Mir216a (microRNA 216a) - Rat Genome Database

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Gene: Mir216a (microRNA 216a) Rattus norvegicus
Analyze
Symbol: Mir216a
Name: microRNA 216a
RGD ID: 2325406
Description: Predicted to be involved in gene expression and mesonephric duct formation. Predicted to act upstream of or within cellular response to leukemia inhibitory factor. Biomarker of pre-eclampsia. Orthologous to human MIR216A (microRNA 216a); INTERACTS WITH ceruletide; metformin; nitrofen.
Type: ncrna (Ensembl: miRNA)
RefSeq Status: PROVISIONAL
Previously known as: microRNA mir-216a; rno-mir-216a
RGD Orthologs
Human
Mouse
Dog
Pig
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr814106,725,077 - 106,725,182 (+)NCBIGRCr8
mRatBN7.214102,524,105 - 102,524,210 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl14102,524,105 - 102,524,210 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx14106,852,319 - 106,852,424 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.014108,088,940 - 108,089,045 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.014104,561,352 - 104,561,457 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.014113,112,129 - 113,112,234 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl14113,112,129 - 113,112,234 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.014112,802,262 - 112,802,367 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera14101,424,234 - 101,424,339 (+)NCBICelera
Cytogenetic Map14q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model



  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Mir216aRatpre-eclampsia amelioratesIEP 213230155 RGD 
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Mir216aRatpancreatitis  ISORGD:135381811554173CTD Direct Evidence: marker/mechanismCTDPMID:27840954

1 to 14 of 14 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Mir216aRatarsenous acid increases expressionISORGD:16076746480464Arsenic Trioxide results in increased expression of MIR216A mRNACTDPMID:35676786
Mir216aRatbenzo[a]pyrene affects methylationISORGD:13538186480464Benzo(a)pyrene affects the methylation of MIR216A promoterCTDPMID:27901495
Mir216aRatceruletide increases expressionEXP 6480464Ceruletide results in increased expression of MIR216A mRNACTDPMID:27521901
Mir216aRatdiarsenic trioxide increases expressionISORGD:16076746480464Arsenic Trioxide results in increased expression of MIR216A mRNACTDPMID:35676786
Mir216aRatlead diacetate decreases expressionISORGD:16076746480464lead acetate results in decreased expression of MIR216A mRNACTDPMID:36183778
Mir216aRatmetformin multiple interactionsEXP 213230155Metformin co-treated with metformin hydrochloride co-treated with N(gamma)-nitro-L-arginine methyl ester inhibits the reaction [pre-eclampsia decreases more ...RGD 
Mir216aRatmetformin increases expression ISORGD:1353818213230155Metformin increases expression of MIR216A RNA in umbilical vein endothelial cellsRGD 
Mir216aRatnitrofen increases expressionEXP 6480464nitrofen results in increased expression of MIR216A mRNACTDPMID:26720608
Mir216aRatquercetin decreases expressionEXP 6480464Quercetin results in decreased expression of MIR216A mRNACTDPMID:26432773
Mir216aRatsodium arsenite decreases expressionISORGD:16076746480464sodium arsenite results in decreased expression of MIR216A mRNACTDPMID:32068019
Mir216aRatsodium arsenite increases expressionISORGD:13538186480464sodium arsenite results in increased expression of MIR216A mRNACTDPMID:34032870
Mir216aRatstreptozocin increases expressionISORGD:16076746480464Streptozocin results in increased expression of MIR216A mRNACTDPMID:27629361
Mir216aRatzinc atom decreases expressionEXP 6480464Zinc deficiency results in decreased expression of MIR216A mRNACTDPMID:22689922
Mir216aRatzinc(0) decreases expressionEXP 6480464Zinc deficiency results in decreased expression of MIR216A mRNACTDPMID:22689922

1 to 14 of 14 rows

Biological Process

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Mir216aRatcellular response to leukemia inhibitory factor acts_upstream_of_or_withinISORGD:16076741624291 PMID:20439489RGDPMID:20439489
Mir216aRatgene expression involved_inISORGD:16076741624291MGI:6361469 PMID:31367007RGDPMID:31367007
Mir216aRatmesonephric duct formation involved_inISORGD:16076741624291MGI:6361469 PMID:31367007RGDPMID:31367007


#
Reference Title
Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
2. Metformin exhibits its therapeutic effect in the treatment of pre-eclampsia via modulating the Met/H19/miR-148a-5p/P28 and Met/H19/miR-216-3p/EBI3 signaling pathways. Shu C, etal.
PMID:16381832   PMID:17604727   PMID:20403161   PMID:20439489   PMID:20857533   PMID:23995054   PMID:30541958   PMID:31378905   PMID:34517790  



Mir216a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr814106,725,077 - 106,725,182 (+)NCBIGRCr8
mRatBN7.214102,524,105 - 102,524,210 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl14102,524,105 - 102,524,210 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx14106,852,319 - 106,852,424 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.014108,088,940 - 108,089,045 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.014104,561,352 - 104,561,457 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.014113,112,129 - 113,112,234 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl14113,112,129 - 113,112,234 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.014112,802,262 - 112,802,367 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera14101,424,234 - 101,424,339 (+)NCBICelera
Cytogenetic Map14q22NCBI
MIR216A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38255,988,950 - 55,989,059 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl255,988,950 - 55,989,059 (-)EnsemblGRCh38hg38GRCh38
GRCh37256,216,085 - 56,216,194 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36256,069,588 - 56,069,697 (-)NCBINCBI36Build 36hg18NCBI36
Celera256,056,494 - 56,056,603 (-)NCBICelera
Cytogenetic Map2p16.1NCBI
HuRef255,951,101 - 55,951,210 (-)NCBIHuRef
CHM1_1256,146,017 - 56,146,126 (-)NCBICHM1_1
T2T-CHM13v2.0255,985,885 - 55,985,994 (-)NCBIT2T-CHM13v2.0
Mir216a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391128,707,012 - 28,707,083 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1128,707,012 - 28,707,083 (+)EnsemblGRCm39 Ensembl
GRCm381128,757,012 - 28,757,083 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1128,757,012 - 28,757,083 (+)EnsemblGRCm38mm10GRCm38
MGSCv371128,657,012 - 28,657,083 (+)NCBIGRCm37MGSCv37mm9NCBIm37
Celera1131,128,544 - 31,128,615 (+)NCBICelera
Cytogenetic Map11A3.3NCBI
cM Map1116.23NCBI
MIR216A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11056,761,430 - 56,761,534 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1056,761,430 - 56,761,534 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1056,717,816 - 56,717,920 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01057,766,339 - 57,766,443 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.11057,465,981 - 57,466,085 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01057,745,555 - 57,745,659 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01058,037,160 - 58,037,264 (-)NCBIUU_Cfam_GSD_1.0
MIR216-1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl385,334,523 - 85,334,627 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1385,334,523 - 85,334,627 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2390,058,975 - 90,059,079 (+)NCBISscrofa10.2Sscrofa10.2susScr3

.

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Variants in Mir216a
1 total Variants

Predicted Targets
Summary Value
Count of predictions:10331
Count of gene targets:6175
Count of transcripts:6678
Interacting mature miRNAs:rno-miR-216a-3p, rno-miR-216a-5p
Prediction methods:Microtar, Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
634328Hc5Hypercalciuria QTL 52.3urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1458184885103184885Rat
1641900Alcrsp11Alcohol response QTL 11alcohol metabolism trait (VT:0015089)blood ethanol level (CMO:0000535)1470053989104886043Rat
1582259Gluco23Glucose level QTL 233.10.0008blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1470053989104886043Rat




ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
mesenchyme
mesoderm
nervous system
reproductive system
respiratory system
2 1 3 1 2 1 3 2 2 10 2


RefSeq Transcripts NR_031928 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JAXUCZ010000014 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000053637
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl14102,524,105 - 102,524,210 (+)Ensembl
Rnor_6.0 Ensembl14113,112,129 - 113,112,234 (+)Ensembl
RefSeq Acc Id: NR_031928
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr814106,725,077 - 106,725,182 (+)NCBI
mRatBN7.214102,524,105 - 102,524,210 (+)NCBI
Rnor_6.014113,112,129 - 113,112,234 (+)NCBI
Rnor_5.014112,802,262 - 112,802,367 (+)NCBI
Celera14101,424,234 - 101,424,339 (+)NCBI
Sequence:

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen



1 to 10 of 10 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-14688 BioCyc
Ensembl Genes ENSRNOG00000035514 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000053637 ENTREZGENE
miRBase MI0000955 ENTREZGENE
NCBI Gene 100314216 ENTREZGENE
PhenoGen Mir216a PhenoGen
RatGTEx ENSRNOG00000035514 RatGTEx
RNAcentral URS00000458CF RNACentral
  URS0000318E24 RNACentral
  URS000075BC37 RNACentral
1 to 10 of 10 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-08-14 Mir216a  microRNA 216a  Mir216a  microRNA mir-216a  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2010-06-02 Mir216a  microRNA mir-216a      Symbol and Name status set to provisional 70820 PROVISIONAL