Ctss (cathepsin S) - Rat Genome Database

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Gene: Ctss (cathepsin S) Rattus norvegicus
Analyze
Symbol: Ctss
Name: cathepsin S
RGD ID: 621513
Description: Enables cysteine-type peptidase activity. Involved in bone resorption; metanephros development; and regulation of sensory perception of pain. Located in cell surface. Biomarker of intracranial aneurysm. Human ortholog(s) of this gene implicated in neuropathy. Orthologous to human CTSS (cathepsin S); PARTICIPATES IN antigen processing and presentation pathway; phagocytosis pathway; tuberculosis pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol; 17beta-estradiol.
Type: protein-coding
RefSeq Status: VALIDATED
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
NCBI Annotation Information: Annotation category: partial on reference assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.22183,089,192 - 183,114,483 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2183,086,437 - 183,114,483 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2190,751,075 - 190,779,335 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.02188,546,398 - 188,574,853 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.02183,383,602 - 183,411,862 (+)NCBIRnor_WKY
Rnor_6.02197,655,780 - 197,679,768 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2197,655,786 - 197,679,458 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02217,144,866 - 217,169,058 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42190,425,290 - 190,466,877 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12190,385,391 - 190,429,631 (+)NCBI
Celera2175,621,979 - 175,645,341 (+)NCBICelera
Cytogenetic Map2q34NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(R)-lipoic acid  (ISO)
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-nitrofluorene  (EXP)
3-chloropropane-1,2-diol  (EXP)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (EXP)
4-hydroxy-TEMPO  (ISO)
4-hydroxyphenyl retinamide  (ISO)
acetamide  (EXP)
aflatoxin B1  (EXP,ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
amphetamine  (EXP)
anagliptin  (ISO)
antirheumatic drug  (ISO)
aristolochic acid A  (EXP,ISO)
arsenous acid  (ISO)
asperphenamate  (ISO)
astaxanthin  (ISO)
bacitracin  (EXP)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
beta-hexachlorocyclohexane  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bleomycin A2  (ISO)
Brusatol  (EXP)
buspirone  (EXP)
cadmium atom  (EXP)
cadmium dichloride  (EXP,ISO)
calcium atom  (ISO)
calcium(0)  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chlormequat chloride  (EXP)
chlorpyrifos  (ISO)
choline  (ISO)
chondroitin sulfate  (ISO)
chromium(6+)  (ISO)
cisplatin  (ISO)
clofibrate  (ISO)
coenzyme Q10  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
corticosterone  (EXP)
Cuprizon  (EXP)
curcumin  (ISO)
cyclosporin A  (ISO)
deguelin  (ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
diclofenac  (ISO)
diuron  (EXP)
doramapimod  (ISO)
doxorubicin  (EXP,ISO)
epoxiconazole  (ISO)
ethanol  (ISO)
flutamide  (EXP)
folic acid  (ISO)
folpet  (ISO)
fumonisin B1  (ISO)
gentamycin  (EXP)
glycolaldehyde  (ISO)
glyoxal  (ISO)
graphene oxide  (ISO)
hydrogen peroxide  (ISO)
imiquimod  (ISO)
kainic acid  (ISO)
ketamine  (EXP)
ketoconazole  (EXP)
L-methionine  (ISO)
lipoic acid  (ISO)
lipopolysaccharide  (ISO)
lycopene  (ISO)
methotrexate  (ISO)
methylglyoxal  (ISO)
mifepristone  (EXP)
N-nitrosodiethylamine  (ISO)
N-nitrosodimethylamine  (EXP)
nickel atom  (ISO)
nickel subsulfide  (EXP)
nimesulide  (EXP)
O-acetyl-L-carnitine  (ISO)
oligopeptide  (ISO)
oxaliplatin  (EXP)
ozone  (ISO)
paclitaxel  (EXP)
paracetamol  (ISO)
phenobarbital  (ISO)
picoxystrobin  (ISO)
pirinixic acid  (EXP)
potassium chromate  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
resveratrol  (EXP)
serpentine asbestos  (ISO)
silicon dioxide  (EXP,ISO)
simvastatin  (ISO)
sodium arsenite  (ISO)
streptozocin  (EXP)
succimer  (ISO)
testosterone  (EXP)
testosterone enanthate  (ISO)
tetrachloromethane  (EXP,ISO)
thifluzamide  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
topotecan  (EXP)
tremolite asbestos  (ISO)
trichloroethene  (EXP)
triptonide  (ISO)
valdecoxib  (EXP)
valproic acid  (ISO)
valsartan  (ISO)
vanadyl sulfate  (EXP)
vancomycin  (EXP,ISO)
vincaleukoblastine  (EXP)
vinclozolin  (EXP)
Yessotoxin  (ISO)
zoledronic acid  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Increased expression of the lysosomal protease cathepsin S in hippocampal microglia following kainate-induced seizures. Akahoshi N, etal., Neurosci Lett. 2007 Dec 18;429(2-3):136-41. Epub 2007 Oct 18.
2. Cathepsin B, K, and S are expressed in cerebral aneurysms and promote the progression of cerebral aneurysms. Aoki T, etal., Stroke. 2008 Sep;39(9):2603-10. Epub 2008 Jul 17.
3. Microglia from Creutzfeldt-Jakob disease-infected brains are infectious and show specific mRNA activation profiles. Baker CA, etal., J Virol. 2002 Nov;76(21):10905-13.
4. Therapeutic dosing of an orally active, selective cathepsin S inhibitor suppresses disease in models of autoimmunity. Baugh M, etal., J Autoimmun. 2011 May;36(3-4):201-9. Epub 2011 Mar 24.
5. Cathepsin S is activated during colitis and causes visceral hyperalgesia by a PAR2-dependent mechanism in mice. Cattaruzza F, etal., Gastroenterology. 2011 Nov;141(5):1864-74.e1-3. Epub 2011 Jul 28.
6. Localization of cysteine protease, cathepsin S, to the surface of vascular smooth muscle cells by association with integrin alphanubeta3. Cheng XW, etal., Am J Pathol. 2006 Feb;168(2):685-94.
7. Spinal cathepsin S and fractalkine contribute to chronic pain in collagen induced arthritis. Clark AK, etal., Arthritis Rheum. 2011 Dec 27. doi: 10.1002/art.34351.
8. Inhibition of spinal microglial cathepsin S for the reversal of neuropathic pain. Clark AK, etal., Proc Natl Acad Sci U S A. 2007 Jun 19;104(25):10655-60. Epub 2007 Jun 5.
9. An orally active reversible inhibitor of cathepsin S inhibits human trans vivo delayed-type hypersensitivity. Desai SN, etal., Eur J Pharmacol. 2006 May 24;538(1-3):168-74. Epub 2006 Mar 28.
10. Genetic variation associated with bortezomib-induced peripheral neuropathy. Favis R, etal., Pharmacogenet Genomics. 2011 Mar;21(3):121-9.
11. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
12. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
13. Impairment of microglial responses to facial nerve axotomy in cathepsin S-deficient mice. Hao HP, etal., J Neurosci Res. 2007 Aug 1;85(10):2196-206.
14. Cathepsins and their endogenous inhibitors cystatins: expression and modulation in multiple sclerosis. Haves-Zburof D, etal., J Cell Mol Med. 2011 Nov;15(11):2421-9. doi: 10.1111/j.1582-4934.2010.01229.x.
15. Genetic and pharmacologic alteration of cathepsin expression influences reovirus pathogenesis. Johnson EM, etal., J Virol. 2009 Oct;83(19):9630-40. Epub 2009 Jul 29.
16. Differential expression of cysteine and aspartic proteases during progression of atherosclerosis in apolipoprotein E-deficient mice. Jormsjo S, etal., Am J Pathol. 2002 Sep;161(3):939-45.
17. Study of the functional share of lysosomal cathepsins by the development of specific inhibitors. Katunuma N, etal., Adv Enzyme Regul. 1999;39:247-60.
18. Differential expression of Cathepsin S and X in the spinal cord of a rat neuropathic pain model. Leichsenring A, etal., BMC Neurosci. 2008 Aug 12;9:80.
19. The lysosomal cysteine protease, cathepsin S, is increased in Alzheimer's disease and Down syndrome brain. An immunocytochemical study. Lemere CA, etal., Am J Pathol. 1995 Apr;146(4):848-60.
20. Baculoviral expression and characterization of rodent cathepsin S. Mason CS, etal., Protein Expr Purif. 2001 Oct;23(1):45-54.
21. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
22. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
23. Sequence analysis, tissue distribution, and expression of rat cathepsin S. Petanceska S and Devi L, J Biol Chem 1992 Dec 25;267(36):26038-43.
24. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
25. GOA pipeline RGD automated data pipeline
26. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
27. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
28. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
29. Expression of the elastolytic cathepsins S and K in human atheroma and regulation of their production in smooth muscle cells. Sukhova GK, etal., J Clin Invest. 1998 Aug 1;102(3):576-83.
30. Functional interface between cathepsins and growth factors in the kidney development. Vattimo Mde F and Santos OF, Ren Fail. 2005;27(5):615-22.
31. cDNA microarray analysis of spinal cord injury and regeneration related genes in rat. Xiao L, etal., Sheng Li Xue Bao. 2005 Dec 25;57(6):705-13.
Additional References at PubMed
PMID:8612130   PMID:9524075   PMID:11854359   PMID:12163455   PMID:12788072   PMID:15196205   PMID:15308097   PMID:16502470   PMID:17178165   PMID:17250968   PMID:19474321   PMID:20629190  
PMID:21217776   PMID:22365146   PMID:22653842   PMID:22864553   PMID:22952693   PMID:25218173   PMID:28039043   PMID:29514215   PMID:30239049   PMID:30248434   PMID:32657442  


Genomics

Comparative Map Data
Ctss
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.22183,089,192 - 183,114,483 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2183,086,437 - 183,114,483 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2190,751,075 - 190,779,335 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.02188,546,398 - 188,574,853 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.02183,383,602 - 183,411,862 (+)NCBIRnor_WKY
Rnor_6.02197,655,780 - 197,679,768 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2197,655,786 - 197,679,458 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02217,144,866 - 217,169,058 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42190,425,290 - 190,466,877 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12190,385,391 - 190,429,631 (+)NCBI
Celera2175,621,979 - 175,645,341 (+)NCBICelera
Cytogenetic Map2q34NCBI
CTSS
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381150,730,188 - 150,765,778 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1150,730,079 - 150,765,957 (-)EnsemblGRCh38hg38GRCh38
GRCh371150,702,664 - 150,738,254 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361148,969,175 - 149,004,929 (-)NCBINCBI36Build 36hg18NCBI36
Build 341147,515,623 - 147,551,378NCBI
Celera1123,818,402 - 123,853,717 (-)NCBICelera
Cytogenetic Map1q21.3NCBI
HuRef1122,080,971 - 122,116,053 (-)NCBIHuRef
CHM1_11152,098,024 - 152,133,771 (-)NCBICHM1_1
T2T-CHM13v2.01149,853,594 - 149,889,583 (-)NCBIT2T-CHM13v2.0
Ctss
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39395,434,097 - 95,463,716 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl395,434,097 - 95,463,714 (+)EnsemblGRCm39 Ensembl
GRCm38395,526,786 - 95,556,405 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl395,526,786 - 95,556,403 (+)EnsemblGRCm38mm10GRCm38
MGSCv37395,330,708 - 95,360,325 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36395,612,248 - 95,641,803 (+)NCBIMGSCv36mm8
Celera396,957,909 - 96,987,824 (+)NCBICelera
Cytogenetic Map3F2.1NCBI
cM Map340.74NCBI
Ctss
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541399,159 - 124,042 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541399,279 - 124,793 (+)NCBIChiLan1.0ChiLan1.0
CTSS
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11129,733,996 - 129,768,318 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1129,733,996 - 129,768,318 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01126,084,249 - 126,118,221 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
CTSS
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11759,893,840 - 59,910,878 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1759,893,840 - 59,910,849 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1759,339,729 - 59,356,741 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01760,909,903 - 60,927,183 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1760,909,903 - 60,947,992 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11759,739,445 - 59,756,448 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01759,823,472 - 59,840,470 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01760,551,720 - 60,568,999 (-)NCBIUU_Cfam_GSD_1.0
Ctss
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505821,932,794 - 21,961,031 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936580963,153 - 991,442 (-)EnsemblSpeTri2.0
SpeTri2.0NW_004936580963,176 - 991,732 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CTSS
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl498,417,883 - 98,442,950 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1498,415,273 - 98,442,952 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.24107,665,975 - 107,691,575 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CTSS
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Vero_WHO_p1.0NW_02366603812,512,460 - 12,548,903 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ctss
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462477218,419,736 - 18,438,786 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462477218,421,905 - 18,446,857 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Ctss
201 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:190
Count of miRNA genes:138
Interacting mature miRNAs:151
Transcripts:ENSRNOT00000028732
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
1298074Bp164Blood pressure QTL 1640.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
1298085Bp165Blood pressure QTL 1650.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)243154682202446871Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)243154682202446871Rat
1354601Slep1Serum leptin concentration QTL 15.39blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)243171017184114403Rat
631266Bp132Blood pressure QTL 1320.0005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)246123260202447032Rat
1331760Bp206Blood pressure QTL 2063.62454arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)256043031202447032Rat
1298080Bp163Blood pressure QTL 1630.02arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118275202447032Rat
1354648Bp239Blood pressure QTL 2390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118463226797303Rat
1354605Rf48Renal function QTL 482.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)274786664206665859Rat
61374Edpm2Estrogen-dependent pituitary mass QTL 24.420.86pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)276539322202447032Rat
1581569Uae32Urinary albumin excretion QTL 320.0001urine protein amount (VT:0005160)urine albumin excretion rate (CMO:0000757)278665619219826953Rat
724534Uae6Urinary albumin excretion QTL 610urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)278665619249053267Rat
8662832Vetf7Vascular elastic tissue fragility QTL 73.5aorta elastin amount (VT:0003905)aorta wall extracellular elastin dry weight to aorta wall dry weight ratio (CMO:0002002)281689826221035911Rat
1354622Kidm16Kidney mass QTL 163kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)281754530222436696Rat
1354649Kidm17Kidney mass QTL 172.9kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)281754530227146641Rat
631507Bp105Blood pressure QTL 1050.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2112456140212696837Rat
634308Sach6Saccharin preference QTL 64.9taste sensitivity trait (VT:0001986)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)2112456140212696837Rat
1359030Bp277Blood pressure QTL 277arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2114837527185876470Rat
1359030Bp277Blood pressure QTL 277arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2114837527185876470Rat
1578648Bss11Bone structure and strength QTL 114.7femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)2114837527211674221Rat
1554319Bmd2Bone mineral density QTL 213.40.0001lumbar vertebra area (VT:0010570)lumbar vertebra cross-sectional area (CMO:0001689)2114837675212549332Rat
1300165Rf9Renal function QTL 93.28kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)2133914684202447032Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2135552573202446871Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2135552573202446871Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2135552573202446871Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)2135552573202446871Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)absolute change in systolic blood pressure (CMO:0000607)2135552573202446871Rat
1298076Bp166Blood pressure QTL 1660.0009arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2136445150202447032Rat
1581502Esta3Estrogen-induced thymic atrophy QTL 3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)2136916935189599348Rat
1359022Ppulsi1Prepulse inhibition QTL 13.63prepulse inhibition trait (VT:0003088)acoustic startle response measurement (CMO:0001519)2136916935213594495Rat
1331794Bp202Blood pressure QTL 2023.66819arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2141194931223265385Rat
1331805Cm29Cardiac mass QTL 293.50746heart mass (VT:0007028)heart wet weight (CMO:0000069)2141194931223265385Rat
71113Cari2Carrageenan-induced inflammation QTL 22.70.009hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)2141596551202447032Rat
724568Uae13Urinary albumin excretion QTL 134.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)2143157029210020885Rat
10043136Iddm54Insulin dependent diabetes mellitus QTL 543.40.0001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2143657411190602963Rat
10043136Iddm54Insulin dependent diabetes mellitus QTL 543.40.0001blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)2143657411190602963Rat
6903312Bw112Body weight QTL 1123.20.0013body mass (VT:0001259)body weight (CMO:0000012)2143657569184114274Rat
61401Niddm2Non-insulin dependent diabetes mellitus QTL 24.54blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2144599348189599348Rat
1598833Bp295Blood pressure QTL 2953.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2147798556192798556Rat
1641925Alcrsp2Alcohol response QTL 2response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2149559561221167075Rat
1641891Alcrsp17Alcohol response QTL 17response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2149559561249053267Rat
1598805Memor8Memory QTL 83exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)2150341585189039377Rat
631501Bp101Blood pressure QTL 1012.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2150341684202446871Rat
2301966Bp322Blood pressure QTL 3223.58arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2150540301202447032Rat
1354609Niddm62Non-insulin dependent diabetes mellitus QTL 624.720.000006insulin secretion trait (VT:0003564)plasma insulin level (CMO:0000342)2150540301202447032Rat
12879836Kidm61Kidney mass QTL 610.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)2152413072185122374Rat
12879837Am2Aortic mass QTL 20.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)2152413072185122374Rat
12879838Cm86Cardiac mass QTL 860.002heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)2152413072185122374Rat
12879839Cm85Cardiac mass QTL 850.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)2152413072185122374Rat
12879840Bw179Body weight QTL 1790.005body mass (VT:0001259)body weight (CMO:0000012)2152413072185122374Rat
1359032Hrtrt18Heart rate QTL 18heart pumping trait (VT:2000009)heart rate (CMO:0000002)2157142078192625452Rat
1358900Bw48Body weight QTL 484.88body mass (VT:0001259)body weight (CMO:0000012)2157142078211086598Rat
8662843Vetf9Vascular elastic tissue fragility QTL 92.05thoracic aorta molecular composition trait (VT:0010568)aorta wall extracellular elastin dry weight to aorta wall extracellular collagen weight ratio (CMO:0002003)2157142078226277316Rat
1302793Bw16Body weight QTL 1650.0001body mass (VT:0001259)body weight (CMO:0000012)2157142209202446871Rat
7488925Bp364Blood pressure QTL 3640.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2160564068205564068Rat
1358356Srcrt1Stress Responsive Cort QTL13.66blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)2161699179222436696Rat
7488927Bp365Blood pressure QTL 3650.008arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2162765032207765032Rat
2306901Bp337Blood pressure QTL 3370.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2164073756227146641Rat
1598838Bp290Blood pressure QTL 2901.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2166539266211539266Rat
1549833Bp257Blood pressure QTL 2570.003arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2168354880185122374Rat
1331734Bp204Blood pressure QTL 2043.61192arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2168358098223265385Rat
2307174Activ3Activity QTL 34.830.000058locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)2168594495213594495Rat
61469Bp16Blood pressure QTL 165.64arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)2169745596214745596Rat
70162Bp63Blood pressure QTL 635.64arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)2169745596214745596Rat
631522Bp74Blood pressure QTL 740.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2172710921184114403Rat
2293084Iddm26Insulin dependent diabetes mellitus QTL 262.9blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2174930955213594495Rat
2300189Bmd48Bone mineral density QTL 485.80.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)2179335906224335906Rat
61417Cia10Collagen induced arthritis QTL 103.4joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)2179946951224946951Rat
8694435Bw166Body weight QTL 16614.080.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)2182171407227171407Rat
9589044Scfw1Subcutaneous fat weight QTL 15.80.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)2182171407227171407Rat
8694383Bw158Body weight QTL 1587.690.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)2182171407227171407Rat
8694194Abfw1Abdominal fat weight QTL 111.70.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)2182171407227171407Rat

Markers in Region
D2Mco48  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_5.02034,115,408 - 34,116,469NCBIRnor5.0
RGSC_v3.42029,853,888 - 29,855,558UniSTSRGSC3.4
RGSC_v3.42190,427,909 - 190,428,097UniSTSRGSC3.4
Celera840,643,459 - 40,644,632UniSTS
Celera2175,624,598 - 175,624,786UniSTS
Cytogenetic Map2q34UniSTS
RH128983  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22183,114,193 - 183,114,407 (+)MAPPERmRatBN7.2
Rnor_6.02197,679,479 - 197,679,692NCBIRnor6.0
Rnor_5.02217,168,769 - 217,168,982UniSTSRnor5.0
RGSC_v3.42190,466,588 - 190,466,801UniSTSRGSC3.4
Celera2175,645,052 - 175,645,265UniSTS
RH 3.4 Map21212.9UniSTS
Cytogenetic Map2q34UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 17 53 37 19 37 8 10 48 28 31 11 8
Low 24 4 4 4 1 26 7 10
Below cutoff 2

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000028732   ⟹   ENSRNOP00000028732
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2183,089,198 - 183,114,483 (+)Ensembl
Rnor_6.0 Ensembl2197,655,786 - 197,679,458 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000102986   ⟹   ENSRNOP00000088061
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2183,089,198 - 183,114,483 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000105420   ⟹   ENSRNOP00000092901
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2183,086,437 - 183,114,483 (+)Ensembl
RefSeq Acc Id: NM_017320   ⟹   NP_059016
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.22183,089,192 - 183,114,483 (+)NCBI
Rnor_6.02197,655,780 - 197,679,768 (+)NCBI
Rnor_5.02217,144,866 - 217,169,058 (+)NCBI
RGSC_v3.42190,425,290 - 190,466,877 (+)RGD
Celera2175,621,979 - 175,645,341 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_059016 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA40994 (Get FASTA)   NCBI Sequence Viewer  
  EDL85703 (Get FASTA)   NCBI Sequence Viewer  
  Q02765 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_059016   ⟸   NM_017320
- Peptide Label: preproprotein
- UniProtKB: A0A8I6AES4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000028732   ⟸   ENSRNOT00000028732
RefSeq Acc Id: ENSRNOP00000088061   ⟸   ENSRNOT00000102986
RefSeq Acc Id: ENSRNOP00000092901   ⟸   ENSRNOT00000105420
Protein Domains
Inhibitor_I29   Pept_C1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q02765-F1-model_v2 AlphaFold Q02765 1-330 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621513 AgrOrtholog
BioCyc Gene G2FUF-52090 BioCyc
Ensembl Genes ENSRNOG00000021157 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000028732.6 UniProtKB/TrEMBL
  ENSRNOP00000088061.1 UniProtKB/TrEMBL
  ENSRNOP00000092901 ENTREZGENE
  ENSRNOP00000092901.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000028732.8 UniProtKB/TrEMBL
  ENSRNOT00000102986.1 UniProtKB/TrEMBL
  ENSRNOT00000105420 ENTREZGENE
  ENSRNOT00000105420.1 UniProtKB/TrEMBL
InterPro Papain-like_cys_pep_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pept_asp_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pept_cys_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pept_his_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_C1A_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_C1A_papain-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot_inhib_I29 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:50654 UniProtKB/Swiss-Prot
NCBI Gene 50654 ENTREZGENE
Pfam Inhibitor_I29 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_C1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Ctss PhenoGen
PRINTS PAPAIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE THIOL_PROTEASE_ASN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  THIOL_PROTEASE_CYS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  THIOL_PROTEASE_HIS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART Inhibitor_I29 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pept_C1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF54001 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I6AES4 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AHZ2_RAT UniProtKB/TrEMBL
  CATS_RAT UniProtKB/Swiss-Prot
  D3ZZR3_RAT UniProtKB/TrEMBL
  Q02765 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-09-10 Ctss  cathepsin S      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Ctss  cathepsin S      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression enriched in brain, ovary, and uterus; present in thyroglobulin containing follicular cells 727522
gene_protein retains proteolytic activity at neutral pH 727522
gene_regulation induced by thyroid-stimulating hormone 727522