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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621699
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Slc22a7
Name: solute carrier family 22 member 7
Acc ID: CHEBI:7476
Term: naproxen
Definition: A methoxynaphthalene that is 2-methoxynaphthalene substituted by a carboxy ethyl group at position 6. Naproxen is a non-steroidal anti-inflammatory drug commonly used for the reduction of pain, fever, inflammation and stiffness caused by conditions such as osteoarthritis, kidney stones, rheumatoid arthritis, psoriatic arthritis, gout, ankylosing spondylitis, menstrual cramps, tendinitis, bursitis, and for the treatment of primary dysmenorrhea. It works by inhibiting both the COX-1 and COX-2 enzymes.
Chemical ID: MESH:D009288
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases activityISORGD:7326866480464CTDNaproxen results in decreased activity of SLC22A7 protein

PMID:12388633
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.