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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:bradykinin
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Accession:CHEBI:3165 term browser browse the term
Definition:A linear nonapeptide messenger belonging to the kinin group of proteins, with amino acid sequence RPPGFSPFR. Enzymatically produced from kallidin in the blood, it is a powerful vasodilator that causes smooth muscle contraction, and may mediate inflammation.
Synonyms:related_synonym: Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg;   BK;   Formula=C50H73N15O11;   InChI=1S/C50H73N15O11/c51-32(16-7-21-56-49(52)53)45(72)65-25-11-20-39(65)47(74)64-24-9-18-37(64)43(70)58-28-40(67)59-34(26-30-12-3-1-4-13-30)41(68)62-36(29-66)46(73)63-23-10-19-38(63)44(71)61-35(27-31-14-5-2-6-15-31)42(69)60-33(48(75)76)17-8-22-57-50(54)55/h1-6,12-15,32-39,66H,7-11,16-29,51H2,(H,58,70)(H,59,67)(H,60,69)(H,61,71)(H,62,68)(H,75,76)(H4,52,53,56)(H4,54,55,57)/t32-,33-,34-,35-,36-,37-,38-,39-/m0/s1;   InChIKey=QXZGBUJJYSLZLT-FDISYFBBSA-N;   L-Arg-L-Pro-L-Pro-Gly-L-Phe-L-Ser-L-Pro-L-Phe-L-Arg;   L-arginyl-L-prolyl-L-prolylglycyl-L-phenylalanyl-L-seryl-L-prolyl-L-phenylalanyl-L-arginine;   L-bradykinin;   RPPGFSPFR;   SMILES=N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O
 xref: CAS:58-82-2
 xref_mesh: MESH:D001920
 xref: PMID:11799074;   PMID:11975815;   PMID:13446366;   PMID:13811230;   PMID:14597148;   PMID:15105283;   PMID:16680069;   PMID:18127230;   PMID:27318425;   PMID:27328010;   PMID:27432758;   PMID:27445816;   PMID:7859389;   PMID:8723398;   PMID:9403361;   Reaxys:24162492;   Reaxys:2801232;   Wikipedia:Bradykinin
 cyclic_relationship: is_conjugate_base_of CHEBI:132988


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bradykinin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nos3 nitric oxide synthase 3 decreases expression ISO Bradykinin results in decreased expression of NOS3 mRNA CTD PMID:24839774 NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19932
    chemical entity 19930
      group 19888
        organic group 19017
          amino-acid residue 11439
            peptide 11439
              oligopeptide 1350
                bradykinin 1
                  NPC-567 0
                  [Hyp(3)]-bradykinin 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19932
    subatomic particle 19930
      composite particle 19930
        hadron 19930
          baryon 19930
            nucleon 19930
              atomic nucleus 19930
                atom 19930
                  main group element atom 19876
                    p-block element atom 19876
                      carbon group element atom 19816
                        carbon atom 19812
                          organic molecular entity 19812
                            heteroorganic entity 19559
                              organochalcogen compound 19317
                                organooxygen compound 19231
                                  carbon oxoacid 18687
                                    carboxylic acid 18684
                                      carboacyl group 17725
                                        univalent carboacyl group 17725
                                          carbamoyl group 17579
                                            carboxamide 17579
                                              peptide 11439
                                                oligopeptide 1350
                                                  bradykinin 1
                                                    NPC-567 0
                                                    [Hyp(3)]-bradykinin 0
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