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Gene: Atp1a1 (ATPase Na+/K+ transporting subunit alpha 1) Rattus norvegicus
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Symbol: Atp1a1
Name: ATPase Na+/K+ transporting subunit alpha 1
Description: Exhibits several functions, including adenyl ribonucleotide binding activity; alkali metal ion binding activity; and ankyrin binding activity. Involved in several processes, including cellular response to mechanical stimulus; inorganic cation transmembrane transport; and membrane hyperpolarization. Localizes to several cellular components, including the T-tubule; intercalated disc; and sodium:potassium-exchanging ATPase complex. Used to study hypertension. Biomarker of hyperhomocysteinemia and sensorineural hearing loss. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease. Orthologous to human ATP1A1 (ATPase Na+/K+ transporting subunit alpha 1); PARTICIPATES IN acebutolol pharmacodynamics pathway; adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway; alfentanil pharmacodynamics pathway; INTERACTS WITH 1,2,4-trimethylbenzene; 17alpha-ethynylestradiol; 17beta-estradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: ATPase, Na+/K+ transporting, alpha 1 polypeptide; ATPase, Na+K+ transporting, alpha 1; na(+)/K(+) ATPase alpha-1 subunit; Nkaa1b; sodium pump subunit alpha-1; sodium/potassium-transporting ATPase subunit alpha-1
Orthologs:
Homo sapiens (human) : ATP1A1 (ATPase Na+/K+ transporting subunit alpha 1)  HGNC  Alliance
Mus musculus (house mouse) : Atp1a1 (ATPase, Na+/K+ transporting, alpha 1 polypeptide)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Atp1a1 (ATPase Na+/K+ transporting subunit alpha 1)
Pan paniscus (bonobo/pygmy chimpanzee) : ATP1A1 (ATPase Na+/K+ transporting subunit alpha 1)
Canis lupus familiaris (dog) : ATP1A1 (ATPase Na+/K+ transporting subunit alpha 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Atp1a1 (ATPase Na+/K+ transporting subunit alpha 1)
Sus scrofa (pig) : ATP1A1 (ATPase Na+/K+ transporting subunit alpha 1)
more info ...
Is Marker For: Strains:   SS.MNS-(Mme-Gca)/Ayd   SS.MNS-(Mme-D2Mit14)/Ayd   SS.MNS-(D2Mit6-Adh1)/Ayd  
QTLs:   Bp10   Bp158   Bp366  
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
NCBI Annotation Information: Annotation category: suggests misassembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.02204,003,742 - 204,032,023 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2204,003,742 - 204,032,023 (-)Ensembl
Rnor_5.02223,440,514 - 223,469,880 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42196,657,749 - 196,687,242 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.12196,620,502 - 196,649,996 (-)NCBI
Celera2181,455,492 - 181,483,650 (-)NCBICelera
Cytogenetic Map2q34NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Candidate Gene Status
Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
Related Rat Strains
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Atp1a1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 2167
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2019-11-05
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.