Ctss (cathepsin S) - Rat Genome Database

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Gene: Ctss (cathepsin S) Mus musculus
Analyze
Symbol: Ctss
Name: cathepsin S
RGD ID: 731651
MGI Page MGI
Description: Enables cysteine-type endopeptidase activity. Involved in basement membrane disassembly; positive regulation of cation channel activity; and proteolysis involved in protein catabolic process. Acts upstream of or within positive regulation of inflammatory response and proteolysis. Located in lysosome and membrane. Is expressed in several structures, including blastocyst; blood vessel; central nervous system; lung; and uterus. Used to study Duchenne muscular dystrophy. Human ortholog(s) of this gene implicated in neuropathy. Orthologous to human CTSS (cathepsin S).
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: Cat S; Cats
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39395,434,097 - 95,463,716 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl395,434,097 - 95,463,714 (+)EnsemblGRCm39 Ensembl
GRCm38395,526,786 - 95,556,405 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl395,526,786 - 95,556,403 (+)EnsemblGRCm38mm10GRCm38
MGSCv37395,330,708 - 95,360,325 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36395,612,248 - 95,641,803 (+)NCBIMGSCv36mm8
Celera396,957,909 - 96,987,824 (+)NCBICelera
Cytogenetic Map3F2.1NCBI
cM Map340.74NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(R)-lipoic acid  (EXP)
1,1-dichloroethene  (EXP)
1,2-dimethylhydrazine  (EXP)
1-naphthyl isothiocyanate  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-nitrofluorene  (ISO)
3-chloropropane-1,2-diol  (ISO)
3H-1,2-dithiole-3-thione  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (ISO)
4-hydroxy-TEMPO  (EXP)
4-hydroxyphenyl retinamide  (EXP)
acetamide  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (ISO)
amphetamine  (ISO)
anagliptin  (ISO)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
arsenous acid  (ISO)
asperphenamate  (ISO)
astaxanthin  (EXP)
bacitracin  (ISO)
benzo[a]pyrene  (EXP)
benzo[b]fluoranthene  (EXP)
beta-hexachlorocyclohexane  (EXP)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP,ISO)
bleomycin A2  (ISO)
Brusatol  (ISO)
buspirone  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
calcium atom  (ISO)
calcium(0)  (ISO)
carbon nanotube  (EXP)
CGP 52608  (ISO)
chlormequat chloride  (ISO)
chlorpyrifos  (EXP)
choline  (EXP)
chondroitin sulfate  (ISO)
chromium(6+)  (EXP)
cisplatin  (ISO)
clofibrate  (EXP)
coenzyme Q10  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
corticosterone  (ISO)
Cuprizon  (ISO)
curcumin  (EXP)
cyclosporin A  (ISO)
deguelin  (ISO)
dextran sulfate  (EXP)
diarsenic trioxide  (ISO)
diclofenac  (EXP)
diuron  (ISO)
doramapimod  (EXP)
doxorubicin  (EXP,ISO)
epoxiconazole  (EXP)
ethanol  (EXP)
flutamide  (ISO)
folic acid  (EXP)
folpet  (EXP)
fumonisin B1  (EXP)
gentamycin  (ISO)
glycolaldehyde  (ISO)
glyoxal  (ISO)
graphene oxide  (EXP)
hydrogen peroxide  (ISO)
imiquimod  (EXP)
kainic acid  (EXP)
ketamine  (ISO)
ketoconazole  (ISO)
L-methionine  (EXP)
lipoic acid  (EXP)
lipopolysaccharide  (EXP)
lycopene  (EXP)
methotrexate  (EXP,ISO)
methylglyoxal  (ISO)
mifepristone  (ISO)
N-nitrosodiethylamine  (EXP)
N-nitrosodimethylamine  (ISO)
nickel atom  (ISO)
nickel subsulfide  (ISO)
nimesulide  (ISO)
O-acetyl-L-carnitine  (EXP)
oligopeptide  (ISO)
oxaliplatin  (ISO)
ozone  (EXP)
paclitaxel  (ISO)
paracetamol  (EXP,ISO)
phenobarbital  (EXP)
picoxystrobin  (ISO)
pirinixic acid  (ISO)
potassium chromate  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
resveratrol  (ISO)
serpentine asbestos  (EXP,ISO)
silicon dioxide  (ISO)
simvastatin  (EXP)
sodium arsenite  (ISO)
streptozocin  (ISO)
succimer  (ISO)
testosterone  (ISO)
testosterone enanthate  (ISO)
tetrachloromethane  (EXP,ISO)
thifluzamide  (ISO)
thioacetamide  (ISO)
titanium dioxide  (EXP)
topotecan  (ISO)
tremolite asbestos  (EXP)
trichloroethene  (ISO)
triptonide  (EXP)
valdecoxib  (ISO)
valproic acid  (ISO)
valsartan  (ISO)
vanadyl sulfate  (ISO)
vancomycin  (EXP,ISO)
vincaleukoblastine  (ISO)
vinclozolin  (ISO)
Yessotoxin  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal B cell physiology  (IAGP)
abnormal B lymphocyte antigen presentation  (IAGP)
abnormal cytokine secretion  (IAGP)
abnormal humoral immune response  (IAGP)
abnormal interleukin secretion  (IAGP)
abnormal leukocyte migration  (IAGP)
abnormal lung volume  (IAGP)
abnormal professional antigen presenting cell physiology  (IAGP)
abnormal skeletal muscle fiber morphology  (IAGP)
abnormal T cell physiology  (IAGP)
abnormal vascular endothelial cell physiology  (IAGP)
centrally nucleated skeletal muscle fibers  (IAGP)
decreased angiogenesis  (IAGP)
decreased circulating cholesterol level  (IAGP)
decreased circulating LDL cholesterol level  (IAGP)
decreased IgG level  (IAGP)
decreased IgM level  (IAGP)
decreased lymphocyte cell number  (IEA)
decreased spleen weight  (IEA)
decreased susceptibility to atherosclerosis  (IAGP)
decreased susceptibility to autoimmune diabetes  (IAGP)
decreased susceptibility to experimental autoimmune myasthenia gravis  (IAGP)
decreased susceptibility to induced arthritis  (IAGP)
dystrophic muscle  (IAGP)
emphysema  (IAGP)
hyperglycemia  (IAGP)
impaired exercise endurance  (IAGP)
impaired humoral immune response  (IEA)
increased apoptosis  (IAGP)
increased circulating creatine kinase level  (IAGP)
increased hematocrit  (IEA)
increased lung compliance  (IAGP)
increased lymphocyte cell number  (IAGP)
increased macrophage cell number  (IAGP)
increased neutrophil cell number  (IAGP)
insulitis  (IAGP)
salivary gland inflammation  (IAGP)
skeletal muscle fiber necrosis  (IAGP)
skeletal muscle fibrosis  (IAGP)
vascular smooth muscle hypoplasia  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Increased expression of the lysosomal protease cathepsin S in hippocampal microglia following kainate-induced seizures. Akahoshi N, etal., Neurosci Lett. 2007 Dec 18;429(2-3):136-41. Epub 2007 Oct 18.
2. Cathepsin B, K, and S are expressed in cerebral aneurysms and promote the progression of cerebral aneurysms. Aoki T, etal., Stroke. 2008 Sep;39(9):2603-10. Epub 2008 Jul 17.
3. Microglia from Creutzfeldt-Jakob disease-infected brains are infectious and show specific mRNA activation profiles. Baker CA, etal., J Virol. 2002 Nov;76(21):10905-13.
4. Therapeutic dosing of an orally active, selective cathepsin S inhibitor suppresses disease in models of autoimmunity. Baugh M, etal., J Autoimmun. 2011 May;36(3-4):201-9. Epub 2011 Mar 24.
5. Cathepsin S is activated during colitis and causes visceral hyperalgesia by a PAR2-dependent mechanism in mice. Cattaruzza F, etal., Gastroenterology. 2011 Nov;141(5):1864-74.e1-3. Epub 2011 Jul 28.
6. Spinal cathepsin S and fractalkine contribute to chronic pain in collagen induced arthritis. Clark AK, etal., Arthritis Rheum. 2011 Dec 27. doi: 10.1002/art.34351.
7. Inhibition of spinal microglial cathepsin S for the reversal of neuropathic pain. Clark AK, etal., Proc Natl Acad Sci U S A. 2007 Jun 19;104(25):10655-60. Epub 2007 Jun 5.
8. Gene expression in scrapie. Cloning of a new scrapie-responsive gene and the identification of increased levels of seven other mRNA transcripts. Dandoy-Dron F, etal., J Biol Chem 1998 Mar 27;273(13):7691-7.
9. An orally active reversible inhibitor of cathepsin S inhibits human trans vivo delayed-type hypersensitivity. Desai SN, etal., Eur J Pharmacol. 2006 May 24;538(1-3):168-74. Epub 2006 Mar 28.
10. Genetic variation associated with bortezomib-induced peripheral neuropathy. Favis R, etal., Pharmacogenet Genomics. 2011 Mar;21(3):121-9.
11. Impairment of microglial responses to facial nerve axotomy in cathepsin S-deficient mice. Hao HP, etal., J Neurosci Res. 2007 Aug 1;85(10):2196-206.
12. Cathepsins and their endogenous inhibitors cystatins: expression and modulation in multiple sclerosis. Haves-Zburof D, etal., J Cell Mol Med. 2011 Nov;15(11):2421-9. doi: 10.1111/j.1582-4934.2010.01229.x.
13. Genetic and pharmacologic alteration of cathepsin expression influences reovirus pathogenesis. Johnson EM, etal., J Virol. 2009 Oct;83(19):9630-40. Epub 2009 Jul 29.
14. Differential expression of cysteine and aspartic proteases during progression of atherosclerosis in apolipoprotein E-deficient mice. Jormsjo S, etal., Am J Pathol. 2002 Sep;161(3):939-45.
15. Differential expression of Cathepsin S and X in the spinal cord of a rat neuropathic pain model. Leichsenring A, etal., BMC Neurosci. 2008 Aug 12;9:80.
16. The lysosomal cysteine protease, cathepsin S, is increased in Alzheimer's disease and Down syndrome brain. An immunocytochemical study. Lemere CA, etal., Am J Pathol. 1995 Apr;146(4):848-60.
17. MGDs mouse GO annotations MGD data from the GO Consortium
18. MGD IEA MGD IEA
19. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
20. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
21. Mouse MP Annotation Import Pipeline RGD automated import pipeline
22. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
23. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
24. Mouse cathepsin M, a placenta-specific lysosomal cysteine protease related to cathepsins L and P. Sol-Church K, etal., Biochim Biophys Acta 2000 Apr 25;1491(1-3):289-94.
25. Expression of the elastolytic cathepsins S and K in human atheroma and regulation of their production in smooth muscle cells. Sukhova GK, etal., J Clin Invest. 1998 Aug 1;102(3):576-83.
26. cDNA microarray analysis of spinal cord injury and regeneration related genes in rat. Xiao L, etal., Sheng Li Xue Bao. 2005 Dec 25;57(6):705-13.
Additional References at PubMed
PMID:8157683   PMID:9096102   PMID:9729401   PMID:9811821   PMID:10072072   PMID:10072073   PMID:10349636   PMID:10395917   PMID:10748235   PMID:11005868   PMID:11042159   PMID:11076861  
PMID:11172053   PMID:11217851   PMID:11754813   PMID:11813165   PMID:11854359   PMID:11884425   PMID:12163455   PMID:12186844   PMID:12477932   PMID:12600886   PMID:12639996   PMID:14607896  
PMID:14610273   PMID:15308097   PMID:15661874   PMID:15661938   PMID:15905550   PMID:15944319   PMID:15947738   PMID:16094690   PMID:16141072   PMID:16141073   PMID:16286017   PMID:16313367  
PMID:16365041   PMID:16397233   PMID:16410454   PMID:16435023   PMID:16481467   PMID:16508006   PMID:16636015   PMID:16895486   PMID:18166659   PMID:18479957   PMID:18591414   PMID:18694734  
PMID:19074353   PMID:19095996   PMID:19307473   PMID:19487544   PMID:19664906   PMID:19805168   PMID:20079903   PMID:20080943   PMID:20093401   PMID:20855652   PMID:21145045   PMID:21251246  
PMID:21267068   PMID:21308776   PMID:21309947   PMID:21576321   PMID:21862448   PMID:21873635   PMID:21944884   PMID:22170489   PMID:22558139   PMID:22864553   PMID:22871592   PMID:22916010  
PMID:22952693   PMID:23012103   PMID:23629809   PMID:23771947   PMID:24067868   PMID:24145449   PMID:24154525   PMID:24282339   PMID:24319016   PMID:24553941   PMID:24780878   PMID:24799565  
PMID:24891017   PMID:24952961   PMID:25118282   PMID:25680278   PMID:25753484   PMID:26075905   PMID:26076475   PMID:26216096   PMID:26358505   PMID:26536497   PMID:26773004   PMID:26899824  
PMID:26966179   PMID:27076615   PMID:27108091   PMID:27365406   PMID:27477282   PMID:27626662   PMID:27831566   PMID:28087651   PMID:28093526   PMID:28216153   PMID:28240259   PMID:28550201  
PMID:28623134   PMID:28951461   PMID:29514215   PMID:29909986   PMID:30126300   PMID:30635555   PMID:30655278   PMID:31115520   PMID:31296090   PMID:31645525   PMID:31932607   PMID:32325033  
PMID:32657442   PMID:33289685   PMID:33303781   PMID:33562815   PMID:33754020   PMID:33790474   PMID:34077394   PMID:34910926   PMID:34963058   PMID:36371010  


Genomics

Comparative Map Data
Ctss
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39395,434,097 - 95,463,716 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl395,434,097 - 95,463,714 (+)EnsemblGRCm39 Ensembl
GRCm38395,526,786 - 95,556,405 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl395,526,786 - 95,556,403 (+)EnsemblGRCm38mm10GRCm38
MGSCv37395,330,708 - 95,360,325 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36395,612,248 - 95,641,803 (+)NCBIMGSCv36mm8
Celera396,957,909 - 96,987,824 (+)NCBICelera
Cytogenetic Map3F2.1NCBI
cM Map340.74NCBI
CTSS
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381150,730,188 - 150,765,778 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1150,730,079 - 150,765,957 (-)EnsemblGRCh38hg38GRCh38
GRCh371150,702,664 - 150,738,254 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361148,969,175 - 149,004,929 (-)NCBINCBI36Build 36hg18NCBI36
Build 341147,515,623 - 147,551,378NCBI
Celera1123,818,402 - 123,853,717 (-)NCBICelera
Cytogenetic Map1q21.3NCBI
HuRef1122,080,971 - 122,116,053 (-)NCBIHuRef
CHM1_11152,098,024 - 152,133,771 (-)NCBICHM1_1
T2T-CHM13v2.01149,853,594 - 149,889,583 (-)NCBIT2T-CHM13v2.0
Ctss
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.22183,089,192 - 183,114,483 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2183,086,437 - 183,114,483 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2190,751,075 - 190,779,335 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.02188,546,398 - 188,574,853 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.02183,383,602 - 183,411,862 (+)NCBIRnor_WKY
Rnor_6.02197,655,780 - 197,679,768 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2197,655,786 - 197,679,458 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02217,144,866 - 217,169,058 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42190,425,290 - 190,466,877 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12190,385,391 - 190,429,631 (+)NCBI
Celera2175,621,979 - 175,645,341 (+)NCBICelera
Cytogenetic Map2q34NCBI
Ctss
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541399,159 - 124,042 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541399,279 - 124,793 (+)NCBIChiLan1.0ChiLan1.0
CTSS
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11129,733,996 - 129,768,318 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1129,733,996 - 129,768,318 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01126,084,249 - 126,118,221 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
CTSS
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11759,893,840 - 59,910,878 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1759,893,840 - 59,910,849 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1759,339,729 - 59,356,741 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01760,909,903 - 60,927,183 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1760,909,903 - 60,947,992 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11759,739,445 - 59,756,448 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01759,823,472 - 59,840,470 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01760,551,720 - 60,568,999 (-)NCBIUU_Cfam_GSD_1.0
Ctss
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505821,932,794 - 21,961,031 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936580963,153 - 991,442 (-)EnsemblSpeTri2.0
SpeTri2.0NW_004936580963,176 - 991,732 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CTSS
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl498,417,883 - 98,442,950 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1498,415,273 - 98,442,952 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.24107,665,975 - 107,691,575 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CTSS
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Vero_WHO_p1.0NW_02366603812,512,460 - 12,548,903 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ctss
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462477218,419,736 - 18,438,786 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462477218,421,905 - 18,446,857 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:344
Count of miRNA genes:221
Interacting mature miRNAs:239
Transcripts:ENSMUST00000015667, ENSMUST00000116304
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
26884436Zlq3_mzygomatic length QTL 3, 10 week (mouse)33265060142405761Mouse
4142399Aec1_mautoimmune exocrinopathy 1 (mouse)Not determined7586174102690034Mouse
26884427Cvht4_mcranial vault height 4, 10 week (mouse)316054164109707316Mouse
13207570Tcq12_mtotal cholesterol QTL 12 (mouse)316504164130163649Mouse
26884422Cvht7_mcranial vault height 7, 16 week (mouse)328954149118893649Mouse
1302056Orgwq4_morgan weight QTL 4 (mouse)Not determined330067588147304689Mouse
1301705Sles3_msystemic lupus erythmatosus suppressor 3 (mouse)Not determined337174862143353183Mouse
13208566Bmiq5_mbody mass index QTL 5 (mouse)340954435115793649Mouse
26884380Skwq1_mskull length QTL 1, 5 week (mouse)343954435101607316Mouse
26884378Skwq6_mskull length QTL 6, 10 week (mouse)351907421102307316Mouse
26884382Bzwq1_mbi-zygomatic width QTL 1, 5 week (mouse)352207421137205761Mouse
11039519Ltpr3_mLeishmania tropica response 3 (mouse)356704102100464137Mouse
4141294Bmd24_mbone mineral density 24 (mouse)Not determined36174006195740241Mouse
1301971Cia5_mcollagen induced arthritis QTL 5 (mouse)Not determined366046658100046795Mouse
25314313Syncl1_msynaptonemal complex length 1 (mouse)367907333128393649Mouse
11251721Ewc3_methanol withdrawal and consumption 3 (mouse)369568554103568554Mouse
1301791Char4_mP. chabaudi malaria resistance QTL 4 (mouse)Not determined369625509100655290Mouse
1301422Sle11_msystematic lupus erythematosus susceptibility 11 (mouse)Not determined370208904104209042Mouse
11049572Lmr11c_mleishmaniasis resistance 11c (mouse)372139967106140094Mouse
1300982Lmr11_mleishmaniasis resistance 11 (mouse)Not determined372139967106140094Mouse
1300595Tmevd2_mTheiler's murine encephalomyelitis virus induced demyelinating disease susceptibility 2 (mouse)Not determined375463302109463549Mouse
1301392Eae3_msusceptibility to experimental allergic encephalomyelitis 3 (mouse)Not determined379548730113548837Mouse
1301947Pcfm3_mperiosteal circumference and femur length 3 (mouse)Not determined381084652115084797Mouse
1301904Iba2_minduction of brown adipocytes 2 (mouse)Not determined382147043116147184Mouse
11041900Lmr11a_mleishmaniasis resistance 11a (mouse)383463991117464137Mouse
11039510Ltpr3d_mLeishmania tropica response 3d (mouse)383463991117464137Mouse
11039511Ltpr3c_mLeishmania tropica response 3c (mouse)383463991117464137Mouse
11039507Ltpr3g_mLeishmania tropica response 3g (mouse)383463991117464137Mouse
11039508Ltpr3f_mLeishmania tropica response 3f (mouse)383463991117464137Mouse
11039509Ltpr3e_mLeishmania tropica response 3e (mouse)383463991117464137Mouse
11039512Ltpr3b_mLeishmania tropica response 3b (mouse)383463991117464137Mouse
1301272Cfsw1_mcystic fibrosis survival to weaning 1 (mouse)Not determined383882912117883044Mouse
4142099Cq3_mcholesterol QTL 3 (mouse)Not determined384888918118889067Mouse
14746984Manh54_mmandible shape 54 (mouse)385289152119289152Mouse
1357583Sle18_msystematic lupus erythematosus susceptibility 18 (mouse)Not determined387208904125316236Mouse
12738440Twq3_mtestis weight QTL 3 (mouse)387228015121228015Mouse
4142178Ctrq2_mC. trachomatis resistance QTL 2 (mouse)Not determined389139967137453008Mouse
10766455Sle22_msystematic lupus erythematosus susceptibility 22 (mouse)390376936124377072Mouse
14747001Mancz4_mmandible centroid size 4 (mouse)390378017124378017Mouse
1301398Rapop3_mradiation-induced apoptosis 3 (mouse)Not determined390511217100464137Mouse
1302052Etohcta4_methanol conditioned taste aversion 4 (mouse)Not determined391000105125008748Mouse
1301349Pgia26_mproteoglycan induced arthritis 26 (mouse)Not determined392251533126251650Mouse

Markers in Region
Ctss  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map3F2.1UniSTS
cM Map342.7UniSTS
AJ002386  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38395,556,242 - 95,556,378UniSTSGRCm38
MGSCv37395,360,164 - 95,360,300UniSTSGRCm37
Celera396,987,663 - 96,987,799UniSTS
Cytogenetic Map3F2.1UniSTS
Whitehead/MRC_RH31085.81UniSTS
Ctss  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map3F2.1UniSTS
Ctss  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map3F2.1UniSTS


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001267695 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_021281 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006500975 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AA255186 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC092203 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF038546 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH005933 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AI607397 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ002386 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ223208 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK028366 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK150274 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK150758 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK150842 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK152191 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK152618 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK153540 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BB072817 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC002125 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC011104 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466620 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  Y18466 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000015667   ⟹   ENSMUSP00000015667
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl395,434,097 - 95,463,711 (+)Ensembl
GRCm38.p6 Ensembl395,526,786 - 95,556,400 (+)Ensembl
RefSeq Acc Id: ENSMUST00000116304   ⟹   ENSMUSP00000112006
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl395,434,097 - 95,463,714 (+)Ensembl
GRCm38.p6 Ensembl395,526,786 - 95,556,403 (+)Ensembl
RefSeq Acc Id: NM_001267695   ⟹   NP_001254624
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39395,434,097 - 95,463,716 (+)NCBI
GRCm38395,526,786 - 95,556,405 (+)NCBI
Celera396,957,909 - 96,987,826 (+)NCBI
Sequence:
RefSeq Acc Id: NM_021281   ⟹   NP_067256
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39395,434,097 - 95,463,716 (+)NCBI
GRCm38395,526,786 - 95,556,405 (+)NCBI
MGSCv37395,330,708 - 95,360,325 (+)RGD
Celera396,957,909 - 96,987,826 (+)NCBI
cM Map3 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006500975   ⟹   XP_006501038
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39395,450,023 - 95,463,714 (+)NCBI
GRCm38395,542,715 - 95,556,403 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_067256   ⟸   NM_021281
- Peptide Label: isoform 2 preproprotein
- UniProtKB: O54973 (UniProtKB/Swiss-Prot),   O70370 (UniProtKB/Swiss-Prot),   Q8BSZ5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001254624   ⟸   NM_001267695
- Peptide Label: isoform 1 preproprotein
- UniProtKB: F6WR04 (UniProtKB/TrEMBL),   Q3UD32 (UniProtKB/TrEMBL),   Q8BSZ5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006501038   ⟸   XM_006500975
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSMUSP00000015667   ⟸   ENSMUST00000015667
RefSeq Acc Id: ENSMUSP00000112006   ⟸   ENSMUST00000116304
Protein Domains
Cathepsin propeptide inhibitor   Peptidase C1A papain C-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O70370-F1-model_v2 AlphaFold O70370 1-340 view protein structure

Promoters
RGD ID:6833611
Promoter ID:MM_KWN:35307
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Spleen
Transcripts:ENSMUST00000015667,   NM_021281
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36395,330,531 - 95,331,031 (+)MPROMDB
RGD ID:6881594
Promoter ID:EPDNEW_M4248
Type:initiation region
Name:Ctss_1
Description:Mus musculus cathepsin S , transcript variant 1, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38395,526,831 - 95,526,891EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:107341 AgrOrtholog
Ensembl Genes ENSMUSG00000038642 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000015667 ENTREZGENE
  ENSMUSP00000015667.4 UniProtKB/TrEMBL
  ENSMUSP00000112006 ENTREZGENE
  ENSMUSP00000112006.3 UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000015667 ENTREZGENE
  ENSMUST00000015667.9 UniProtKB/TrEMBL
  ENSMUST00000116304 ENTREZGENE
  ENSMUST00000116304.3 UniProtKB/Swiss-Prot
Gene3D-CATH Cysteine proteinases UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Papain-like_cys_pep_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pept_asp_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pept_cys_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pept_his_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_C1A UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_C1A_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_C1A_papain-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot_inhib_I29 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:13040 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:107341 ENTREZGENE
NCBI Gene 13040 ENTREZGENE
PANTHER CATHEPSIN S UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CYSTEINE PROTEASE FAMILY C1-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Inhibitor_I29 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_C1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Ctss PhenoGen
PRINTS PAPAIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE THIOL_PROTEASE_ASN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  THIOL_PROTEASE_CYS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  THIOL_PROTEASE_HIS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART Inhibitor_I29 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pept_C1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF54001 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt CATS_MOUSE UniProtKB/Swiss-Prot
  F6WR04 ENTREZGENE, UniProtKB/TrEMBL
  O54973 ENTREZGENE
  O70370 ENTREZGENE
  Q3U5K1_MOUSE UniProtKB/TrEMBL
  Q3UBR4_MOUSE UniProtKB/TrEMBL
  Q3UD32 ENTREZGENE, UniProtKB/TrEMBL
  Q8BSZ5 ENTREZGENE, UniProtKB/TrEMBL
  Q99M14_MOUSE UniProtKB/TrEMBL
UniProt Secondary E9QK18 UniProtKB/Swiss-Prot
  O54973 UniProtKB/Swiss-Prot