Yap1 (Yes1 associated transcriptional regulator) - Rat Genome Database

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Gene: Yap1 (Yes1 associated transcriptional regulator) Rattus norvegicus
Analyze
Symbol: Yap1
Name: Yes1 associated transcriptional regulator
RGD ID: 1306035
Description: Predicted to enable several functions, including RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; proline-rich region binding activity; and transcription coregulator activity. Predicted to be involved in several processes, including cardiac muscle tissue regeneration; intracellular signal transduction; and regulation of gene expression. Predicted to act upstream of or within several processes, including regulation of epithelial cell differentiation; regulation of epithelial cell proliferation; and tube morphogenesis. Predicted to be located in several cellular components, including cell-cell junction; cytosol; and nucleus. Predicted to be part of TEAD-YAP complex. Predicted to be active in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in uveal coloboma-cleft lip and palate-intellectual disability. Orthologous to human YAP1 (Yes1 associated transcriptional regulator); PARTICIPATES IN transforming growth factor-beta Smad dependent signaling pathway; INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 65 kDa Yes-associated protein; LOC363014; transcriptional coactivator YAP1; Yap; YAP65; yes-associated protein; yes-associated protein 1; yes-associated protein YAP65 homolog; yorkie homolog
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8813,380,551 - 13,451,640 (-)NCBIGRCr8
mRatBN7.285,095,705 - 5,166,808 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl85,095,722 - 5,167,010 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx89,049,437 - 9,120,258 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.087,347,114 - 7,417,927 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.085,355,414 - 5,426,296 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.086,133,014 - 6,204,240 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl86,135,493 - 6,203,579 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.086,131,653 - 6,202,586 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.484,780,845 - 4,848,881 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.184,780,674 - 4,881,302 (-)NCBI
Celera86,655,412 - 6,723,571 (-)NCBICelera
Cytogenetic Map8q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(1->4)-beta-D-glucan  (ISO)
(20S)-ginsenoside Rg3  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
acetamide  (EXP)
aconitine  (EXP)
acrolein  (ISO)
aflatoxin B1  (ISO)
alpha-pinene  (ISO)
antirheumatic drug  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
belinostat  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
Brodifacoum  (EXP)
cadmium dichloride  (ISO)
caffeine  (ISO)
captan  (ISO)
carbamazepine  (ISO)
chlorpromazine  (ISO)
choline  (ISO)
chrysene  (ISO)
cisplatin  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
coumarin  (ISO)
crocidolite asbestos  (ISO)
Cuprizon  (EXP)
cycloheximide  (ISO)
deoxynivalenol  (ISO)
dexamethasone  (ISO)
dextran sulfate  (ISO)
dibutyl phthalate  (ISO)
dichloroacetic acid  (ISO)
dioxygen  (ISO)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
fipronil  (EXP)
fisetin  (ISO)
folic acid  (ISO)
fonofos  (ISO)
formaldehyde  (ISO)
FR900359  (ISO)
fulvestrant  (ISO)
furan  (EXP)
gemcitabine  (ISO)
gingerol  (ISO)
glyphosate  (EXP)
hexadecanoic acid  (ISO)
ibuprofen  (ISO)
indometacin  (ISO)
ivermectin  (ISO)
jaspamide  (ISO)
L-methionine  (ISO)
lead diacetate  (EXP)
Licochalcone A  (ISO)
limonin  (ISO)
MeIQx  (ISO)
melatonin  (EXP)
methylmercury chloride  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-nitrosodiethylamine  (ISO)
ochratoxin A  (EXP)
octreotide  (ISO)
oleic acid  (ISO)
ozone  (ISO)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
paraoxon  (ISO)
parathion  (ISO)
pentachlorophenol  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenylmercury acetate  (ISO)
quartz  (ISO)
quercetin  (ISO)
SB 431542  (ISO)
sodium arsenite  (ISO)
sorafenib  (ISO)
sunitinib  (ISO)
terbufos  (ISO)
tetrachloromethane  (EXP,ISO)
theophylline  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
trichloroethene  (ISO)
trichostatin A  (ISO)
triptonide  (ISO)
valproic acid  (ISO)
vemurafenib  (ISO)
verteporfin  (EXP,ISO)
vinclozolin  (EXP,ISO)
wortmannin  (ISO)
Xmu-MP-1  (ISO)
zearalenone  (ISO)
zinc atom  (ISO)
zinc dichloride  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
blastocyst development  (ISO)
bud elongation involved in lung branching  (IEA,ISO)
canonical Wnt signaling pathway  (IEA,ISO)
cardiac muscle tissue regeneration  (IEA,ISO)
cell morphogenesis  (IEA,ISO)
cell population proliferation  (ISO)
cellular response to gamma radiation  (IEA,ISO,ISS)
cellular response to retinoic acid  (IEA,ISO)
DNA damage response  (IEA,ISO)
embryonic heart tube morphogenesis  (IEA,ISO)
enterocyte differentiation  (IEA,ISO)
epithelial cell proliferation  (IEA,ISO,ISS)
extrinsic apoptotic signaling pathway  (IEA,ISO)
glandular epithelial cell differentiation  (IEA,ISO)
heart process  (IEA,ISO)
hippo signaling  (IBA,IEA,ISO)
interleukin-6-mediated signaling pathway  (IEA,ISO)
intestinal epithelial cell development  (IEA,ISO)
intestinal epithelial cell differentiation  (ISO)
keratinocyte differentiation  (IEA,ISO)
lateral mesoderm development  (IEA,ISO)
lung epithelial cell differentiation  (IEA,ISO)
negative regulation of cilium assembly  (IEA,ISO,ISS)
negative regulation of epithelial cell apoptotic process  (IEA,ISO)
negative regulation of epithelial cell differentiation  (IEA,ISO)
negative regulation of extrinsic apoptotic signaling pathway  (IEA,ISO)
negative regulation of fat cell differentiation  (IEA,ISO)
negative regulation of gene expression  (IEA,ISO)
negative regulation of stem cell differentiation  (IEA,ISO)
negative regulation of transcription by RNA polymerase II  (IEA,ISO,ISS)
notochord development  (IEA,ISO)
organ growth  (IEA,ISO,ISS)
paraxial mesoderm development  (IEA,ISO)
positive regulation of canonical Wnt signaling pathway  (IEA,ISO)
positive regulation of cardiac muscle cell proliferation  (IEA,ISO)
positive regulation of cell growth  (IEA,ISO)
positive regulation of cell population proliferation  (ISO)
positive regulation of DNA-templated transcription  (ISO)
positive regulation of epithelial cell proliferation  (IEA,ISO)
positive regulation of gene expression  (IEA,ISO)
positive regulation of Notch signaling pathway  (IEA,ISO)
positive regulation of organ growth  (ISO)
positive regulation of osteoblast differentiation  (IEA,ISO)
positive regulation of protein localization to nucleus  (IEA,ISO,ISS)
positive regulation of stem cell population maintenance  (IEA,ISO)
positive regulation of transcription by RNA polymerase II  (IBA,IEA,ISO)
protein-containing complex assembly  (IEA,ISO)
regulation of canonical Wnt signaling pathway  (ISO)
regulation of cell population proliferation  (ISO)
regulation of gene expression  (ISO)
regulation of keratinocyte proliferation  (IEA,ISO)
regulation of metanephric nephron tubule epithelial cell differentiation  (IEA,ISO)
regulation of neurogenesis  (IEA,ISO)
regulation of stem cell proliferation  (IEA,ISO)
response to progesterone  (IEA,ISO)
signal transduction in response to DNA damage  (ISS)
somatic stem cell population maintenance  (IEA,ISO)
tissue homeostasis  (IEA,ISO)
trophectodermal cell differentiation  (IEA,ISO)
vasculogenesis  (IEA,ISO)
wound healing  (IEA,ISO)

Cellular Component
cell junction  (ISO)
cell-cell junction  (IEA,ISO,ISS)
cytoplasm  (IBA,IEA,ISO,ISS)
cytosol  (IEA,ISO,TAS)
female germ cell nucleus  (IEA,ISO)
membrane  (IEA,ISO)
nucleoplasm  (IEA,ISO,TAS)
nucleus  (IBA,IEA,ISO,ISS)
TEAD-YAP complex  (IEA,ISO)
tight junction  (ISO)
transcription regulator complex  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. TAZ is a coactivator for Pax8 and TTF-1, two transcription factors involved in thyroid differentiation. Di Palma T, etal., Exp Cell Res. 2009 Jan 15;315(2):162-75. doi: 10.1016/j.yexcr.2008.10.016. Epub 2008 Oct 28.
2. LINC00689 participates in proliferation, chemoresistance and metastasis via miR-31-5p/YAP/β-catenin axis in colorectal cancer. Du YL, etal., Exp Cell Res. 2020 Oct 1;395(1):112176. doi: 10.1016/j.yexcr.2020.112176. Epub 2020 Jul 16.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. Drug-eluting stent specifically designed to target vascular smooth muscle cell phenotypic modulation attenuated restenosis through the YAP pathway. Huang C, etal., Am J Physiol Heart Circ Physiol. 2019 Sep 1;317(3):H541-H551. doi: 10.1152/ajpheart.00089.2019. Epub 2019 Jul 12.
6. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
7. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
8. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
9. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
10. ErbB4 protects against neuronal apoptosis via activation of YAP/PIK3CB signaling pathway in a rat model of subarachnoid hemorrhage. Yan F, etal., Exp Neurol. 2017 Nov;297:92-100. doi: 10.1016/j.expneurol.2017.07.014. Epub 2017 Jul 27.
Additional References at PubMed
PMID:9305852   PMID:12477932   PMID:16207754   PMID:16332960   PMID:16354681   PMID:16461361   PMID:16772533   PMID:17689488   PMID:17974916   PMID:17980593   PMID:18158288   PMID:18280240  
PMID:18332127   PMID:18369314   PMID:19004856   PMID:19289085   PMID:19853564   PMID:19952108   PMID:20123905   PMID:20368466   PMID:20516196   PMID:20868367   PMID:21385842   PMID:21512031  
PMID:22232070   PMID:22308401   PMID:22411986   PMID:22529382   PMID:22922963   PMID:23442010   PMID:23543231   PMID:23824537   PMID:23863479   PMID:23918388   PMID:23974041   PMID:23998984  
PMID:24147051   PMID:24875096   PMID:25043473   PMID:25249570   PMID:25433207   PMID:25796446   PMID:26306672   PMID:26333362   PMID:26574480   PMID:26625714   PMID:26694636   PMID:26902285  
PMID:27288457   PMID:27359056   PMID:27369082   PMID:27371368   PMID:27683908   PMID:27889666   PMID:28087714   PMID:28169360   PMID:28428044   PMID:28552397   PMID:28642262   PMID:28915934  
PMID:28951205   PMID:29066438   PMID:29355736   PMID:29356923   PMID:29403039   PMID:29403552   PMID:30039887   PMID:31325776   PMID:31518341   PMID:31940260   PMID:32059976   PMID:32111918  
PMID:32239716   PMID:32279070   PMID:32451801   PMID:32951332   PMID:33236141   PMID:33296068   PMID:33373332   PMID:33568044   PMID:33610591   PMID:33993470   PMID:34062912   PMID:34188130  
PMID:35084661   PMID:35129018   PMID:35400714   PMID:36063391   PMID:36878020   PMID:36878833   PMID:37030120   PMID:37442439   PMID:37541340   PMID:37585277   PMID:37930731   PMID:38112463  
PMID:38136638   PMID:38494855   PMID:38610069  


Genomics

Comparative Map Data
Yap1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8813,380,551 - 13,451,640 (-)NCBIGRCr8
mRatBN7.285,095,705 - 5,166,808 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl85,095,722 - 5,167,010 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx89,049,437 - 9,120,258 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.087,347,114 - 7,417,927 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.085,355,414 - 5,426,296 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.086,133,014 - 6,204,240 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl86,135,493 - 6,203,579 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.086,131,653 - 6,202,586 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.484,780,845 - 4,848,881 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.184,780,674 - 4,881,302 (-)NCBI
Celera86,655,412 - 6,723,571 (-)NCBICelera
Cytogenetic Map8q11NCBI
YAP1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3811102,110,447 - 102,233,424 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl11102,110,447 - 102,233,424 (+)EnsemblGRCh38hg38GRCh38
GRCh3711101,981,178 - 102,104,155 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3611101,486,541 - 101,609,359 (+)NCBINCBI36Build 36hg18NCBI36
Build 3411101,486,540 - 101,609,356NCBI
Celera1199,142,746 - 99,265,700 (+)NCBICelera
Cytogenetic Map11q22.1NCBI
HuRef1197,907,865 - 98,030,476 (+)NCBIHuRef
CHM1_111101,864,181 - 101,987,123 (+)NCBICHM1_1
T2T-CHM13v2.011102,112,538 - 102,235,509 (+)NCBIT2T-CHM13v2.0
Yap1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3997,932,000 - 8,004,890 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl97,932,000 - 8,004,597 (-)EnsemblGRCm39 Ensembl
GRCm3897,931,999 - 8,004,638 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl97,931,999 - 8,004,596 (-)EnsemblGRCm38mm10GRCm38
MGSCv3797,931,999 - 8,004,596 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3697,932,520 - 8,005,109 (-)NCBIMGSCv36mm8
Celera95,324,108 - 5,396,890 (-)NCBICelera
Cytogenetic Map9A1NCBI
cM Map92.46NCBI
Yap1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554125,423,855 - 5,534,408 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554125,423,866 - 5,533,728 (+)NCBIChiLan1.0ChiLan1.0
YAP1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v29102,911,890 - 103,039,644 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan111104,002,427 - 104,128,009 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01197,061,367 - 97,186,961 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.111100,556,689 - 100,681,301 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl11100,552,424 - 100,681,301 (+)Ensemblpanpan1.1panPan2
YAP1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1529,394,760 - 29,495,977 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl529,394,541 - 29,496,251 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha529,340,746 - 29,445,498 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0529,444,603 - 29,550,383 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl529,447,525 - 29,551,237 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1529,501,168 - 29,606,791 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0529,358,262 - 29,463,735 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0529,533,412 - 29,638,553 (-)NCBIUU_Cfam_GSD_1.0
Yap1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494785,795,986 - 85,901,455 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365515,634,751 - 5,740,567 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365515,638,383 - 5,740,523 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
YAP1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl932,811,416 - 32,925,603 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1932,811,629 - 32,924,926 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2936,760,481 - 36,872,904 (+)NCBISscrofa10.2Sscrofa10.2susScr3
YAP1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1193,479,478 - 93,605,340 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl193,479,135 - 93,606,808 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604332,256,708 - 32,382,950 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Yap1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624878621,214 - 776,363 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Yap1
213 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:378
Count of miRNA genes:134
Interacting mature miRNAs:148
Transcripts:ENSRNOT00000007866, ENSRNOT00000008074, ENSRNOT00000031189
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
9590084Insglur5Insulin/glucose ratio QTL 518.540.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)8124597739Rat
2317882Alcrsp24Alcohol response QTL 243.20.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)8125902202Rat
12880023Bw184Body weight QTL 1840.001body mass (VT:0001259)body weight (CMO:0000012)8209764047097640Rat
12880025Cm102Cardiac mass QTL 1020.044heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)8209764047097640Rat
12880028Cm103Cardiac mass QTL 1030.02heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)8209764047097640Rat
12880044Am9Aortic mass QTL 90.007aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)8209764047097640Rat
2317032Ginf2Gastrointestinal inflammation QTL 23.210.005liver integrity trait (VT:0010547)liver granuloma severity score (CMO:0002157)8470581049705810Rat
2317036Livw3Liver weight QTL 32.430.01liver mass (VT:0003402)liver weight to body weight ratio (CMO:0000633)8470581049705810Rat
2317048Ginf1Gastrointestinal inflammation QTL 13.520.005cecum mucosa thickness (VT:0010234)enterocolitis severity score (CMO:0002138)8470581049705810Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 43 51 41 13 41 8 11 61 35 40 11 8
Low 1 6 6 13 1
Below cutoff

Sequence


RefSeq Acc Id: ENSRNOT00000007866   ⟹   ENSRNOP00000007866
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl85,095,722 - 5,167,010 (-)Ensembl
Rnor_6.0 Ensembl86,140,270 - 6,203,579 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000008074   ⟹   ENSRNOP00000008074
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl85,098,233 - 5,167,010 (-)Ensembl
Rnor_6.0 Ensembl86,135,542 - 6,203,579 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000031189   ⟹   ENSRNOP00000034369
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl85,095,739 - 5,167,010 (-)Ensembl
Rnor_6.0 Ensembl86,135,542 - 6,203,579 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000085285   ⟹   ENSRNOP00000074302
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl85,095,739 - 5,167,010 (-)Ensembl
Rnor_6.0 Ensembl86,135,542 - 6,203,579 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000087278   ⟹   ENSRNOP00000071631
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl85,098,233 - 5,167,010 (-)Ensembl
Rnor_6.0 Ensembl86,135,493 - 6,203,515 (-)Ensembl
RefSeq Acc Id: NM_001394328   ⟹   NP_001381257
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8813,380,551 - 13,451,437 (-)NCBI
mRatBN7.285,095,705 - 5,166,601 (-)NCBI
RefSeq Acc Id: NM_001394329   ⟹   NP_001381258
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8813,380,551 - 13,451,437 (-)NCBI
mRatBN7.285,095,705 - 5,166,601 (-)NCBI
RefSeq Acc Id: NR_172096
RefSeq Status: VALIDATED
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8813,380,551 - 13,451,437 (-)NCBI
mRatBN7.285,095,705 - 5,166,601 (-)NCBI
RefSeq Acc Id: XM_006242488   ⟹   XP_006242550
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8813,380,551 - 13,451,640 (-)NCBI
mRatBN7.285,095,705 - 5,166,808 (-)NCBI
Rnor_6.086,133,014 - 6,204,240 (-)NCBI
Rnor_5.086,131,653 - 6,202,586 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006242489   ⟹   XP_006242551
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8813,380,551 - 13,451,628 (-)NCBI
mRatBN7.285,095,705 - 5,166,794 (-)NCBI
Rnor_6.086,133,014 - 6,204,236 (-)NCBI
Rnor_5.086,131,653 - 6,202,586 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006242490   ⟹   XP_006242552
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8813,380,551 - 13,451,634 (-)NCBI
mRatBN7.285,095,705 - 5,166,802 (-)NCBI
Rnor_6.086,133,014 - 6,204,238 (-)NCBI
Rnor_5.086,131,653 - 6,202,586 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006242492   ⟹   XP_006242554
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8813,380,551 - 13,451,630 (-)NCBI
mRatBN7.285,095,705 - 5,166,797 (-)NCBI
Rnor_6.086,133,014 - 6,204,237 (-)NCBI
Rnor_5.086,131,653 - 6,202,586 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008765893   ⟹   XP_008764115
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8813,380,551 - 13,451,638 (-)NCBI
mRatBN7.285,095,705 - 5,166,806 (-)NCBI
Rnor_6.086,133,014 - 6,204,239 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008765894   ⟹   XP_008764116
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8813,380,551 - 13,451,626 (-)NCBI
mRatBN7.285,095,705 - 5,166,792 (-)NCBI
Rnor_6.086,133,014 - 6,204,235 (-)NCBI
Sequence:
RefSeq Acc Id: XP_006242552   ⟸   XM_006242490
- Peptide Label: isoform X3
- UniProtKB: R9PXS9 (UniProtKB/TrEMBL),   A0A0G2K0Y6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006242550   ⟸   XM_006242488
- Peptide Label: isoform X1
- UniProtKB: A0A0G2K0Y6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006242551   ⟸   XM_006242489
- Peptide Label: isoform X2
- UniProtKB: A0A8L2QHR7 (UniProtKB/TrEMBL),   A0A0G2K0Y6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006242554   ⟸   XM_006242492
- Peptide Label: isoform X6
- UniProtKB: A0A0G2K0Y6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008764115   ⟸   XM_008765893
- Peptide Label: isoform X4
- UniProtKB: A0A0G2K0Y6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008764116   ⟸   XM_008765894
- Peptide Label: isoform X5
- UniProtKB: A0A8L2R8L7 (UniProtKB/TrEMBL),   A0A0G2K0Y6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000034369   ⟸   ENSRNOT00000031189
RefSeq Acc Id: ENSRNOP00000008074   ⟸   ENSRNOT00000008074
RefSeq Acc Id: ENSRNOP00000074302   ⟸   ENSRNOT00000085285
RefSeq Acc Id: ENSRNOP00000071631   ⟸   ENSRNOT00000087278
RefSeq Acc Id: ENSRNOP00000007866   ⟸   ENSRNOT00000007866
RefSeq Acc Id: NP_001381258   ⟸   NM_001394329
- Peptide Label: 2
- UniProtKB: Q3LRU5 (UniProtKB/Swiss-Prot),   Q3LRU4 (UniProtKB/Swiss-Prot),   Q2EJA0 (UniProtKB/Swiss-Prot),   Q3LRU6 (UniProtKB/Swiss-Prot),   A0A0G2K0Y6 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001381257   ⟸   NM_001394328
- Peptide Label: 1
- UniProtKB: A0A0G2K0Y6 (UniProtKB/TrEMBL)
Protein Domains
WW

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q2EJA0-F1-model_v2 AlphaFold Q2EJA0 1-469 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1306035 AgrOrtholog
BioCyc Gene G2FUF-31761 BioCyc
Ensembl Genes ENSRNOG00000005933 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000007866.7 UniProtKB/TrEMBL
  ENSRNOT00000008074.8 UniProtKB/Swiss-Prot
  ENSRNOT00000031189.8 UniProtKB/TrEMBL
  ENSRNOT00000085285.2 UniProtKB/TrEMBL
  ENSRNOT00000087278 UniProtKB/TrEMBL
  ENSRNOT00000087278.2 UniProtKB/Swiss-Prot
Gene3D-CATH 2.20.70.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  6.20.430.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro WW_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WW_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:363014 UniProtKB/Swiss-Prot
NCBI Gene 363014 ENTREZGENE
PANTHER TRANSCRIPTIONAL COACTIVATOR YAP1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  YES-ASSOCIATED PROTEIN YAP1 FAMILY MEMBER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam PF00397 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Yap1 PhenoGen
PROSITE WW_DOMAIN_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WW_DOMAIN_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000005933 RatGTEx
SMART SM00456 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF51045 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2K0Y6 ENTREZGENE, UniProtKB/TrEMBL
  A0A8L2QHR7 ENTREZGENE, UniProtKB/TrEMBL
  A0A8L2R8L7 ENTREZGENE, UniProtKB/TrEMBL
  Q2EJA0 ENTREZGENE
  Q3LRU4 ENTREZGENE
  Q3LRU5 ENTREZGENE
  Q3LRU6 ENTREZGENE
  R9PXS9 ENTREZGENE, UniProtKB/TrEMBL
  YAP1_RAT UniProtKB/Swiss-Prot
UniProt Secondary Q3LRU4 UniProtKB/Swiss-Prot
  Q3LRU5 UniProtKB/Swiss-Prot
  Q3LRU6 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2020-01-09 Yap1  Yes1 associated transcriptional regulator  Yap1  yes-associated protein 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Yap1  yes-associated protein 1  Yap  yes-associated protein  Symbol and Name updated 1299863 APPROVED
2005-12-06 Yap  yes-associated protein  Yap_predicted  yes-associated protein (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Yap_predicted  yes-associated protein (predicted)      Symbol and Name status set to approved 70820 APPROVED