1749,867,036 - 49,874,196 (-)NCBICelera
Cytogenetic Map17CNCBI
cM Map1722.9NCBI
Slc22a7
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554379,204,322 - 9,210,086 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554379,204,414 - 9,210,350 (+)NCBIChiLan1.0ChiLan1.0
SLC22A7
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2557,798,445 - 57,805,672 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1653,668,286 - 53,675,511 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0642,888,110 - 42,897,556 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1644,182,287 - 44,189,567 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl644,182,288 - 44,189,097 (+)Ensemblpanpan1.1panPan2
SLC22A7
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11211,781,623 - 11,788,256 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1211,808,639 - 11,814,376 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01212,265,706 - 12,271,443 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.11211,791,445 - 11,797,183 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01211,875,644 - 11,881,384 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01211,970,737 - 11,976,476 (+)NCBIUU_Cfam_GSD_1.0
Slc22a7
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494647,279,993 - 47,284,825 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647616,675,026 - 16,680,209 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647616,675,377 - 16,680,209 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SLC22A7
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl738,328,419 - 38,334,878 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1738,328,474 - 38,334,879 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2743,828,928 - 43,834,428 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SLC22A7
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11728,848,115 - 28,856,298 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1728,846,791 - 28,855,355 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604443,359,183 - 43,366,555 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Slc22a7
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475416,276,437 - 16,281,741 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475416,275,689 - 16,282,141 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Slc22a7
36 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:90
Count of miRNA genes:75
Interacting mature miRNAs:79
Transcripts:ENSRNOT00000025094
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631211Bw4Body weight QTL45.31retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)9510982650109826Rat
2303559Gluco54Glucose level QTL 542blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)9125408446254084Rat
7411609Foco16Food consumption QTL 1625.60.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)9895256053952560Rat
61450Ciaa3CIA Autoantibody QTL 36.5blood autoantibody amount (VT:0003725)calculated serum anti-type 2 collagen antibody titer (CMO:0001279)9795472022071169Rat
9589055Scfw5Subcutaneous fat weight QTL 55.550.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)9137999212Rat
1641911Alcrsp13Alcohol response QTL 13response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)9143718459Rat
1354650Despr5Despair related QTL 54.010.0017locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)9125408446254084Rat
1300124Cm4Cardiac mass QTL 43.55heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)9140594091Rat
61425Cia15Collagen induced arthritis QTL 154.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)9510982642921101Rat
70226Eae4Experimental allergic encephalomyelitis QTL 4nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)9125661317Rat
9589158Gluco65Glucose level QTL 656.820.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)9137999212Rat
10054125Srcrt7Stress Responsive Cort QTL 73.330.0011blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)9187073594Rat
1600365Mcs20Mammary carcinoma susceptibility QTL 203mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)91353377042791750Rat
11353947Bp392Blood pressure QTL 392arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)9728325252283252Rat
7411592Foco8Food consumption QTL 87.40.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)9137999212Rat
1331757Cdexp1CD45RC expression in CD8 T cells QTL 14.3CD8-positive T cell quantity (VT:0008077)blood CD45RC(high) CD8 T cell count to CD45RC(low) CD8 T cell count ratio (CMO:0001990)9102453767509080Rat
1298088Edpm11Estrogen-dependent pituitary mass QTL 112.5pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)9143718459Rat
9589133Insul26Insulin level QTL 2617.960.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)9895256053952560Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 23 23 23 7
Low 7 6 6 2 14 2
Below cutoff 16 10 7 10 2 2 61 2 11 10 2

Sequence


Ensembl Acc Id: ENSRNOT00000025094   ⟹   ENSRNOP00000025094
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl914,547,849 - 14,553,921 (+)Ensembl
Rnor_6.0 Ensembl916,924,520 - 16,931,766 (+)Ensembl
RefSeq Acc Id: NM_053537   ⟹   NP_445989
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8922,045,498 - 22,051,296 (+)NCBI
mRatBN7.2914,547,909 - 14,553,707 (+)NCBI
Rnor_6.0916,925,321 - 16,931,119 (+)NCBI
Rnor_5.0915,822,368 - 15,828,166 (+)NCBI
RGSC_v3.499,934,309 - 9,940,107 (+)RGD
Celera912,295,095 - 12,300,893 (+)RGD
Sequence:
RefSeq Acc Id: XM_039084304   ⟹   XP_038940232
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8922,044,977 - 22,052,051 (+)NCBI
mRatBN7.2914,547,381 - 14,554,354 (+)NCBI
RefSeq Acc Id: XM_039084305   ⟹   XP_038940233
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8922,044,672 - 22,052,020 (+)NCBI
mRatBN7.2914,547,073 - 14,554,354 (+)NCBI
RefSeq Acc Id: NP_445989   ⟸   NM_053537
- UniProtKB: Q63314 (UniProtKB/Swiss-Prot),   Q5RLM2 (UniProtKB/Swiss-Prot),   A6JIQ9 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000025094   ⟸   ENSRNOT00000025094
RefSeq Acc Id: XP_038940233   ⟸   XM_039084305
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038940232   ⟸   XM_039084304
- Peptide Label: isoform X1
Protein Domains
Major facilitator superfamily (MFS) profile

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q5RLM2-F1-model_v2 AlphaFold Q5RLM2 1-535 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696520
Promoter ID:EPDNEW_R7045
Type:multiple initiation site
Name:Slc22a7_2
Description:solute carrier family 22 member 7
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R7046  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0916,924,502 - 16,924,562EPDNEW
RGD ID:13696521
Promoter ID:EPDNEW_R7046
Type:initiation region
Name:Slc22a7_1
Description:solute carrier family 22 member 7
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R7045  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0916,925,258 - 16,925,318EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621699 AgrOrtholog
BioCyc Gene G2FUF-28226 BioCyc
Ensembl Genes ENSRNOG00000018420 Ensembl, UniProtKB/Swiss-Prot
  ENSRNOG00055007370 UniProtKB/Swiss-Prot
  ENSRNOG00060023561 UniProtKB/Swiss-Prot
  ENSRNOG00065026912 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000025094.6 UniProtKB/Swiss-Prot
  ENSRNOT00055012269 UniProtKB/Swiss-Prot
  ENSRNOT00060040836 UniProtKB/Swiss-Prot
  ENSRNOT00065046445 UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.1250.20 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro MFS_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MFS_sugar_transport-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MFS_trans_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Orgcat_transp/SVOP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:89776 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 89776 ENTREZGENE
PANTHER SOLUTE CARRIER FAMILY 22 MEMBER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SOLUTE CARRIER FAMILY 22 MEMBER 7 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Sugar_tr UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB SLC22A7 RGD
PhenoGen Slc22a7 PhenoGen
PROSITE MFS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000018420 RatGTEx
  ENSRNOG00055007370 RatGTEx
  ENSRNOG00060023561 RatGTEx
  ENSRNOG00065026912 RatGTEx
Superfamily-SCOP MFS general substrate transporter UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
UniProt A6JIQ9 ENTREZGENE, UniProtKB/TrEMBL
  Q5RLM2 ENTREZGENE
  Q63314 ENTREZGENE
  S22A7_RAT UniProtKB/Swiss-Prot
UniProt Secondary Q63314 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-24 Slc22a7  solute carrier family 22 member 7  Slc22a7  solute carrier family 22 (organic anion transporter), member 7  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-02-26 Slc22a7  solute carrier family 22 (organic anion transporter), member 7      Symbol and Name status set to approved 625702 APPROVED
2002-08-07 Slc22a7  solute carrier family 22 (organic anion transporter), member 7      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression abundant in male liver compared to kidney; higher expression in female livers and kidneys 70250
gene_regulation testosterone down regulates expression 70250