Ptges3 (prostaglandin E synthase 3) - Rat Genome Database

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Gene: Ptges3 (prostaglandin E synthase 3) Mus musculus
Analyze
Symbol: Ptges3
Name: prostaglandin E synthase 3
RGD ID: 1620858
MGI Page MGI
Description: Enables DNA polymerase binding activity and prostaglandin-E synthase activity. Involved in cyclooxygenase pathway and telomerase holoenzyme complex assembly. Acts upstream of with a positive effect on telomere maintenance via telomerase. Acts upstream of or within several processes, including glycogen biosynthetic process; nuclear receptor-mediated glucocorticoid signaling pathway; and prostaglandin biosynthetic process. Is active in cytosol. Is expressed in several structures, including liver and skin. Orthologous to human PTGES3 (prostaglandin E synthase 3).
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: 5730442A20Rik; cPG; cPGES; cytosolic prostaglandin E2 synthase; hsp90 co-chaperone; p23; p23 cochaperone; progesterone receptor complex p23; prostaglandin E synthase 3 (cytosolic); Ptg; Ptges; sid 3177; sid31; sid3177; Teb; Tebp; telomerase binding protein, p23; telomerase-binding protein p23
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3910127,894,851 - 127,913,123 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl10127,894,823 - 127,913,141 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm3810128,058,982 - 128,077,254 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl10128,058,954 - 128,077,272 (+)Ensemblmm10GRCm38
MGSCv3710127,496,038 - 127,514,310 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv3610127,461,931 - 127,480,203 (+)NCBIMGSCv36mm8
Celera10130,453,617 - 130,471,989 (+)NCBICelera
Cytogenetic Map10D3NCBI
cM Map1076.39NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (ISO)
(-)-citrinin  (ISO)
(1->4)-beta-D-glucan  (EXP)
1,2-dimethylhydrazine  (EXP)
17beta-estradiol  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,6-dimethoxyphenol  (ISO)
2-methylcholine  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
6-propyl-2-thiouracil  (ISO)
acrylamide  (ISO)
actinomycin D  (ISO)
albendazole  (ISO)
amitrole  (ISO)
ammonium chloride  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
beauvericin  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
Benzo[ghi]perylene  (ISO)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
cadmium dichloride  (ISO)
chelerythrine  (ISO)
chloropicrin  (ISO)
chlorpyrifos  (EXP)
cisplatin  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
cyclophosphamide  (ISO)
cyclosporin A  (ISO)
DDE  (ISO)
dextran sulfate  (EXP)
diarsenic trioxide  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (ISO)
disulfiram  (ISO)
enniatin  (ISO)
enzyme inhibitor  (ISO)
ethanol  (EXP)
folic acid  (EXP)
FR900359  (ISO)
furfural  (ISO)
gentamycin  (ISO)
hexadecanoic acid  (ISO)
hydrogen peroxide  (ISO)
hypochlorous acid  (EXP)
isoniazide  (ISO)
ivermectin  (ISO)
lead diacetate  (EXP)
lipopolysaccharide  (ISO)
mancozeb  (EXP)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
mercury dichloride  (ISO)
methimazole  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
nickel subsulfide  (ISO)
nitrates  (EXP)
Nutlin-3  (ISO)
ochratoxin A  (ISO)
paclitaxel  (ISO)
perfluorooctane-1-sulfonic acid  (EXP)
PhIP  (ISO)
quercetin  (ISO)
reactive oxygen species  (ISO)
resveratrol  (EXP)
serpentine asbestos  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (ISO)
sodium chloride  (ISO)
sodium dichromate  (ISO)
staurosporine  (ISO)
sulfadimethoxine  (ISO)
tetrachloromethane  (EXP,ISO)
thapsigargin  (ISO)
trichloroethene  (EXP)
uranium atom  (ISO)
valdecoxib  (ISO)
vincaleukoblastine  (ISO)
vorinostat  (ISO)
zearalenone  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Microsomal prostaglandin E synthase-1 is a major terminal synthase that is selectively up-regulated during cyclooxygenase-2-dependent prostaglandin E2 production in the rat adjuvant-induced arthritis model. Claveau D, etal., J Immunol. 2003 May 1;170(9):4738-44.
2. Prostanoids as regulators of innate and adaptive immunity. Hirata T and Narumiya S, Adv Immunol. 2012;116:143-74. doi: 10.1016/B978-0-12-394300-2.00005-3.
3. Downregulation of cytosolic prostaglandin E2 synthase results in decreased nociceptive behavior in rats. Hofacker A, etal., J Neurosci. 2005 Sep 28;25(39):9005-9.
4. Molecular mechanisms regulating the vascular prostacyclin pathways and their adaptation during pregnancy and in the newborn. Majed BH and Khalil RA, Pharmacol Rev. 2012 Jul;64(3):540-82. doi: 10.1124/pr.111.004770. Epub 2012 Jun 7.
5. Cytosolic prostaglandin E2 synthase/p23 but not apoptosis-linked gene 2 is downregulated in human atherosclerotic plaques. Martinet W, etal., Cardiovasc Res. 2004 Feb 1;61(2):360-1.
6. The terminal prostaglandin synthases mPGES-1, mPGES-2, and cPGES are all overexpressed in human gliomas. Mattila S, etal., Neuropathology. 2009 Apr;29(2):156-65.
7. Knockout mice lacking cPGES/p23, a constitutively expressed PGE2 synthetic enzyme, are peri-natally lethal. Nakatani Y, etal., Biochem Biophys Res Commun. 2007 Oct 19;362(2):387-92. Epub 2007 Aug 9.
8. Chaperoning of glucocorticoid receptors. Pratt WB, etal., Handb Exp Pharmacol. 2006;(172):111-38.
9. Mouse MP Annotation Import Pipeline RGD automated import pipeline
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
11. High levels of Hsp90 cochaperone p23 promote tumor progression and poor prognosis in breast cancer by increasing lymph node metastases and drug resistance. Simpson NE, etal., Cancer Res. 2010 Nov 1;70(21):8446-56. Epub 2010 Sep 16.
12. Minireview: the intersection of steroid receptors with molecular chaperones: observations and questions. Smith DF and Toft DO, Mol Endocrinol. 2008 Oct;22(10):2229-40. Epub 2008 May 1.
13. Interactions of the mineralocorticoid receptor--within and without. Yang J and Fuller PJ, Mol Cell Endocrinol. 2012 Mar 24;350(2):196-205. doi: 10.1016/j.mce.2011.07.001. Epub 2011 Jul 18.
Additional References at PubMed
PMID:8772199   PMID:10197982   PMID:10349636   PMID:10512203   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12466851   PMID:12477932   PMID:12520002   PMID:12835322   PMID:12904583  
PMID:14563409   PMID:14566340   PMID:14610273   PMID:15118109   PMID:15345747   PMID:15378723   PMID:15489334   PMID:15840001   PMID:16141072   PMID:16141073   PMID:17000766   PMID:17110338  
PMID:17114649   PMID:17283187   PMID:17438133   PMID:17967808   PMID:18362168   PMID:18723680   PMID:18799693   PMID:19447165   PMID:21267068   PMID:21323770   PMID:21334450   PMID:21691801  
PMID:21853119   PMID:21873635   PMID:22123826   PMID:22277657   PMID:22759865   PMID:23022381   PMID:23022695   PMID:24457600   PMID:25737280   PMID:26365490   PMID:27281784   PMID:28650975  
PMID:32325033   PMID:32414920   PMID:36114006   PMID:37142655   PMID:39142281  


Genomics

Comparative Map Data
Ptges3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3910127,894,851 - 127,913,123 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl10127,894,823 - 127,913,141 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm3810128,058,982 - 128,077,254 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl10128,058,954 - 128,077,272 (+)Ensemblmm10GRCm38
MGSCv3710127,496,038 - 127,514,310 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv3610127,461,931 - 127,480,203 (+)NCBIMGSCv36mm8
Celera10130,453,617 - 130,471,989 (+)NCBICelera
Cytogenetic Map10D3NCBI
cM Map1076.39NCBI
PTGES3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381256,663,349 - 56,688,284 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1256,663,341 - 56,688,408 (-)Ensemblhg38GRCh38
GRCh371257,057,133 - 57,082,068 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361255,343,649 - 55,368,156 (-)NCBIBuild 36Build 36hg18NCBI36
Celera1256,709,596 - 56,735,126 (-)NCBICelera
Cytogenetic Map12q13.3NCBI
HuRef1254,096,410 - 54,121,394 (-)NCBIHuRef
CHM1_11257,024,664 - 57,049,890 (-)NCBICHM1_1
T2T-CHM13v2.01256,631,338 - 56,658,334 (-)NCBIT2T-CHM13v2.0
Ptges3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr871,075,230 - 1,092,363 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl71,075,227 - 1,092,695 (+)EnsemblGRCr8
mRatBN7.27490,698 - 507,759 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7490,656 - 508,084 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx73,248,927 - 3,266,205 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.075,124,939 - 5,142,219 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.075,426,505 - 5,443,663 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.072,479,267 - 2,497,024 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl72,479,311 - 2,497,013 (+)Ensemblrn6Rnor6.0
Rnor_5.072,459,082 - 2,476,400 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.471,351,206 - 1,368,857 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera7370,050 - 386,953 (+)NCBICelera
Cytogenetic Map7q11NCBI
Ptges3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554584,203,076 - 4,209,910 (-)Ensembl
ChiLan1.0NW_0049554584,203,075 - 4,209,967 (-)NCBIChiLan1.0ChiLan1.0
PTGES3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21037,634,948 - 37,663,906 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11237,634,392 - 37,660,421 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01232,221,908 - 32,247,228 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11232,475,989 - 32,503,181 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1232,476,835 - 32,503,181 (+)EnsemblpanPan2panpan1.1
PTGES3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.110885,744 - 903,814 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl10870,392 - 909,161 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha10948,938 - 967,016 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.010895,074 - 912,966 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl10879,724 - 919,087 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.110871,924 - 889,991 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0101,115,085 - 1,132,100 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0101,238,847 - 1,256,742 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Ptges3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494557,879,818 - 57,900,555 (+)NCBIHiC_Itri_2
SpeTri2.0NW_004936646969,674 - 990,532 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PTGES3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl522,000,341 - 22,021,660 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1522,000,335 - 22,022,830 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2523,674,707 - 23,696,337 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PTGES3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11152,609,460 - 52,634,490 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666037193,344,739 - 193,370,949 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ptges3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462480211,360,041 - 11,395,390 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462480211,360,056 - 11,392,911 (+)NCBIHetGla 1.0HetGla 1.0hetGla2

Variants

.
Variants in Ptges3
621 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:662
Count of miRNA genes:321
Interacting mature miRNAs:368
Transcripts:ENSMUST00000052798, ENSMUST00000084771, ENSMUST00000148943
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4142461Bmd25_mbone mineral density 25 (mouse)Not determined1097217101130530862Mouse
1301968Estq4_mestradiol regulated response QTL 4 (mouse)Not determined10100986516130530862Mouse
12904000Opfaq7_mopen field activity QTL 7 (mouse)10127746318129466375Mouse
12904001Opfaq10_mopen field activity QTL 10 (mouse)10125633671129466375Mouse
12879490Frct3_mfear conditioning traits 3 (mouse)10122785970129466996Mouse
11049570Lmr25b_mleishmaniasis resistance 25b (mouse)10108575094130530862Mouse
27226772Tibl13_mtibia length 13, 10 week (mouse)1018875748129635869Mouse
11533921Mvb2_mmodifier of vibrator 2 (mouse)1097217101130530862Mouse
4141361Cfmq3_mcystic fibrosis modifier QTL 3 (mouse)Not determined10101497164130530862Mouse
4141487Tgq21_mtriglyceride QTL 21 (mouse)Not determined104110021130530862Mouse
27226764Tibl19_mtibia length 19, 16 week (mouse)1039175996129635869Mouse
1301895Exq1_mexploratory and excitability QTL 1 (mouse)Not determined10102847852130530862Mouse
1300679Nociq2_mnociceptive sensitivity inflammatory QTL 2 (mouse)Not determined10105041304130530862Mouse
1300678Leg2_mlongevity extending gene 2 (mouse)Not determined10102506908130530862Mouse
14746996Manh69_mmandible shape 69 (mouse)10104763638130530862Mouse
12880413V125Dq9_mvitamin D active form serum level QTL 9 (mouse)1097535905130530862Mouse
1301901Im5_mimmunoregulatory 5 (mouse)Not determined10101497164130530862Mouse
4141153Ltgq2_mliver triglyceride QTL 2 (mouse)Not determined108515907130530862Mouse
11039496Ltpr5b_mLeishmania tropica response 5b (mouse)10108575094130530862Mouse
1357744Cfbw4_mcystic fibrosis body weight 4 (mouse)Not determined10100986516130530862Mouse
4141402T2dm1sa_mtype 2 diabetes mellitus 1 in SMXA RI mice (mouse)Not determined97758644130530862Mouse
11041664Lmr25_mleishmaniasis resistance 25 (mouse)10108575094130530862Mouse
1302200Sle12_msystematic lupus erythematosus susceptibility 12 (mouse)Not determined10105041304130530862Mouse
26884405Huml2_mhumerus length 2, 5 week (mouse)1069735830130430862Mouse
11533919Mvb4_mmodifier of vibrator 4 (mouse)397217101130530862Mouse
4141007Obrq10_mobesity resistance QTL 10 (mouse)Not determined103243727130530862Mouse
12911221Frct3d_mfear conditioning traits 3d (mouse)10127675574129466996Mouse
12911220Frct3c_mfear conditioning traits 3c (mouse)10122785970129466996Mouse
11049563Lmr25a_mleishmaniasis resistance 25a (mouse)10108575094130530862Mouse
4142089Obrq9_mobesity resistance QTL 9 (mouse)Not determined108515907130530862Mouse
12911219Frct3b_mfear conditioning traits 3b (mouse)10127675574129466996Mouse
14696727Kidrq2_mkidney weight, right QTL 2 (mouse)10102902508130530862Mouse
12911218Frct3a_mfear conditioning traits 3a (mouse)10122785970129466996Mouse
11040593Lmr5e_mleishmaniasis resistance 5e (mouse)1099220635130530862Mouse
27095911Pglq15_mpelvic girdle length QTL 15, 16 week (mouse)1039175996129635869Mouse
11040594Lmr5f_mleishmaniasis resistance 5f (mouse)10105179713130530862Mouse
11040595Lmr5c_mleishmaniasis resistance 5c (mouse)1099220635130530862Mouse
1357544Vtbt10_mvertebral trabecular bone trait 10 (mouse)Not determined1097217101130530862Mouse
11040596Lmr5d_mleishmaniasis resistance 5d (mouse)10105179713130530862Mouse
11040597Lmr5a_mleishmaniasis resistance 5a (mouse)1099220635130530862Mouse
1357482Nhdlq4_mnon-HDL QTL 4 (mouse)Not determined10105041304130530862Mouse
11040598Lmr5b_mleishmaniasis resistance 5b (mouse)10105179713130530862Mouse

Markers in Region
UniSTS:236483  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3810128,075,640 - 128,075,850UniSTSGRCm38
MGSCv3710127,512,696 - 127,512,906UniSTSGRCm37
Celera10130,470,375 - 130,470,585UniSTS
Cytogenetic Map10D3UniSTS


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_019766 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB024935 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC131120 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF153479 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK008805 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK010636 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK017742 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK075932 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK075987 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK077538 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK088321 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK167443 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK168073 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK168210 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK168721 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY281130 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC003708 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC085264 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466578 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSMUST00000052798   ⟹   ENSMUSP00000050292
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl10127,894,823 - 127,913,141 (+)Ensembl
GRCm38.p6 Ensembl10128,058,954 - 128,077,272 (+)Ensembl
Ensembl Acc Id: ENSMUST00000084771   ⟹   ENSMUSP00000081827
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl10127,894,880 - 127,912,847 (+)Ensembl
GRCm38.p6 Ensembl10128,059,011 - 128,076,978 (+)Ensembl
Ensembl Acc Id: ENSMUST00000148943
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl10127,905,141 - 127,908,243 (+)Ensembl
GRCm38.p6 Ensembl10128,069,272 - 128,072,374 (+)Ensembl
RefSeq Acc Id: NM_019766   ⟹   NP_062740
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3910127,894,851 - 127,913,123 (+)NCBI
GRCm3810128,058,982 - 128,077,254 (+)NCBI
MGSCv3710127,496,038 - 127,514,310 (+)RGD
Celera10130,453,617 - 130,471,989 (+)RGD
cM Map10 ENTREZGENE
Sequence:
RefSeq Acc Id: NP_062740   ⟸   NM_019766
- UniProtKB: Q9D7V0 (UniProtKB/Swiss-Prot),   Q542V4 (UniProtKB/Swiss-Prot),   Q9WV83 (UniProtKB/Swiss-Prot),   Q9R0Q7 (UniProtKB/Swiss-Prot),   Q3TJG6 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSMUSP00000050292   ⟸   ENSMUST00000052798
Ensembl Acc Id: ENSMUSP00000081827   ⟸   ENSMUST00000084771
Protein Domains
CS

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9R0Q7-F1-model_v2 AlphaFold Q9R0Q7 1-160 view protein structure

Promoters
RGD ID:6819802
Promoter ID:MM_KWN:5951
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:ENSMUST00000045621,   ENSMUST00000084771,   OTTMUST00000049509
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv3610127,495,281 - 127,496,267 (+)MPROMDB
RGD ID:6819774
Promoter ID:MM_KWN:5952
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Liver
Transcripts:OTTMUST00000049511
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv3610127,506,431 - 127,506,931 (+)MPROMDB
RGD ID:8673560
Promoter ID:EPDNEW_M14811
Type:initiation region
Name:Ptges3_1
Description:Mus musculus prostaglandin E synthase 3 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M14812  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3810128,059,014 - 128,059,074EPDNEW
RGD ID:8673562
Promoter ID:EPDNEW_M14812
Type:initiation region
Name:Ptges3_2
Description:Mus musculus prostaglandin E synthase 3 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M14811  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3810128,059,145 - 128,059,205EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1929282 AgrOrtholog
Ensembl Genes ENSMUSG00000071072 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000052798 ENTREZGENE
  ENSMUST00000052798.14 UniProtKB/Swiss-Prot
Gene3D-CATH 2.60.40.790 UniProtKB/Swiss-Prot
InterPro CS_dom UniProtKB/Swiss-Prot
  HSP20-like_chaperone UniProtKB/Swiss-Prot
  p23-like UniProtKB/Swiss-Prot
KEGG Report mmu:56351 UniProtKB/Swiss-Prot
MGD MGI:1929282 ENTREZGENE
NCBI Gene 56351 ENTREZGENE
PANTHER PROSTAGLANDIN E SYNTHASE 3 UniProtKB/Swiss-Prot
  PTHR22932 UniProtKB/Swiss-Prot
Pfam PF04969 UniProtKB/Swiss-Prot
PhenoGen Ptges3 PhenoGen
PROSITE PS51203 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF49764 UniProtKB/Swiss-Prot
UniProt D3Z7C6_MOUSE UniProtKB/TrEMBL
  Q3TJG6 ENTREZGENE, UniProtKB/TrEMBL
  Q542V4 ENTREZGENE
  Q9CRH1_MOUSE UniProtKB/TrEMBL
  Q9D7V0 ENTREZGENE
  Q9R0Q7 ENTREZGENE
  Q9WV83 ENTREZGENE
  TEBP_MOUSE UniProtKB/Swiss-Prot
UniProt Secondary Q542V4 UniProtKB/Swiss-Prot
  Q9D7V0 UniProtKB/Swiss-Prot
  Q9WV83 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-05-16 Ptges3  prostaglandin E synthase 3    prostaglandin E synthase 3 (cytosolic)  Symbol and/or name change 5135510 APPROVED