Ctss (cathepsin S) - Rat Genome Database

Name: Ctss
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

Gene: Ctss (cathepsin S) Heterocephalus glaber

Analyze

Symbol:

Ctss

Name:

cathepsin S

RGD ID:

18927202

Description:

ENCODES a protein that exhibits collagen binding (ortholog); cysteine-type peptidase activity (ortholog); fibronectin binding (ortholog); INVOLVED IN adaptive immune response (ortholog); antigen processing and presentation of exogenous peptide antigen via MHC class II (ortholog); antigen processing and presentation of peptide antigen (ortholog); ASSOCIATED WITH Alzheimer's disease (ortholog); atherosclerosis (ortholog); carotid artery disease (ortholog); FOUND IN cell surface (ortholog); intracellular membrane-bounded organelle (ortholog); late endosome (ortholog)

Type:

protein-coding

RefSeq Status:

RGD Orthologs

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	CTSS (cathepsin S)	NCBI	Ortholog
Mus musculus (house mouse):	Ctss (cathepsin S)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus norvegicus (Norway rat):	Ctss (cathepsin S)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Ctss (cathepsin S)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	CTSS (cathepsin S)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	CTSS (cathepsin S)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Ctss (cathepsin S)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	CTSS (cathepsin S)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	CTSS (cathepsin S)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline

Latest Assembly:

HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly

Position:

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624772	18,419,736 - 18,438,786 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624772	18,421,905 - 18,446,857 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Alzheimer's disease (ISO)

atherosclerosis (ISO)

carotid artery disease (ISO)

colitis (ISO)

contact dermatitis (ISO)

Creutzfeldt-Jakob disease (ISO)

Delayed Hypersensitivity (ISO)

Down syndrome (ISO)

Experimental Arthritis (ISO)

Experimental Autoimmune Encephalomyelitis (ISO)

Experimental Liver Cirrhosis (ISO)

Facial Nerve Injuries (ISO)

gastrointestinal stromal tumor (ISO)

genetic disease (ISO)

Hyperalgesia (ISO)

immunodeficiency 42 (ISO)

intracranial aneurysm (ISO)

MHC class II deficiency (ISO)

Neoplasm Invasiveness (ISO)

Neuralgia (ISO)

neuropathy (ISO)

obesity (ISO)

parathyroid carcinoma (ISO)

relapsing-remitting multiple sclerosis (ISO)

Reoviridae Infections (ISO)

severe congenital neutropenia 3 (ISO)

severe congenital neutropenia 5 (ISO)

Spinal Cord Injuries (ISO)

visual epilepsy (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

adaptive immune response (ISO)

antigen processing and presentation of exogenous peptide antigen via MHC class II (ISO)

antigen processing and presentation of peptide antigen (ISO)

apoptotic process (IEA)

basement membrane disassembly (ISO)

bone resorption (ISO)

cellular response to thyroid hormone stimulus (ISO)

collagen catabolic process (ISO)

immune response (IEA)

metanephros development (ISO)

positive regulation of apoptotic signaling pathway (IEA)

positive regulation of inflammatory response (ISO)

protein processing (ISO)

proteolysis (IEA,ISO)

proteolysis involved in protein catabolic process (IEA)

response to acidic pH (ISO)

Cellular Component

cell surface (ISO)

cytoplasmic vesicle (IEA)

extracellular region (IEA)

extracellular space (IEA)

intracellular membrane-bounded organelle (ISO)

late endosome (ISO)

lysosome (IEA)

membrane (ISO)

phagocytic vesicle (IEA)

Molecular Function

collagen binding (ISO)

cysteine-type endopeptidase activator activity involved in apoptotic process (IEA)

cysteine-type endopeptidase activity (IEA)

cysteine-type peptidase activity (IEA,ISO)

fibronectin binding (ISO)

laminin binding (ISO)

peptidase activity (ISO)

proteoglycan binding (ISO)

References

Additional References at PubMed

PMID:30032202

Genomics

Comparative Map Data

Ctss
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624772	18,419,736 - 18,438,786 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624772	18,421,905 - 18,446,857 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

CTSS
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	1	150,730,188 - 150,765,778 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	1	150,730,079 - 150,765,957 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	1	150,702,664 - 150,738,254 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	1	148,969,175 - 149,004,929 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	1	147,515,623 - 147,551,378	NCBI
Celera	1	123,818,402 - 123,853,717 (-)	NCBI		Celera
Cytogenetic Map	1	q21.3	NCBI
HuRef	1	122,080,971 - 122,116,053 (-)	NCBI		HuRef
CHM1_1	1	152,098,024 - 152,133,771 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	1	149,853,594 - 149,889,583 (-)	NCBI		T2T-CHM13v2.0

Ctss
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	3	95,434,097 - 95,463,716 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	3	95,434,097 - 95,463,714 (+)	Ensembl		GRCm39 Ensembl
GRCm38	3	95,526,786 - 95,556,405 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	3	95,526,786 - 95,556,403 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	3	95,330,708 - 95,360,325 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	3	95,612,248 - 95,641,803 (+)	NCBI		MGSCv36	mm8
Celera	3	96,957,909 - 96,987,824 (+)	NCBI		Celera
Cytogenetic Map	3	F2.1	NCBI
cM Map	3	40.74	NCBI

Ctss
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	2	185,775,316 - 185,803,440 (+)	NCBI		GRCr8
mRatBN7.2	2	183,086,437 - 183,114,483 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	2	183,086,437 - 183,114,483 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	2	190,751,075 - 190,779,335 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	2	188,546,398 - 188,574,853 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	2	183,383,602 - 183,411,862 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	2	197,655,780 - 197,679,768 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	2	197,655,786 - 197,679,458 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	2	217,144,866 - 217,169,058 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	2	190,425,290 - 190,466,877 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	2	190,385,391 - 190,429,631 (+)	NCBI
Celera	2	175,621,979 - 175,645,341 (+)	NCBI		Celera
Cytogenetic Map	2	q34	NCBI

Ctss
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955413	99,159 - 124,042 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955413	99,279 - 124,793 (+)	NCBI	ChiLan1.0	ChiLan1.0

CTSS
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	1	99,064,378 - 99,097,165 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	1	98,818,135 - 98,852,978 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	1	126,084,249 - 126,118,221 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	1	129,733,996 - 129,768,318 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	1	129,733,996 - 129,768,318 (-)	Ensembl	panpan1.1		panPan2

CTSS
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	17	59,893,840 - 59,910,878 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	17	59,893,840 - 59,910,849 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	17	59,339,729 - 59,356,741 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	17	60,909,903 - 60,927,183 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	17	60,909,903 - 60,947,992 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	17	59,739,445 - 59,756,448 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	17	59,823,472 - 59,840,470 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	17	60,551,720 - 60,568,999 (-)	NCBI		UU_Cfam_GSD_1.0

Ctss
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405058	21,932,794 - 21,961,031 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936580	963,153 - 991,442 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936580	963,176 - 991,732 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

CTSS
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	4	98,417,883 - 98,442,950 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	4	98,415,273 - 98,442,952 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	4	107,665,975 - 107,691,575 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

CTSS
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Vero_WHO_p1.0	NW_023666038	12,512,460 - 12,548,903 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_004853991	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AHKG01051483	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AHKG01051484	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AHKG01051485	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AHKG01051486	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSHGLT00000022295 ⟹ ENSHGLP00000022084

Type:

CODING

Position:

Naked Mole-Rat Assembly	Chr	Position (strand)	Source
HetGla_female_1.0 Ensembl	NW_004624772	18,419,736 - 18,438,786 (-)	Ensembl

RefSeq Acc Id:

XM_004853991 ⟹ XP_004854048

Type:

CODING

Position:

Naked Mole-Rat Assembly	Chr	Position (strand)	Source
HetGla 1.0	NW_004624772	18,421,905 - 18,446,857 (-)	NCBI

Protein Sequences


Protein RefSeqs	XP_004854048	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSHGLP00000022084

RefSeq Acc Id:	XP_004854048 ⟸ XM_004853991
- UniProtKB:	G5BH45 (UniProtKB/TrEMBL)

RefSeq Acc Id:

ENSHGLP00000022084 ⟸ ENSHGLT00000022295

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSHGLG00000015756	Ensembl, ENTREZGENE
Ensembl Transcript	ENSHGLT00000022295	ENTREZGENE
Gene3D-CATH	Cysteine proteinases	UniProtKB/TrEMBL
InterPro	Papain-like_cys_pep_sf	UniProtKB/TrEMBL
	Pept_asp_AS	UniProtKB/TrEMBL
	Pept_cys_AS	UniProtKB/TrEMBL
	Pept_his_AS	UniProtKB/TrEMBL
	Peptidase_C1A	UniProtKB/TrEMBL
	Peptidase_C1A_C	UniProtKB/TrEMBL
	Peptidase_C1A_papain-like	UniProtKB/TrEMBL
	Prot_inhib_I29	UniProtKB/TrEMBL
NCBI Gene	Ctss	ENTREZGENE
PANTHER	CATHEPSIN S	UniProtKB/TrEMBL
	CYSTEINE PROTEASE FAMILY C1-RELATED	UniProtKB/TrEMBL
Pfam	Inhibitor_I29	UniProtKB/TrEMBL
	Peptidase_C1	UniProtKB/TrEMBL
PRINTS	PAPAIN	UniProtKB/TrEMBL
PROSITE	THIOL_PROTEASE_ASN	UniProtKB/TrEMBL
	THIOL_PROTEASE_CYS	UniProtKB/TrEMBL
	THIOL_PROTEASE_HIS	UniProtKB/TrEMBL
SMART	Inhibitor_I29	UniProtKB/TrEMBL
	Pept_C1	UniProtKB/TrEMBL
Superfamily-SCOP	Cysteine proteinases	UniProtKB/TrEMBL
UniProt	G5BH45	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Send us a Message

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD