PTGES3 (prostaglandin E synthase 3) - Rat Genome Database

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Gene: PTGES3 (prostaglandin E synthase 3) Homo sapiens
Analyze
Symbol: PTGES3
Name: prostaglandin E synthase 3
RGD ID: 1606321
HGNC Page HGNC:16049
Description: Enables several functions, including DNA polymerase binding activity; Hsp90 protein binding activity; and prostaglandin-E synthase activity. Involved in several processes, including chaperone cofactor-dependent protein refolding; protein stabilization; and protein-containing complex assembly. Located in nucleus. Part of protein folding chaperone complex and telomerase holoenzyme complex. Biomarker of atherosclerosis; breast cancer; and oligodendroglioma.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: cPGES; cytosolic prostaglandin E synthase; cytosolic prostaglandin E2 synthase; Hsp90 co-chaperone; P23; progesterone receptor complex p23; prostaglandin E synthase 3 (cytosolic); TEBP; telomerase-binding protein p23; unactive progesterone receptor, 23 kD
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Related Pseudogenes: PTGES3P1   PTGES3P2   PTGES3P3   PTGES3P4   PTGES3P5  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381256,663,349 - 56,688,284 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1256,663,341 - 56,688,408 (-)EnsemblGRCh38hg38GRCh38
GRCh371257,057,133 - 57,082,068 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361255,343,649 - 55,368,156 (-)NCBINCBI36Build 36hg18NCBI36
Celera1256,709,596 - 56,735,126 (-)NCBICelera
Cytogenetic Map12q13.3NCBI
HuRef1254,096,410 - 54,121,394 (-)NCBIHuRef
CHM1_11257,024,664 - 57,049,890 (-)NCBICHM1_1
T2T-CHM13v2.01256,631,338 - 56,658,334 (-)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (ISO)
(1->4)-beta-D-glucan  (ISO)
1,2-dimethylhydrazine  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-methylcholine  (EXP)
4,4'-sulfonyldiphenol  (ISO)
6-propyl-2-thiouracil  (ISO)
acrylamide  (EXP)
albendazole  (EXP)
amitrole  (ISO)
ammonium chloride  (ISO)
aristolochic acid A  (EXP,ISO)
arsenite(3-)  (EXP)
arsenous acid  (EXP)
beauvericin  (EXP)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (EXP)
Benzo[ghi]perylene  (EXP)
bisphenol A  (EXP,ISO)
Bisphenol B  (EXP)
bisphenol F  (EXP,ISO)
chelerythrine  (EXP)
chloropicrin  (EXP)
chlorpyrifos  (ISO)
cisplatin  (EXP)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) sulfate  (EXP)
cyclophosphamide  (ISO)
cyclosporin A  (EXP)
dextran sulfate  (ISO)
diarsenic trioxide  (EXP)
dibutyl phthalate  (ISO)
disulfiram  (EXP)
enniatin  (EXP)
enzyme inhibitor  (EXP)
ethanol  (ISO)
folic acid  (ISO)
FR900359  (EXP)
gentamycin  (ISO)
hexadecanoic acid  (EXP)
hydrogen peroxide  (EXP)
hypochlorous acid  (ISO)
ivermectin  (EXP)
lead diacetate  (ISO)
lipopolysaccharide  (EXP)
mancozeb  (ISO)
mercury dichloride  (ISO)
methimazole  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (EXP)
N-methyl-4-phenylpyridinium  (ISO)
nickel subsulfide  (ISO)
paclitaxel  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
PhIP  (ISO)
quercetin  (EXP)
reactive oxygen species  (EXP)
resveratrol  (ISO)
serpentine asbestos  (EXP)
silver atom  (EXP)
silver(0)  (EXP)
sodium arsenite  (EXP)
sodium chloride  (ISO)
sodium dichromate  (ISO)
staurosporine  (EXP)
sulfadimethoxine  (ISO)
tetrachloromethane  (ISO)
thapsigargin  (ISO)
trichloroethene  (ISO)
uranium atom  (EXP)
valdecoxib  (ISO)
vincaleukoblastine  (EXP)
vorinostat  (EXP)
zearalenone  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Microsomal prostaglandin E synthase-1 is a major terminal synthase that is selectively up-regulated during cyclooxygenase-2-dependent prostaglandin E2 production in the rat adjuvant-induced arthritis model. Claveau D, etal., J Immunol. 2003 May 1;170(9):4738-44.
2. Prostanoids as regulators of innate and adaptive immunity. Hirata T and Narumiya S, Adv Immunol. 2012;116:143-74. doi: 10.1016/B978-0-12-394300-2.00005-3.
3. Downregulation of cytosolic prostaglandin E2 synthase results in decreased nociceptive behavior in rats. Hofacker A, etal., J Neurosci. 2005 Sep 28;25(39):9005-9.
4. Molecular mechanisms regulating the vascular prostacyclin pathways and their adaptation during pregnancy and in the newborn. Majed BH and Khalil RA, Pharmacol Rev. 2012 Jul;64(3):540-82. doi: 10.1124/pr.111.004770. Epub 2012 Jun 7.
5. Cytosolic prostaglandin E2 synthase/p23 but not apoptosis-linked gene 2 is downregulated in human atherosclerotic plaques. Martinet W, etal., Cardiovasc Res. 2004 Feb 1;61(2):360-1.
6. The terminal prostaglandin synthases mPGES-1, mPGES-2, and cPGES are all overexpressed in human gliomas. Mattila S, etal., Neuropathology. 2009 Apr;29(2):156-65.
7. Chaperoning of glucocorticoid receptors. Pratt WB, etal., Handb Exp Pharmacol. 2006;(172):111-38.
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
9. High levels of Hsp90 cochaperone p23 promote tumor progression and poor prognosis in breast cancer by increasing lymph node metastases and drug resistance. Simpson NE, etal., Cancer Res. 2010 Nov 1;70(21):8446-56. Epub 2010 Sep 16.
10. Minireview: the intersection of steroid receptors with molecular chaperones: observations and questions. Smith DF and Toft DO, Mol Endocrinol. 2008 Oct;22(10):2229-40. Epub 2008 May 1.
11. Interactions of the mineralocorticoid receptor--within and without. Yang J and Fuller PJ, Mol Cell Endocrinol. 2012 Mar 24;350(2):196-205. doi: 10.1016/j.mce.2011.07.001. Epub 2011 Jul 18.
Additional References at PubMed
PMID:8114727   PMID:8772199   PMID:8889548   PMID:9148915   PMID:9222609   PMID:9261129   PMID:9727490   PMID:9817749   PMID:10095121   PMID:10197982   PMID:10207098   PMID:10543959  
PMID:10642522   PMID:10691735   PMID:10811660   PMID:10922363   PMID:11013261   PMID:11259606   PMID:11274138   PMID:11413142   PMID:11447118   PMID:11597177   PMID:11809754   PMID:11812147  
PMID:11847219   PMID:11879970   PMID:12077419   PMID:12135483   PMID:12324468   PMID:12477932   PMID:12519887   PMID:12853476   PMID:14507910   PMID:14675759   PMID:14702039   PMID:14761955  
PMID:14987994   PMID:15004035   PMID:15319539   PMID:15342556   PMID:15489334   PMID:15916966   PMID:16094384   PMID:16289154   PMID:16344560   PMID:16403413   PMID:16565516   PMID:16723087  
PMID:16807684   PMID:16809759   PMID:16916647   PMID:17010336   PMID:17081983   PMID:17110338   PMID:17283187   PMID:17353931   PMID:17697149   PMID:18029348   PMID:18172314   PMID:18285346  
PMID:18388150   PMID:18723680   PMID:18854154   PMID:19001348   PMID:19167051   PMID:19254810   PMID:19738201   PMID:19740745   PMID:19751963   PMID:19875381   PMID:19996313   PMID:20039095  
PMID:20048054   PMID:20071522   PMID:20159553   PMID:20385819   PMID:20661446   PMID:20959453   PMID:21183720   PMID:21502318   PMID:21630459   PMID:21691801   PMID:21853119   PMID:21873635  
PMID:21988832   PMID:22074947   PMID:22139419   PMID:22174317   PMID:22190034   PMID:22277657   PMID:22315411   PMID:22451931   PMID:22504172   PMID:22677230   PMID:22729780   PMID:22759865  
PMID:22806877   PMID:22863883   PMID:22899854   PMID:22939629   PMID:23022381   PMID:23376485   PMID:23413029   PMID:23438482   PMID:23602568   PMID:23741051   PMID:24345775   PMID:24366813  
PMID:24711448   PMID:24797263   PMID:24981860   PMID:24999758   PMID:25036637   PMID:25202009   PMID:25241147   PMID:25277244   PMID:25324306   PMID:25659154   PMID:25737280   PMID:25912394  
PMID:25940091   PMID:25963833   PMID:26151834   PMID:26344197   PMID:26638075   PMID:26777405   PMID:26804907   PMID:26972000   PMID:27353360   PMID:27432908   PMID:27483141   PMID:27609421  
PMID:28292943   PMID:28330616   PMID:28514442   PMID:28515276   PMID:28581483   PMID:28675297   PMID:29117863   PMID:29127155   PMID:29128334   PMID:29229926   PMID:29334217   PMID:29507755  
PMID:29555469   PMID:29615496   PMID:29777862   PMID:30021884   PMID:30463901   PMID:30575818   PMID:30833792   PMID:30890647   PMID:30948266   PMID:31006538   PMID:31073040   PMID:31091453  
PMID:31257629   PMID:31536960   PMID:31586073   PMID:31763849   PMID:31980649   PMID:32072232   PMID:32129710   PMID:32414129   PMID:32529326   PMID:32552912   PMID:32640226   PMID:32707033  
PMID:32807901   PMID:32989298   PMID:33306668   PMID:33547294   PMID:33644029   PMID:33660365   PMID:33766124   PMID:33916271   PMID:33957083   PMID:33961781   PMID:34428256   PMID:34662580  
PMID:34709727   PMID:34917906   PMID:34920330   PMID:34937936   PMID:35032548   PMID:35256949   PMID:35271311   PMID:35384245   PMID:35439318   PMID:35446349   PMID:35509820   PMID:35562734  
PMID:35563538   PMID:35760815   PMID:35831314   PMID:35844135   PMID:35914814   PMID:35944360   PMID:36057605   PMID:36114006   PMID:36180527   PMID:36215168   PMID:36520307   PMID:36634849  
PMID:37416927   PMID:38113892   PMID:38245717  


Genomics

Comparative Map Data
PTGES3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381256,663,349 - 56,688,284 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1256,663,341 - 56,688,408 (-)EnsemblGRCh38hg38GRCh38
GRCh371257,057,133 - 57,082,068 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361255,343,649 - 55,368,156 (-)NCBINCBI36Build 36hg18NCBI36
Celera1256,709,596 - 56,735,126 (-)NCBICelera
Cytogenetic Map12q13.3NCBI
HuRef1254,096,410 - 54,121,394 (-)NCBIHuRef
CHM1_11257,024,664 - 57,049,890 (-)NCBICHM1_1
T2T-CHM13v2.01256,631,338 - 56,658,334 (-)NCBIT2T-CHM13v2.0
Ptges3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3910127,894,851 - 127,913,123 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl10127,894,823 - 127,913,141 (+)EnsemblGRCm39 Ensembl
GRCm3810128,058,982 - 128,077,254 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl10128,058,954 - 128,077,272 (+)EnsemblGRCm38mm10GRCm38
MGSCv3710127,496,038 - 127,514,310 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3610127,461,931 - 127,480,203 (+)NCBIMGSCv36mm8
Celera10130,453,617 - 130,471,989 (+)NCBICelera
Cytogenetic Map10D3NCBI
cM Map1076.39NCBI
Ptges3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr871,075,230 - 1,092,363 (+)NCBIGRCr8
mRatBN7.27490,698 - 507,759 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7490,656 - 508,084 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx73,248,927 - 3,266,205 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.075,124,939 - 5,142,219 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.075,426,505 - 5,443,663 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.072,479,267 - 2,497,024 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl72,479,311 - 2,497,013 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.072,459,082 - 2,476,400 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.471,351,206 - 1,368,857 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera7370,050 - 386,953 (+)NCBICelera
Cytogenetic Map7q11NCBI
Ptges3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554584,203,076 - 4,209,910 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554584,203,075 - 4,209,967 (-)NCBIChiLan1.0ChiLan1.0
PTGES3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21037,634,948 - 37,663,906 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11237,634,392 - 37,660,421 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01232,221,908 - 32,247,228 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11232,475,989 - 32,503,181 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1232,476,835 - 32,503,181 (+)Ensemblpanpan1.1panPan2
PTGES3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.110885,744 - 903,814 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl10870,392 - 909,161 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha10948,938 - 967,016 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.010895,074 - 912,966 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl10879,724 - 919,087 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.110871,924 - 889,991 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0101,115,085 - 1,132,100 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0101,238,847 - 1,256,742 (-)NCBIUU_Cfam_GSD_1.0
Ptges3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494557,879,818 - 57,900,555 (+)NCBIHiC_Itri_2
SpeTri2.0NW_004936646969,674 - 990,532 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PTGES3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl522,000,341 - 22,021,660 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1522,000,335 - 22,022,830 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2523,674,707 - 23,696,337 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PTGES3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11152,609,460 - 52,634,490 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666037193,344,739 - 193,370,949 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ptges3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462480211,360,041 - 11,395,390 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462480211,360,056 - 11,392,911 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in PTGES3
4 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 12p13.33-q24.33(chr12:121271-133196807)x3 copy number gain See cases [RCV000139555] Chr12:121271..133196807 [GRCh38]
Chr12:282465..133773393 [GRCh37]
Chr12:100698..132283466 [NCBI36]
Chr12:12p13.33-q24.33
pathogenic
GRCh37/hg19 12p13.33-q24.33(chr12:1-133851895)x3 copy number gain See cases [RCV000258805] Chr12:1..133851895 [GRCh37]
Chr12:12p13.33-q24.33
pathogenic|likely pathogenic
GRCh37/hg19 12p13.33-q24.33(chr12:173787-133777902)x3 copy number gain See cases [RCV000510482] Chr12:173787..133777902 [GRCh37]
Chr12:12p13.33-q24.33
pathogenic
GRCh37/hg19 12p13.33-q24.33(chr12:173787-133777902) copy number gain See cases [RCV000511643] Chr12:173787..133777902 [GRCh37]
Chr12:12p13.33-q24.33
pathogenic
GRCh37/hg19 12p13.33-q24.33(chr12:621220-133779118)x3 copy number gain not provided [RCV000750253] Chr12:621220..133779118 [GRCh37]
Chr12:12p13.33-q24.33
pathogenic
GRCh37/hg19 12p13.33-q24.33(chr12:191619-133777645)x3 copy number gain not provided [RCV000750246] Chr12:191619..133777645 [GRCh37]
Chr12:12p13.33-q24.33
pathogenic
GRCh37/hg19 12q13.3(chr12:56996002-57064063)x1 copy number loss not provided [RCV000737904] Chr12:56996002..57064063 [GRCh37]
Chr12:12q13.3
benign
NM_006601.7(PTGES3):c.2+1116_2+1117del deletion not provided [RCV000947463] Chr12:56686881..56686882 [GRCh38]
Chr12:57080665..57080666 [GRCh37]
Chr12:12q13.3
benign
GRCh37/hg19 12q13.2-14.1(chr12:55552371-62126304)x3 copy number gain not provided [RCV001006505] Chr12:55552371..62126304 [GRCh37]
Chr12:12q13.2-14.1
pathogenic
Single allele duplication not specified [RCV002286382] Chr12:55986511..56885590 [GRCh38]
Chr12:12q13.2-13.3
uncertain significance
NM_006601.7(PTGES3):c.405T>G (p.Asp135Glu) single nucleotide variant Inborn genetic diseases [RCV002812501] Chr12:56666237 [GRCh38]
Chr12:57060021 [GRCh37]
Chr12:12q13.3
uncertain significance
GRCh37/hg19 12q13.3-14.1(chr12:57064059-59314016)x1 copy number loss not provided [RCV003222783] Chr12:57064059..59314016 [GRCh37]
Chr12:12q13.3-14.1
likely pathogenic
miRNA Target Status

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
MIR101-2hsa-miR-101-3pOncomiRDBexternal_infoNANA22677230
MIR101-1hsa-miR-101-3pOncomiRDBexternal_infoNANA22677230

Predicted Target Of
Summary Value
Count of predictions:1139
Count of miRNA genes:393
Interacting mature miRNAs:427
Transcripts:ENST00000262033, ENST00000414274, ENST00000436399, ENST00000448157, ENST00000456859, ENST00000537473
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Markers in Region
G29926  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371257,057,156 - 57,057,339UniSTSGRCh37
Build 361255,343,423 - 55,343,606RGDNCBI36
Celera1256,709,627 - 56,709,810RGD
Cytogenetic Map12q13.3UniSTS
HuRef1254,096,441 - 54,096,624UniSTS
RH92953  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371257,077,949 - 57,078,075UniSTSGRCh37
Build 361255,364,216 - 55,364,342RGDNCBI36
Celera1256,731,007 - 56,731,133RGD
Cytogenetic Map12q13.3UniSTS
HuRef1254,117,275 - 54,117,401UniSTS
GeneMap99-GB4 RH Map12252.42UniSTS
SHGC-75126  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37189,570,124 - 89,570,350UniSTSGRCh37
Build 36189,342,712 - 89,342,938RGDNCBI36
Celera187,815,922 - 87,816,148RGD
Cytogenetic Map12q13.3UniSTS
Cytogenetic Map1p22.2UniSTS
HuRef187,687,473 - 87,687,699UniSTS
TNG Radiation Hybrid Map143221.0UniSTS
GeneMap99-GB4 RH Map1253.16UniSTS
SHGC-23727  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371257,079,851 - 57,080,099UniSTSGRCh37
Build 361255,366,118 - 55,366,366RGDNCBI36
Celera1256,732,901 - 56,733,154RGD
Cytogenetic Map12q13.3UniSTS
HuRef1254,119,169 - 54,119,422UniSTS
TNG Radiation Hybrid Map1226529.0UniSTS
RH45308  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371257,062,025 - 57,062,248UniSTSGRCh37
Build 361255,348,292 - 55,348,515RGDNCBI36
Celera1256,714,495 - 56,714,718RGD
Cytogenetic Map12q13.3UniSTS
HuRef1254,101,309 - 54,101,532UniSTS
GeneMap99-GB4 RH Map12252.42UniSTS
NCBI RH Map12458.1UniSTS
UniSTS:234880  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37226,045,103 - 26,045,365UniSTSGRCh37
Build 36225,898,607 - 25,898,869RGDNCBI36
Celera225,885,435 - 25,885,697RGD
HuRef225,782,165 - 25,782,427UniSTS
D15S1477  
Human AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map4q32-q35UniSTS
Cytogenetic Map5q11UniSTS
Cytogenetic Map10p12.1UniSTS
Cytogenetic Map10p12.1-p11.2UniSTS
Cytogenetic Map15q13UniSTS
Cytogenetic Map21q21.3UniSTS
Cytogenetic Map12p13.3UniSTS
Cytogenetic Map1q25UniSTS
Cytogenetic Map20q13.3UniSTS
Cytogenetic Map14q11.2UniSTS
Cytogenetic Map11p15.4UniSTS
Cytogenetic Map12q12UniSTS
Cytogenetic Map3p24.3UniSTS
Cytogenetic Map5q14UniSTS
Cytogenetic Map3q29UniSTS
Cytogenetic Map1p36.13UniSTS
Cytogenetic Map7q36.3UniSTS
Cytogenetic Map7p21.3UniSTS
Cytogenetic Map1q22UniSTS
Cytogenetic Map14q32.33UniSTS
Cytogenetic Map14q23.3UniSTS
Cytogenetic Map19q13.4UniSTS
Cytogenetic Map2q11.2UniSTS
Cytogenetic Map14q31-q32UniSTS
Cytogenetic Map10q25.2UniSTS
Cytogenetic Map16p13.13-p13.12UniSTS
Cytogenetic Map3q12.3UniSTS
Cytogenetic Map14q24.3UniSTS
Cytogenetic Map10p15.3UniSTS
Cytogenetic Map2p22.1UniSTS
Cytogenetic Map13q13.1UniSTS
Cytogenetic Map5q23.3UniSTS
Cytogenetic Map15q21.1UniSTS
Cytogenetic Map19q13.42UniSTS
Cytogenetic Map17q21UniSTS
Cytogenetic Map3p21.3UniSTS
Cytogenetic Map12q24.13UniSTS
Cytogenetic Map4q21.1UniSTS
Cytogenetic Map19q13.3UniSTS
Cytogenetic Map2q37.3UniSTS
Cytogenetic Map2p15UniSTS
Cytogenetic Map17q25.3UniSTS
Cytogenetic Map19p13UniSTS
Cytogenetic Map4p16.3UniSTS
Cytogenetic Map1p35.1UniSTS
Cytogenetic Map17q11.2UniSTS
Cytogenetic Map1p31.3UniSTS
Cytogenetic Map20q13.31UniSTS
Cytogenetic Map10q22UniSTS
Cytogenetic Map1q41UniSTS
Cytogenetic Map9q34.3UniSTS
Cytogenetic Map9p13.3UniSTS
Cytogenetic Map12q24.31UniSTS
Cytogenetic Map2p13.1UniSTS
Cytogenetic Map19q13.12UniSTS
Cytogenetic Map10q24.2UniSTS
Cytogenetic Map1q42.11UniSTS
Cytogenetic Map1q32.1UniSTS
Cytogenetic Map2p23.3UniSTS
Cytogenetic Map2p13.3UniSTS
Cytogenetic Map7p22.1UniSTS
Cytogenetic Map11q24UniSTS
Cytogenetic Map6q16.2UniSTS
Cytogenetic Map2q14UniSTS
Cytogenetic Map19q13.1UniSTS
Cytogenetic Map16q24UniSTS
Cytogenetic MapXq26.3UniSTS
Cytogenetic Map10q23.1UniSTS
Cytogenetic Map3p21.31UniSTS
Cytogenetic Map4q12UniSTS
Cytogenetic Map19p13.2UniSTS
Cytogenetic Map2p11.2UniSTS
Cytogenetic Map7q21.2UniSTS
Cytogenetic Map17q22.2UniSTS
Cytogenetic Map8q22.3UniSTS
Cytogenetic Map4q25UniSTS
Cytogenetic Map11q14.2UniSTS
Cytogenetic Map19p13.3UniSTS
Cytogenetic Map5q23UniSTS
Cytogenetic Map16p13.3UniSTS
Cytogenetic Map16q22.1UniSTS
Cytogenetic Map13q12.1UniSTS
Cytogenetic Map6p21.32UniSTS
Cytogenetic Map2q31UniSTS
Cytogenetic Map10p14UniSTS
Cytogenetic Map6p21.3UniSTS
Cytogenetic Map3p21.2UniSTS
Cytogenetic Map1q21.3UniSTS
Cytogenetic Map19p12UniSTS
Cytogenetic Map7q22.1UniSTS
Cytogenetic Map14q12UniSTS
Cytogenetic Map8p11.22UniSTS
Cytogenetic Map19q13.32UniSTS
Cytogenetic Map17q21.31UniSTS
Cytogenetic Map4q28.2UniSTS
Cytogenetic Map1p13.2UniSTS
Cytogenetic Map22q12.3UniSTS
Cytogenetic Map19p13.11UniSTS
Cytogenetic Map16p12.3UniSTS
Cytogenetic Map15q22.31UniSTS
Cytogenetic Map2q31.1UniSTS
Cytogenetic Map2q33.2UniSTS
Cytogenetic Map1p34.3UniSTS
Cytogenetic Map1p36.31UniSTS
Cytogenetic Map3q21.3UniSTS
Cytogenetic Map17q25UniSTS
Cytogenetic Map11p13UniSTS
Cytogenetic Map12q13.3UniSTS
Cytogenetic Map1p36.21UniSTS
Cytogenetic Map1p35.3UniSTS
Cytogenetic Map19q13.2UniSTS
Cytogenetic Map4p14UniSTS
Cytogenetic Map15q11-q13UniSTS
Cytogenetic Map19pUniSTS
Cytogenetic Map7q22UniSTS
Cytogenetic Map9q22.3UniSTS
Cytogenetic Map3p25.3UniSTS
Cytogenetic Map11q13UniSTS
Cytogenetic Map8q11.21UniSTS
Cytogenetic Map15q15UniSTS
Cytogenetic Map15q15.1UniSTS
Cytogenetic Map2q22.3UniSTS
Cytogenetic Map1p34.2UniSTS
Cytogenetic Map5q13.2UniSTS
Cytogenetic Map10q23.2UniSTS
Cytogenetic Map7p22.3UniSTS
Cytogenetic Map9q34.13UniSTS
Cytogenetic Map1q32UniSTS
Cytogenetic Map1q31.3UniSTS
Cytogenetic Map4q35UniSTS
Cytogenetic Map9p13UniSTS
Cytogenetic Map3p24.2UniSTS
Cytogenetic Map3q23UniSTS
Cytogenetic Map6q25.2-q25.3UniSTS
Cytogenetic Map15q21UniSTS
Cytogenetic Map16p11.2UniSTS
Cytogenetic Map1q42.3UniSTS
Cytogenetic Map7q22.3UniSTS
Cytogenetic Map9q34.2UniSTS
Cytogenetic Map17q24UniSTS
Cytogenetic Map17q25.1UniSTS
Cytogenetic Map19q13.3-q13.4UniSTS
Cytogenetic Map22q11.23UniSTS
Cytogenetic Map3q21UniSTS
Cytogenetic Map20q13UniSTS
Cytogenetic Map22q12.2UniSTS
Cytogenetic Map19p13.12UniSTS
Cytogenetic Map14q22.1UniSTS
Cytogenetic Map11q23.1UniSTS
Cytogenetic Map17q22-q23UniSTS
Cytogenetic MapXp22.33UniSTS
Cytogenetic MapYp11.3UniSTS
Cytogenetic Map6p21.1UniSTS
Cytogenetic Map22q13.1UniSTS
Cytogenetic Map7p15.2UniSTS
Cytogenetic Map1q21UniSTS
Cytogenetic Map12q23.1UniSTS
Cytogenetic Map16q12.2UniSTS
Cytogenetic Map13q11UniSTS
Cytogenetic MapXp22.3UniSTS
Cytogenetic Map3p25-p24UniSTS
Cytogenetic Map22q13.2UniSTS
Cytogenetic Map2p21UniSTS
Cytogenetic MapXq22.1UniSTS
Cytogenetic MapXp11.3UniSTS
Cytogenetic Map3p12UniSTS
Cytogenetic Map1q25.1UniSTS
Cytogenetic Map17p11.2UniSTS
Cytogenetic MapXp11.2UniSTS
Cytogenetic Map11q13.1-q13.2UniSTS
Cytogenetic Map8q24.3UniSTS
Cytogenetic Map17p13UniSTS
Cytogenetic Map5p13.2UniSTS
Cytogenetic Map7q21-q22UniSTS
Cytogenetic Map9q34.11UniSTS
Cytogenetic Map3q26.2UniSTS
Cytogenetic Map20q11.22UniSTS
Cytogenetic Map8p22UniSTS
Cytogenetic Map4q35.1UniSTS
Cytogenetic Map10q23.31UniSTS
Cytogenetic Map6p21.1-p12.2UniSTS
Cytogenetic Map12q14.1UniSTS
Cytogenetic Map7p11.2UniSTS
Cytogenetic Map11p15.5UniSTS
Cytogenetic Map1p35UniSTS
Cytogenetic Map12qUniSTS
Cytogenetic Map1q21.2UniSTS
Cytogenetic Map8q23.1UniSTS
Cytogenetic Map1p13.3UniSTS
Cytogenetic Map14q11.1UniSTS
Cytogenetic Map21q22.11UniSTS
Cytogenetic Map3p14.1UniSTS
Cytogenetic Map5q31UniSTS
Cytogenetic Map19p13.3-p13.2UniSTS
Cytogenetic Map1p36.11-p34.2UniSTS
Cytogenetic Map9p22UniSTS
Cytogenetic Map1q42.12UniSTS
Cytogenetic Map2q35UniSTS
Cytogenetic Map9p22.1UniSTS
Cytogenetic Map11q24.2UniSTS
Cytogenetic Map12q15UniSTS
Cytogenetic Map17p13.2UniSTS
Cytogenetic Map8q22.1UniSTS
Cytogenetic Map9q21.13UniSTS
Cytogenetic Map11p15.1UniSTS
Cytogenetic Map1p32.3UniSTS
Cytogenetic Map12q21.1UniSTS
Cytogenetic Map20q13.33UniSTS
Cytogenetic Map3p21UniSTS
Cytogenetic Map20p11.23UniSTS
Cytogenetic Map15q15.2UniSTS
Cytogenetic Map8p21.1UniSTS
Cytogenetic Map1p36.33UniSTS
Cytogenetic Map18q12.1UniSTS
Cytogenetic Map8q12.1UniSTS
Cytogenetic Map14q21.2UniSTS
Cytogenetic Map3q27.1UniSTS
Cytogenetic Map3p14.3UniSTS
Cytogenetic Map17p13.1UniSTS
Cytogenetic Map6p22.1UniSTS
Cytogenetic Map12p13.2UniSTS
Cytogenetic Map12q13.13UniSTS
Cytogenetic Map15q21.3UniSTS
Cytogenetic MapXp11.22UniSTS
Cytogenetic Map12p12UniSTS
Cytogenetic Map15q15.3UniSTS
Cytogenetic Map18q12.3UniSTS
Cytogenetic Map21q22.3UniSTS
Cytogenetic Map12q11-q12UniSTS
Cytogenetic Map3q13.33UniSTS
Cytogenetic Map11q13.4UniSTS
Cytogenetic Map2p24UniSTS
Cytogenetic Map8q24.21UniSTS
Cytogenetic Map12q22-q23.1UniSTS
Cytogenetic Map3q26.33UniSTS
Cytogenetic Map5q32UniSTS
Cytogenetic Map15q21-q22UniSTS
Cytogenetic Map8p21.2UniSTS
Cytogenetic Map10q23UniSTS
Cytogenetic Map1p22UniSTS
Cytogenetic Map16p13.13UniSTS
Cytogenetic Map17p13.3UniSTS
Cytogenetic Map10q24UniSTS
Cytogenetic Map8q11.2UniSTS
Cytogenetic Map7p14-p13UniSTS
Cytogenetic Map11q22-q23UniSTS
Cytogenetic Map6q22-q23UniSTS
Cytogenetic Map2p16.1UniSTS
Cytogenetic Map15q26.3UniSTS
Cytogenetic Map7p14.3UniSTS
Cytogenetic Map4q21.22UniSTS
Cytogenetic Map1q21.1UniSTS
Cytogenetic Map17q21.33UniSTS
Cytogenetic Map17q12UniSTS
Cytogenetic Map16p12.1UniSTS
Cytogenetic Map14q32.31UniSTS
Cytogenetic Map11q24.3UniSTS
Cytogenetic Map11q13.1-q13.3UniSTS
Cytogenetic Map14q24.2UniSTS
Cytogenetic Map17q23.3UniSTS
Cytogenetic Map2q24UniSTS
Cytogenetic Map1q23.3UniSTS
Cytogenetic Map10q25UniSTS
Cytogenetic Map9q32UniSTS
Cytogenetic Map3q25.33UniSTS
Cytogenetic Map2p14UniSTS
Cytogenetic Map15q21-q23UniSTS
Cytogenetic Map7q11.23UniSTS
Cytogenetic Map3p22.1UniSTS
Cytogenetic Map19q13.11UniSTS
Cytogenetic Map15q25.2UniSTS
Cytogenetic Map10q26.3UniSTS
Cytogenetic Map6p21UniSTS
Cytogenetic Map2p25.2UniSTS
Cytogenetic Map14q23.1UniSTS
Cytogenetic Map1p31.1UniSTS
Cytogenetic Map15q14-q15UniSTS
Cytogenetic Map5q31.1UniSTS
Cytogenetic Map1p34UniSTS
Cytogenetic MapXq22.3UniSTS
Cytogenetic Map7p15.3UniSTS
Cytogenetic Map6p25.2UniSTS
Cytogenetic Map6q25.1UniSTS
Cytogenetic Map12p12.1UniSTS
Cytogenetic MapXq25UniSTS
Cytogenetic Map14q23.2UniSTS
Cytogenetic Map11q12UniSTS
Cytogenetic Map2p25.1UniSTS
Cytogenetic Map5q35UniSTS
Cytogenetic Map16q21UniSTS
Cytogenetic Map6p23UniSTS
Cytogenetic Map7q34UniSTS
Cytogenetic Map4p16.1UniSTS
Cytogenetic Map3q25.31UniSTS
Cytogenetic Map2q33.1UniSTS
Cytogenetic Map17q21.2UniSTS
Cytogenetic Map19q13.41UniSTS
Cytogenetic Map11q12.3UniSTS
Cytogenetic Map11q13.1UniSTS
Cytogenetic Map10q24.31UniSTS
Cytogenetic Map20q13.13UniSTS
Cytogenetic Map1p22.1UniSTS
Cytogenetic Map10q22.2UniSTS
Cytogenetic Map6q13UniSTS
Cytogenetic Map10q21.3UniSTS
Cytogenetic Map17p12UniSTS
Cytogenetic Map11q23.3UniSTS
Cytogenetic Map4q31.1UniSTS
Cytogenetic Map19q13.43UniSTS
Cytogenetic Map18q21.3UniSTS
Cytogenetic Map11q21UniSTS
Cytogenetic Map5q13UniSTS
Cytogenetic Map11q23.2UniSTS
Cytogenetic Map8q12UniSTS
Cytogenetic Map4q28-q32UniSTS
Cytogenetic Map19q13.33UniSTS
Cytogenetic Map15q21.2UniSTS
Cytogenetic Map16q24.1UniSTS
Cytogenetic Map9q34UniSTS
Cytogenetic Map5q12.3UniSTS
Cytogenetic Map12q24.11UniSTS
Cytogenetic Map9q21.12UniSTS
Cytogenetic Map9q33.3UniSTS
Cytogenetic Map11q22.3UniSTS
Cytogenetic Map20p11.22-p11.1UniSTS
Cytogenetic Map10q24.32UniSTS
Cytogenetic Map20p13UniSTS
Cytogenetic Map16q23.1UniSTS
Cytogenetic Map13q14.2UniSTS
Cytogenetic Map2q24.3UniSTS
Cytogenetic Map8p12UniSTS
Cytogenetic Map7p13UniSTS
Cytogenetic Map9q31-q33UniSTS
Cytogenetic Map6p24.1UniSTS
Cytogenetic Map10p11.23UniSTS
Cytogenetic Map6q15UniSTS
Cytogenetic Map5q35.2UniSTS
Cytogenetic Map14q32UniSTS
Cytogenetic Map3q26.1-q26.2UniSTS
Cytogenetic Map5q11.2-q13.2UniSTS
Cytogenetic Map1p36.11UniSTS
Cytogenetic Map1q25.2UniSTS
Cytogenetic MapXp11.4UniSTS
Cytogenetic MapXq13.3UniSTS
Cytogenetic Map8q22.2UniSTS
Cytogenetic Map7q11.21UniSTS
Cytogenetic Map5q35.1UniSTS
Cytogenetic Map5q33.1UniSTS
Cytogenetic Map4q21.21UniSTS
Cytogenetic Map2q21.1UniSTS
Cytogenetic Map22q11.21UniSTS
Cytogenetic Map18p11.21UniSTS
Cytogenetic MapXq13.1UniSTS
Cytogenetic MapXq21.1UniSTS
Cytogenetic Map10p11.21UniSTS
Cytogenetic Map12q14.3UniSTS
Cytogenetic Map5q34UniSTS
Cytogenetic Map2q36.1UniSTS
Cytogenetic Map12p11.21UniSTS
Cytogenetic Map5q33.3UniSTS
Cytogenetic Map16q23.2UniSTS
Cytogenetic Map9q31.3UniSTS
Cytogenetic Map15q24UniSTS
Cytogenetic Map11q13.2UniSTS
Cytogenetic Map12q21UniSTS
Cytogenetic Map8p11.2UniSTS
Cytogenetic Map7q22-q31UniSTS
Cytogenetic Map22q12UniSTS
Cytogenetic Map4q22UniSTS
Cytogenetic Map17q21.32UniSTS
Cytogenetic Map12q14UniSTS
Cytogenetic Map11q23.1-q23.2UniSTS
Cytogenetic Map13q14UniSTS
Cytogenetic Map13q32.2UniSTS
Cytogenetic Map17qUniSTS
Cytogenetic Map2q33UniSTS
Cytogenetic Map7qUniSTS
Cytogenetic Map16p12.2UniSTS
Cytogenetic Map10q11.23UniSTS
Cytogenetic Map20q13.12UniSTS
Cytogenetic Map22q13.33UniSTS
Cytogenetic Map13q22.1UniSTS
Cytogenetic Map3p25.2UniSTS
Cytogenetic Map5q21.3UniSTS
Cytogenetic Map9q22.2UniSTS
Cytogenetic Map3p22.2UniSTS
Cytogenetic Map6p24.2UniSTS
PTGES3  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371257,065,561 - 57,066,552UniSTSGRCh37
GRCh37226,045,493 - 26,045,593UniSTSGRCh37
Celera1256,718,038 - 56,719,029UniSTS
Celera225,885,825 - 25,885,925UniSTS
HuRef225,782,555 - 25,782,655UniSTS
HuRef1254,104,852 - 54,105,843UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High 1 2 2 37 7 2
Medium 2438 2953 1726 624 1938 465 4357 2172 3732 418 1423 1606 175 1 1202 2788 6 2
Low 36 11 25 2 1
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001282601 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001282602 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001282603 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001282604 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001282605 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_006601 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_104219 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_005268576 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006719199 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011537773 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011537774 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017018716 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054370819 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054370820 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054370821 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054370822 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054370823 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC117378 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK098214 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK291945 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK293139 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK295208 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK298147 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK298160 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL603017 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC003005 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC021167 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BG927063 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BM541503 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BP194632 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BU167210 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BU732883 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CA773263 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471054 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068266 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DA556848 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L24804 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  Z69891 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENST00000262033   ⟹   ENSP00000262033
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1256,663,349 - 56,688,284 (-)Ensembl
RefSeq Acc Id: ENST00000414274   ⟹   ENSP00000405299
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1256,663,613 - 56,688,287 (-)Ensembl
RefSeq Acc Id: ENST00000436399   ⟹   ENSP00000402385
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1256,664,085 - 56,688,162 (-)Ensembl
RefSeq Acc Id: ENST00000448157   ⟹   ENSP00000414892
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1256,664,167 - 56,688,284 (-)Ensembl
RefSeq Acc Id: ENST00000456859   ⟹   ENSP00000389090
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1256,664,273 - 56,688,375 (-)Ensembl
RefSeq Acc Id: ENST00000537473
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1256,663,341 - 56,687,997 (-)Ensembl
RefSeq Acc Id: ENST00000614328   ⟹   ENSP00000482075
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1256,663,343 - 56,688,408 (-)Ensembl
RefSeq Acc Id: NM_001282601   ⟹   NP_001269530
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381256,663,349 - 56,688,284 (-)NCBI
HuRef1254,096,410 - 54,121,508 (-)NCBI
CHM1_11257,024,664 - 57,050,004 (-)NCBI
T2T-CHM13v2.01256,631,338 - 56,656,287 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001282602   ⟹   NP_001269531
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381256,663,349 - 56,688,284 (-)NCBI
HuRef1254,096,410 - 54,121,508 (-)NCBI
CHM1_11257,024,664 - 57,050,004 (-)NCBI
T2T-CHM13v2.01256,631,338 - 56,656,287 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001282603   ⟹   NP_001269532
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381256,663,349 - 56,688,284 (-)NCBI
HuRef1254,096,410 - 54,121,508 (-)NCBI
CHM1_11257,024,664 - 57,050,004 (-)NCBI
T2T-CHM13v2.01256,631,338 - 56,656,287 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001282604   ⟹   NP_001269533
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381256,663,349 - 56,688,284 (-)NCBI
HuRef1254,096,410 - 54,121,508 (-)NCBI
CHM1_11257,024,664 - 57,050,004 (-)NCBI
T2T-CHM13v2.01256,631,338 - 56,656,287 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001282605   ⟹   NP_001269534
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381256,663,349 - 56,688,284 (-)NCBI
HuRef1254,096,410 - 54,121,508 (-)NCBI
CHM1_11257,024,664 - 57,050,004 (-)NCBI
T2T-CHM13v2.01256,631,338 - 56,656,287 (-)NCBI
Sequence:
RefSeq Acc Id: NM_006601   ⟹   NP_006592
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381256,663,349 - 56,688,284 (-)NCBI
GRCh371257,057,125 - 57,082,138 (-)NCBI
Build 361255,343,649 - 55,368,156 (-)NCBI Archive
HuRef1254,096,410 - 54,121,508 (-)NCBI
CHM1_11257,024,664 - 57,050,004 (-)NCBI
T2T-CHM13v2.01256,631,338 - 56,656,287 (-)NCBI
Sequence:
RefSeq Acc Id: NR_104219
RefSeq Status: REVIEWED
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381256,663,349 - 56,688,284 (-)NCBI
HuRef1254,096,410 - 54,121,508 (-)NCBI
CHM1_11257,024,664 - 57,049,593 (-)NCBI
T2T-CHM13v2.01256,631,338 - 56,656,287 (-)NCBI
Sequence:
RefSeq Acc Id: XM_005268576   ⟹   XP_005268633
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381256,663,349 - 56,688,284 (-)NCBI
GRCh371257,057,125 - 57,082,138 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006719199   ⟹   XP_006719262
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381256,663,349 - 56,688,284 (-)NCBI
Sequence:
RefSeq Acc Id: XM_011537773   ⟹   XP_011536075
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381256,664,807 - 56,688,284 (-)NCBI
Sequence:
RefSeq Acc Id: XM_011537774   ⟹   XP_011536076
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381256,663,349 - 56,688,284 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017018716   ⟹   XP_016874205
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381256,664,807 - 56,688,284 (-)NCBI
Sequence:
RefSeq Acc Id: XM_054370819   ⟹   XP_054226794
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01256,632,807 - 56,658,334 (-)NCBI
RefSeq Acc Id: XM_054370820   ⟹   XP_054226795
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01256,631,338 - 56,658,334 (-)NCBI
RefSeq Acc Id: XM_054370821   ⟹   XP_054226796
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01256,632,807 - 56,656,287 (-)NCBI
RefSeq Acc Id: XM_054370822   ⟹   XP_054226797
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01256,631,338 - 56,658,334 (-)NCBI
RefSeq Acc Id: XM_054370823   ⟹   XP_054226798
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01256,631,338 - 56,658,334 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001269530 (Get FASTA)   NCBI Sequence Viewer  
  NP_001269531 (Get FASTA)   NCBI Sequence Viewer  
  NP_001269532 (Get FASTA)   NCBI Sequence Viewer  
  NP_001269533 (Get FASTA)   NCBI Sequence Viewer  
  NP_001269534 (Get FASTA)   NCBI Sequence Viewer  
  NP_006592 (Get FASTA)   NCBI Sequence Viewer  
  XP_005268633 (Get FASTA)   NCBI Sequence Viewer  
  XP_006719262 (Get FASTA)   NCBI Sequence Viewer  
  XP_011536075 (Get FASTA)   NCBI Sequence Viewer  
  XP_011536076 (Get FASTA)   NCBI Sequence Viewer  
  XP_016874205 (Get FASTA)   NCBI Sequence Viewer  
  XP_054226794 (Get FASTA)   NCBI Sequence Viewer  
  XP_054226795 (Get FASTA)   NCBI Sequence Viewer  
  XP_054226796 (Get FASTA)   NCBI Sequence Viewer  
  XP_054226797 (Get FASTA)   NCBI Sequence Viewer  
  XP_054226798 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA18537 (Get FASTA)   NCBI Sequence Viewer  
  AAH03005 (Get FASTA)   NCBI Sequence Viewer  
  AAH21167 (Get FASTA)   NCBI Sequence Viewer  
  BAF84634 (Get FASTA)   NCBI Sequence Viewer  
  BAG53594 (Get FASTA)   NCBI Sequence Viewer  
  BAG56687 (Get FASTA)   NCBI Sequence Viewer  
  BAG58204 (Get FASTA)   NCBI Sequence Viewer  
  BAG60423 (Get FASTA)   NCBI Sequence Viewer  
  BAG60433 (Get FASTA)   NCBI Sequence Viewer  
  EAW96953 (Get FASTA)   NCBI Sequence Viewer  
  EAW96954 (Get FASTA)   NCBI Sequence Viewer  
  EAW96955 (Get FASTA)   NCBI Sequence Viewer  
  EAW96956 (Get FASTA)   NCBI Sequence Viewer  
  EAW96957 (Get FASTA)   NCBI Sequence Viewer  
  EAW96958 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSP00000262033
  ENSP00000262033.6
  ENSP00000389090.2
  ENSP00000402385
  ENSP00000402385.2
  ENSP00000405299
  ENSP00000405299.3
  ENSP00000414892
  ENSP00000414892.2
  ENSP00000482075
  ENSP00000482075.1
GenBank Protein Q15185 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_006592   ⟸   NM_006601
- Peptide Label: isoform a
- UniProtKB: B4DP21 (UniProtKB/Swiss-Prot),   B4DP11 (UniProtKB/Swiss-Prot),   B4DHP2 (UniProtKB/Swiss-Prot),   A8K7D0 (UniProtKB/Swiss-Prot),   Q8WU70 (UniProtKB/Swiss-Prot),   Q15185 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_005268633   ⟸   XM_005268576
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: NP_001269532   ⟸   NM_001282603
- Peptide Label: isoform d
- UniProtKB: Q15185 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001269534   ⟸   NM_001282605
- Peptide Label: isoform f
- UniProtKB: Q15185 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001269531   ⟸   NM_001282602
- Peptide Label: isoform c
- UniProtKB: Q15185 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001269530   ⟸   NM_001282601
- Peptide Label: isoform b
- UniProtKB: Q15185 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001269533   ⟸   NM_001282604
- Peptide Label: isoform e
- UniProtKB: A0A087WYT3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006719262   ⟸   XM_006719199
- Peptide Label: isoform X5
- Sequence:
RefSeq Acc Id: XP_011536076   ⟸   XM_011537774
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: XP_011536075   ⟸   XM_011537773
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_016874205   ⟸   XM_017018716
- Peptide Label: isoform X1
- UniProtKB: B3KUY2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSP00000405299   ⟸   ENST00000414274
RefSeq Acc Id: ENSP00000389090   ⟸   ENST00000456859
RefSeq Acc Id: ENSP00000482075   ⟸   ENST00000614328
RefSeq Acc Id: ENSP00000262033   ⟸   ENST00000262033
RefSeq Acc Id: ENSP00000414892   ⟸   ENST00000448157
RefSeq Acc Id: ENSP00000402385   ⟸   ENST00000436399
RefSeq Acc Id: XP_054226798   ⟸   XM_054370823
- Peptide Label: isoform X5
RefSeq Acc Id: XP_054226797   ⟸   XM_054370822
- Peptide Label: isoform X4
RefSeq Acc Id: XP_054226795   ⟸   XM_054370820
- Peptide Label: isoform X2
RefSeq Acc Id: XP_054226794   ⟸   XM_054370819
- Peptide Label: isoform X1
- UniProtKB: B3KUY2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_054226796   ⟸   XM_054370821
- Peptide Label: isoform X3
Protein Domains
CS

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q15185-F1-model_v2 AlphaFold Q15185 1-160 view protein structure

Promoters
RGD ID:6790394
Promoter ID:HG_KWN:15926
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:K562
Transcripts:NM_006601,   UC001SLV.2,   UC001SLW.2,   UC009ZOX.1
Position:
Human AssemblyChrPosition (strand)Source
Build 361255,369,086 - 55,369,586 (-)MPROMDB
RGD ID:7224455
Promoter ID:EPDNEW_H17973
Type:initiation region
Name:PTGES3_2
Description:prostaglandin E synthase 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H17974  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381256,688,131 - 56,688,191EPDNEW
RGD ID:7224459
Promoter ID:EPDNEW_H17974
Type:initiation region
Name:PTGES3_1
Description:prostaglandin E synthase 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H17973  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381256,688,284 - 56,688,344EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:16049 AgrOrtholog
COSMIC PTGES3 COSMIC
Ensembl Genes ENSG00000110958 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENST00000262033 ENTREZGENE
  ENST00000262033.11 UniProtKB/Swiss-Prot
  ENST00000414274 ENTREZGENE
  ENST00000414274.7 UniProtKB/Swiss-Prot
  ENST00000436399 ENTREZGENE
  ENST00000436399.6 UniProtKB/Swiss-Prot
  ENST00000448157 ENTREZGENE
  ENST00000448157.6 UniProtKB/Swiss-Prot
  ENST00000456859.2 UniProtKB/TrEMBL
  ENST00000537473 ENTREZGENE
  ENST00000614328 ENTREZGENE
  ENST00000614328.4 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.790 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000110958 GTEx
HGNC ID HGNC:16049 ENTREZGENE
Human Proteome Map PTGES3 Human Proteome Map
InterPro CS_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HSP20-like_chaperone UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  p23-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:10728 UniProtKB/Swiss-Prot
NCBI Gene 10728 ENTREZGENE
OMIM 607061 OMIM
PANTHER PROSTAGLANDIN E SYNTHASE 3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR22932 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam PF04969 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA142671118 PharmGKB
PROSITE PS51203 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF49764 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A087WYT3 ENTREZGENE, UniProtKB/TrEMBL
  A8K7D0 ENTREZGENE
  B3KUY2 ENTREZGENE, UniProtKB/TrEMBL
  B4DDC6_HUMAN UniProtKB/TrEMBL
  B4DHP2 ENTREZGENE
  B4DP11 ENTREZGENE
  B4DP21 ENTREZGENE
  Q15185 ENTREZGENE
  Q8WU70 ENTREZGENE
  TEBP_HUMAN UniProtKB/Swiss-Prot
UniProt Secondary A8K7D0 UniProtKB/Swiss-Prot
  B4DHP2 UniProtKB/Swiss-Prot
  B4DP11 UniProtKB/Swiss-Prot
  B4DP21 UniProtKB/Swiss-Prot
  Q8WU70 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-12-08 PTGES3  prostaglandin E synthase 3    prostaglandin E synthase 3 (cytosolic)  Symbol and/or name change 5135510 APPROVED