Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 619868
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Gclc
Name: glutamate-cysteine ligase, catalytic subunit
Acc ID: CHEBI:17515
Term: L-gamma-glutamyl-L-cysteine
Definition: A molecular entity formed when L-cysteine amino group binds to the gamma-carbonyl of L-glutamic acid.
Chemical ID: MESH:C017341
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gclcincreases chemical synthesisEXP 6480464CTDGCLC protein results in increased chemical synthesis of gamma-glutamylcysteine

PMID:15115889
Gclcmultiple interactionsEXP 6480464CTDButhionine Sulfoximine inhibits the reaction [GCLC protein results in increased chemical synthesis of gamma-glutamylcysteine] Cysteine promotes the reaction [GCLC protein results in increased chemical synthesis of gamma-glutamylcysteine] Excitatory Amino Acid Agents promotes the reaction [GCLC protein results in increased chemical synthesis of gamma-glutamylcysteine]

PMID:15115889
Go Back to source page   Continue to Ontology report