Gene: Hdac6 (histone deacetylase 6) Rattus norvegicus
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Symbol:
Hdac6
Name:
histone deacetylase 6
Description:
Exhibits deacetylase activity. Involved in several processes, including generation of neurons; regulation of protein modification process; and response to glucocorticoid. Localizes to the axon and centrosome. Predicted to colocalize with the cytoplasmic microtubule and dynein complex. Used to study polycystic kidney disease and polycystic liver disease. Biomarker of hypertension and polycystic liver disease. Orthologous to human HDAC6 (histone deacetylase 6); PARTICIPATES IN histone modification pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; 2,6-dinitrotoluene.
Type:
protein-coding
RefSeq Status:
MODEL
Also known as:
histone deacetylase 6-like; LOC100911205
Orthologs:
Species
Gene symbol and name
Data Source
Assertion derived from
less info ...
Orthologs 1
Homo sapiens (human):
HDAC6 (histone deacetylase 6) HGNC
Ensembl, HomoloGene, Inparanoid, OMA, OrthoDB, Panther, Treefam
Mus musculus (house mouse):
Hdac6 (histone deacetylase 6) HGNC
Treefam, OMA, HomoloGene, Inparanoid, Panther, OrthoDB, Ensembl
Chinchilla lanigera (long-tailed chinchilla):
Hdac6 (histone deacetylase 6) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):
HDAC6 (histone deacetylase 6) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Canis lupus familiaris (dog):
HDAC6 (histone deacetylase 6) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):
Hdac6 (histone deacetylase 6) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Sus scrofa (pig):
HDAC6 (histone deacetylase 6) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Alliance orthologs 3
Homo sapiens (human):
HDAC6 (histone deacetylase 6)
Alliance
DIOPT (Ensembl Compara, HGNC, OMA, OrthoFinder, PANTHER)
Mus musculus (house mouse):
Hdac6 (histone deacetylase 6)
Alliance
DIOPT (Ensembl Compara, OMA, OrthoFinder, PANTHER)
Danio rerio (zebrafish):
hdac6 (histone deacetylase 6)
Alliance
DIOPT (Ensembl Compara, OMA, OrthoFinder, PANTHER)
Saccharomyces cerevisiae (baker's yeast):
HDA1
Alliance
DIOPT (Ensembl Compara, OrthoFinder, PANTHER)
Drosophila melanogaster (fruit fly):
HDAC6
Alliance
DIOPT (Ensembl Compara, OMA, OrthoFinder, PANTHER)
Caenorhabditis elegans (roundworm):
hda-6
Alliance
DIOPT (Ensembl Compara, OMA, OrthoFinder, PANTHER)
Latest Assembly:
Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl Rnor_6.0 X 15,295,372 - 15,316,673 (+) NCBI Rnor6.0 Rnor_6.0 rn6 Rnor6.0 Rnor_6.0 Ensembl X 15,295,473 - 15,316,671 (+) Ensembl Rnor_5.0 X 16,075,029 - 16,096,914 (+) NCBI Rnor5.0 Rnor_5.0 rn5 Rnor5.0 RGSC_v3.4 X 26,585,852 - 26,606,999 (+) NCBI RGSC3.4 rn4 RGSC3.4 RGSC_v3.1 X 26,658,892 - 26,659,565 (+) NCBI Celera X 14,635,909 - 14,657,201 (+) NCBI Celera Cytogenetic Map X q12 NCBI
JBrowse:
View Region in Genome Browser (JBrowse)
Model
Disease Annotations
Imported Annotations - ClinVar
autistic disorder ISO RGD:1351463 8554872 ClinVar Annotator: match by term: Autistic disorder of childhood onset ClinVar PMID:21681106 , PMID:30208311 Chondrodysplasia with Platyspondyly, Distinctive Brachydactyly, Hydrocephaly, and Microphthalmia ISO RGD:1351463 8554872 ClinVar Annotator: match by OMIM:300863 ClinVar PMID:16001442 , PMID:20181727 congenital disorder of glycosylation type IIm ISO RGD:1351463 8554872 ClinVar Annotator: match by term: CONGENITAL DISORDER OF GLYCOSYLATION, TYPE IIm ClinVar PMID:28492532 Malformations of Cortical Development, Group II ISO RGD:1351463 8554872 ClinVar Annotator: match by term: Neuronal migration disorder ClinVar syndromic X-linked intellectual disability Lubs type ISO RGD:1351463 8554872 ClinVar Annotator: match by term: MECP2 duplication syndrome ClinVar PMID:25741868
Imported Annotations - CTD
melanoma ISO RGD:1351463 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:22535842 Ovarian Neoplasms ISO RGD:1351463 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:19010849 Prostatic Neoplasms ISO RGD:1351463 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:24763052 Imported Annotations - OMIM
Chondrodysplasia with Platyspondyly, Distinctive Brachydactyly, Hydrocephaly, and Microphthalmia ISO RGD:1351463 7240710 OMIM
(20S)-ginsenoside Rh2 decreases expression ISO RGD:1351463 6480464 ginsenoside Rh2 results in decreased expression of HDAC6 protein CTD PMID:26482938 17alpha-ethynylestradiol multiple interactions ISO RGD:1552302 6480464 [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in decreased expression of HDAC6 mRNA CTD PMID:17942748 17alpha-ethynylestradiol affects expression ISO RGD:1552302 6480464 Ethinyl Estradiol affects the expression of HDAC6 mRNA CTD PMID:17555576 17beta-estradiol increases expression ISO RGD:1351463 6480464 Estradiol results in increased expression of HDAC6 mRNA CTD PMID:30684530 17beta-estradiol multiple interactions ISO RGD:1351463 6480464 sulforafan inhibits the reaction [Estradiol results in increased expression of HDAC6 mRNA] CTD PMID:30684530 2,3,7,8-tetrachlorodibenzodioxine decreases expression ISO RGD:1552302 6480464 Tetrachlorodibenzodioxin results in decreased expression of HDAC6 mRNA CTD PMID:26290441 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO RGD:1552302 6480464 Tetrachlorodibenzodioxin affects the expression of HDAC6 mRNA CTD PMID:21570461 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO RGD:1552302 6480464 [Tetrachlorodibenzodioxin co-treated with AHR gene mutant form] results in increased expression of HDAC6 mRNA, [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in decreased expression of HDAC6 mRNA CTD PMID:17942748 , PMID:19465110 2,3,7,8-tetrachlorodibenzodioxine increases expression EXP 6480464 Tetrachlorodibenzodioxin results in increased expression of HDAC6 mRNA CTD PMID:22493514 2,3,7,8-tetrachlorodibenzodioxine decreases expression EXP 6480464 Tetrachlorodibenzodioxin results in decreased expression of HDAC6 mRNA CTD PMID:21215274 2,4-dinitrotoluene affects expression EXP 6480464 2, 4-dinitrotoluene affects the expression of HDAC6 mRNA CTD PMID:21346803 2,6-dinitrotoluene affects expression EXP 6480464 2, 6-dinitrotoluene affects the expression of HDAC6 mRNA CTD PMID:21346803 3',5'-cyclic AMP affects abundance ISO RGD:1552302 6480464 HDAC6 protein affects the abundance of Cyclic AMP CTD PMID:28887310 4-hydroxyphenyl retinamide increases expression ISO RGD:1552302 6480464 Fenretinide results in increased expression of HDAC6 mRNA CTD PMID:28973697 acrylamide increases expression EXP 6480464 Acrylamide results in increased expression of HDAC6 mRNA CTD PMID:28959563 aflatoxin B1 decreases expression ISO RGD:1351463 6480464 Aflatoxin B1 results in decreased expression of HDAC6 mRNA CTD PMID:27153756 aflatoxin B2 increases methylation ISO RGD:1351463 6480464 aflatoxin B2 results in increased methylation of HDAC6 promoter CTD PMID:30157460 ammonium chloride affects expression EXP 6480464 Ammonium Chloride affects the expression of HDAC6 mRNA CTD PMID:16483693 amphetamine increases expression EXP 6480464 Amphetamine results in increased expression of HDAC6 mRNA CTD PMID:30779732 bis(2-ethylhexyl) phthalate decreases expression ISO RGD:1351463 6480464 Diethylhexyl Phthalate results in decreased expression of HDAC6 protein CTD PMID:31163220 bisphenol A increases expression ISO RGD:1351463 6480464 bisphenol A results in increased expression of HDAC6 mRNA CTD PMID:26546977 bortezomib decreases response to substance ISO RGD:1351463 6480464 HDAC6 results in decreased susceptibility to Bortezomib CTD PMID:16585204 Butylbenzyl phthalate increases response to substance ISO RGD:1351463 6480464 HDAC6 results in increased susceptibility to butylbenzyl phthalate CTD PMID:22552774 Butylbenzyl phthalate increases expression ISO RGD:1351463 6480464 butylbenzyl phthalate results in increased expression of HDAC6 mRNA, butylbenzyl phthalate results in increased expression of HDAC6 protein CTD PMID:22552774 Butylbenzyl phthalate multiple interactions ISO RGD:1351463 6480464 [butylbenzyl phthalate promotes the reaction [TFAP2A protein binds to HDAC6 promoter]] which results in increased expression of HDAC6 mRNA more ... CTD PMID:22552774 butyric acid multiple interactions ISO RGD:1351463 6480464 Butyric Acid promotes the reaction [SRSF2 protein binds to HDAC6 protein], HDAC6 protein promotes the reaction [Butyric Acid results in increased expression of SRSF2 protein] CTD PMID:21555914 cadmium dichloride affects localization ISO RGD:1351463 6480464 Cadmium Chloride affects the localization of HDAC6 protein CTD PMID:18261755 cadmium dichloride affects localization EXP 6480464 Cadmium Chloride affects the localization of HDAC6 protein CTD PMID:18261755 cadmium dichloride affects localization ISO RGD:1552302 6480464 Cadmium Chloride affects the localization of HDAC6 protein CTD PMID:18261755 carbon nanotube increases expression ISO RGD:1552302 6480464 Nanotubes, Carbon results in increased expression of HDAC6 mRNA CTD PMID:25554681 cisplatin multiple interactions ISO RGD:1351463 6480464 HDAC6 protein promotes the reaction [Cisplatin results in increased expression of SRSF2 protein] CTD PMID:21157427 curcumin decreases expression ISO RGD:1351463 6480464 Curcumin analog results in decreased expression of HDAC6 mRNA CTD PMID:26409325 cyclosporin A decreases expression ISO RGD:1552302 6480464 Cyclosporine results in decreased expression of HDAC6 mRNA CTD PMID:19770486 decabromodiphenyl ether increases expression EXP 6480464 decabromobiphenyl ether results in increased expression of HDAC6 mRNA CTD PMID:23640034 dibutyl phthalate increases expression ISO RGD:1351463 6480464 Dibutyl Phthalate results in increased expression of HDAC6 mRNA, Dibutyl Phthalate results in increased expression of HDAC6 protein CTD PMID:22552774 dibutyl phthalate decreases expression ISO RGD:1552302 6480464 Dibutyl Phthalate results in decreased expression of HDAC6 mRNA CTD PMID:17361019 , PMID:21266533 dibutyl phthalate increases response to substance ISO RGD:1351463 6480464 HDAC6 results in increased susceptibility to Dibutyl Phthalate CTD PMID:22552774 dibutyl phthalate multiple interactions ISO RGD:1351463 6480464 [Dibutyl Phthalate promotes the reaction [TFAP2A protein binds to HDAC6 promoter]] which results in increased expression of HDAC6 mRNA more ... CTD PMID:22552774 dorsomorphin multiple interactions ISO RGD:1351463 6480464 [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of HDAC6 mRNA CTD PMID:27188386 doxorubicin decreases expression EXP 6480464 Doxorubicin results in decreased expression of HDAC6 mRNA CTD PMID:28865727 endosulfan decreases expression ISO RGD:1351463 6480464 Endosulfan results in decreased expression of HDAC6 mRNA, Endosulfan results in decreased expression of HDAC6 protein CTD PMID:29054638 ethanol affects splicing ISO RGD:1552302 6480464 Ethanol affects the splicing of HDAC6 mRNA CTD PMID:30319688 finasteride increases expression EXP 6480464 Finasteride results in increased expression of HDAC6 mRNA CTD PMID:24136188 genistein decreases expression ISO RGD:1552302 6480464 Genistein results in decreased expression of HDAC6 mRNA CTD PMID:21048042 genistein increases expression ISO RGD:1351463 6480464 Genistein results in increased expression of HDAC6 mRNA CTD PMID:30684530 genistein multiple interactions ISO RGD:1351463 6480464 sulforafan inhibits the reaction [Genistein results in increased expression of HDAC6 mRNA] CTD PMID:30684530 hydrogen peroxide affects expression ISO RGD:1351463 6480464 Hydrogen Peroxide affects the expression of HDAC6 mRNA CTD PMID:20044591 hypochlorous acid decreases expression ISO RGD:1552302 6480464 Hypochlorous Acid results in decreased expression of HDAC6 mRNA CTD PMID:19376150 indole-3-methanol multiple interactions ISO RGD:1552302 6480464 indole-3-carbinol inhibits the reaction [enterotoxin B, staphylococcal results in decreased expression of HDAC6 mRNA] CTD PMID:24200994 mancozeb decreases activity ISO RGD:1351463 6480464 mancozeb results in decreased activity of HDAC6 protein CTD PMID:21251949 maneb decreases activity ISO RGD:1351463 6480464 Maneb results in decreased activity of HDAC6 protein CTD PMID:21251949 methamphetamine decreases expression EXP 6480464 Methamphetamine results in decreased expression of HDAC6 mRNA CTD PMID:25452209 methotrexate increases mutagenesis ISO RGD:1552302 6480464 Methotrexate results in increased mutagenesis of HDAC6 gene CTD PMID:22806879 metiram decreases activity ISO RGD:1351463 6480464 polymarcine results in decreased activity of HDAC6 protein CTD PMID:21251949 miconazole increases expression EXP 6480464 Miconazole results in increased expression of HDAC6 mRNA CTD PMID:22262564 nefazodone increases expression EXP 6480464 nefazodone results in increased expression of HDAC6 mRNA CTD PMID:24136188 phenobarbital affects expression ISO RGD:1351463 6480464 Phenobarbital affects the expression of HDAC6 mRNA CTD PMID:19159669 pirinixic acid increases expression ISO RGD:1552302 6480464 pirinixic acid results in increased expression of HDAC6 mRNA CTD PMID:23811191 SB 431542 multiple interactions ISO RGD:1351463 6480464 [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of HDAC6 mRNA CTD PMID:27188386 silicon dioxide decreases expression ISO RGD:1351463 6480464 Silicon Dioxide results in decreased expression of HDAC6 mRNA CTD PMID:23623845 sodium arsenite affects localization ISO RGD:1351463 6480464 sodium arsenite affects the localization of HDAC6 protein CTD PMID:22367689 sodium arsenite multiple interactions ISO RGD:1552302 6480464 [sodium arsenite co-treated with Dietary Fats] results in increased expression of HDAC6 mRNA CTD PMID:30097599 sodium arsenite affects response to substance ISO RGD:1351463 6480464 HDAC6 protein affects the susceptibility to sodium arsenite CTD PMID:22367689 sorafenib decreases expression ISO RGD:1351463 6480464 sorafenib results in decreased expression of HDAC6 mRNA CTD PMID:26409325 sulforaphane multiple interactions ISO RGD:1351463 6480464 HDAC6 protein inhibits the reaction [sulforafan results in decreased expression of AR protein] more ... CTD PMID:19805354 , PMID:30684530 sulforaphane decreases activity ISO RGD:1351463 6480464 sulforafan results in decreased activity of HDAC6 protein CTD PMID:19805354 tamoxifen affects expression ISO RGD:1552302 6480464 Tamoxifen affects the expression of HDAC6 mRNA CTD PMID:17555576 tetrachloromethane increases expression ISO RGD:1552302 6480464 Carbon Tetrachloride results in increased expression of HDAC6 mRNA CTD PMID:27396813 tetrachloromethane multiple interactions ISO RGD:1552302 6480464 Carbon Tetrachloride deficiency inhibits the reaction [Carbon Tetrachloride results in increased expression of HDAC6 mRNA] CTD PMID:27396813 thapsigargin increases expression ISO RGD:1552302 6480464 Thapsigargin results in increased expression of HDAC6 protein CTD PMID:24648495 trichostatin A decreases activity ISO RGD:1351463 6480464 trichostatin A results in decreased activity of HDAC6 protein CTD PMID:15930892 valproic acid increases methylation ISO RGD:1351463 6480464 Valproic Acid results in increased methylation of HDAC6 gene CTD PMID:29154799 valproic acid decreases expression ISO RGD:1351463 6480464 Valproic Acid results in decreased expression of HDAC6 mRNA CTD PMID:23179753 more ... valproic acid multiple interactions ISO RGD:1351463 6480464 [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of HDAC6 mRNA CTD PMID:27188386 vorinostat decreases activity ISO RGD:1351463 6480464 vorinostat results in decreased activity of HDAC6 protein CTD PMID:15930892 vorinostat multiple interactions ISO RGD:1351463 6480464 [vorinostat co-treated with monomethylarsonous acid] results in decreased expression of HDAC6 mRNA CTD PMID:23891734 zinc atom multiple interactions ISO RGD:1552302 6480464 Zinc binds to and results in increased activity of HDAC6 protein CTD PMID:16439135 zinc(0) multiple interactions ISO RGD:1552302 6480464 Zinc binds to and results in increased activity of HDAC6 protein CTD PMID:16439135
Biological Process aggresome assembly ISO RGD:1351463 1624291 (PMID:14675537) RGD PMID:14675537 aggresome assembly ISO RGD:1552302 1624291 MGI:MGI:99919 (MGI:MGI:3653156 , PMID:16810319) RGD MGI:MGI:3653156 , PMID:16810319 axonal transport of mitochondrion IMP 9681555 RGD cellular response to hydrogen peroxide ISO RGD:1351463 1624291 (PMID:18606987) RGD PMID:18606987 cellular response to misfolded protein ISO RGD:1552302 1624291 MGI:MGI:3776868 (MGI:MGI:3757892 , PMID:17785525) RGD MGI:MGI:3757892 , PMID:17785525 cellular response to oxidative stress IEP 9681717 RGD cellular response to parathyroid hormone stimulus IEP 9681006 RGD cellular response to topologically incorrect protein ISO RGD:1351463 1624291 (PMID:16192271) RGD PMID:16192271 collateral sprouting ISO RGD:1552302 1624291 (MGI:MGI:5547631, PMID:24113571) RGD MGI:MGI:5547631 , PMID:24113571 dendritic spine morphogenesis ISO RGD:1552302 1624291 (MGI:MGI:5547631, PMID:24113571) RGD MGI:MGI:5547631 , PMID:24113571 histone deacetylation ISO RGD:1351463 1624291 (PMID:10220385) RGD PMID:10220385 Hsp90 deacetylation ISO RGD:1351463 1624291 (PMID:19158084) RGD PMID:19158084 Hsp90 deacetylation ISO RGD:1552302 1624291 MGI:MGI:3776868 (MGI:MGI:3757892 , PMID:17785525) RGD MGI:MGI:3757892 , PMID:17785525 intracellular protein transport ISO RGD:1351463 1624291 (PMID:16192271) RGD PMID:16192271 lysosome localization ISO RGD:1351463 1624291 (PMID:16192271) RGD PMID:16192271 mitochondrion localization ISO RGD:1552302 1624291 (MGI:MGI:5616310, PMID:20457763) RGD MGI:MGI:5616310 , PMID:20457763 myotube differentiation ISO RGD:1552302 1624291 (MGI:MGI:5315068, PMID:22174839) RGD MGI:MGI:5315068 , PMID:22174839 negative regulation of axon extension involved in axon guidance IMP 9681717 RGD negative regulation of microtubule depolymerization ISO RGD:1552302 1624291 (MGI:MGI:2447264, PMID:12486003) RGD MGI:MGI:2447264 , PMID:12486003 negative regulation of neuron projection development IMP 9681717 RGD negative regulation of protein acetylation IMP 9681552 RGD negative regulation of protein-containing complex assembly ISO RGD:1351463 1624291 (PMID:23962722) RGD PMID:23962722 negative regulation of protein-containing complex disassembly ISO RGD:1351463 1624291 (PMID:15916966) RGD PMID:15916966 negative regulation of proteolysis ISO RGD:1351463 1624291 (PMID:18356165) RGD PMID:18356165 neuron differentiation IEP 704464 RGD parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization ISO RGD:1351463 1624291 UniProtKB:Q9JK66 , UniProtKB:Q9Z2V5 (PMID:20457763) RGD PMID:20457763 peptidyl-lysine deacetylation ISO RGD:1351463 1624291 (PMID:18356165), (PMID:18606987), (PMID:23962722) RGD PMID:18356165 more ... peptidyl-lysine deacetylation ISO RGD:1552302 1624291 (MGI:MGI:6114855, PMID:23962722) RGD MGI:MGI:6114855 , PMID:23962722 polyamine deacetylation NOT ISO RGD:1351463 1624291 (PMID:28516954) RGD PMID:28516954 polyubiquitinated misfolded protein transport ISO RGD:1351463 1624291 (PMID:14675537) RGD PMID:14675537 positive regulation of chaperone-mediated protein complex assembly ISO RGD:1351463 1624291 (PMID:19158084) RGD PMID:19158084 positive regulation of cholangiocyte proliferation IMP 9681551 RGD positive regulation of dendrite morphogenesis IMP 2306262 RGD positive regulation of epithelial cell migration ISO RGD:1351463 1624291 (PMID:12024216) RGD PMID:12024216 positive regulation of hydrogen peroxide-mediated programmed cell death ISO RGD:1351463 1624291 (PMID:18606987) RGD PMID:18606987 positive regulation of mitophagy in response to mitochondrial depolarization ISO RGD:1552302 1624291 UniProtKB:Q9JK66 (MGI:MGI:5616310 , PMID:20457763) RGD MGI:MGI:5616310 , PMID:20457763 positive regulation of oxidative stress-induced neuron death IMP 9681717 RGD positive regulation of peptidyl-serine phosphorylation ISO RGD:1351463 1624291 (PMID:23962722) RGD PMID:23962722 positive regulation of peptidyl-serine phosphorylation ISO RGD:1552302 1624291 (MGI:MGI:6114855, PMID:23962722) RGD MGI:MGI:6114855 , PMID:23962722 positive regulation of receptor biosynthetic process ISO RGD:1351463 1624291 (PMID:15916966), (PMID:18316616) RGD PMID:15916966 , PMID:18316616 positive regulation of signal transduction ISO RGD:1351463 1624291 (PMID:19158084) RGD PMID:19158084 positive regulation of synaptic transmission, glutamatergic IMP 9681553 RGD positive regulation of tubulin deacetylation IMP 9681552 RGD protein deacetylation ISO RGD:1552302 1624291 (MGI:MGI:2447264, PMID:12486003) RGD MGI:MGI:2447264 , PMID:12486003 protein deacetylation ISO RGD:1351463 1624291 (PMID:15916966), (PMID:28516954) RGD PMID:15916966 , PMID:28516954 protein polyubiquitination ISO RGD:1552302 1624291 (MGI:MGI:2153694, PMID:11689694) RGD MGI:MGI:2153694 , PMID:11689694 protein quality control for misfolded or incompletely synthesized proteins ISO RGD:1351463 1624291 (PMID:14675537) RGD PMID:14675537 protein-containing complex disassembly ISO RGD:1552302 1624291 MGI:MGI:96238 more ... RGD MGI:MGI:3757892 , PMID:17785525 regulation of establishment of protein localization ISO RGD:1552302 1624291 (MGI:MGI:5446594, PMID:22792322) RGD MGI:MGI:5446594 , PMID:22792322 regulation of fat cell differentiation ISO RGD:1552302 1624291 (MGI:MGI:5470016, PMID:23126280) RGD MGI:MGI:5470016 , PMID:23126280 regulation of gene expression, epigenetic ISO RGD:1351463 1624291 (PMID:24413532) RGD PMID:24413532 regulation of macroautophagy ISO RGD:1351463 1624291 (PMID:16192271) RGD PMID:16192271 regulation of microtubule cytoskeleton organization IMP 9681552 RGD regulation of mitochondrion organization IMP 9681555 RGD regulation of protein phosphorylation IMP 9681552 RGD regulation of protein stability ISO RGD:1351463 1624291 (PMID:23580651) RGD PMID:23580651 regulation of signaling receptor activity ISO RGD:1351463 1624291 (PMID:19158084) RGD PMID:19158084 response to amphetamine IEP 9681719 RGD response to corticosterone IMP 9681553 RGD response to dexamethasone IEP 7364733 RGD response to growth factor ISO RGD:1351463 1624291 (PMID:18356165) RGD PMID:18356165 response to immobilization stress IEP 6902920 RGD response to misfolded protein ISO RGD:1351463 1624291 (PMID:14675537) RGD PMID:14675537 response to organic substance ISO RGD:1351463 1624291 (PMID:19158084) RGD PMID:19158084 response to toxic substance ISO RGD:1351463 1624291 (PMID:19158084) RGD PMID:19158084 skeletal muscle tissue development ISO RGD:1552302 1624291 (MGI:MGI:5315068, PMID:22174839) RGD MGI:MGI:5315068 , PMID:22174839 spermidine deacetylation NOT ISO RGD:1351463 1624291 (PMID:28516954) RGD PMID:28516954 tubulin deacetylation ISO RGD:1552302 1624291 MGI:MGI:3776868 (MGI:MGI:2651953 more ... RGD MGI:MGI:2651953 more ... tubulin deacetylation ISO RGD:1351463 1624291 (PMID:19228685), (PMID:20308065), (PMID:23093407) RGD PMID:19228685 more ... tubulin deacetylation ISO RGD:1351463 1624291 (PMID:19228685) RGD PMID:19228685 ubiquitin-dependent protein catabolic process ISO RGD:1552302 1624291 MGI:MGI:3776868 more ... RGD MGI:MGI:3653156 , PMID:16810319 ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway ISO RGD:1552302 1624291 MGI:MGI:3776868 (MGI:MGI:3757892 , PMID:17785525) RGD MGI:MGI:3757892 , PMID:17785525 Cellular Component aggresome ISO RGD:1351463 1624291 (PMID:14675537) RGD PMID:14675537 axon IDA 9681555 RGD axon ISO RGD:1552302 1624291 (MGI:MGI:5567913, PMID:16933150) RGD MGI:MGI:5567913 , PMID:16933150 axon cytoplasm IEA GO:0019896 1600115 GO_REF:0000108 GOC GO_REF:0000108 caveola ISO RGD:1351463 1624291 (PMID:18356165) RGD PMID:18356165 cell body ISO RGD:1552302 1624291 (MGI:MGI:5547631, PMID:24113571) RGD MGI:MGI:5547631 , PMID:24113571 cell leading edge ISO RGD:1351463 1624291 (PMID:12024216) RGD PMID:12024216 centrosome IDA 2306262 RGD cytoplasm ISO RGD:1351463 1624291 (PMID:24687993) RGD PMID:24687993 cytoplasm ISO RGD:1552302 1624291 (MGI:MGI:2153694, PMID:11689694) RGD MGI:MGI:2153694 , PMID:11689694 cytoplasmic microtubule colocalizes_with ISO RGD:1552302 1624291 (MGI:MGI:2651953, PMID:12606581) RGD MGI:MGI:2651953 , PMID:12606581 cytosol ISO RGD:1552302 1624291 (MGI:MGI:4820954, PMID:19893491) RGD MGI:MGI:4820954 , PMID:19893491 dendrite ISO RGD:1552302 1624291 (MGI:MGI:5567913, PMID:16933150) RGD MGI:MGI:5567913 , PMID:16933150 dynein complex colocalizes_with ISO RGD:1351463 1624291 (PMID:14675537) RGD PMID:14675537 histone deacetylase complex ISO RGD:1351463 1624291 (PMID:11948178) RGD PMID:11948178 inclusion body ISO RGD:1351463 1624291 (PMID:16192271) RGD PMID:16192271 microtubule ISO RGD:1351463 1624291 (PMID:12620231) RGD PMID:12620231 microtubule associated complex ISO RGD:1351463 1624291 (PMID:19228685) RGD PMID:19228685 neuron projection ISO RGD:1552302 1624291 (MGI:MGI:5547631, PMID:24113571) RGD MGI:MGI:5547631 , PMID:24113571 nucleoplasm ISO RGD:1351463 1624291 RGD GO_REF:0000052 nucleus ISO RGD:1552302 1624291 (MGI:MGI:4820954, PMID:19893491) RGD MGI:MGI:4820954 , PMID:19893491 perikaryon ISO RGD:1552302 1624291 (MGI:MGI:5567913, PMID:16933150) RGD MGI:MGI:5567913 , PMID:16933150 perinuclear region of cytoplasm ISO RGD:1351463 1624291 (PMID:12024216) RGD PMID:12024216 protein-containing complex ISO RGD:1552302 1624291 UniProtKB:P38532 more ... RGD MGI:MGI:3757892 , PMID:17785525 Molecular Function acetylspermidine deacetylase activity NOT ISO RGD:1351463 1624291 (PMID:28516954) RGD PMID:28516954 alpha-tubulin binding ISO RGD:1351463 1624291 (PMID:19228685) RGD PMID:19228685 alpha-tubulin binding ISO RGD:1552302 1624291 (MGI:MGI:5315068, PMID:22174839) RGD MGI:MGI:5315068 , PMID:22174839 beta-catenin binding ISO RGD:1351463 1624291 UniProtKB:P35222 (PMID:18356165) RGD PMID:18356165 beta-tubulin binding ISO RGD:1552302 1624291 (MGI:MGI:2651953, PMID:12606581) RGD MGI:MGI:2651953 , PMID:12606581 deacetylase activity IDA 9681716 RGD dynein complex binding ISO RGD:1351463 1624291 (PMID:14675537) RGD PMID:14675537 histone deacetylase activity ISO RGD:1351463 1624291 (PMID:10220385), (PMID:23322205) RGD PMID:10220385 , PMID:23322205 histone deacetylase activity ISO RGD:1552302 1624291 (MGI:MGI:1328628 more ... RGD MGI:MGI:1328628 more ... histone deacetylase binding ISO RGD:1351463 1624291 UniProtKB:Q8IXJ6 (PMID:12620231) RGD PMID:12620231 Hsp90 protein binding ISO RGD:1351463 1624291 (PMID:15916966) RGD PMID:15916966 microtubule binding ISO RGD:1552302 1624291 (MGI:MGI:4820954, PMID:19893491) RGD MGI:MGI:4820954 , PMID:19893491 microtubule binding ISO RGD:1351463 1624291 (PMID:19228685) RGD PMID:19228685 misfolded protein binding ISO RGD:1351463 1624291 (PMID:17785525) RGD PMID:17785525 polyubiquitin modification-dependent protein binding ISO RGD:1351463 1624291 (PMID:14675537) RGD PMID:14675537 protein binding IPI RGD:620477 2306262 RGD protein binding ISO RGD:1552302 1624291 UniProtKB:O55131 more ... RGD MGI:MGI:2153694 more ... protein binding ISO RGD:1351463 1624291 UniProtKB:A8MTZ0 more ... RGD PMID:16919237 more ... protein binding ISO RGD:1351463 1624291 UniProtKB:A8MTZ0 more ... RGD PMID:16919237 more ... protein deacetylase activity ISO RGD:1351463 1624291 (PMID:28516954) RGD PMID:28516954 RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO RGD:1351463 1624291 (PMID:24413532) RGD PMID:24413532 tau protein binding ISO RGD:1351463 1624291 (PMID:18636984) RGD PMID:18636984 tau protein binding ISO RGD:1552302 1624291 UniProtKB:P10637 (MGI:MGI:6119868 , PMID:19457097) RGD MGI:MGI:6119868 , PMID:19457097 tubulin deacetylase activity ISO RGD:1351463 1624291 (PMID:12620231), (PMID:19228685), (PMID:19457097) RGD PMID:12620231 more ... tubulin deacetylase activity ISO RGD:1552302 1624291 UniProtKB:Q5EG47 more ... RGD MGI:MGI:2651953 more ... tubulin deacetylase activity ISO RGD:1351463 1624291 (PMID:12620231), (PMID:19228685), (PMID:19457097), (PMID:20308065) RGD PMID:12620231 more ... ubiquitin binding ISO RGD:1552302 1624291 (MGI:MGI:3653156, PMID:16810319) RGD MGI:MGI:3653156 , PMID:16810319 ubiquitin protein ligase binding ISO RGD:1351463 1624291 UniProtKB:O60260 (PMID:21753002) RGD PMID:21753002 zinc ion binding IEA InterPro:IPR001607 1600115 GO_REF:0000002 InterPro GO_REF:0000002
Gene-Chemical Interaction Annotations
