Lpin1 (lipin 1) - Rat Genome Database

Name: Lpin1
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

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Gene: Lpin1 (lipin 1) Rattus norvegicus

Analyze

Symbol:

Lpin1

Name:

lipin 1

RGD ID:

1307646

Description:

Predicted to enable several functions, including histone deacetylase binding activity; peroxisome proliferator activated receptor binding activity; and phosphatidate phosphatase activity. Involved in several processes, including cellular response to insulin stimulus; negative regulation of myelination; and phosphatidic acid biosynthetic process. Predicted to be located in cytoplasm and nuclear membrane. Predicted to be part of transcription regulator complex. Predicted to be active in several cellular components, including cytosol; endoplasmic reticulum membrane; and mitochondrial outer membrane. Biomarker of end stage renal disease. Orthologous to human LPIN1 (lipin 1); PARTICIPATES IN mTOR signaling pathway; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

LOC313977; phosphatidate phosphatase LPIN1

RGD Orthologs

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	LPIN1 (lipin 1)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Lpin1 (lipin 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Lpin1 (lipin 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	LPIN1 (lipin 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	LPIN1 (lipin 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Lpin1 (lipin 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	LPIN1 (lipin 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	LPIN1 (lipin 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Lpin1 (lipin 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	ZNF667 (zinc finger protein 667)	HGNC	OMA
Alliance orthologs ³
Homo sapiens (human):	LPIN1 (lipin 1)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Lpin1 (lipin 1)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	lpin1 (lipin 1)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	PAH1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	Lpin	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	lpin-1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|PANTHER\|SonicParanoid)
Danio rerio (zebrafish):	lpin1b	Alliance	DIOPT (OrthoFinder\|PANTHER\|PhylomeDB)
Xenopus tropicalis (tropical clawed frog):	lpin1	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|PANTHER\|PhylomeDB)

Allele / Splice:

Lpin1^em1Mcwi Lpin1^m1Hubr

Genetic Models:

SS-Lpin1^em1Mcwi WI-Lpin1^m1Hubr

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	6	39,309,198 - 39,417,034 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	6	39,312,748 - 39,417,097 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	6	39,644,137 - 39,711,411 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	6	39,958,820 - 40,026,103 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	6	39,392,085 - 39,459,366 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	6	41,796,214 - 41,905,149 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	6	41,799,749 - 41,870,046 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	6	51,532,422 - 51,638,090 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	6	40,253,664 - 40,297,195 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	6	40,292,340 - 40,300,145 (-)	NCBI
Celera	6	38,623,057 - 38,690,436 (-)	NCBI		Celera
Cytogenetic Map	6	q16	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Acute Recurrent Myoglobinuria, Autosomal Recessive (ISO)

Cachexia (IEP)

end stage renal disease (IEP)

Experimental Diabetes Mellitus (IEP)

genetic disease (ISO)

Insulin Resistance (ISO)

lipodystrophy (ISS)

morbid obesity (ISO)

schizophrenia (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(-)-epigallocatechin 3-gallate (ISO)

(1->4)-beta-D-glucan (ISO)

(2,4,5-trichlorophenoxy)acetic acid (ISO)

1,2-dichloroethane (ISO)

1,2-dimethylhydrazine (ISO)

17beta-estradiol (EXP)

2,2',4,4',5,5'-hexachlorobiphenyl (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,4-dinitrotoluene (EXP)

2,6-dinitrotoluene (EXP)

2-amino-2-deoxy-D-glucopyranose (ISO)

3,3',4,4',5-pentachlorobiphenyl (EXP)

3,3',5,5'-tetrabromobisphenol A (ISO)

3,4-methylenedioxymethamphetamine (ISO)

3-chloropropane-1,2-diol (EXP)

3-isobutyl-1-methyl-7H-xanthine (ISO)

4,4'-diaminodiphenylmethane (ISO)

4,4'-sulfonyldiphenol (ISO)

4-hydroxynon-2-enal (ISO)

6-propyl-2-thiouracil (EXP)

aflatoxin B1 (ISO)

Aflatoxin B2 alpha (ISO)

aldehydo-D-glucosamine (ISO)

aldrin (ISO)

all-trans-retinoic acid (ISO)

amphetamine (EXP)

amphotericin B (ISO)

ampicillin (ISO)

avobenzone (ISO)

Azaspiracid (ISO)

baicalein (ISO)

Benoxacor (ISO)

benzo[a]pyrene (ISO)

benzo[b]fluoranthene (ISO)

beta-D-glucosamine (ISO)

beta-naphthoflavone (EXP)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP,ISO)

bromobenzene (EXP)

butan-1-ol (ISO)

Butylparaben (ISO)

cadmium atom (ISO)

cadmium dichloride (ISO)

caffeine (ISO)

cannabidiol (ISO)

captan (ISO)

carbon nanotube (ISO)

celastrol (ISO)

chloroprene (ISO)

chrysene (ISO)

ciguatoxin CTX1B (ISO)

cisplatin (ISO)

clofibrate (ISO)

cobalt dichloride (ISO)

copper atom (ISO)

copper(0) (ISO)

copper(II) sulfate (ISO)

crocidolite asbestos (ISO)

cyclosporin A (ISO)

decabromodiphenyl ether (EXP)

dexamethasone (ISO)

dibenz[a,h]anthracene (ISO)

dichloroacetic acid (ISO)

disodium selenite (ISO)

dorsomorphin (ISO)

elemental selenium (ISO)

endosulfan (EXP)

entinostat (ISO)

epoxiconazole (ISO)

Erionite (ISO)

erythromycin estolate (EXP)

ethanol (ISO)

farnesol (ISO)

fluoranthene (ISO)

flutamide (EXP)

furan (EXP)

gedunin (ISO)

gentamycin (EXP)

glyphosate (ISO)

GW 4064 (ISO)

indole-3-methanol (EXP)

inulin (ISO)

isobutanol (ISO)

isotretinoin (ISO)

leflunomide (EXP)

levofloxacin (EXP)

linoleic acid (ISO)

lipopolysaccharide (ISO)

manganese(II) chloride (EXP)

methimazole (EXP)

methotrexate (ISO)

metronidazole (ISO)

mitomycin C (ISO)

monocrotophos (EXP)

monosodium L-glutamate (ISO)

N-acetyl-L-cysteine (EXP)

N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal (ISO)

N-methyl-4-phenylpyridinium (EXP)

N-nitrosodiethylamine (EXP)

nefazodone (EXP)

neomycin (ISO)

nevirapine (EXP)

nitrofen (EXP)

obeticholic acid (ISO)

oleic acid (ISO)

paracetamol (EXP,ISO)

parathion (ISO)

pentachlorophenol (ISO)

perfluorooctane-1-sulfonic acid (ISO)

phenformin (EXP)

phenobarbital (ISO)

phenytoin (ISO)

phytosterols (ISO)

pirinixic acid (ISO)

potassium chromate (ISO)

pregnenolone 16alpha-carbonitrile (ISO)

progesterone (ISO)

resveratrol (ISO)

SB 431542 (ISO)

selenium atom (ISO)

silibinin (ISO)

silicon dioxide (ISO)

sodium arsenite (ISO)

sunitinib (ISO)

tamibarotene (ISO)

tamoxifen (ISO)

temozolomide (ISO)

tert-butyl hydroperoxide (ISO)

testosterone (ISO)

tetrachloroethene (ISO)

tetrachloromethane (ISO)

tetraphene (ISO)

thapsigargin (ISO)

thioacetamide (EXP)

titanium dioxide (ISO)

tributylstannane (EXP)

trichloroethene (EXP)

triclosan (ISO)

triphenyl phosphate (EXP)

Triptolide (ISO)

triptonide (ISO)

troglitazone (ISO)

trovafloxacin (EXP)

uranium atom (ISO)

valproic acid (ISO)

vancomycin (ISO)

vinclozolin (EXP)

vitamin E (ISO)

zaragozic acid A (EXP,ISO)

zoledronic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

actin cytoskeleton organization (ISO)

animal organ regeneration (IEP)

cellular lipid metabolic process (ISO)

cellular response to insulin stimulus (IBA,IDA,ISO)

fatty acid catabolic process (IBA,ISO)

immune response (ISO)

lipid metabolic process (ISO)

mitochondrial fission (ISO)

negative regulation of myelination (IMP)

negative regulation of phosphatidate phosphatase activity (IMP)

negative regulation of transcription by RNA polymerase II (ISO)

phosphatidic acid biosynthetic process (IEP)

phosphatidic acid metabolic process (ISO)

positive regulation of cold-induced thermogenesis (ISO,ISS)

positive regulation of DNA replication (IMP)

positive regulation of transcription by RNA polymerase II (IBA,ISO)

regulation of fat cell differentiation (ISO)

ruffle organization (ISO)

triglyceride biosynthetic process (IBA,ISO)

triglyceride mobilization (ISO)

Cellular Component

cytoplasm (ISO)

cytosol (ISO)

endoplasmic reticulum (ISO)

endoplasmic reticulum membrane (ISO)

mitochondrial outer membrane (IBA,ISO)

nuclear membrane (ISO)

nucleus (IBA,ISO)

transcription regulator complex (ISO)

Molecular Function

histone deacetylase binding (ISO)

peroxisome proliferator activated receptor binding (ISO)

phosphatidate phosphatase activity (IBA,ISO)

protein binding (ISO)

RNA polymerase II-specific DNA-binding transcription factor binding (ISO)

transcription coactivator activity (IBA,ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

mTOR signaling pathway (IMP)

Phenotype Annotations Click to see Annotation Detail View

Mammalian Phenotype

abnormal sciatic nerve morphology (IMP)

dysmyelination (IMP)

increased cell proliferation (IMP)

lipodystrophy (IMP)

weight loss (IMP)

References

References - curated

#	Reference Title	Reference Citation
1.	Hepatic Lipin 1{beta} Expression is Diminished in Insulin-Resistant Obese Subjects and is Reactivated by Marked Weight Loss.	Croce MA, etal., Diabetes. 2007 Jun 11;.
2.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3.	Insulin-stimulated phosphorylation of lipin mediated by the mammalian target of rapamycin.	Huffman TA, etal., Proc Natl Acad Sci U S A. 2002 Jan 22;99(2):1047-52. Epub 2002 Jan 15.
4.	Multiple types of skeletal muscle atrophy involve a common program of changes in gene expression.	Lecker SH, etal., FASEB J. 2004 Jan;18(1):39-51.
5.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
6.	A hypomorphic mutation in Lpin1 induces progressively improving neuropathy and lipodystrophy in the rat.	Mul JD, etal., J Biol Chem. 2011 Jul 29;286(30):26781-93. doi: 10.1074/jbc.M110.197947. Epub 2011 Jun 1.
7.	Cell autonomous lipin 1 function is essential for development and maintenance of white and brown adipose tissue.	Nadra K, etal., Mol Cell Biol. 2012 Dec;32(23):4794-810. doi: 10.1128/MCB.00512-12. Epub 2012 Oct 1.
8.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline
9.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
10.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
11.	Comprehensive gene review and curation	RGD comprehensive gene curation

Additional References at PubMed

PMID:2722772	PMID:10438476	PMID:11138012	PMID:12477932	PMID:14522948	PMID:16950137	PMID:17158099	PMID:18245816	PMID:18656451	PMID:18694939	PMID:19753306	PMID:20385772
PMID:21397848	PMID:21549711	PMID:21911493	PMID:22134922	PMID:22231922	PMID:22337502	PMID:23505321	PMID:24788483	PMID:26475860	PMID:28653652	PMID:33123308	PMID:34435332
PMID:36625880

Genomics

Comparative Map Data

Lpin1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	6	39,309,198 - 39,417,034 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	6	39,312,748 - 39,417,097 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	6	39,644,137 - 39,711,411 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	6	39,958,820 - 40,026,103 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	6	39,392,085 - 39,459,366 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	6	41,796,214 - 41,905,149 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	6	41,799,749 - 41,870,046 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	6	51,532,422 - 51,638,090 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	6	40,253,664 - 40,297,195 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	6	40,292,340 - 40,300,145 (-)	NCBI
Celera	6	38,623,057 - 38,690,436 (-)	NCBI		Celera
Cytogenetic Map	6	q16	NCBI

LPIN1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	2	11,677,544 - 11,827,409 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	2	11,677,595 - 11,827,409 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	2	11,817,670 - 11,967,535 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	2	11,804,191 - 11,884,986 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	2	11,837,337 - 11,918,129	NCBI
Celera	2	11,803,878 - 11,884,673 (+)	NCBI		Celera
Cytogenetic Map	2	p25.1	NCBI
HuRef	2	11,669,235 - 11,818,856 (+)	NCBI		HuRef
CHM1_1	2	11,747,316 - 11,897,077 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	2	11,710,702 - 11,860,525 (+)	NCBI		T2T-CHM13v2.0

Lpin1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	12	16,585,670 - 16,697,020 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	12	16,585,670 - 16,696,967 (-)	Ensembl		GRCm39 Ensembl
GRCm38	12	16,535,669 - 16,653,903 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	12	16,535,669 - 16,646,966 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	12	16,542,475 - 16,596,576 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	12	16,562,116 - 16,615,250 (-)	NCBI		MGSCv36	mm8
Celera	12	16,861,042 - 16,914,762 (-)	NCBI		Celera
Cytogenetic Map	12	A1.1	NCBI
cM Map	12	7.9	NCBI

Lpin1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955487	6,138,926 - 6,210,012 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955487	6,139,188 - 6,207,316 (+)	NCBI	ChiLan1.0	ChiLan1.0

LPIN1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1	2A	114,703,663 - 114,854,404 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	2A	11,664,727 - 11,815,497 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	2A	11,847,419 - 11,961,551 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	2A	11,857,961 - 11,961,551 (+)	Ensembl	panpan1.1		panPan2

LPIN1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	17	8,348,860 - 8,480,447 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	17	8,348,886 - 8,478,863 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	17	8,279,917 - 8,411,687 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	17	8,451,896 - 8,584,013 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	17	8,451,917 - 8,584,010 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	17	8,382,241 - 8,466,963 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	17	8,340,808 - 8,472,566 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	17	8,359,796 - 8,491,836 (+)	NCBI		UU_Cfam_GSD_1.0

Lpin1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024406292	52,788,616 - 52,899,844 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936532	7,605,965 - 7,652,573 (+)	Ensembl	SpeTri2.0
SpeTri2.0	NW_004936532	7,596,279 - 7,654,139 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

LPIN1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	3	124,940,561 - 125,074,122 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	3	124,940,557 - 125,074,137 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	3	133,660,296 - 133,740,965 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3
Pig Cytomap	3	q21-q27	NCBI

LPIN1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	14	95,777,976 - 95,926,420 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	14	95,780,478 - 95,926,419 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666045	16,446,229 - 16,526,834 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Lpin1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624865	4,219,081 - 4,258,448 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624865	4,220,047 - 4,258,014 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Lpin1
693 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	59
Count of miRNA genes:	58
Interacting mature miRNAs:	59
Transcripts:	ENSRNOT00000005863
Prediction methods:	Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
7411603	Foco13	Food consumption QTL 13	5.5	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	6	1	41223769	Rat
8552962	Pigfal16	Plasma insulin-like growth factor 1 level QTL 16	9.4		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	6	1	41223769	Rat
7411542	Bw127	Body weight QTL 127	5.5	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	6	1	41223769	Rat
9589129	Insul24	Insulin level QTL 24	19.06	0.001	blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	6	1	41223769	Rat
9589048	Scfw3	Subcutaneous fat weight QTL 3	4.57	0.001	subcutaneous adipose mass (VT:1000472)	abdominal subcutaneous fat pad weight (CMO:0002069)	6	1	41223769	Rat
2293709	Bss23	Bone structure and strength QTL 23	5.18	0.0001	femur morphology trait (VT:0000559)	femur cross-sectional area (CMO:0001661)	6	1	42487980	Rat
2293650	Bss31	Bone structure and strength QTL 31	5.05	0.0001	femur strength trait (VT:0010010)	femur midshaft polar moment of inertia (CMO:0001669)	6	1	42487980	Rat
2293656	Bss28	Bone structure and strength QTL 28	6.79	0.0001	femur morphology trait (VT:0000559)	femur midshaft cortical cross-sectional area (CMO:0001663)	6	1	42487980	Rat
7411584	Foco4	Food consumption QTL 4	4.3	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	6	1	42838846	Rat
738024	Sach5	Saccharine consumption QTL 5	3.9	0.00039	consumption behavior trait (VT:0002069)	saccharin intake volume to total fluid intake volume ratio (CMO:0001601)	6	1	43394190	Rat
2301972	Bp325	Blood pressure QTL 325	4.8		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	6	1	72227641	Rat
1300164	Rf15	Renal function QTL 15	3.12		renal blood flow trait (VT:2000006)	absolute change in renal blood flow rate (CMO:0001168)	6	5074497	54641141	Rat
4145119	Mcs25	Mammary carcinoma susceptibility QTL 25		0.0001	mammary gland integrity trait (VT:0010552)	ratio of deaths to total study population during a period of time (CMO:0001023)	6	10894415	110548006	Rat
1578665	Bss16	Bone structure and strength QTL 16	4.4		femur morphology trait (VT:0000559)	bone trabecular cross-sectional area (CMO:0002311)	6	11735669	72593685	Rat
1578668	Bmd14	Bone mineral density QTL 14	3.8		femur mineral mass (VT:0010011)	total volumetric bone mineral density (CMO:0001728)	6	11735669	72593685	Rat
10401812	Kidm54	Kidney mass QTL 54			kidney mass (VT:0002707)	both kidneys wet weight (CMO:0000085)	6	14368788	59368788	Rat
10401800	Kidm49	Kidney mass QTL 49			kidney mass (VT:0002707)	both kidneys wet weight (CMO:0000085)	6	14368788	59368788	Rat
1576309	Emca7	Estrogen-induced mammary cancer QTL 7	4		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	6	15107216	107351382	Rat
2292589	Emca10	Estrogen-induced mammary cancer QTL 10		0.048	mammary gland integrity trait (VT:0010552)	post-insult time to mammary tumor formation (CMO:0000345)	6	16536140	61536140	Rat
1354664	Slep2	Serum leptin concentration QTL 2	4.49		blood leptin amount (VT:0005667)	serum leptin level (CMO:0000780)	6	16536140	71636405	Rat
1641898	Colcr4	Colorectal carcinoma resistance QTL4	3.71	0.0007	intestine integrity trait (VT:0010554)	well differentiated malignant colorectal tumor surface area measurement (CMO:0002077)	6	20338777	62613667	Rat
2293839	Kiddil2	Kidney dilation QTL 2	4.8		kidney pelvis morphology trait (VT:0004194)	hydronephrosis severity score (CMO:0001208)	6	20866422	81133036	Rat
2293841	Kiddil4	Kidney dilation QTL 4	4.4		kidney pelvis morphology trait (VT:0004194)	hydronephrosis severity score (CMO:0001208)	6	20866422	81133036	Rat
1331779	Rf38	Renal function QTL 38	2.876		kidney blood vessel physiology trait (VT:0100012)	absolute change in renal vascular resistance (CMO:0001900)	6	32074428	72227641	Rat
634318	Bw118	Body weight QTL 118	3.55		abdominal fat pad mass (VT:1000711)	abdominal fat pad weight (CMO:0000088)	6	33309549	57730294	Rat
6893340	Cm77	Cardiac mass QTL 77	0.26	0.57	heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	6	33309549	81132889	Rat
1300143	Rf14	Renal function QTL 14	2.92		renal blood flow trait (VT:2000006)	absolute change in renal blood flow rate (CMO:0001168)	6	34434137	77102317	Rat
1354632	Scl29	Serum cholesterol level QTL 29	3.74		blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	6	35098709	71636405	Rat
634307	Bp141	Blood pressure QTL 141	4		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	6	35230417	80230417	Rat
70199	Coreg1	Compensatory renal growth QTL 1	11.8		kidney mass (VT:0002707)	compensatory renal growth score (CMO:0001894)	6	35691618	57730540	Rat
9590290	Uminl2	Urine mineral level QTL 2	3.96	0.001	urine mineral amount (VT:0015086)	urine electrolyte level (CMO:0000593)	6	38783989	83783989	Rat
9590306	Scort18	Serum corticosterone level QTL 18	2.88	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	6	38783989	83783989	Rat
9590140	Scort4	Serum corticosterone level QTL 4	14.49	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	6	38783989	83783989	Rat

Genetic Models

This gene Lpin1 is modified in the following models/strains

SS-Lpin1^em1Mcwi

WI-Lpin1^m1Hubr

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium	1	26	45	31	15	31	8	11	56		13	5	8
Low	2	17	12	10	4	10			18	35	28	6
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001012111	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008764593	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039112195	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039112196	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039112197	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039112199	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039112200	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039112201	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039112202	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039112203	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039112204	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039112205	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_005505510	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	BC083651	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473947	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000164	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSRNOT00000005863 ⟹ ENSRNOP00000005863

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	6	39,312,748 - 39,380,176 (-)	Ensembl
Rnor_6.0 Ensembl	6	41,799,749 - 41,870,046 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000084155 ⟹ ENSRNOP00000069689

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	6	39,312,748 - 39,417,097 (-)	Ensembl
Rnor_6.0 Ensembl	6	41,799,788 - 41,842,817 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000114735 ⟹ ENSRNOP00000080344

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	6	39,312,748 - 39,417,097 (-)	Ensembl

RefSeq Acc Id:

NM_001012111 ⟹ NP_001012111

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	6	39,312,747 - 39,380,176 (-)	NCBI
Rnor_6.0	6	41,799,748 - 41,870,046 (-)	NCBI
Rnor_5.0	6	51,532,422 - 51,638,090 (-)	NCBI
RGSC_v3.4	6	40,253,664 - 40,297,195 (-)	RGD
Celera	6	38,623,057 - 38,690,436 (-)	RGD

Sequence:

show sequence

GAGAGAATAAGTGGGGGGAAGTGGGGGAGGGAGGATGGGGAGGAAAGAACAGGAAGAGGGAGAC
TCGGGGAGCCAGTCATGCCTACCCTAATCGAAACCACAGAGGGTGGGTCTAGGAGACTAATACC
TATAGGACGGTGAGGAAAAAAGAACAATCCACTGGGGTACTAAAAAGTTCACAAGCAGGGACCT
TCCTGTGAAGCTGATGGAAGAAAAATGGAGTCCTCACAGGAGAAGAGGCTTTCTTCAGGCAACT
AAGGTTCAGACAATGAATTACGTGGGGCAGTTGGCCGGCCAGGTGTTTGTGACGGTGAAGGAGC
TCTACAAGGGACTGAACCCTGCCACGCTGTCAGGATGCATCGACATCATTGTTGTCCGCCAGCC
CAATGGCAGTCTGCAGTGCTCCCCGTTCCACGTCCGCTTCGGGAAGATGGGTGTCCTACGCTCC
CGAGAGAAAGTGGTGGACATAGAAATCAATGGGGAGTCTGTGGATTTGCACATGAAGTTGGGAG
ACAACGGAGAAGCGTTTTTTGTTCAAGAGACTGACAACGATCAGGAAGTCATCCCCATGTACCT
AGCCACGTCCCCCATCCTGTCAGAAGGAGCTTCGAGAATGGAAAGCCAGCTGAAAAGGAACTCT
GTGGACAGAATCCGGGGCCTGGATCCCACTACAGCTGCCCAGGGCCTGCCTCCCAGCGACACCC
CATCCACTGGTTCTCTGGGGAAGAAGAGAAGGAAAAGGAGGAGGAAGGCCCATTTGGACAATCT
CAAAAGAGATGACAATGTCAACACATCTGAGGACGAGGACATGTTTCCCATAGAGATGAGCTCG
GATGAGGACACAGCACTGATGGATGGGAGCAGAGCTCTTCCTAATGATGTACCACCATTCCAAG
ATGATATTCCTAAGGAAAACCTCCCCTCGATTTCAACATATCCCCAGTCAGCATCGTACCCCAA
TTCAGACAGAGAGTGGTCCCCCAGCCCCAGCAGCCTGGTAGATTGTCAGAGGACTCCCCCTCAC
CTGGCCGAGGGAGTTCTCTCTAGCTCTTGTCCTCTGCAGTCTTGCCACTTCCATGCTTCGGAAA
GTCCTTCAGGCTCCCGGCCCTCAACACCAAAAAGTGATTCTGAGCTGGTCAGTAAGTCTGCAGA
CAGATTGACGCCAAAGAATAACCTGGAAATGCTCTGGCTATGGGGTGAATTGCCACAGGCTGCA
AAGTCGTCTTCTCCACACAAGATGAAAGACTCCAGCCCCTTAGGAGGTCGGAAGATGGCTGATA
AAATCCACTTCCAGACCATTCACAGCGAGTCTTCAGACACTTTCAGTGACCAGTCCCCAACAAT
GGCCCGGGGGCTGCTCATCCACCAGAGCAAGGCTCAGACGGAAATGCAGTTTGTGAATGAGGAG
GACCTTGAGGCCTTGGGGGCCGCAGCCCCACCTTTGTCTGTAGCCGAAGAGCTCAAGGCCCCAG
CCTCCAGCACAGCACAGACATCAAGCAAGTCAGATTCCCCTTCCAGAAAAAAAGATAAACGAAG
CCGGCACCTCGGAGCTGATGGCGTTTATCTGGATGACCTCACAGACATGGACCCGGAAGTGGCT
GCCCTGTATTTCCCCAAGAATGGGGATCCCGGTGGGCTTCCCAAACAAGCGAGTGACAACGGAG
CCAGGTCAGCCAACCAGTCCCCACAGTCGGTGGGTAGCTCGGGCATTGACAGCGGCGTGGAGAG
CACCTCCGACAGCCTGAGGGACCTGCCGTCCATCGCCATCTCCCTCTGCGGTGGCCTCAGTGAC
CACAGAGAGATCACCAAAGATGCATTTTTGGAACAAGCCGTGTCATATCAGCAATTTGCCGACA
ACCCTGCTATCATCGATGATCCCAACCTCGTGGTCAAGATTGGTAATAAGTACTACAACTGGAC
AACAGCAGCTCCTCTACTTCTGGCGATGCAGGCTTTCCAGAAACCTTTGCCAAAGGCCACTGTG
GAATCCATCATGAGAGATAAGATGCCCAAAAAGGGAGGGAGATGGTGGTTTTCCTGGAGAGGAA
GAAACGCCACAATCAAAGAGGAGAGCAAGCCTGAGCAGGGCCTGCCTGGGAAGGGCCACAATAC
CGGAGAGCAGCCTGCACAGCTTGGCCTGACCACCAGAATAAAGCATGAGTCATCCTCTAGTGAT
GAAGAGCACTCAGCTACCAAGCCATCGAGCTCGAGCCACCTCTCTCTCTTGTCCAACGTCAGCT
ACAAAAAGACCCTGCGGCTCACATCGGAGCAGTTGAAAAGCTTGAAGTTGAAGAATGGCCCCAA
CGATGTGGTGTTCAGTGTCACTACCCAGTACCAGGGCACCTGTCGCTGTGAGGGTACCATCTAC
CTGTGGAATTGGGATGACAAAGTCATCATCTCAGATATCGATGGTACCATCACAAGATCTGATA
CTCTTGGTCACATATTGCCCACACTGGGAAAGGATTGGACTCACCAGGGCATCGCAAAGCTGTA
TCACAAAGTAAGCCAGAATGGCTACAAGTTTCTCTATTGTTCTGCACGTGCCATTGGGATGGCA
GACATGACGAGGGGCTATCTGCACTGGGTCAACGAGAGGGGCACAGTGCTGCCACAGGGGCCGC
TTCTGCTGAGCCCCAGCAGCCTCTTCTCCGCCTTGCACAGAGAAGTGATTGAAAAGAAGCCAGA
AAAGTTCAAAGTCCAGTGTTTGACAGACATCAAAAACCTGTTTTTCCCAAACACAGAGCCCTTT
TATGCTGCTTTTGGGAACCGGCCTGCCGATGTGTATTCCTACAAGCAAGTGGGAGTGTCCCTGA
ATAGAATCTTCACCGTCAACCCCAAGGGTGAGCTGGTGCAGGAGCATGCCAAGACCAACATCAG
CTCGTATGTGCGGCTCTGCGAAGTGGTCGACCACGTCTTCCCCTTGCTGAAGAGAAGCCATTCC
TGCGACTTCCCCTGTTCAGACACTTTCAGTAACTTCACCTTTTGGAGAGAGCCACTGCCACCCT
TTGAAAACCAGGACGTGCATTCAGCCTCAGCTTGATTCGACCCAGCATTAAAGGATAGGTTGTG
GGGACCCTGGAAAAAAAAAAAAAAAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

XM_039112195 ⟹ XP_038968123

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	6	39,309,198 - 39,417,033 (-)	NCBI

RefSeq Acc Id:

XM_039112196 ⟹ XP_038968124

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	6	39,309,198 - 39,417,033 (-)	NCBI

RefSeq Acc Id:

XM_039112197 ⟹ XP_038968125

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	6	39,309,198 - 39,417,032 (-)	NCBI

RefSeq Acc Id:

XM_039112199 ⟹ XP_038968127

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	6	39,309,198 - 39,417,033 (-)	NCBI

RefSeq Acc Id:

XM_039112200 ⟹ XP_038968128

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	6	39,309,198 - 39,417,033 (-)	NCBI

RefSeq Acc Id:

XM_039112201 ⟹ XP_038968129

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	6	39,309,198 - 39,366,226 (-)	NCBI

RefSeq Acc Id:

XM_039112202 ⟹ XP_038968130

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	6	39,309,198 - 39,366,061 (-)	NCBI

RefSeq Acc Id:

XM_039112203 ⟹ XP_038968131

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	6	39,309,198 - 39,417,033 (-)	NCBI

RefSeq Acc Id:

XM_039112204 ⟹ XP_038968132

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	6	39,309,198 - 39,348,617 (-)	NCBI

RefSeq Acc Id:

XM_039112205 ⟹ XP_038968133

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	6	39,309,198 - 39,348,617 (-)	NCBI

RefSeq Acc Id:

XR_005505510

Type:

NON-CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	6	39,312,806 - 39,417,034 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_001012111	(Get FASTA)	NCBI Sequence Viewer
	XP_038968123	(Get FASTA)	NCBI Sequence Viewer
	XP_038968124	(Get FASTA)	NCBI Sequence Viewer
	XP_038968125	(Get FASTA)	NCBI Sequence Viewer
	XP_038968127	(Get FASTA)	NCBI Sequence Viewer
	XP_038968128	(Get FASTA)	NCBI Sequence Viewer
	XP_038968129	(Get FASTA)	NCBI Sequence Viewer
	XP_038968130	(Get FASTA)	NCBI Sequence Viewer
	XP_038968131	(Get FASTA)	NCBI Sequence Viewer
	XP_038968132	(Get FASTA)	NCBI Sequence Viewer
	XP_038968133	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH83651	(Get FASTA)	NCBI Sequence Viewer
	EDM03131	(Get FASTA)	NCBI Sequence Viewer
	EDM03132	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_001012111 ⟸ NM_001012111

- UniProtKB:

Q5XIM8 (UniProtKB/TrEMBL), A6HAS7 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MNYVGQLAGQVFVTVKELYKGLNPATLSGCIDIIVVRQPNGSLQCSPFHVRFGKMGVLRSREKV
VDIEINGESVDLHMKLGDNGEAFFVQETDNDQEVIPMYLATSPILSEGASRMESQLKRNSVDRI
RGLDPTTAAQGLPPSDTPSTGSLGKKRRKRRRKAHLDNLKRDDNVNTSEDEDMFPIEMSSDEDT
ALMDGSRALPNDVPPFQDDIPKENLPSISTYPQSASYPNSDREWSPSPSSLVDCQRTPPHLAEG
VLSSSCPLQSCHFHASESPSGSRPSTPKSDSELVSKSADRLTPKNNLEMLWLWGELPQAAKSSS
PHKMKDSSPLGGRKMADKIHFQTIHSESSDTFSDQSPTMARGLLIHQSKAQTEMQFVNEEDLEA
LGAAAPPLSVAEELKAPASSTAQTSSKSDSPSRKKDKRSRHLGADGVYLDDLTDMDPEVAALYF
PKNGDPGGLPKQASDNGARSANQSPQSVGSSGIDSGVESTSDSLRDLPSIAISLCGGLSDHREI
TKDAFLEQAVSYQQFADNPAIIDDPNLVVKIGNKYYNWTTAAPLLLAMQAFQKPLPKATVESIM
RDKMPKKGGRWWFSWRGRNATIKEESKPEQGLPGKGHNTGEQPAQLGLTTRIKHESSSSDEEHS
ATKPSSSSHLSLLSNVSYKKTLRLTSEQLKSLKLKNGPNDVVFSVTTQYQGTCRCEGTIYLWNW
DDKVIISDIDGTITRSDTLGHILPTLGKDWTHQGIAKLYHKVSQNGYKFLYCSARAIGMADMTR
GYLHWVNERGTVLPQGPLLLSPSSLFSALHREVIEKKPEKFKVQCLTDIKNLFFPNTEPFYAAF
GNRPADVYSYKQVGVSLNRIFTVNPKGELVQEHAKTNISSYVRLCEVVDHVFPLLKRSHSCDFP
CSDTFSNFTFWREPLPPFENQDVHSASA

hide sequence

RefSeq Acc Id:

ENSRNOP00000069689 ⟸ ENSRNOT00000084155

RefSeq Acc Id:

ENSRNOP00000005863 ⟸ ENSRNOT00000005863

RefSeq Acc Id:	XP_038968131 ⟸ XM_039112203
- Peptide Label:	isoform X7
- UniProtKB:	A0A8I5ZPU6 (UniProtKB/TrEMBL), A6HAS7 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038968128 ⟸ XM_039112200
- Peptide Label:	isoform X5
- UniProtKB:	A6HAS7 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038968127 ⟸ XM_039112199
- Peptide Label:	isoform X4
- UniProtKB:	A6HAS7 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038968124 ⟸ XM_039112196
- Peptide Label:	isoform X2
- UniProtKB:	A6HAS7 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038968123 ⟸ XM_039112195
- Peptide Label:	isoform X1
- UniProtKB:	A6HAS7 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038968125 ⟸ XM_039112197
- Peptide Label:	isoform X3
- UniProtKB:	A0A0G2JW03 (UniProtKB/TrEMBL), A6HAS6 (UniProtKB/TrEMBL), A6HAS7 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038968129 ⟸ XM_039112201
- Peptide Label:	isoform X6
- UniProtKB:	F7FDH2 (UniProtKB/TrEMBL), A6HAS7 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038968130 ⟸ XM_039112202
- Peptide Label:	isoform X6
- UniProtKB:	F7FDH2 (UniProtKB/TrEMBL), A6HAS7 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038968133 ⟸ XM_039112205
- Peptide Label:	isoform X9

RefSeq Acc Id:	XP_038968132 ⟸ XM_039112204
- Peptide Label:	isoform X8

RefSeq Acc Id:

ENSRNOP00000080344 ⟸ ENSRNOT00000114735

Protein Domains

LNS2/PITP

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-A0A0G2JW03-F1-model_v2	AlphaFold	A0A0G2JW03	1-924	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1307646	AgrOrtholog
BioCyc Gene	G2FUF-38066	BioCyc
BioCyc Pathway	PWY-7782 [plasmalogen biosynthesis]	BioCyc
	PWY-8052 [2-arachidonoylglycerol biosynthesis]	BioCyc
	PWY-8053 [anandamide biosynthesis II]	BioCyc
	TRIGLSYN-PWY [diacylglycerol and triacylglycerol biosynthesis]	BioCyc
Ensembl Genes	ENSRNOG00000004377	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein	ENSRNOP00000005863	ENTREZGENE
	ENSRNOP00000005863.5	UniProtKB/TrEMBL
	ENSRNOP00000069689	ENTREZGENE
	ENSRNOP00000069689.2	UniProtKB/TrEMBL
	ENSRNOP00000080344	ENTREZGENE
	ENSRNOP00000080344.1	UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000005863	ENTREZGENE
	ENSRNOT00000005863.7	UniProtKB/TrEMBL
	ENSRNOT00000084155	ENTREZGENE
	ENSRNOT00000084155.2	UniProtKB/TrEMBL
	ENSRNOT00000114735	ENTREZGENE
	ENSRNOT00000114735.1	UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7135110	IMAGE-MGC_LOAD
InterPro	HAD-like_sf	UniProtKB/TrEMBL
	LIPIN	UniProtKB/TrEMBL
	Lipin_mid	UniProtKB/TrEMBL
	Lipin_N	UniProtKB/TrEMBL
	LNS2	UniProtKB/TrEMBL
	LNS2/PITP	UniProtKB/TrEMBL
KEGG Report	rno:313977	UniProtKB/TrEMBL
MGC_CLONE	MGC:94481	IMAGE-MGC_LOAD
NCBI Gene	313977	ENTREZGENE
PANTHER	PTHR12181	UniProtKB/TrEMBL
	PTHR12181:SF10	UniProtKB/TrEMBL
Pfam	Lipin_mid	UniProtKB/TrEMBL
	Lipin_N	UniProtKB/TrEMBL
	LNS2	UniProtKB/TrEMBL
PhenoGen	Lpin1	PhenoGen
SMART	LNS2	UniProtKB/TrEMBL
Superfamily-SCOP	HAD-like_dom	UniProtKB/TrEMBL
UniProt	A0A0G2JW03	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I5ZPU6	ENTREZGENE, UniProtKB/TrEMBL
	A6HAS6	ENTREZGENE, UniProtKB/TrEMBL
	A6HAS7	ENTREZGENE, UniProtKB/TrEMBL
	F7FDH2	ENTREZGENE, UniProtKB/TrEMBL
	Q5XIM8	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2005-12-06	Lpin1	lipin 1	Lpin1_predicted	lipin 1 (predicted)	Symbol and Name updated	1559027	APPROVED
2005-01-12	Lpin1_predicted	lipin 1 (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - MGI

Imported Disease Annotations - OMIM

RGD Manual Annotations

Mammalian Phenotype

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - MGI

Imported Disease Annotations - OMIM

RGD Manual Annotations

Mammalian Phenotype