RGD Reference Report - The cationic amino acid transporters CAT1 and CAT3 mediate NMDA receptor activation-dependent changes in elaboration of neuronal processes via the mammalian target of rapamycin mTOR pathway. - Rat Genome Database

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The cationic amino acid transporters CAT1 and CAT3 mediate NMDA receptor activation-dependent changes in elaboration of neuronal processes via the mammalian target of rapamycin mTOR pathway.

Authors: Huang, Y  Kang, BN  Tian, J  Liu, Y  Luo, HR  Hester, L  Snyder, SH 
Citation: Huang Y, etal., J Neurosci. 2007 Jan 17;27(3):449-58.
RGD ID: 1642930
Pubmed: (View Article at PubMed) PMID:17234578
DOI: Full-text: DOI:10.1523/JNEUROSCI.4489-06.2007

Neuronal activity influences protein synthesis and neuronal growth. Availability of nutrients, especially leucine and arginine, regulates the mammalian target of rapamycin (mTOR) pathway that controls cell growth. We show that NMDA receptor activation markedly reduces arginine transport by decreasing surface expression of the cationic amino acid transporters (CAT) 1 and 3. Depletion of CAT1 and CAT3 by RNA interference blocks influences of NMDA receptor activation on the mTOR pathway and neuronal process formation. Thus, the CATs mediate influences of NMDA receptor activation on the mTOR pathway that regulates neuronal processes.

Annotation

Gene Ontology Annotations    

Biological Process

Cellular Component

Molecular Function

Objects Annotated

Genes (Rattus norvegicus)
Slc7a1  (solute carrier family 7 member 1)
Slc7a3  (solute carrier family 7 member 3)


Additional Information