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Gene: Nlgn3 (neuroligin 3) Rattus norvegicus
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Symbol: Nlgn3
Name: neuroligin 3
Description: Exhibits cell adhesion molecule binding activity; neurexin family protein binding activity; and signaling receptor activity. Involved in several processes, including inhibitory postsynaptic potential; modulation of chemical synaptic transmission; and nervous system development. Localizes to several cellular components, including the GABA-ergic synapse; glutamatergic synapse; and integral component of postsynaptic specialization membrane. Colocalizes with the dendrite. Used to study autism spectrum disorder. Biomarker of sciatic neuropathy. Human ortholog(s) of this gene implicated in Asperger syndrome and autistic disorder. Orthologous to human NLGN3 (neuroligin 3); INTERACTS WITH 17alpha-ethynylestradiol; 2,2',4,4'-Tetrabromodiphenyl ether; acrylamide.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: gliotactin homolog; neuroligin-3
Orthologs:
Homo sapiens (human) : NLGN3 (neuroligin 3)  HGNC  Alliance
Mus musculus (house mouse) : Nlgn3 (neuroligin 3)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Nlgn3 (neuroligin 3)
Pan paniscus (bonobo/pygmy chimpanzee) : NLGN3 (neuroligin 3)
Canis lupus familiaris (dog) : NLGN3 (neuroligin 3)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Nlgn3 (neuroligin 3)
Sus scrofa (pig) : NLGN3 (neuroligin 3)
more info ...
Allele / Splice: Nlgn3em1Sage  
Genetic Models: SD-Nlgn3em1Sage
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0X71,199,390 - 71,227,460 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX71,199,491 - 71,222,732 (+)Ensembl
Rnor_5.0X72,051,846 - 72,075,119 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X89,376,193 - 89,398,665 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1X89,449,625 - 89,471,949 (+)NCBI
CeleraX66,785,377 - 66,807,774 (+)NCBICelera
Cytogenetic MapXq22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
Genetic Models
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Nlgn3
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 621119
Created: 2002-08-06
Species: Rattus norvegicus
Last Modified: 2019-08-20
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.