CTSS (cathepsin S) - Rat Genome Database

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Gene: CTSS (cathepsin S) Homo sapiens
Analyze
Symbol: CTSS
Name: cathepsin S
RGD ID: 1350928
HGNC Page HGNC:2545
Description: Enables several functions, including collagen binding activity; fibronectin binding activity; and laminin binding activity. Involved in several processes, including antigen processing and presentation of exogenous peptide antigen via MHC class II; collagen catabolic process; and proteolysis. Located in cytoplasmic vesicle; extracellular space; and lysosome. Implicated in neuropathy. Biomarker of Alzheimer's disease; Down syndrome; carotid artery disease; intracranial aneurysm; and relapsing-remitting multiple sclerosis.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: FLJ50259; MGC3886
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
NCBI Annotation Information: Note: This gene has been reviewed for its involvement in coronavirus biology, and is involved in immune response or antiviral activity.
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381150,730,188 - 150,765,778 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1150,730,079 - 150,765,957 (-)EnsemblGRCh38hg38GRCh38
GRCh371150,702,664 - 150,738,254 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361148,969,175 - 149,004,929 (-)NCBINCBI36Build 36hg18NCBI36
Build 341147,515,623 - 147,551,378NCBI
Celera1123,818,402 - 123,853,717 (-)NCBICelera
Cytogenetic Map1q21.3NCBI
HuRef1122,080,971 - 122,116,053 (-)NCBIHuRef
CHM1_11152,098,024 - 152,133,771 (-)NCBICHM1_1
T2T-CHM13v2.01149,853,594 - 149,889,583 (-)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(R)-lipoic acid  (ISO)
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
17beta-estradiol 3-benzoate  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-nitrofluorene  (ISO)
3-chloropropane-1,2-diol  (ISO)
3H-1,2-dithiole-3-thione  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (ISO)
4-hydroxy-TEMPO  (ISO)
4-hydroxyphenyl retinamide  (ISO)
acetamide  (ISO)
aflatoxin B1  (EXP,ISO)
all-trans-retinoic acid  (EXP)
ammonium chloride  (ISO)
amphetamine  (ISO)
anagliptin  (EXP)
antirheumatic drug  (EXP)
aristolochic acid A  (EXP,ISO)
arsenous acid  (EXP)
asperphenamate  (EXP)
astaxanthin  (ISO)
bacitracin  (ISO)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
beta-hexachlorocyclohexane  (ISO)
bisphenol A  (ISO)
bisphenol F  (ISO)
bleomycin A2  (EXP)
Brusatol  (ISO)
buspirone  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
calcium atom  (EXP)
calcium(0)  (EXP)
carbon nanotube  (ISO)
CGP 52608  (EXP)
chlormequat chloride  (ISO)
chlorpyrifos  (ISO)
choline  (ISO)
chondroitin sulfate  (EXP)
chromium(6+)  (ISO)
cisplatin  (EXP)
clofibrate  (ISO)
coenzyme Q10  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
corticosterone  (ISO)
Cuprizon  (ISO)
curcumin  (ISO)
cyclosporin A  (EXP)
deguelin  (EXP)
dextran sulfate  (ISO)
diarsenic trioxide  (EXP)
diclofenac  (ISO)
diuron  (ISO)
doramapimod  (ISO)
doxorubicin  (EXP,ISO)
epoxiconazole  (ISO)
ethanol  (ISO)
flutamide  (ISO)
folic acid  (ISO)
folpet  (ISO)
fumonisin B1  (ISO)
gentamycin  (ISO)
glycolaldehyde  (EXP)
glyoxal  (EXP)
graphene oxide  (ISO)
hydrogen peroxide  (EXP)
imiquimod  (ISO)
kainic acid  (ISO)
ketamine  (ISO)
ketoconazole  (ISO)
L-methionine  (ISO)
lipoic acid  (ISO)
lipopolysaccharide  (ISO)
lycopene  (ISO)
methotrexate  (EXP,ISO)
methylglyoxal  (EXP)
mifepristone  (ISO)
N-nitrosodiethylamine  (ISO)
N-nitrosodimethylamine  (ISO)
nickel atom  (EXP)
nickel subsulfide  (ISO)
nimesulide  (ISO)
O-acetyl-L-carnitine  (ISO)
oligopeptide  (EXP)
oxaliplatin  (ISO)
ozone  (ISO)
paclitaxel  (ISO)
paracetamol  (EXP,ISO)
phenobarbital  (ISO)
picoxystrobin  (EXP)
pirinixic acid  (ISO)
potassium chromate  (EXP)
pregnenolone 16alpha-carbonitrile  (ISO)
resveratrol  (ISO)
serpentine asbestos  (EXP,ISO)
silicon dioxide  (EXP,ISO)
simvastatin  (ISO)
sodium arsenite  (EXP)
streptozocin  (ISO)
succimer  (EXP)
testosterone  (ISO)
testosterone enanthate  (EXP)
tetrachloromethane  (ISO)
thifluzamide  (EXP)
thioacetamide  (ISO)
titanium dioxide  (ISO)
topotecan  (ISO)
tremolite asbestos  (ISO)
trichloroethene  (ISO)
triptonide  (ISO)
valdecoxib  (ISO)
valproic acid  (EXP)
valsartan  (EXP)
vanadyl sulfate  (ISO)
vancomycin  (ISO)
vincaleukoblastine  (ISO)
vinclozolin  (ISO)
Yessotoxin  (EXP)
zoledronic acid  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype
References

References - curated
# Reference Title Reference Citation
1. Increased expression of the lysosomal protease cathepsin S in hippocampal microglia following kainate-induced seizures. Akahoshi N, etal., Neurosci Lett. 2007 Dec 18;429(2-3):136-41. Epub 2007 Oct 18.
2. Cathepsin B, K, and S are expressed in cerebral aneurysms and promote the progression of cerebral aneurysms. Aoki T, etal., Stroke. 2008 Sep;39(9):2603-10. Epub 2008 Jul 17.
3. Microglia from Creutzfeldt-Jakob disease-infected brains are infectious and show specific mRNA activation profiles. Baker CA, etal., J Virol. 2002 Nov;76(21):10905-13.
4. Therapeutic dosing of an orally active, selective cathepsin S inhibitor suppresses disease in models of autoimmunity. Baugh M, etal., J Autoimmun. 2011 May;36(3-4):201-9. Epub 2011 Mar 24.
5. Cathepsin S is activated during colitis and causes visceral hyperalgesia by a PAR2-dependent mechanism in mice. Cattaruzza F, etal., Gastroenterology. 2011 Nov;141(5):1864-74.e1-3. Epub 2011 Jul 28.
6. Spinal cathepsin S and fractalkine contribute to chronic pain in collagen induced arthritis. Clark AK, etal., Arthritis Rheum. 2011 Dec 27. doi: 10.1002/art.34351.
7. Inhibition of spinal microglial cathepsin S for the reversal of neuropathic pain. Clark AK, etal., Proc Natl Acad Sci U S A. 2007 Jun 19;104(25):10655-60. Epub 2007 Jun 5.
8. An orally active reversible inhibitor of cathepsin S inhibits human trans vivo delayed-type hypersensitivity. Desai SN, etal., Eur J Pharmacol. 2006 May 24;538(1-3):168-74. Epub 2006 Mar 28.
9. Genetic variation associated with bortezomib-induced peripheral neuropathy. Favis R, etal., Pharmacogenet Genomics. 2011 Mar;21(3):121-9.
10. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
11. Impairment of microglial responses to facial nerve axotomy in cathepsin S-deficient mice. Hao HP, etal., J Neurosci Res. 2007 Aug 1;85(10):2196-206.
12. Cathepsins and their endogenous inhibitors cystatins: expression and modulation in multiple sclerosis. Haves-Zburof D, etal., J Cell Mol Med. 2011 Nov;15(11):2421-9. doi: 10.1111/j.1582-4934.2010.01229.x.
13. Genetic and pharmacologic alteration of cathepsin expression influences reovirus pathogenesis. Johnson EM, etal., J Virol. 2009 Oct;83(19):9630-40. Epub 2009 Jul 29.
14. Differential expression of cysteine and aspartic proteases during progression of atherosclerosis in apolipoprotein E-deficient mice. Jormsjo S, etal., Am J Pathol. 2002 Sep;161(3):939-45.
15. Differential expression of Cathepsin S and X in the spinal cord of a rat neuropathic pain model. Leichsenring A, etal., BMC Neurosci. 2008 Aug 12;9:80.
16. The lysosomal cysteine protease, cathepsin S, is increased in Alzheimer's disease and Down syndrome brain. An immunocytochemical study. Lemere CA, etal., Am J Pathol. 1995 Apr;146(4):848-60.
17. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
18. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
19. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
20. Expression of the elastolytic cathepsins S and K in human atheroma and regulation of their production in smooth muscle cells. Sukhova GK, etal., J Clin Invest. 1998 Aug 1;102(3):576-83.
21. cDNA microarray analysis of spinal cord injury and regeneration related genes in rat. Xiao L, etal., Sheng Li Xue Bao. 2005 Dec 25;57(6):705-13.
Additional References at PubMed
PMID:1373132   PMID:1377692   PMID:2044774   PMID:7575468   PMID:7890620   PMID:8083219   PMID:8157683   PMID:8612130   PMID:8706894   PMID:9076588   PMID:9099979   PMID:9143502  
PMID:9164868   PMID:9524075   PMID:9545324   PMID:9548757   PMID:9876921   PMID:10395917   PMID:10721671   PMID:10852705   PMID:11115496   PMID:11134363   PMID:11241311   PMID:11435427  
PMID:11710834   PMID:11856830   PMID:11884425   PMID:12164923   PMID:12437117   PMID:12477932   PMID:12643447   PMID:12742663   PMID:12748383   PMID:12788072   PMID:12819022   PMID:14718574  
PMID:14966190   PMID:15196205   PMID:15489334   PMID:16140306   PMID:16338279   PMID:16354158   PMID:16394095   PMID:16410454   PMID:16502470   PMID:16550604   PMID:16710414   PMID:16825321  
PMID:16839849   PMID:17075137   PMID:17227755   PMID:17601350   PMID:17622942   PMID:17878156   PMID:18029348   PMID:18410260   PMID:18565099   PMID:18957408   PMID:18977241   PMID:19101991  
PMID:19104823   PMID:19336475   PMID:19404922   PMID:19487544   PMID:19553543   PMID:19593952   PMID:19700239   PMID:19849712   PMID:19913121   PMID:19939935   PMID:20045715   PMID:20164293  
PMID:20180636   PMID:20356901   PMID:20628086   PMID:20880494   PMID:20881085   PMID:21038029   PMID:21094118   PMID:21112096   PMID:21217776   PMID:21223957   PMID:21250859   PMID:21585286  
PMID:21756348   PMID:21873635   PMID:21878432   PMID:21896479   PMID:21963895   PMID:21967108   PMID:21989182   PMID:22101325   PMID:22365146   PMID:22424724   PMID:22571763   PMID:22730330  
PMID:22761382   PMID:22796222   PMID:22844403   PMID:22844527   PMID:22864553   PMID:22923671   PMID:22952693   PMID:23152404   PMID:23362198   PMID:23439581   PMID:23585552   PMID:23707200  
PMID:23742758   PMID:23747398   PMID:23871919   PMID:23892358   PMID:24064335   PMID:24335416   PMID:24390241   PMID:24523067   PMID:24580730   PMID:24583396   PMID:24644101   PMID:24667918  
PMID:24690038   PMID:24727728   PMID:24875536   PMID:24940638   PMID:24964046   PMID:25037231   PMID:25086747   PMID:25118282   PMID:25626674   PMID:26029922   PMID:26079659   PMID:26081835  
PMID:26960148   PMID:27058412   PMID:27249607   PMID:27372424   PMID:27387133   PMID:27595325   PMID:27771373   PMID:28236030   PMID:28240259   PMID:28289191   PMID:28344315   PMID:28514442  
PMID:28981104   PMID:29181829   PMID:29362520   PMID:29622023   PMID:29624112   PMID:29749483   PMID:29915952   PMID:29976774   PMID:30006610   PMID:30185799   PMID:30261474   PMID:30341237  
PMID:30423938   PMID:30549421   PMID:30612035   PMID:30641028   PMID:30848029   PMID:31017016   PMID:31137114   PMID:31319889   PMID:31405651   PMID:31605630   PMID:32007579   PMID:32307906  
PMID:32330455   PMID:32476947   PMID:32515028   PMID:32657442   PMID:32887380   PMID:33062070   PMID:33148388   PMID:33746900   PMID:33754020   PMID:33786919   PMID:33961781   PMID:34709727  
PMID:34756892   PMID:35023538   PMID:35186462   PMID:35264209   PMID:35831314   PMID:35868042  


Genomics

Comparative Map Data
CTSS
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381150,730,188 - 150,765,778 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1150,730,079 - 150,765,957 (-)EnsemblGRCh38hg38GRCh38
GRCh371150,702,664 - 150,738,254 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361148,969,175 - 149,004,929 (-)NCBINCBI36Build 36hg18NCBI36
Build 341147,515,623 - 147,551,378NCBI
Celera1123,818,402 - 123,853,717 (-)NCBICelera
Cytogenetic Map1q21.3NCBI
HuRef1122,080,971 - 122,116,053 (-)NCBIHuRef
CHM1_11152,098,024 - 152,133,771 (-)NCBICHM1_1
T2T-CHM13v2.01149,853,594 - 149,889,583 (-)NCBIT2T-CHM13v2.0
Ctss
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39395,434,097 - 95,463,716 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl395,434,097 - 95,463,714 (+)EnsemblGRCm39 Ensembl
GRCm38395,526,786 - 95,556,405 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl395,526,786 - 95,556,403 (+)EnsemblGRCm38mm10GRCm38
MGSCv37395,330,708 - 95,360,325 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36395,612,248 - 95,641,803 (+)NCBIMGSCv36mm8
Celera396,957,909 - 96,987,824 (+)NCBICelera
Cytogenetic Map3F2.1NCBI
cM Map340.74NCBI
Ctss
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.22183,089,192 - 183,114,483 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2183,086,437 - 183,114,483 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2190,751,075 - 190,779,335 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.02188,546,398 - 188,574,853 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.02183,383,602 - 183,411,862 (+)NCBIRnor_WKY
Rnor_6.02197,655,780 - 197,679,768 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2197,655,786 - 197,679,458 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02217,144,866 - 217,169,058 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42190,425,290 - 190,466,877 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12190,385,391 - 190,429,631 (+)NCBI
Celera2175,621,979 - 175,645,341 (+)NCBICelera
Cytogenetic Map2q34NCBI
Ctss
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541399,159 - 124,042 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541399,279 - 124,793 (+)NCBIChiLan1.0ChiLan1.0
CTSS
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11129,733,996 - 129,768,318 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1129,733,996 - 129,768,318 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01126,084,249 - 126,118,221 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
CTSS
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11759,893,840 - 59,910,878 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1759,893,840 - 59,910,849 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1759,339,729 - 59,356,741 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01760,909,903 - 60,927,183 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1760,909,903 - 60,947,992 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11759,739,445 - 59,756,448 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01759,823,472 - 59,840,470 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01760,551,720 - 60,568,999 (-)NCBIUU_Cfam_GSD_1.0
Ctss
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505821,932,794 - 21,961,031 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936580963,153 - 991,442 (-)EnsemblSpeTri2.0
SpeTri2.0NW_004936580963,176 - 991,732 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CTSS
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl498,417,883 - 98,442,950 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1498,415,273 - 98,442,952 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.24107,665,975 - 107,691,575 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CTSS
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Vero_WHO_p1.0NW_02366603812,512,460 - 12,548,903 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ctss
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462477218,419,736 - 18,438,786 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462477218,421,905 - 18,446,857 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in CTSS
11 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
NM_001199739.1(CTSS):c.798A>G (p.Lys266=) single nucleotide variant Malignant melanoma [RCV000064126] Chr1:150733094 [GRCh38]
Chr1:150705570 [GRCh37]
Chr1:148972194 [NCBI36]
Chr1:1q21.3		 not provided
GRCh38/hg38 1q21.2-25.2(chr1:149854269-180267197)x3 copy number gain See cases [RCV000143515] Chr1:149854269..180267197 [GRCh38]
Chr1:149825831..180236332 [GRCh37]
Chr1:148092455..178502955 [NCBI36]
Chr1:1q21.2-25.2		 pathogenic
GRCh37/hg19 1q21.1-21.3(chr1:144927578-153223600)x3 copy number gain Chromosome 1q21.1 duplication syndrome [RCV000223957] Chr1:144927578..153223600 [GRCh37]
Chr1:1q21.1-21.3		 pathogenic
GRCh37/hg19 1q21.1-21.3(chr1:143753740-151399970)x3 copy number gain See cases [RCV000447109] Chr1:143753740..151399970 [GRCh37]
Chr1:1q21.1-21.3		 pathogenic
GRCh37/hg19 1p36.33-q44(chr1:849467-249224684)x3 copy number gain See cases [RCV000510383] Chr1:849467..249224684 [GRCh37]
Chr1:1p36.33-q44		 pathogenic
GRCh37/hg19 1p36.33-q44(chr1:849467-249224684) copy number gain See cases [RCV000510926] Chr1:849467..249224684 [GRCh37]
Chr1:1p36.33-q44		 pathogenic
GRCh37/hg19 1p36.33-q44(chr1:47851-249228449)x3 copy number gain not provided [RCV000736295] Chr1:47851..249228449 [GRCh37]
Chr1:1p36.33-q44		 pathogenic
GRCh37/hg19 1p36.33-q44(chr1:82154-249218992)x3 copy number gain not provided [RCV000736305] Chr1:82154..249218992 [GRCh37]
Chr1:1p36.33-q44		 pathogenic
NM_004079.5(CTSS):c.888G>T (p.Val296=) single nucleotide variant not provided [RCV000958491] Chr1:150747785 [GRCh38]
Chr1:150720261 [GRCh37]
Chr1:1q21.3		 benign
NM_004079.5(CTSS):c.627+9T>A single nucleotide variant not provided [RCV000906664] Chr1:150751772 [GRCh38]
Chr1:150724248 [GRCh37]
Chr1:1q21.3		 benign
GRCh37/hg19 1q21.3(chr1:150611086-150941270)x1 copy number loss not provided [RCV001258473] Chr1:150611086..150941270 [GRCh37]
Chr1:1q21.3		 uncertain significance
GRCh37/hg19 1q21.3(chr1:150687807-150775422)x1 copy number loss not provided [RCV001258474] Chr1:150687807..150775422 [GRCh37]
Chr1:1q21.3		 uncertain significance
NC_000001.10:g.(?_130980840)_(248900000_?)dup duplication Gastrointestinal stromal tumor [RCV001300221]|Parathyroid carcinoma [RCV001341077] Chr1:130980840..248900000 [GRCh37]
Chr1:1q12-44		 uncertain significance
NC_000001.10:g.(?_149895434)_(156851434_?)dup duplication Autosomal recessive mendelian susceptibility to mycobacterial diseases due to complete RORgamma receptor deficiency [RCV001958273]|Congenital neutropenia-myelofibrosis-nephromegaly syndrome [RCV001958271]|Kostmann syndrome [RCV003120769]|MHC class II deficiency [RCV001992607]|Symmetrical dyschromatosis of extremities [RCV001958272] Chr1:149895434..156851434 [GRCh37]
Chr1:1q21.2-23.1		 uncertain significance
NM_004079.5(CTSS):c.667A>G (p.Thr223Ala) single nucleotide variant Inborn genetic diseases [RCV002905298] Chr1:150750132 [GRCh38]
Chr1:150722608 [GRCh37]
Chr1:1q21.3		 uncertain significance
NM_004079.5(CTSS):c.727G>A (p.Ala243Thr) single nucleotide variant Inborn genetic diseases [RCV002683734] Chr1:150750072 [GRCh38]
Chr1:150722548 [GRCh37]
Chr1:1q21.3		 uncertain significance
NM_004079.5(CTSS):c.578T>C (p.Ile193Thr) single nucleotide variant Inborn genetic diseases [RCV002936206] Chr1:150751830 [GRCh38]
Chr1:150724306 [GRCh37]
Chr1:1q21.3		 uncertain significance
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1785
Count of miRNA genes:776
Interacting mature miRNAs:873
Transcripts:ENST00000368985, ENST00000448301, ENST00000472977, ENST00000480760, ENST00000483930, ENST00000607427
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Markers in Region
RH44919  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371150,704,892 - 150,705,128UniSTSGRCh37
Build 361148,971,516 - 148,971,752RGDNCBI36
Celera1123,820,743 - 123,820,979RGD
Cytogenetic Map1q21UniSTS
HuRef1122,083,191 - 122,083,427UniSTS
GeneMap99-GB4 RH Map1542.25UniSTS
NCBI RH Map11060.9UniSTS
RH68555  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371150,704,887 - 150,705,050UniSTSGRCh37
Build 361148,971,511 - 148,971,674RGDNCBI36
Celera1123,820,738 - 123,820,901RGD
Cytogenetic Map1q21UniSTS
HuRef1122,083,186 - 122,083,349UniSTS
GeneMap99-GB4 RH Map1553.76UniSTS
NCBI RH Map11008.0UniSTS
RH80467  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371150,704,892 - 150,705,052UniSTSGRCh37
Build 361148,971,516 - 148,971,676RGDNCBI36
Celera1123,820,743 - 123,820,903RGD
Cytogenetic Map1q21UniSTS
HuRef1122,083,191 - 122,083,351UniSTS
GeneMap99-GB4 RH Map1553.44UniSTS
AL034054  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371150,705,614 - 150,705,788UniSTSGRCh37
Build 361148,972,238 - 148,972,412RGDNCBI36
Celera1123,821,465 - 123,821,639RGD
Cytogenetic Map1q21UniSTS
HuRef1122,083,913 - 122,084,087UniSTS
RH119963  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371150,709,219 - 150,709,410UniSTSGRCh37
Build 361148,975,843 - 148,976,034RGDNCBI36
Celera1123,825,066 - 123,825,257RGD
Cytogenetic Map1q21UniSTS
HuRef1122,087,519 - 122,087,710UniSTS
CTSS_573  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371150,704,737 - 150,705,493UniSTSGRCh37
Build 361148,971,361 - 148,972,117RGDNCBI36
Celera1123,820,588 - 123,821,344RGD
HuRef1122,083,036 - 122,083,792UniSTS
WI-18164  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371150,702,692 - 150,702,818UniSTSGRCh37
Build 361148,969,316 - 148,969,442RGDNCBI36
Celera1123,818,543 - 123,818,669RGD
Cytogenetic Map1q21UniSTS
HuRef1122,080,991 - 122,081,117UniSTS
GeneMap99-GB4 RH Map1544.74UniSTS
GeneMap99-GB4 RH Map1543.09UniSTS
Whitehead-RH Map1638.0UniSTS
SHGC-35262  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371150,705,325 - 150,705,505UniSTSGRCh37
Build 361148,971,949 - 148,972,129RGDNCBI36
Celera1123,821,176 - 123,821,356RGD
Cytogenetic Map1q21UniSTS
HuRef1122,083,624 - 122,083,804UniSTS
GeneMap99-GB4 RH Map1540.09UniSTS
Whitehead-RH Map1643.6UniSTS
NCBI RH Map11055.8UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High 14 15 1 3
Medium 1380 1582 973 427 1896 292 1543 324 782 252 453 1206 142 1169 779 2
Low 1038 1387 746 194 33 169 2613 1846 2887 160 977 358 29 1 35 1996 1 1
Below cutoff 17 2 5 2 6 4 188 22 44 7 21 46 2 13 2

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001199739 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_004079 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AH005369 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK024855 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK226095 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK301472 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK314482 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL356292 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC002642 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BQ006623 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471121 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068277 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CR541676 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JA885097 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M86553 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M90696 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  S93414 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000368985   ⟹   ENSP00000357981
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1150,730,188 - 150,765,778 (-)Ensembl
RefSeq Acc Id: ENST00000448301   ⟹   ENSP00000408414
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1150,732,658 - 150,765,773 (-)Ensembl
RefSeq Acc Id: ENST00000472977   ⟹   ENSP00000475176
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1150,730,192 - 150,765,778 (-)Ensembl
RefSeq Acc Id: ENST00000480760
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1150,754,881 - 150,765,803 (-)Ensembl
RefSeq Acc Id: ENST00000483930   ⟹   ENSP00000475812
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1150,732,385 - 150,765,782 (-)Ensembl
RefSeq Acc Id: ENST00000607427   ⟹   ENSP00000475557
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1150,730,196 - 150,765,815 (-)Ensembl
RefSeq Acc Id: ENST00000679512   ⟹   ENSP00000505113
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1150,730,188 - 150,765,778 (-)Ensembl
RefSeq Acc Id: ENST00000679582   ⟹   ENSP00000504885
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1150,751,006 - 150,765,782 (-)Ensembl
RefSeq Acc Id: ENST00000679898   ⟹   ENSP00000505326
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1150,730,188 - 150,765,768 (-)Ensembl
RefSeq Acc Id: ENST00000680288   ⟹   ENSP00000506001
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1150,730,079 - 150,765,957 (-)Ensembl
RefSeq Acc Id: ENST00000680311   ⟹   ENSP00000505020
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1150,732,382 - 150,765,789 (-)Ensembl
RefSeq Acc Id: ENST00000680466
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1150,764,226 - 150,765,765 (-)Ensembl
RefSeq Acc Id: ENST00000680471   ⟹   ENSP00000506603
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1150,732,418 - 150,765,728 (-)Ensembl
RefSeq Acc Id: ENST00000680664   ⟹   ENSP00000506248
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1150,730,188 - 150,765,778 (-)Ensembl
RefSeq Acc Id: ENST00000680931   ⟹   ENSP00000504934
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1150,732,476 - 150,765,778 (-)Ensembl
RefSeq Acc Id: ENST00000681357
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1150,732,527 - 150,748,062 (-)Ensembl
RefSeq Acc Id: ENST00000681444   ⟹   ENSP00000505359
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1150,732,380 - 150,765,778 (-)Ensembl
RefSeq Acc Id: ENST00000681728   ⟹   ENSP00000505313
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1150,749,794 - 150,765,811 (-)Ensembl
RefSeq Acc Id: ENST00000681863
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1150,757,291 - 150,765,844 (-)Ensembl
RefSeq Acc Id: NM_001199739   ⟹   NP_001186668
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381150,730,188 - 150,765,778 (-)NCBI
GRCh371150,702,672 - 150,738,433 (-)ENTREZGENE
HuRef1122,080,971 - 122,116,053 (-)ENTREZGENE
CHM1_11152,098,024 - 152,133,771 (-)NCBI
T2T-CHM13v2.01149,853,594 - 149,889,583 (-)NCBI
Sequence:
RefSeq Acc Id: NM_004079   ⟹   NP_004070
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381150,730,188 - 150,765,778 (-)NCBI
GRCh371150,702,672 - 150,738,433 (-)ENTREZGENE
Build 361148,969,175 - 149,004,929 (-)NCBI Archive
HuRef1122,080,971 - 122,116,053 (-)ENTREZGENE
CHM1_11152,098,024 - 152,133,771 (-)NCBI
T2T-CHM13v2.01149,853,594 - 149,889,583 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_001186668   ⟸   NM_001199739
- Peptide Label: isoform 2 preproprotein
- UniProtKB: P25774 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_004070   ⟸   NM_004079
- Peptide Label: isoform 1 preproprotein
- UniProtKB: Q9BUG3 (UniProtKB/Swiss-Prot),   P25774 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSP00000475812   ⟸   ENST00000483930
RefSeq Acc Id: ENSP00000357981   ⟸   ENST00000368985
RefSeq Acc Id: ENSP00000475176   ⟸   ENST00000472977
RefSeq Acc Id: ENSP00000408414   ⟸   ENST00000448301
RefSeq Acc Id: ENSP00000475557   ⟸   ENST00000607427
RefSeq Acc Id: ENSP00000506248   ⟸   ENST00000680664
RefSeq Acc Id: ENSP00000505113   ⟸   ENST00000679512
RefSeq Acc Id: ENSP00000506001   ⟸   ENST00000680288
RefSeq Acc Id: ENSP00000505313   ⟸   ENST00000681728
RefSeq Acc Id: ENSP00000505326   ⟸   ENST00000679898
RefSeq Acc Id: ENSP00000505020   ⟸   ENST00000680311
RefSeq Acc Id: ENSP00000505359   ⟸   ENST00000681444
RefSeq Acc Id: ENSP00000506603   ⟸   ENST00000680471
RefSeq Acc Id: ENSP00000504934   ⟸   ENST00000680931
RefSeq Acc Id: ENSP00000504885   ⟸   ENST00000679582
Protein Domains
Cathepsin propeptide inhibitor   Peptidase C1A papain C-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P25774-F1-model_v2 AlphaFold P25774 1-331 view protein structure

Promoters
RGD ID:6784985
Promoter ID:HG_KWN:4952
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Lymphoblastoid
Transcripts:OTTHUMT00000084738
Position:
Human AssemblyChrPosition (strand)Source
Build 361149,004,546 - 149,005,046 (-)MPROMDB
RGD ID:6784986
Promoter ID:HG_KWN:4953
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   K562,   Lymphoblastoid,   NB4
Transcripts:OTTHUMT00000084737,   UC001EVO.1
Position:
Human AssemblyChrPosition (strand)Source
Build 361149,004,639 - 149,005,139 (-)MPROMDB
RGD ID:6856990
Promoter ID:EPDNEW_H1660
Type:initiation region
Name:CTSS_1
Description:cathepsin S
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H1661  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381150,765,775 - 150,765,835EPDNEW
RGD ID:6856992
Promoter ID:EPDNEW_H1661
Type:initiation region
Name:CTSS_2
Description:cathepsin S
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H1660  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381150,765,954 - 150,766,014EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:2545 AgrOrtholog
COSMIC CTSS COSMIC
Ensembl Genes ENSG00000163131 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSP00000357981 ENTREZGENE
  ENSP00000357981.3 UniProtKB/Swiss-Prot
  ENSP00000408414.2 UniProtKB/TrEMBL
  ENSP00000475176 UniProtKB/TrEMBL
  ENSP00000475176.2 UniProtKB/Swiss-Prot
  ENSP00000475557.2 UniProtKB/Swiss-Prot
  ENSP00000475812.2 UniProtKB/TrEMBL
  ENSP00000504885.1 UniProtKB/TrEMBL
  ENSP00000504934.1 UniProtKB/TrEMBL
  ENSP00000505020.1 UniProtKB/TrEMBL
  ENSP00000505113.1 UniProtKB/TrEMBL
  ENSP00000505313.1 UniProtKB/TrEMBL
  ENSP00000505326.1 UniProtKB/TrEMBL
  ENSP00000505359.1 UniProtKB/Swiss-Prot
  ENSP00000506001 ENTREZGENE
  ENSP00000506001.1 UniProtKB/Swiss-Prot
  ENSP00000506248.1 UniProtKB/TrEMBL
  ENSP00000506603.1 UniProtKB/TrEMBL
Ensembl Transcript ENST00000368985 ENTREZGENE
  ENST00000368985.8 UniProtKB/Swiss-Prot
  ENST00000448301.7 UniProtKB/TrEMBL
  ENST00000472977 UniProtKB/TrEMBL
  ENST00000472977.7 UniProtKB/Swiss-Prot
  ENST00000483930.2 UniProtKB/TrEMBL
  ENST00000607427.2 UniProtKB/Swiss-Prot
  ENST00000679512.1 UniProtKB/TrEMBL
  ENST00000679582.1 UniProtKB/TrEMBL
  ENST00000679898.1 UniProtKB/TrEMBL
  ENST00000680288 ENTREZGENE
  ENST00000680288.1 UniProtKB/Swiss-Prot
  ENST00000680311.1 UniProtKB/TrEMBL
  ENST00000680471.1 UniProtKB/TrEMBL
  ENST00000680664.1 UniProtKB/TrEMBL
  ENST00000680931.1 UniProtKB/TrEMBL
  ENST00000681444.1 UniProtKB/Swiss-Prot
  ENST00000681728.1 UniProtKB/TrEMBL
Gene3D-CATH Cysteine proteinases UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000163131 GTEx
HGNC ID HGNC:2545 ENTREZGENE
Human Proteome Map CTSS Human Proteome Map
InterPro Papain-like_cys_pep_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pept_asp_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pept_cys_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pept_his_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_C1A UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_C1A_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_C1A_papain-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot_inhib_I29 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:1520 UniProtKB/Swiss-Prot
NCBI Gene 1520 ENTREZGENE
OMIM 116845 OMIM
PANTHER CATHEPSIN S UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CYSTEINE PROTEASE FAMILY C1-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Inhibitor_I29 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_C1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA27041 PharmGKB
PRINTS PAPAIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE THIOL_PROTEASE_ASN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  THIOL_PROTEASE_CYS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  THIOL_PROTEASE_HIS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART Inhibitor_I29 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pept_C1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF54001 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A7P0T7Z6_HUMAN UniProtKB/TrEMBL
  A0A7P0T844_HUMAN UniProtKB/TrEMBL
  A0A7P0T8A1_HUMAN UniProtKB/TrEMBL
  A0A7P0T8H4_HUMAN UniProtKB/TrEMBL
  A0A7P0T8U1_HUMAN UniProtKB/TrEMBL
  A0A7P0T904_HUMAN UniProtKB/TrEMBL
  A0A7P0TAQ0_HUMAN UniProtKB/TrEMBL
  A0A7P0TB77_HUMAN UniProtKB/TrEMBL
  A0A804DAZ0_HUMAN UniProtKB/TrEMBL
  CATS_HUMAN UniProtKB/Swiss-Prot, ENTREZGENE
  Q9BUG3 ENTREZGENE
  U3KPS4_HUMAN UniProtKB/TrEMBL
  U3KQE7_HUMAN UniProtKB/TrEMBL
UniProt Secondary B4DWC9 UniProtKB/Swiss-Prot
  D3DV05 UniProtKB/Swiss-Prot
  Q5T5I0 UniProtKB/Swiss-Prot
  Q6FHS5 UniProtKB/Swiss-Prot
  Q9BUG3 UniProtKB/Swiss-Prot