Mbl1 (mannose binding lectin 1) - Rat Genome Database

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Gene: Mbl1 (mannose binding lectin 1) Rattus norvegicus
Analyze
Symbol: Mbl1
Name: mannose binding lectin 1
RGD ID: 3055
Description: Exhibits several functions, including calcium-dependent carbohydrate binding activity; mannose binding activity; and phosphatidylinositol-4-phosphate binding activity. Involved in complement activation, lectin pathway and protein homotrimerization. Localizes to extracellular space. Orthologous to human MBL1P (mannose binding lectin 1, pseudogene); PARTICIPATES IN coagulation cascade pathway; complement system pathway; phagocytosis pathway; INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: mannan-binding protein; mannose binding lectin (A); mannose binding lectin 1, protein A; mannose binding lectin 2, protein C; Mannose binding protein A serum; Mannose binding protein A, serum; mannose-binding lectin (protein A) 1; mannose-binding protein A; MBP-A; Mbpa; Mlb1
RGD Orthologs
Human
Mouse
Alliance Genes
More Info more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21617,029,146 - 17,035,187 (+)NCBI
Rnor_6.0 Ensembl1618,736,154 - 18,742,193 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01618,736,154 - 18,742,193 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01618,604,750 - 18,610,789 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41617,591,820 - 17,597,859 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11617,591,817 - 17,597,857 (+)NCBI
Celera1617,254,917 - 17,260,956 (+)NCBICelera
RH 3.4 Map16167.5RGD
Cytogenetic Map16p14NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
1. Clemons KV, etal., Immunol Lett. 2010 Feb 16;128(2):105-7. doi: 10.1016/j.imlet.2009.12.021. Epub 2010 Jan 12.
2. de Vries B, etal., Am J Pathol. 2004 Nov;165(5):1677-88.
3. Drickamer K and McCreary V, J Biol Chem 1987 Feb 25;262(6):2582-9.
4. Drickamer K, etal., J Biol Chem 1986 May 25;261(15):6878-87.
5. Fernandez-Real JM, etal., Diabetologia. 2006 Oct;49(10):2402-11. Epub 2006 Aug 29.
6. Gadjeva M, etal., Clin Exp Immunol. 2004 Nov;138(2):304-11.
7. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
8. Heise CT, etal., J Immunol. 2000 Aug 1;165(3):1403-9.
9. Jordan JE, etal., Circulation. 2001 Sep 18;104(12):1413-8.
10. Kuroki Y, etal., FEBS Lett. 1997 Sep 8;414(2):387-92.
11. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
12. La Bonte LR, etal., Diab Vasc Dis Res. 2009 Jul;6(3):172-80.
13. MGD data from the GO Consortium
14. Miller A, etal., J Biol Chem. 2012 Feb 3;287(6):3930-45. doi: 10.1074/jbc.M111.320341. Epub 2011 Dec 13.
15. Nakamura A, etal., Clin Immunol. 2014 Jul;153(1):64-72. doi: 10.1016/j.clim.2014.03.019. Epub 2014 Apr 8.
16. NCBI rat LocusLink and RefSeq merged data July 26, 2002
17. Ng KK, etal., J Biol Chem. 1996 Jan 12;271(2):663-74.
18. Ng KK, etal., J Biol Chem. 2002 May 3;277(18):16088-95. doi: 10.1074/jbc.M200493200. Epub 2002 Feb 15.
19. Pipeline to import KEGG annotations from KEGG into RGD
20. RGD automated data pipeline
21. RGD automated import pipeline for gene-chemical interactions
22. Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
23. Venkatraman Girija U, etal., J Biol Chem. 2010 Apr 2;285(14):10546-52. doi: 10.1074/jbc.M109.097493. Epub 2010 Jan 29.
24. Wallis R and Dodd RB, J Biol Chem 2000 Oct 6;275(40):30962-9.
25. Wallis R J Immunol 2002 May 1;168(9):4553-8.
26. Wallis R, etal., J Immunol. 2005 Nov 15;175(10):6846-51.
27. Walsh MC, etal., J Immunol. 2005 Jul 1;175(1):541-6.
28. Zhang M, etal., J Immunol. 2006 Oct 1;177(7):4727-34.
Additional References at PubMed
PMID:1436090   PMID:1721241   PMID:3584121   PMID:7704532   PMID:9922165   PMID:12477932   PMID:14724269   PMID:15060079   PMID:15148336   PMID:15489334   PMID:21866632   PMID:22879370  


Genomics

Comparative Map Data
Mbl1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21617,029,146 - 17,035,187 (+)NCBI
Rnor_6.0 Ensembl1618,736,154 - 18,742,193 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01618,736,154 - 18,742,193 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01618,604,750 - 18,610,789 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41617,591,820 - 17,597,859 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11617,591,817 - 17,597,857 (+)NCBI
Celera1617,254,917 - 17,260,956 (+)NCBICelera
RH 3.4 Map16167.5RGD
Cytogenetic Map16p14NCBI
MBL1P
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1079,920,178 - 79,923,119 (+)EnsemblGRCh38hg38GRCh38
GRCh381079,920,178 - 79,923,119 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371081,679,934 - 81,682,875 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361081,669,914 - 81,672,855 (+)NCBINCBI36hg18NCBI36
Build 341081,669,913 - 81,672,855NCBI
Celera1075,670,857 - 75,673,805 (+)NCBI
Cytogenetic Map10q22.3NCBI
HuRef1075,522,689 - 75,525,630 (+)NCBIHuRef
CHM1_11081,962,581 - 81,965,522 (+)NCBICHM1_1
Mbl1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391440,873,413 - 40,885,861 (+)NCBIGRCm39mm39
GRCm39 Ensembl1440,873,415 - 40,881,558 (+)Ensembl
GRCm381441,151,456 - 41,163,904 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1441,151,458 - 41,159,601 (+)EnsemblGRCm38mm10GRCm38
MGSCv371441,964,745 - 41,972,248 (+)NCBIGRCm37mm9NCBIm37
MGSCv361440,060,169 - 40,067,672 (+)NCBImm8
Celera1437,311,454 - 37,318,966 (+)NCBICelera
Cytogenetic Map14BNCBI
cM Map1422.36NCBI

Position Markers
D16Wox9  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21617,033,876 - 17,034,023 (+)MAPPER
Rnor_6.01618,740,885 - 18,741,029NCBIRnor6.0
Rnor_5.01618,609,481 - 18,609,625UniSTSRnor5.0
RGSC_v3.41617,596,550 - 17,596,695RGDRGSC3.4
RGSC_v3.41617,596,551 - 17,596,695UniSTSRGSC3.4
RGSC_v3.11617,596,548 - 17,596,693RGD
Celera1617,259,648 - 17,259,792UniSTS
Cytogenetic Map16p14UniSTS
D6Mit11  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21617,033,869 - 17,034,109 (+)MAPPER
Rnor_6.01618,740,878 - 18,741,115NCBIRnor6.0
Rnor_5.01618,609,474 - 18,609,711UniSTSRnor5.0
RGSC_v3.41617,596,543 - 17,596,781RGDRGSC3.4
RGSC_v3.41617,596,544 - 17,596,781UniSTSRGSC3.4
RGSC_v3.11617,596,541 - 17,596,779RGD
Celera1617,259,641 - 17,259,878UniSTS
RH 3.4 Map16171.9RGD
RH 3.4 Map16171.9UniSTS
Cytogenetic Map16p14UniSTS
D16Arb5  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21617,033,783 - 17,034,077 (+)MAPPER
Rnor_6.01618,740,792 - 18,741,083NCBIRnor6.0
Rnor_5.01618,609,388 - 18,609,679UniSTSRnor5.0
RGSC_v3.41617,596,457 - 17,596,749RGDRGSC3.4
RGSC_v3.41617,596,458 - 17,596,749UniSTSRGSC3.4
RGSC_v3.11617,596,455 - 17,596,747RGD
Celera1617,259,555 - 17,259,846UniSTS
SHRSP x BN Map165.64UniSTS
SHRSP x BN Map165.64RGD
FHH x ACI Map1612.1799RGD
Cytogenetic Map16p14UniSTS
RH94874  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21617,034,959 - 17,035,087 (+)MAPPER
Rnor_6.01618,741,966 - 18,742,093NCBIRnor6.0
Rnor_5.01618,610,562 - 18,610,689UniSTSRnor5.0
RGSC_v3.41617,597,632 - 17,597,759UniSTSRGSC3.4
Celera1617,260,729 - 17,260,856UniSTS
RH 3.4 Map16167.5UniSTS
Cytogenetic Map16p14UniSTS
BI289113  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21617,034,959 - 17,035,174 (+)MAPPER
Rnor_6.01618,741,966 - 18,742,180NCBIRnor6.0
Rnor_5.01618,610,562 - 18,610,776UniSTSRnor5.0
RGSC_v3.41617,597,632 - 17,597,846UniSTSRGSC3.4
Celera1617,260,729 - 17,260,943UniSTS
RH 3.4 Map16166.71UniSTS
Cytogenetic Map16p14UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1600369Hcas8Hepatocarcinoma susceptibility QTL 8liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)16124228366Rat
631830Alc7Alcohol consumption QTL 72.9consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)16127556253Rat
634355Rends4Renal damage susceptibility QTL 40.05kidney blood vessel morphology trait (VT:0000530)organ lesion measurement (CMO:0000677)16127556253Rat
1582235Insul8Insulin level QTL 83.30.0063blood insulin amount (VT:0001560)calculated serum insulin level (CMO:0000359)16127556253Rat
9590151Scort8Serum corticosterone level QTL 88.450.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)16131816439Rat
2302380Slep6Serum leptin concentration QTL 63.36blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)16133160624Rat
2307172Activ4Activity QTL 43.710.00023locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)16134465490Rat
1354584Despr6Despair related QTL 63.10.0067locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)16141240937Rat
2303566Bw90Body weight QTL 902body mass (VT:0001259)body weight (CMO:0000012)16141240937Rat
631561Hcuc2Hepatic copper content QTL 22.8hepatic copper amount (VT:0003065)liver total copper weight (CMO:0001507)16141240957Rat
6903319Bw114Body weight QTL 1142.70.0037body mass (VT:0001259)body weight (CMO:0000012)1624459345244593Rat
1600378Arunc4Aerobic running capacity QTL 40.03exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)16109005486162972Rat
7411664Foco30Food consumption QTL 30110.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)16134074146340741Rat
2293343Glom16Glomerulus QTL 167.4kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)16155018749247447Rat
2312660Bw95Body weight QTL 950.05inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)16155018763210301Rat
2312663Slep9Serum leptin concentration QTL 90.001blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)16155018763210301Rat
2312666Insul16Insulin level QTL 160.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)16155018763210301Rat
2312669Stl23Serum triglyceride level QTL 230.01blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)16155018763210301Rat
1354625Despr7Despair related QTL 73.160.016locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)16172829746728297Rat
1300133Rf24Renal function QTL 243.64blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)16413635523105837Rat
2306902Bp339Blood pressure QTL 3390.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16413635545905331Rat
70183BpQTLcluster13Blood pressure QTL cluster 133.654arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)16501380245905331Rat
70183BpQTLcluster13Blood pressure QTL cluster 133.654arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16501380245905331Rat
70183BpQTLcluster13Blood pressure QTL cluster 133.654arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)16501380245905331Rat
61338Bp23Blood pressure QTL 234.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16501380250013802Rat
737819Hcas4Hepatocarcinoma susceptibility QTL 44.43liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)16501380250169318Rat
61405Niddm6Non-insulin dependent diabetes mellitus QTL 63.660.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)16501380252144919Rat
737826Alc11Alcohol consumption QTL 113.2consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)16501380264012784Rat
61372Bp40Blood pressure QTL 402.2blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)16509870419398181Rat
631517Scl9Serum cholesterol level QTL 93.3blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)161730939622744540Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:426
Count of miRNA genes:149
Interacting mature miRNAs:163
Transcripts:ENSRNOT00000015723, ENSRNOT00000072985
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 37 37 37 4
Low 7 4 2 4 2 2 1 9 8 11 2
Below cutoff 6 12 16 3 3 24 8 10 3

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000015723   ⟹   ENSRNOP00000015723
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1618,736,154 - 18,742,193 (+)Ensembl
RefSeq Acc Id: NM_012599   ⟹   NP_036731
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21617,029,146 - 17,035,187 (+)NCBI
Rnor_6.01618,736,154 - 18,742,193 (+)NCBI
Rnor_5.01618,604,750 - 18,610,789 (+)NCBI
RGSC_v3.41617,591,820 - 17,597,859 (+)RGD
Celera1617,254,917 - 17,260,956 (+)RGD
Sequence:
RefSeq Acc Id: XM_039094193   ⟹   XP_038950121
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21617,031,627 - 17,035,185 (+)NCBI
Reference Sequences
RefSeq Acc Id: NP_036731   ⟸   NM_012599
- Peptide Label: precursor
- UniProtKB: P19999 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000015723   ⟸   ENSRNOT00000015723
RefSeq Acc Id: XP_038950121   ⟸   XM_039094193
- Peptide Label: isoform X1
Protein Domains
C-type lectin   Collagen-like

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699976
Promoter ID:EPDNEW_R10498
Type:initiation region
Name:Mbl1_1
Description:mannose-binding lectin 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01618,736,135 - 18,736,195EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3055 AgrOrtholog
Ensembl Genes ENSRNOG00000011706 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSRNOP00000015723 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000015723 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 3.10.100.10 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7326244 IMAGE-MGC_LOAD
InterPro C-type_lectin-like UniProtKB/Swiss-Prot
  C-type_lectin-like/link_sf UniProtKB/Swiss-Prot
  C-type_lectin_CS UniProtKB/Swiss-Prot
  Collagen UniProtKB/Swiss-Prot
  Collectin_CTLD UniProtKB/Swiss-Prot
  CTDL_fold UniProtKB/Swiss-Prot
  Mannose-binding_protein_A UniProtKB/Swiss-Prot
KEGG Report rno:24548 UniProtKB/Swiss-Prot
MGC_CLONE MGC:108743 IMAGE-MGC_LOAD
NCBI Gene 24548 ENTREZGENE
PANTHER PTHR24024:SF35 UniProtKB/Swiss-Prot
Pfam Collagen UniProtKB/Swiss-Prot
  Lectin_C UniProtKB/Swiss-Prot
PhenoGen Mbl1 PhenoGen
PROSITE C_TYPE_LECTIN_1 UniProtKB/Swiss-Prot
  C_TYPE_LECTIN_2 UniProtKB/Swiss-Prot
SMART CLECT UniProtKB/Swiss-Prot
Superfamily-SCOP SSF56436 UniProtKB/Swiss-Prot
TIGR TC234245
UniProt MBL1_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2020-08-13 Mbl1  mannose binding lectin 1  Mbl1  mannose-binding lectin (protein A) 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-11-11 Mbl1  mannose-binding lectin (protein A) 1  Mbl1  mannose binding lectin (A)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-15 Mbl1  mannose binding lectin (A)  Mbl1  mannose binding lectin 1, protein A  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-09-12 Mbl1  mannose binding lectin 1, protein A  Mlb1  mannose binding lectin 2, protein C  Symbol and Name updated 1299863 APPROVED
2003-04-09 Mlb1  mannose binding lectin 2, protein C  Mbpa  Mannose binding protein A, serum  Symbol and Name updated 629477 APPROVED
2002-06-10 Mbpa  Mannose binding protein A, serum      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_disease deficiency leads to increased susceptibility to infections 625609
gene_domains N-terminus collagenous and cystine rich domain disrupts the interactions with associated proteases 625609
gene_physical_interaction dimers bind with dimers of the serine proteases and the trimers and tetramers bind to multiple serine proteases 625609
gene_process involved in reducing susceptibility to infections caused by a wide range of pathogenic microorganisms 625609
gene_product member of the collecting family 625609
gene_product member of the collectin family 625609