(+)-schisandrin B multiple interactions ISO RGD:1561913 6480464 schizandrin B inhibits the reaction [Carbon Tetrachloride results in increased expression of PTGES3 mRNA] CTD PMID:31150632 1,2-dimethylhydrazine multiple interactions EXP 6480464 [1, 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of PTGES3 mRNA CTD PMID:22206623 1,2-dimethylhydrazine decreases expression EXP 6480464 1, 2-Dimethylhydrazine results in decreased expression of PTGES3 mRNA CTD PMID:22206623 2,2',4,4'-Tetrabromodiphenyl ether affects expression EXP 6480464 2 more ... CTD PMID:30294300 2,3,7,8-tetrachlorodibenzodioxine increases expression ISO RGD:1606321 6480464 Tetrachlorodibenzodioxin results in increased expression of PTGES3 mRNA CTD PMID:21998131 2,3,7,8-tetrachlorodibenzodioxine affects expression EXP 6480464 Tetrachlorodibenzodioxin affects the expression of PTGES3 mRNA CTD PMID:21570461 2-methylcholine affects expression ISO RGD:1606321 6480464 beta-methylcholine affects the expression of PTGES3 mRNA CTD PMID:21179406 albendazole multiple interactions ISO RGD:1606321 6480464 [Ivermectin co-treated with Albendazole] results in increased expression of PTGES3 mRNA CTD PMID:16861626 ammonium chloride increases expression ISO RGD:1561913 6480464 Ammonium Chloride results in increased expression of PTGES3 mRNA CTD PMID:12420312 arsenous acid increases expression ISO RGD:1606321 6480464 Arsenic Trioxide results in increased expression of PTGES3 mRNA CTD PMID:20458559 beauvericin multiple interactions ISO RGD:1606321 6480464 [beauvericin co-treated with enniatins] results in increased expression of PTGES3 protein CTD PMID:32407736 benzo[a]pyrene decreases expression ISO RGD:1561913 6480464 Benzo(a)pyrene results in decreased expression of PTGES3 mRNA CTD PMID:21839799 benzo[a]pyrene multiple interactions ISO RGD:1606321 6480464 [PTGES3 protein results in increased degradation of and results in decreased expression of AHR protein] which results in decreased susceptibility to Benzo(a)pyrene more ... CTD PMID:30204910 benzo[a]pyrene increases expression EXP 6480464 Benzo(a)pyrene results in increased expression of PTGES3 mRNA CTD PMID:19770486 more ... benzo[a]pyrene diol epoxide I decreases expression ISO RGD:1606321 6480464 7 more ... CTD PMID:20382639 bisphenol A increases expression ISO RGD:1561913 6480464 bisphenol A results in increased expression of PTGES3 mRNA CTD PMID:25181051 , PMID:30816183 bisphenol A decreases expression ISO RGD:1606321 6480464 bisphenol A results in decreased expression of PTGES3 mRNA CTD PMID:29275510 chelerythrine increases cleavage ISO RGD:1606321 6480464 chelerythrine results in increased cleavage of PTGES3 protein CTD PMID:26124276 chloropicrin increases expression ISO RGD:1606321 6480464 chloropicrin results in increased expression of PTGES3 mRNA CTD PMID:26352163 cisplatin decreases expression ISO RGD:1606321 6480464 Cisplatin results in decreased expression of PTGES3 mRNA CTD PMID:27392435 copper atom affects binding ISO RGD:1606321 6480464 PTGES3 protein binds to Copper CTD PMID:15359738 copper atom multiple interactions ISO RGD:1606321 6480464 [Disulfiram binds to Copper] which results in decreased expression of PTGES3 mRNA CTD PMID:24690739 copper(0) affects binding ISO RGD:1606321 6480464 PTGES3 protein binds to Copper CTD PMID:15359738 copper(0) multiple interactions ISO RGD:1606321 6480464 [Disulfiram binds to Copper] which results in decreased expression of PTGES3 mRNA CTD PMID:24690739 copper(II) sulfate increases expression ISO RGD:1606321 6480464 Copper Sulfate results in increased expression of PTGES3 mRNA CTD PMID:19549813 cyclophosphamide increases expression ISO RGD:1561913 6480464 Cyclophosphamide results in increased expression of PTGES3 mRNA CTD PMID:11599041 cyclosporin A increases expression ISO RGD:1606321 6480464 Cyclosporine results in increased expression of PTGES3 mRNA CTD PMID:20106945 diarsenic trioxide increases expression ISO RGD:1606321 6480464 Arsenic Trioxide results in increased expression of PTGES3 mRNA CTD PMID:20458559 dibutyl phthalate decreases expression ISO RGD:1561913 6480464 Dibutyl Phthalate results in decreased expression of PTGES3 mRNA CTD PMID:21266533 disulfiram multiple interactions ISO RGD:1606321 6480464 [Disulfiram binds to Copper] which results in decreased expression of PTGES3 mRNA CTD PMID:24690739 enniatin multiple interactions ISO RGD:1606321 6480464 [beauvericin co-treated with enniatins] results in increased expression of PTGES3 protein CTD PMID:32407736 enzyme inhibitor multiple interactions ISO RGD:1606321 6480464 [Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of PTGES3 protein CTD PMID:23301498 ethanol affects expression EXP 6480464 Ethanol affects the expression of PTGES3 mRNA CTD PMID:30319688 folic acid multiple interactions EXP 6480464 [1, 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of PTGES3 mRNA CTD PMID:22206623 hexadecanoic acid increases phosphorylation ISO RGD:1606321 6480464 Palmitic Acid results in increased phosphorylation of PTGES3 protein CTD PMID:28073184 hydrogen peroxide affects expression ISO RGD:1606321 6480464 Hydrogen Peroxide affects the expression of PTGES3 mRNA CTD PMID:21179406 hypochlorous acid increases expression EXP 6480464 Hypochlorous Acid results in increased expression of PTGES3 mRNA CTD PMID:19376150 ivermectin multiple interactions ISO RGD:1606321 6480464 [Ivermectin co-treated with Albendazole] results in increased expression of PTGES3 mRNA CTD PMID:16861626 lead diacetate decreases expression EXP 6480464 lead acetate results in decreased expression of PTGES3 mRNA CTD PMID:21829687 mercury dichloride increases expression ISO RGD:1561913 6480464 Mercuric Chloride results in increased expression of PTGES3 mRNA CTD PMID:16507785 N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal decreases degradation ISO RGD:1606321 6480464 benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased degradation of PTGES3 protein CTD PMID:19118525 N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal multiple interactions ISO RGD:1606321 6480464 4-tosylcyclonovobiocic acid promotes the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased degradation of PTGES3 protein] CTD PMID:19118525 N-methyl-4-phenylpyridinium multiple interactions ISO RGD:1561913 6480464 1-Methyl-4-phenylpyridinium promotes the reaction [EGLN1 protein binds to PTGES3 protein] CTD PMID:29471019 N-methyl-4-phenylpyridinium increases response to substance ISO RGD:1561913 6480464 PTGES3 results in increased susceptibility to 1-Methyl-4-phenylpyridinium CTD PMID:29471019 nickel subsulfide increases expression ISO RGD:1561913 6480464 nickel subsulfide results in increased expression of PTGES3 mRNA CTD PMID:21086188 paclitaxel affects response to substance ISO RGD:1606321 6480464 PTGES3 protein affects the susceptibility to Paclitaxel CTD PMID:16217747 PhIP increases expression ISO RGD:1561913 6480464 2-amino-1-methyl-6-phenylimidazo(4, 5-b)pyridine results in increased expression of PTGES3 mRNA CTD PMID:15215175 quercetin decreases expression ISO RGD:1606321 6480464 Quercetin results in decreased expression of PTGES3 mRNA CTD PMID:21632981 reactive oxygen species multiple interactions ISO RGD:1606321 6480464 PTGES3 protein affects the reaction [Benzo(a)pyrene results in increased abundance of Reactive Oxygen Species] CTD PMID:30204910 resveratrol increases expression EXP 6480464 resveratrol results in increased expression of PTGES3 protein CTD PMID:25505154 serpentine asbestos decreases methylation ISO RGD:1606321 6480464 Asbestos, Serpentine results in decreased methylation of PTGES3 gene CTD PMID:29523930 silver atom increases expression ISO RGD:1606321 6480464 Silver results in increased expression of PTGES3 mRNA CTD PMID:26014281 silver(0) increases expression ISO RGD:1606321 6480464 Silver results in increased expression of PTGES3 mRNA CTD PMID:26014281 sodium arsenite decreases expression ISO RGD:1606321 6480464 sodium arsenite results in decreased expression of PTGES3 protein CTD PMID:21925251 sodium chloride multiple interactions ISO RGD:1561913 6480464 [AGT protein co-treated with Sodium Chloride] affects the expression of PTGES3 mRNA CTD PMID:27225954 sodium dichromate increases expression ISO RGD:1561913 6480464 sodium bichromate results in increased expression of PTGES3 mRNA CTD PMID:12325037 staurosporine increases cleavage ISO RGD:1606321 6480464 Staurosporine results in increased cleavage of PTGES3 protein CTD PMID:26124276 tetrachloromethane multiple interactions ISO RGD:1561913 6480464 schizandrin B inhibits the reaction [Carbon Tetrachloride results in increased expression of PTGES3 mRNA] CTD PMID:31150632 tetrachloromethane increases expression EXP 6480464 Carbon Tetrachloride results in increased expression of PTGES3 mRNA CTD PMID:31919559 tetrachloromethane increases expression ISO RGD:1561913 6480464 Carbon Tetrachloride results in increased expression of PTGES3 mRNA CTD PMID:31150632 trichloroethene decreases expression EXP 6480464 Trichloroethylene results in decreased expression of PTGES3 mRNA CTD PMID:15363585 uranium atom affects expression ISO RGD:1606321 6480464 Uranium affects the expression of PTGES3 mRNA CTD PMID:15672453 valdecoxib increases expression ISO RGD:1561913 6480464 valdecoxib results in increased expression of PTGES3 mRNA CTD PMID:24136188 vincaleukoblastine affects response to substance ISO RGD:1606321 6480464 PTGES3 protein affects the susceptibility to Vinblastine CTD PMID:16217747 vorinostat decreases expression ISO RGD:1606321 6480464 vorinostat results in decreased expression of PTGES3 protein CTD PMID:17593366 , PMID:20543569
Biological Process cell population proliferation IMP MGI:MGI:3701300 2290270 (MGI:MGI:3714109, PMID:17438133) MGI MGI:MGI:3714109 , PMID:17438133 chaperone cofactor-dependent protein refolding ISO UniProtKB:Q15185 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 chaperone-mediated protein complex assembly ISO UniProtKB:Q15185 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 chaperone-mediated protein complex assembly IBA PANTHER:PTN000532593 2290270 (MGI:MGI:6201960, PMID:21873635) GO_Central MGI:MGI:6201960 , PMID:21873635 fatty acid biosynthetic process IEA UniProtKB-KW:KW-0275 2290270 UniProtKB GO_REF:0000004, MGI:MGI:1354194 fatty acid metabolic process IEA UniProtKB-KW:KW-0276 2290270 UniProtKB GO_REF:0000004, MGI:MGI:1354194 glucocorticoid receptor signaling pathway IMP MGI:MGI:3701300 2290270 (MGI:MGI:3714109, PMID:17438133) MGI MGI:MGI:3714109 , PMID:17438133 glycogen biosynthetic process IMP MGI:MGI:3701300 2290270 (MGI:MGI:3714109, PMID:17438133) MGI MGI:MGI:3714109 , PMID:17438133 lipid metabolic process IEA UniProtKB-KW:KW-0443 2290270 UniProtKB GO_REF:0000004, MGI:MGI:1354194 lung saccule development IMP MGI:MGI:3701300 2290270 (MGI:MGI:3714109, PMID:17438133) MGI MGI:MGI:3714109 , PMID:17438133 negative regulation of cell death ISO RGD:1561913 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 positive regulation of gene expression ISO RGD:1561913 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 positive regulation of phosphorylation ISO UniProtKB:Q15185 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 positive regulation of telomerase activity IDA 2290270 (MGI:MGI:5819359, PMID:10197982) BHF-UCL MGI:MGI:5819359 , PMID:10197982 positive regulation of telomerase activity ISO UniProtKB:Q15185 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 prostaglandin biosynthetic process IMP MGI:MGI:3701300 2290270 (MGI:MGI:3714109, PMID:17438133) MGI MGI:MGI:3714109 , PMID:17438133 prostaglandin biosynthetic process IBA PANTHER:PTN002741359 2290270 (MGI:MGI:6201960, PMID:21873635) GO_Central MGI:MGI:6201960 , PMID:21873635 prostaglandin biosynthetic process ISO UniProtKB:Q15185 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 prostaglandin biosynthetic process ISO RGD:1561913 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 prostaglandin metabolic process ISO RGD:1561913 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 protein folding IBA PANTHER:PTN000532593 2290270 (MGI:MGI:6201960, PMID:21873635) GO_Central MGI:MGI:6201960 , PMID:21873635 protein stabilization ISO UniProtKB:Q15185 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 sensory perception of pain ISO RGD:1561913 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 skin development IMP MGI:MGI:3701300 2290270 (MGI:MGI:3714109, PMID:17438133) MGI MGI:MGI:3714109 , PMID:17438133 telomerase holoenzyme complex assembly IDA 2290270 (MGI:MGI:5819359, PMID:10197982) BHF-UCL MGI:MGI:5819359 , PMID:10197982 telomerase holoenzyme complex assembly IBA PANTHER:PTN002741359 2290270 (MGI:MGI:6201960, PMID:21873635) GO_Central MGI:MGI:6201960 , PMID:21873635 telomerase holoenzyme complex assembly ISO UniProtKB:Q15185 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 telomere maintenance via telomerase IDA 2290270 (MGI:MGI:5819359, PMID:10197982) BHF-UCL MGI:MGI:5819359 , PMID:10197982 telomere maintenance via telomerase IBA PANTHER:PTN002741359 2290270 (MGI:MGI:6201960, PMID:21873635) GO_Central MGI:MGI:6201960 , PMID:21873635 telomere maintenance via telomerase ISO UniProtKB:Q15185 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 Cellular Component actin filament ISO RGD:1561913 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 chaperone complex ISO UniProtKB:Q15185 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 cytoplasm IBA PANTHER:PTN000532593 2290270 (MGI:MGI:6201960, PMID:21873635) GO_Central MGI:MGI:6201960 , PMID:21873635 cytosol IBA PANTHER:PTN000532593 2290270 (MGI:MGI:6201960, PMID:21873635) GO_Central MGI:MGI:6201960 , PMID:21873635 intracellular membrane-bounded organelle ISO RGD:1561913 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 neuron projection ISO RGD:1561913 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 neuronal cell body ISO RGD:1561913 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 nucleus IBA PANTHER:PTN000532593 2290270 (MGI:MGI:6201960, PMID:21873635) GO_Central MGI:MGI:6201960 , PMID:21873635 perinuclear region of cytoplasm ISO RGD:1561913 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 protein-containing complex ISO UniProtKB:Q15185 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 protein-containing complex ISO RGD:1561913 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 telomerase holoenzyme complex ISO UniProtKB:Q15185 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 Molecular Function chaperone binding IBA PANTHER:PTN000532593 2290270 (MGI:MGI:6201960, PMID:21873635) GO_Central MGI:MGI:6201960 , PMID:21873635 DNA polymerase binding IPI UniProtKB:O14746 2290270 (MGI:MGI:5819359, PMID:10197982) BHF-UCL MGI:MGI:5819359 , PMID:10197982 DNA polymerase binding ISO UniProtKB:Q15185 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 enzyme binding ISO RGD:1561913 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 Hsp90 protein binding ISO RGD:1561913 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 Hsp90 protein binding IBA PANTHER:PTN000532593 2290270 (MGI:MGI:6201960, PMID:21873635) GO_Central MGI:MGI:6201960 , PMID:21873635 Hsp90 protein binding ISO UniProtKB:Q15185 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 isomerase activity IEA UniProtKB-KW:KW-0413 2290270 UniProtKB GO_REF:0000004, MGI:MGI:1354194 p53 binding ISO RGD:1561913 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 prostaglandin-E synthase activity ISO RGD:1561913 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 prostaglandin-E synthase activity IBA PANTHER:PTN002741359 2290270 (MGI:MGI:6201960, PMID:21873635) GO_Central MGI:MGI:6201960 , PMID:21873635 prostaglandin-E synthase activity ISO UniProtKB:Q15185 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 protein binding ISO UniProtKB:Q9UKV8 9068941 (PMID:23741051) IntAct PMID:23741051 protein binding ISO UniProtKB:Q9P278 9068941 (PMID:27353360) UniProtKB PMID:27353360 protein binding ISO UniProtKB:Q8TF40 9068941 (PMID:27353360) UniProtKB PMID:27353360 protein binding ISO UniProtKB:P07900 9068941 (PMID:19875381), (PMID:21988832), (PMID:25036637), (PMID:27353360), (PMID:9817749) IntAct PMID:19875381 more ... protein binding ISO UniProtKB:P08238 9068941 (PMID:21183720), (PMID:21988832), (PMID:25036637) IntAct PMID:21183720 more ... protein binding ISO UniProtKB:Q8NFG4 9068941 (PMID:27353360) UniProtKB PMID:27353360 protein binding ISO UniProtKB:O14654 9068941 (PMID:25036637) IntAct PMID:25036637 telomerase activity ISO UniProtKB:Q15185 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 unfolded protein binding ISO UniProtKB:Q15185 2290270 MGI GO_REF:0000096, MGI:MGI:4834177
Gene-Chemical Interaction Annotations
