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Imported Disease Annotations - CTDTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | toxic encephalopathy | | ISO | RGD:1606321 | 11554173 | CTD Direct Evidence: marker/mechanism | CTD | PMID:29471019 | |
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Imported Disease Annotations - CTDTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | toxic encephalopathy | | ISO | RGD:1606321 | 11554173 | CTD Direct Evidence: marker/mechanism | CTD | PMID:29471019 | |
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# | Reference Title | Reference Citation |
1. | Endoplasmic reticulum stress-induced cell death in dopaminergic cells: effect of resveratrol. | Chinta SJ, etal., J Mol Neurosci. 2009 Sep;39(1-2):157-68. Epub 2009 Jan 15. |
2. | Microsomal prostaglandin E synthase-1 is a major terminal synthase that is selectively up-regulated during cyclooxygenase-2-dependent prostaglandin E2 production in the rat adjuvant-induced arthritis model. | Claveau D, etal., J Immunol. 2003 May 1;170(9):4738-44. |
3. | Immunofluorescence localization of the 90-kDa heat-shock protein to cytoskeleton. | Czar MJ, etal., Eur J Cell Biol. 1996 Aug;70(4):322-30. |
4. | Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. | Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27. |
5. | Prostanoids as regulators of innate and adaptive immunity. | Hirata T and Narumiya S, Adv Immunol. 2012;116:143-74. doi: 10.1016/B978-0-12-394300-2.00005-3. |
6. | Downregulation of cytosolic prostaglandin E2 synthase results in decreased nociceptive behavior in rats. | Hofacker A, etal., J Neurosci. 2005 Sep 28;25(39):9005-9. |
7. | Molecular mechanisms regulating the vascular prostacyclin pathways and their adaptation during pregnancy and in the newborn. | Majed BH and Khalil RA, Pharmacol Rev. 2012 Jul;64(3):540-82. doi: 10.1124/pr.111.004770. Epub 2012 Jun 7. |
8. | Cytosolic prostaglandin E2 synthase/p23 but not apoptosis-linked gene 2 is downregulated in human atherosclerotic plaques. | Martinet W, etal., Cardiovasc Res. 2004 Feb 1;61(2):360-1. |
9. | The terminal prostaglandin synthases mPGES-1, mPGES-2, and cPGES are all overexpressed in human gliomas. | Mattila S, etal., Neuropathology. 2009 Apr;29(2):156-65. |
10. | Involvement of the constitutive prostaglandin E synthase cPGES/p23 in expression of an initial prostaglandin E2 inactivating enzyme, 15-PGDH. | Nakatani Y, etal., Prostaglandins Other Lipid Mediat. 2011 Apr;94(3-4):112-7. Epub 2011 Feb 17. |
11. | Chaperoning of glucocorticoid receptors. | Pratt WB, etal., Handb Exp Pharmacol. 2006;(172):111-38. |
12. | Subcellular rearrangement of hsp90-binding immunophilins accompanies neuronal differentiation and neurite outgrowth. | Quinta HR, etal., J Neurochem. 2010 Nov;115(3):716-34. doi: 10.1111/j.1471-4159.2010.06970.x. Epub 2010 Sep 28. |
13. | Data Import for Chemical-Gene Interactions | RGD automated import pipeline for gene-chemical interactions |
14. | Comprehensive gene review and curation | RGD comprehensive gene curation |
15. | High levels of Hsp90 cochaperone p23 promote tumor progression and poor prognosis in breast cancer by increasing lymph node metastases and drug resistance. | Simpson NE, etal., Cancer Res. 2010 Nov 1;70(21):8446-56. Epub 2010 Sep 16. |
16. | Minireview: the intersection of steroid receptors with molecular chaperones: observations and questions. | Smith DF and Toft DO, Mol Endocrinol. 2008 Oct;22(10):2229-40. Epub 2008 May 1. |
17. | Regulation of cytosolic prostaglandin E2 synthase by 90-kDa heat shock protein. | Tanioka T, etal., Biochem Biophys Res Commun. 2003 Apr 18;303(4):1018-23. |
18. | Molecular identification of cytosolic prostaglandin E2 synthase that is functionally coupled with cyclooxygenase-1 in immediate prostaglandin E2 biosynthesis. | Tanioka T, etal., J Biol Chem. 2000 Oct 20;275(42):32775-82. |
19. | Intracellular-specific colocalization of prostaglandin E2 synthases and cyclooxygenases in the brain. | Vazquez-Tello A, etal., Am J Physiol Regul Integr Comp Physiol. 2004 Nov;287(5):R1155-63. Epub 2004 Jul 29. |
20. | The physical association of multiple molecular chaperone proteins with mutant p53 is altered by geldanamycin, an hsp90-binding agent. | Whitesell L, etal., Mol Cell Biol. 1998 Mar;18(3):1517-24. |
21. | Interactions of the mineralocorticoid receptor--within and without. | Yang J and Fuller PJ, Mol Cell Endocrinol. 2012 Mar 24;350(2):196-205. doi: 10.1016/j.mce.2011.07.001. Epub 2011 Jul 18. |
PMID:10197982 | PMID:10543959 | PMID:10811660 | PMID:12077419 | PMID:12135483 | PMID:12477932 | PMID:12853476 | PMID:17438133 | PMID:19740745 | PMID:19751963 | PMID:21630459 | PMID:22871113 |
PMID:23376485 | PMID:29093345 | PMID:29127155 |
Ptges3 (Rattus norvegicus - Norway rat) |
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PTGES3 (Homo sapiens - human) |
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Ptges3 (Mus musculus - house mouse) |
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Ptges3 (Chinchilla lanigera - long-tailed chinchilla) |
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PTGES3 (Pan paniscus - bonobo/pygmy chimpanzee) |
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PTGES3 (Canis lupus familiaris - dog) |
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Ptges3 (Ictidomys tridecemlineatus - thirteen-lined ground squirrel) |
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PTGES3 (Sus scrofa - pig) |
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PTGES3 (Chlorocebus sabaeus - green monkey) |
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Ptges3 (Heterocephalus glaber - naked mole-rat) |
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Variants in Ptges3
72 total Variants ![]() |
The detailed report is available here: | ![]() | Full Report | ![]() | CSV | ![]() | TAB | ![]() | Printer |
miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/). For more information about miRGate, see PMID:25858286 or access the full paper here. |
The following QTLs overlap with this region. | ![]() | Full Report | ![]() | CSV | ![]() | TAB | ![]() | Printer | ![]() | Gviewer |
RH127823 |
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UniSTS:234880 |
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alimentary part of gastrointestinal system | circulatory system | endocrine system | exocrine system | hemolymphoid system | hepatobiliary system | integumental system | musculoskeletal system | nervous system | renal system | reproductive system | respiratory system | appendage | |
High | |||||||||||||
Medium | 3 | 43 | 57 | 41 | 19 | 41 | 8 | 11 | 74 | 35 | 41 | 11 | 8 |
Low | |||||||||||||
Below cutoff |
RefSeq Transcripts | NM_001130989 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles |
XM_008765026 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
GenBank Nucleotide | BC166579 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles |
CH474104 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
FQ224980 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
JACYVU010000171 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles |
RefSeq Acc Id: | ENSRNOT00000003787 ⟹ ENSRNOP00000003787 | ||||||||||||
RefSeq Status: | |||||||||||||
Type: | CODING | ||||||||||||
Position: |
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RefSeq Acc Id: | ENSRNOT00000094676 ⟹ ENSRNOP00000082352 | ||||||||
RefSeq Status: | |||||||||
Type: | CODING | ||||||||
Position: |
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RefSeq Acc Id: | ENSRNOT00000097034 ⟹ ENSRNOP00000080703 | ||||||||
RefSeq Status: | |||||||||
Type: | CODING | ||||||||
Position: |
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RefSeq Acc Id: | ENSRNOT00000097314 ⟹ ENSRNOP00000085230 | ||||||||
RefSeq Status: | |||||||||
Type: | CODING | ||||||||
Position: |
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RefSeq Acc Id: | ENSRNOT00000097618 ⟹ ENSRNOP00000096830 | ||||||||
RefSeq Status: | |||||||||
Type: | CODING | ||||||||
Position: |
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RefSeq Acc Id: | ENSRNOT00000101866 ⟹ ENSRNOP00000096607 | ||||||||
RefSeq Status: | |||||||||
Type: | CODING | ||||||||
Position: |
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RefSeq Acc Id: | ENSRNOT00000104676 ⟹ ENSRNOP00000096677 | ||||||||
RefSeq Status: | |||||||||
Type: | CODING | ||||||||
Position: |
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RefSeq Acc Id: | NM_001130989 ⟹ NP_001124461 | ||||||||||||||||||||||||
RefSeq Status: | PROVISIONAL | ||||||||||||||||||||||||
Type: | CODING | ||||||||||||||||||||||||
Position: |
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Sequence: |
Protein RefSeqs | NP_001124461 | (Get FASTA) | NCBI Sequence Viewer |
GenBank Protein | AAI66579 | (Get FASTA) | NCBI Sequence Viewer |
EDL84891 | (Get FASTA) | NCBI Sequence Viewer | |
P83868 | (Get FASTA) | NCBI Sequence Viewer |
RefSeq Acc Id: | NP_001124461 ⟸ NM_001130989 |
- UniProtKB: | P83868 (UniProtKB/Swiss-Prot), B2GV92 (UniProtKB/TrEMBL), R9PXR7 (UniProtKB/TrEMBL) |
- Sequence: |
RefSeq Acc Id: | ENSRNOP00000003787 ⟸ ENSRNOT00000003787 |
RefSeq Acc Id: | ENSRNOP00000082352 ⟸ ENSRNOT00000094676 |
RefSeq Acc Id: | ENSRNOP00000096677 ⟸ ENSRNOT00000104676 |
RefSeq Acc Id: | ENSRNOP00000085230 ⟸ ENSRNOT00000097314 |
RefSeq Acc Id: | ENSRNOP00000096607 ⟸ ENSRNOT00000101866 |
RefSeq Acc Id: | ENSRNOP00000096830 ⟸ ENSRNOT00000097618 |
RefSeq Acc Id: | ENSRNOP00000080703 ⟸ ENSRNOT00000097034 |
Name | Modeler | Protein Id | AA Range | Protein Structure |
AF-P83868-F1-model_v2 | AlphaFold | P83868 | 1-160 | view protein structure |
eQTL | View at Phenogen | |
WGCNA | View at Phenogen | |
Tissue/Strain Expression | View at Phenogen |
RGD ID: | 13694921 | ||||||||
Promoter ID: | EPDNEW_R5446 | ||||||||
Type: | initiation region | ||||||||
Name: | Ptges3_1 | ||||||||
Description: | prostaglandin E synthase 3 | ||||||||
SO ACC ID: | SO:0000170 | ||||||||
Source: | EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/) | ||||||||
Experiment Methods: | Single-end sequencing. | ||||||||
Position: |
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Database | Acc Id | Source(s) |
AGR Gene | RGD:1561913 | AgrOrtholog |
BioCyc Gene | G2FUF-35400 | BioCyc |
BioCyc Pathway | PWY66-374 [C20 prostanoid biosynthesis] | BioCyc |
Ensembl Genes | ENSRNOG00000002642 | Ensembl, ENTREZGENE, UniProtKB/TrEMBL |
Ensembl Protein | ENSRNOP00000003787 | ENTREZGENE |
ENSRNOP00000003787.8 | UniProtKB/TrEMBL | |
ENSRNOP00000080703.1 | UniProtKB/TrEMBL | |
ENSRNOP00000082352.1 | UniProtKB/TrEMBL | |
ENSRNOP00000085230.1 | UniProtKB/TrEMBL | |
ENSRNOP00000096607.1 | UniProtKB/TrEMBL | |
ENSRNOP00000096677.1 | UniProtKB/TrEMBL | |
ENSRNOP00000096830.1 | UniProtKB/TrEMBL | |
Ensembl Transcript | ENSRNOT00000003787 | ENTREZGENE |
ENSRNOT00000003787.8 | UniProtKB/TrEMBL | |
ENSRNOT00000094676.1 | UniProtKB/TrEMBL | |
ENSRNOT00000097034.1 | UniProtKB/TrEMBL | |
ENSRNOT00000097314.1 | UniProtKB/TrEMBL | |
ENSRNOT00000097618.1 | UniProtKB/TrEMBL | |
ENSRNOT00000101866.1 | UniProtKB/TrEMBL | |
ENSRNOT00000104676.1 | UniProtKB/TrEMBL | |
Gene3D-CATH | 2.60.40.790 | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
InterPro | CS_dom | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
HSP20-like_chaperone | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
p23-like | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
KEGG Report | rno:362809 | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
NCBI Gene | 362809 | ENTREZGENE |
PANTHER | PTHR22932 | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
Pfam | PF04969 | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
PhenoGen | Ptges3 | PhenoGen |
PROSITE | PS51203 | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
Superfamily-SCOP | SSF49764 | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
UniProt | A0A8I5ZQW8_RAT | UniProtKB/TrEMBL |
A0A8I5ZTE4_RAT | UniProtKB/TrEMBL | |
A0A8I5ZZQ2_RAT | UniProtKB/TrEMBL | |
A0A8I6AQE2_RAT | UniProtKB/TrEMBL | |
A0A8I6AQZ3_RAT | UniProtKB/TrEMBL | |
A0A8I6ATR8_RAT | UniProtKB/TrEMBL | |
A0A8L2Q1B4_RAT | UniProtKB/TrEMBL | |
B2GV92 | ENTREZGENE, UniProtKB/TrEMBL | |
P83868 | ENTREZGENE | |
R9PXR7 | ENTREZGENE | |
TEBP_RAT | UniProtKB/Swiss-Prot | |
UniProt Secondary | R9PXR7 | UniProtKB/TrEMBL |
Date | Current Symbol | Current Name | Previous Symbol | Previous Name | Description | Reference | Status |
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2015-12-10 | Ptges3 | prostaglandin E synthase 3 | Ptges3 | prostaglandin E synthase 3 (cytosolic) | Nomenclature updated to reflect human and mouse nomenclature | 1299863 | APPROVED |
2008-04-30 | Ptges3 | prostaglandin E synthase 3 (cytosolic) | Ptges3_predicted | prostaglandin E synthase 3 (cytosolic) (predicted) | 'predicted' is removed | 2292626 | APPROVED |
2006-03-30 | Ptges3_predicted | prostaglandin E synthase 3 (cytosolic) (predicted) | RGD1561913_predicted | similar to Sid3177p (predicted) | Symbol and Name updated | 1299863 | APPROVED |
2006-03-07 | RGD1561913_predicted | similar to Sid3177p (predicted) | LOC362809 | similar to Sid3177p | Symbol and Name status set to approved | 1299863 | APPROVED |
2006-02-09 | LOC362809 | similar to Sid3177p | Symbol and Name status set to provisional | 70820 | PROVISIONAL |