Slc7a3 (solute carrier family 7 member 3) - Rat Genome Database

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Gene: Slc7a3 (solute carrier family 7 member 3) Rattus norvegicus
Analyze
Symbol: Slc7a3
Name: solute carrier family 7 member 3
RGD ID: 68342
Description: Enables L-arginine transmembrane transporter activity; L-lysine transmembrane transporter activity; and L-ornithine transmembrane transporter activity. Involved in amino acid transport and regulation of TOR signaling. Predicted to be active in plasma membrane. Orthologous to human SLC7A3 (solute carrier family 7 member 3); INTERACTS WITH 1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane; 17beta-estradiol 3-benzoate; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: amino acid transporter cationic 3; amino acid transporter, cationic 3; Atrc3; cat-3; Cat3; cationic amino acid transporter 3; cationic amino acid transporter y+; Slc7a2; solute carrier family 7 (cationic amino acid transporter y+ system) member 3; solute carrier family 7 (cationic amino acid transporter, y+ system), member 3; solute carrier family 7, member 3
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X70,250,089 - 70,256,610 (-)NCBIGRCr8
mRatBN7.2X66,210,071 - 66,216,482 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX66,210,081 - 66,215,708 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX67,693,428 - 67,698,141 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X71,193,823 - 71,198,536 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X68,754,728 - 68,759,443 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X70,972,767 - 70,979,466 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX70,972,765 - 70,978,952 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X71,824,798 - 71,831,477 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X89,159,603 - 89,164,314 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1X89,233,045 - 89,237,747 (-)NCBI
CeleraX66,566,815 - 66,571,524 (-)NCBICelera
Cytogenetic MapXq22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
plasma membrane  (IBA,IEA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Cloning and characterization of a brain-specific cationic amino acid transporter. Hosokawa H, etal., J Biol Chem 1997 Mar 28;272(13):8717-22.
3. The cationic amino acid transporters CAT1 and CAT3 mediate NMDA receptor activation-dependent changes in elaboration of neuronal processes via the mammalian target of rapamycin mTOR pathway. Huang Y, etal., J Neurosci. 2007 Jan 17;27(3):449-58.
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
6. GOA pipeline RGD automated data pipeline
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
8. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
Additional References at PubMed
PMID:9334265  


Genomics

Comparative Map Data
Slc7a3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X70,250,089 - 70,256,610 (-)NCBIGRCr8
mRatBN7.2X66,210,071 - 66,216,482 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX66,210,081 - 66,215,708 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX67,693,428 - 67,698,141 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X71,193,823 - 71,198,536 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X68,754,728 - 68,759,443 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X70,972,767 - 70,979,466 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX70,972,765 - 70,978,952 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X71,824,798 - 71,831,477 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X89,159,603 - 89,164,314 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1X89,233,045 - 89,237,747 (-)NCBI
CeleraX66,566,815 - 66,571,524 (-)NCBICelera
Cytogenetic MapXq22NCBI
SLC7A3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X70,925,579 - 70,931,096 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX70,925,579 - 70,931,125 (-)EnsemblGRCh38hg38GRCh38
GRCh37X70,145,429 - 70,150,946 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X70,062,154 - 70,067,684 (-)NCBINCBI36Build 36hg18NCBI36
Build 34X69,928,452 - 69,933,951NCBI
CeleraX70,499,018 - 70,504,564 (-)NCBICelera
Cytogenetic MapXq13.1NCBI
HuRefX63,965,473 - 63,969,918 (-)NCBIHuRef
CHM1_1X70,036,878 - 70,042,423 (-)NCBICHM1_1
T2T-CHM13v2.0X69,359,629 - 69,365,145 (-)NCBIT2T-CHM13v2.0
Slc7a3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X100,122,752 - 100,134,058 (-)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX100,122,816 - 100,129,626 (-)EnsemblGRCm39 Ensembl
GRCm38X101,079,146 - 101,090,452 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX101,079,210 - 101,086,020 (-)EnsemblGRCm38mm10GRCm38
MGSCv37X98,274,560 - 98,280,691 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X97,281,940 - 97,288,071 (-)NCBIMGSCv36mm8
CeleraX87,997,561 - 88,004,049 (-)NCBICelera
Cytogenetic MapXC3- DNCBI
cM MapX43.72NCBI
Slc7a3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495547510,457,787 - 10,464,514 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495547510,457,859 - 10,463,828 (-)NCBIChiLan1.0ChiLan1.0
SLC7A3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X70,603,135 - 70,608,707 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X70,606,738 - 70,612,310 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X60,193,997 - 60,199,564 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X70,253,432 - 70,258,991 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX70,253,441 - 70,258,991 (-)Ensemblpanpan1.1panPan2
SLC7A3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X55,282,474 - 55,289,513 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX46,109,853 - 46,233,444 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0X56,251,502 - 56,375,048 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1X54,219,879 - 54,343,367 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X55,551,479 - 55,674,950 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X55,478,334 - 55,601,870 (-)NCBIUU_Cfam_GSD_1.0
Slc7a3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X46,899,348 - 46,905,103 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936762661,491 - 667,298 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936762661,532 - 667,277 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SLC7A3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX56,937,086 - 56,942,357 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X56,937,081 - 56,942,331 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X64,467,441 - 64,473,169 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SLC7A3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X60,714,846 - 60,721,813 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 EnsemblX60,714,896 - 60,719,594 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660652,576,649 - 2,582,634 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Slc7a3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046249031,100,424 - 1,107,087 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046249031,100,518 - 1,106,993 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Slc7a3
4 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:41
Count of miRNA genes:39
Interacting mature miRNAs:40
Transcripts:ENSRNOT00000005580
Prediction methods:Miranda, Pita, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61430Cia18Collagen induced arthritis QTL 183.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)X14843113120568734Rat
1598837Memor13Memory QTL 133.2exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)X41052407146860749Rat
738035Stresp1Stress response QTL 14.960.000011stress-related behavior trait (VT:0010451)defensive burying - copingX41304447112935181Rat
61431Cia19Collagen induced arthritis QTL 194.4joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)X65612192120568734Rat

Markers in Region
U70859  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X66,210,102 - 66,210,243 (+)MAPPERmRatBN7.2
Rnor_6.0X70,972,799 - 70,972,939NCBIRnor6.0
Rnor_5.0X71,824,830 - 71,824,970UniSTSRnor5.0
RGSC_v3.4X89,159,635 - 89,159,775UniSTSRGSC3.4
CeleraX66,566,847 - 66,566,987UniSTS
Cytogenetic MapXq31UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 35
Low 3 20 12 4 18 4 39 17 28 5
Below cutoff 22 20 12 1 12 8 11 13 13 6 8

Sequence


RefSeq Acc Id: ENSRNOT00000076336   ⟹   ENSRNOP00000068115
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX66,210,081 - 66,215,708 (-)Ensembl
Rnor_6.0 EnsemblX70,972,779 - 70,978,714 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000076378
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 EnsemblX70,972,765 - 70,978,750 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000076910   ⟹   ENSRNOP00000068222
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 EnsemblX70,972,767 - 70,978,952 (-)Ensembl
RefSeq Acc Id: NM_017217   ⟹   NP_058913
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X70,250,089 - 70,254,800 (-)NCBI
mRatBN7.2X66,210,071 - 66,214,782 (-)NCBI
Rnor_6.0X70,972,767 - 70,977,628 (-)NCBI
Rnor_5.0X71,824,798 - 71,831,477 (-)NCBI
RGSC_v3.4X89,159,603 - 89,164,314 (-)RGD
CeleraX66,566,815 - 66,571,524 (-)RGD
Sequence:
RefSeq Acc Id: XM_006257059   ⟹   XP_006257121
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X70,250,089 - 70,256,610 (-)NCBI
mRatBN7.2X66,210,071 - 66,216,482 (-)NCBI
Rnor_6.0X70,972,767 - 70,979,466 (-)NCBI
Rnor_5.0X71,824,798 - 71,831,477 (-)NCBI
Sequence:
RefSeq Acc Id: XM_063279852   ⟹   XP_063135922
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X70,250,089 - 70,255,740 (-)NCBI
RefSeq Acc Id: NP_058913   ⟸   NM_017217
- UniProtKB: O08812 (UniProtKB/Swiss-Prot),   G3V6I8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006257121   ⟸   XM_006257059
- Peptide Label: isoform X1
- UniProtKB: A6IQ96 (UniProtKB/TrEMBL),   G3V6I8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000068222   ⟸   ENSRNOT00000076910
RefSeq Acc Id: ENSRNOP00000068115   ⟸   ENSRNOT00000076336
RefSeq Acc Id: XP_063135922   ⟸   XM_063279852
- Peptide Label: isoform X1
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O08812-F1-model_v2 AlphaFold O08812 1-619 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701874
Promoter ID:EPDNEW_R12393
Type:single initiation site
Name:Slc7a3_1
Description:solute carrier family 7 member 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0X70,978,757 - 70,978,817EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:68342 AgrOrtholog
BioCyc Gene G2FUF-2113 BioCyc
Ensembl Genes ENSRNOG00000004133 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000076336 ENTREZGENE
  ENSRNOT00000076336.2 UniProtKB/TrEMBL
Gene3D-CATH Amino acid/polyamine transporter I UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro AA/rel_permease1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cat_AA_permease UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CAT_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:29485 UniProtKB/Swiss-Prot
NCBI Gene Slc7a3 ENTREZGENE
PANTHER INNER MEMBRANE TRANSPORTER YGJI-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR43243:SF20 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam AA_permease_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  AA_permease_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Slc7a3 PhenoGen
PIRSF AA_transporter UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000004133 RatGTEx
TIGR TC222614
UniProt A6IQ96 ENTREZGENE, UniProtKB/TrEMBL
  A6IQ97_RAT UniProtKB/TrEMBL
  CTR3_RAT UniProtKB/Swiss-Prot
  G3V6I8 ENTREZGENE, UniProtKB/TrEMBL
  O08812 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-09 Slc7a3  solute carrier family 7 member 3  Slc7a3  solute carrier family 7 (cationic amino acid transporter, y+ system), member 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Slc7a3  solute carrier family 7 (cationic amino acid transporter, y+ system), member 3    solute carrier family 7, member 3  Name updated 1299863 APPROVED
2002-06-10 Slc7a3  solute carrier family 7, member 3      Name updated 70584 APPROVED
2002-02-27 Slc7a3  solute carrier family 7 (cationic amino acid transporter, y+ system), member 3      Symbol and Name updated to reflect Human and Mouse nomenclature 70292 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression mRNA is expressed specifically in brain 68219