Glud1 (glutamate dehydrogenase 1) - Rat Genome Database

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Gene: Glud1 (glutamate dehydrogenase 1) Rattus norvegicus
Analyze
Symbol: Glud1
Name: glutamate dehydrogenase 1
RGD ID: 2708
Description: Exhibits enzyme binding activity and glutamate dehydrogenase (NAD+) activity. Involved in cerebellum development; long-term memory; and response to aluminum ion. Localizes to mitochondrion. Biomarker of brain disease (multiple) and fascioliasis. Human ortholog(s) of this gene implicated in familial hyperinsulinemic hypoglycemia 6; hyperinsulinism; hypoglycemia; and late onset Parkinson's disease. Orthologous to several human genes including GLUD1 (glutamate dehydrogenase 1); PARTICIPATES IN 2-hydroxyglutaric aciduria pathway; AGAT deficiency pathway; arginine and proline metabolic pathway; INTERACTS WITH (+)-pilocarpine; 1,1,2-trichloroethane; 1,2-dichlorobenzene.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: Ac2-281; GDH 1; Gdh1; Glud; Gludeha; glutamate dehydrogenase; glutamate dehydrogenase 1, mitochondrial; memory related gene 2; memory-related gene 2; memory-related protein 2; MGC93608; MRG-2; RNGLUDEHA
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Is Marker For: QTLs:   BpQTLcluster13  
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2169,640,312 - 9,673,961 (+)NCBI
Rnor_6.0 Ensembl1610,662,021 - 10,695,557 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01610,661,486 - 10,695,557 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0168,980,352 - 9,014,005 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4169,965,718 - 9,999,254 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1169,965,715 - 9,999,248 (+)NCBI
Celera165,542,860 - 5,576,454 (-)NCBICelera
Cytogenetic Map16p15NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (EXP)
(-)-epigallocatechin 3-gallate  (ISO)
(aminooxy)acetic acid  (ISO)
1,1,2-trichloroethane  (EXP)
1,2-dichlorobenzene  (EXP,ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,3,7,8-tetrabromodibenzodioxine  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (EXP)
2,5-hexanedione  (EXP)
2-hydroxyglutaric acid  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
acrylamide  (EXP)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (EXP)
all-trans-retinoic acid  (ISO)
amiodarone  (EXP)
ammonia  (ISO)
ammonium chloride  (EXP)
aniline  (EXP)
Aroclor 1254  (EXP)
arsenous acid  (ISO)
atrazine  (ISO)
azathioprine  (ISO)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP,ISO)
bromobenzene  (EXP)
butan-2-one  (EXP,ISO)
caffeine  (ISO)
calcitriol  (ISO)
capsaicin  (ISO)
casticin  (ISO)
ceruletide  (EXP)
citric acid  (ISO)
clofibrate  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) chloride  (ISO)
copper(II) sulfate  (ISO)
CU-O LINKAGE  (ISO)
cyclohexanone  (EXP,ISO)
cyclosporin A  (ISO)
cyproconazole  (ISO)
D-glucose  (EXP)
dexamethasone  (EXP)
diarsenic trioxide  (ISO)
dioxygen  (EXP,ISO)
dipicolinic acid  (ISO)
disodium selenite  (ISO)
diuron  (EXP)
elemental selenium  (EXP)
enalaprilat dihydrate  (EXP)
epoxiconazole  (ISO)
ethanol  (EXP,ISO)
folic acid  (ISO)
gentamycin  (EXP)
ginsenoside Rg1  (EXP)
glafenine  (EXP)
glucose  (EXP)
hexadecanoic acid  (ISO)
lead(0)  (ISO)
lead(2+)  (ISO)
lithium chloride  (EXP)
manganese atom  (ISO)
manganese(0)  (ISO)
methapyrilene  (EXP)
Methyl isobutyl ketone  (EXP,ISO)
methylisothiazolinone  (ISO)
methylmercury chloride  (ISO)
monosodium L-glutamate  (EXP)
N-acetyl-L-cysteine  (ISO)
N-nitrosomorpholine  (EXP)
NADP zwitterion  (ISO)
NADP(+)  (ISO)
nefazodone  (EXP)
nimesulide  (EXP)
O-methyleugenol  (ISO)
oleic acid  (ISO)
paracetamol  (EXP,ISO)
paroxetine  (ISO)
perfluorooctanoic acid  (ISO)
potassium dichromate  (EXP)
pregnenolone 16alpha-carbonitrile  (EXP)
propiconazole  (ISO)
Propiverine  (EXP)
quercetin  (ISO)
sarin  (ISO)
selenium atom  (EXP)
sodium fluoride  (ISO)
styrene  (EXP)
tamoxifen  (ISO)
tauroursodeoxycholic acid  (EXP)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
tetracycline  (EXP)
thioacetamide  (ISO)
titanium dioxide  (ISO)
trichostatin A  (ISO)
valdecoxib  (EXP)
valproic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
1. Amuro N, etal., Nucleic Acids Res 1989 Mar 25;17(6):2356.
2. Burbaeva GSh, etal., Neurochem Res. 2005 Nov;30(11):1443-51.
3. Cavallaro S, etal., Proc Natl Acad Sci U S A 1997 Sep 2;94(18):9669-73.
4. Das AT, etal., Eur J Biochem 1993 Aug 1;215(3):777-85.
5. Das AT, etal., Eur J Biochem 1993 Feb 1;211(3):795-803.
6. Das AT, etal., Nucleic Acids Res 1989 Mar 25;17(6):2355.
7. Dutuit M, etal., Glia. 2000 Oct;32(1):15-24.
8. Erakovic V, etal., Epilepsia. 2001 Feb;42(2):181-9.
9. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
10. GOA data from the GO Consortium
11. Hammer J, etal., Glia. 2008 Jun;56(8):856-68.
12. Hardin-Pouzet H, etal., Glia. 1997 May;20(1):79-85.
13. Holownia A, etal., Mater Med Pol. 1994 Jan-Mar;26(1):25-7.
14. KEGG
15. Korolainen MA, etal., Neurobiol Aging. 2006 Jan;27(1):42-53. Epub 2005 Jan 23.
16. Li C, etal., J Biol Chem. 2010 Oct 8;285(41):31806-18. Epub 2010 Jul 29.
17. Martinez-Rodriguez R, etal., Cell Mol Biol. 1982;28(6):513-20.
18. MGD data from the GO Consortium
19. Miki Y, etal., J Pediatr. 2000 Jan;136(1):69-72.
20. NCBI rat LocusLink and RefSeq merged data July 26, 2002
21. OMIM Disease Annotation Pipeline
22. Paz A, etal., Parasitol Res. 1999 Aug;85(8-9):770-5.
23. Pipeline to import KEGG annotations from KEGG into RGD
24. Pipeline to import SMPDB annotations from SMPDB into RGD
25. RGD automated data pipeline
26. RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
27. RGD automated import pipeline for gene-chemical interactions
28. Schroeder JM, etal., Am J Physiol Renal Physiol. 2003 Aug;285(2):F258-65. Epub 2003 Apr 8.
29. Schwerdt G, etal., Biochem J. 1991 Dec 1;280 ( Pt 2):353-7.
30. Stanley CA, etal., N Engl J Med 1998 May 7;338(19):1352-7.
31. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
32. Surendran S, etal., Neurosci Lett. 2004 Mar 18;358(1):29-32.
33. Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
34. Thomas JW, etal., Metab Brain Dis. 1988 Jun;3(2):81-90.
35. Zatta P, etal., Eur J Biochem. 2000 May;267(10):3049-55.
36. Zhang X, etal., J Biol Chem. 2004 Oct 8;279(41):43035-45. Epub 2004 Jul 23.
Additional References at PubMed
PMID:6121377   PMID:11032875   PMID:11502802   PMID:11792727   PMID:11903050   PMID:12193607   PMID:12742085   PMID:12865426   PMID:14651853   PMID:14760703   PMID:15489334   PMID:15578726  
PMID:16959573   PMID:17923681   PMID:18614015   PMID:18688271   PMID:19858196   PMID:20332361   PMID:22926577   PMID:23281078   PMID:23663782   PMID:24319738   PMID:24625528   PMID:26767982  
PMID:29784783  


Genomics

Comparative Map Data
Glud1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2169,640,312 - 9,673,961 (+)NCBI
Rnor_6.0 Ensembl1610,662,021 - 10,695,557 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01610,661,486 - 10,695,557 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0168,980,352 - 9,014,005 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4169,965,718 - 9,999,254 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1169,965,715 - 9,999,248 (+)NCBI
Celera165,542,860 - 5,576,454 (-)NCBICelera
Cytogenetic Map16p15NCBI
GLUD1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1087,050,202 - 87,094,843 (-)EnsemblGRCh38hg38GRCh38
GRCh381087,050,202 - 87,094,843 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371088,809,959 - 88,854,600 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361088,800,223 - 88,844,603 (-)NCBINCBI36hg18NCBI36
Build 341088,800,224 - 88,844,603NCBI
Celera1082,812,987 - 82,857,799 (-)NCBI
Cytogenetic Map10q23.2NCBI
HuRef1082,663,600 - 82,708,547 (-)NCBIHuRef
CHM1_11089,091,700 - 89,136,534 (-)NCBICHM1_1
Glud1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391434,032,684 - 34,066,990 (+)NCBIGRCm39mm39
GRCm39 Ensembl1434,032,684 - 34,067,222 (+)Ensembl
GRCm381434,310,727 - 34,345,033 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1434,310,727 - 34,345,265 (+)EnsemblGRCm38mm10GRCm38
MGSCv371435,123,913 - 35,158,219 (+)NCBIGRCm37mm9NCBIm37
MGSCv361433,139,843 - 33,173,999 (+)NCBImm8
Celera1430,576,519 - 30,610,613 (+)NCBICelera
Cytogenetic Map14BNCBI
cM Map1420.8NCBI
Glud1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049555105,987,811 - 6,021,001 (-)NCBIChiLan1.0ChiLan1.0
GLUD1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Mhudiblu_PPA_v01083,498,338 - 83,540,730 (-)NCBIMhudiblu_PPA_v0panPan3
GLUD1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1434,629,046 - 34,662,711 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha434,620,536 - 34,654,550 (-)NCBI
ROS_Cfam_1.0434,989,453 - 35,023,479 (-)NCBI
UMICH_Zoey_3.1434,834,668 - 34,868,716 (-)NCBI
UNSW_CanFamBas_1.0435,003,687 - 35,037,703 (-)NCBI
UU_Cfam_GSD_1.0435,510,039 - 35,544,117 (-)NCBI
Glud1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721343,783,257 - 43,803,587 (+)NCBI
SpeTri2.0NW_0049366015,415,857 - 5,435,964 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GLUD1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1487,968,850 - 88,005,550 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11487,968,850 - 88,005,375 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21495,361,081 - 95,397,604 (-)NCBISscrofa10.2Sscrofa10.2susScr3
GLUD1
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1944,653,044 - 44,690,142 (+)NCBI
ChlSab1.1 Ensembl944,653,289 - 44,688,954 (+)Ensembl
Glud1
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624841133,267 - 171,324 (+)NCBI

Position Markers
D16Mgh3  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2169,638,913 - 9,639,137 (+)MAPPER
Rnor_6.01610,660,513 - 10,660,736NCBIRnor6.0
Rnor_5.0168,978,954 - 8,979,177UniSTSRnor5.0
RGSC_v3.4169,964,209 - 9,964,433RGDRGSC3.4
RGSC_v3.4169,964,210 - 9,964,433UniSTSRGSC3.4
RGSC_v3.1169,964,207 - 9,964,431RGD
Celera165,577,625 - 5,577,848UniSTS
Cytogenetic Map16p16UniSTS
D16Mco9  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2169,638,921 - 9,639,125 (+)MAPPER
Rnor_6.01610,660,521 - 10,660,724NCBIRnor6.0
Rnor_5.0168,978,962 - 8,979,165UniSTSRnor5.0
RGSC_v3.4169,964,217 - 9,964,421RGDRGSC3.4
RGSC_v3.4169,964,218 - 9,964,421UniSTSRGSC3.4
RGSC_v3.1169,964,215 - 9,964,419RGD
Celera165,577,637 - 5,577,840UniSTS
Cytogenetic Map16p16UniSTS
D16Arb11  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2169,639,189 - 9,639,391 (+)MAPPER
Rnor_6.01610,660,789 - 10,660,990NCBIRnor6.0
Rnor_5.0168,979,230 - 8,979,431UniSTSRnor5.0
RGSC_v3.4169,964,485 - 9,964,687RGDRGSC3.4
RGSC_v3.4169,964,486 - 9,964,687UniSTSRGSC3.4
RGSC_v3.1169,964,483 - 9,964,685RGD
Celera165,577,371 - 5,577,572UniSTS
Cytogenetic Map16p16UniSTS
RH127502  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2169,673,547 - 9,673,747 (+)MAPPER
Rnor_6.01610,695,144 - 10,695,343NCBIRnor6.0
Rnor_5.0169,013,592 - 9,013,791UniSTSRnor5.0
RGSC_v3.4169,998,841 - 9,999,040UniSTSRGSC3.4
Celera165,543,074 - 5,543,273UniSTS
RH 3.4 Map1694.9UniSTS
Cytogenetic Map16p16UniSTS
RH127664  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2169,673,037 - 9,673,217 (+)MAPPER
Rnor_6.01610,694,634 - 10,694,813NCBIRnor6.0
Rnor_5.0169,013,082 - 9,013,261UniSTSRnor5.0
RGSC_v3.4169,998,331 - 9,998,510UniSTSRGSC3.4
Celera165,543,604 - 5,543,783UniSTS
RH 3.4 Map1696.4UniSTS
Cytogenetic Map16p16UniSTS
RH94868  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2169,673,648 - 9,673,819 (+)MAPPER
Rnor_6.01610,695,245 - 10,695,415NCBIRnor6.0
Rnor_5.0169,013,693 - 9,013,863UniSTSRnor5.0
RGSC_v3.4169,998,942 - 9,999,112UniSTSRGSC3.4
Celera165,543,002 - 5,543,172UniSTS
Cytogenetic Map16p16UniSTS
RH94869  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2169,673,651 - 9,673,834 (+)MAPPER
Rnor_6.01610,695,248 - 10,695,430NCBIRnor6.0
Rnor_5.0169,013,696 - 9,013,878UniSTSRnor5.0
RGSC_v3.4169,998,945 - 9,999,127UniSTSRGSC3.4
Celera165,542,987 - 5,543,169UniSTS
Cytogenetic Map16p16UniSTS
GDB:277890  
Rat AssemblyChrPosition (strand)SourceJBrowse
Celera165,575,880 - 5,576,138UniSTS
Cytogenetic Map16p16UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70183BpQTLcluster13Blood pressure QTL cluster 133.654arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)16501380245905331Rat
70183BpQTLcluster13Blood pressure QTL cluster 133.654arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16501380245905331Rat
70183BpQTLcluster13Blood pressure QTL cluster 133.654arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)16501380245905331Rat
2303566Bw90Body weight QTL 902body mass (VT:0001259)body weight (CMO:0000012)16141240937Rat
631830Alc7Alcohol consumption QTL 72.9consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)16127556253Rat
737819Hcas4Hepatocarcinoma susceptibility QTL 44.43liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)16501380250169318Rat
737825Alc13Alcohol consumption QTL 134.5consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)16501380218360147Rat
737826Alc11Alcohol consumption QTL 113.2consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)16501380264012784Rat
631561Hcuc2Hepatic copper content QTL 22.8hepatic copper amount (VT:0003065)liver total copper weight (CMO:0001507)16141240957Rat
1354584Despr6Despair related QTL 63.10.0067locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)16141240937Rat
1582235Insul8Insulin level QTL 83.30.0063blood insulin amount (VT:0001560)calculated serum insulin level (CMO:0000359)16127556253Rat
2307172Activ4Activity QTL 43.710.00023locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)16134465490Rat
2312660Bw95Body weight QTL 950.05inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)16155018763210301Rat
2312663Slep9Serum leptin concentration QTL 90.001blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)16155018763210301Rat
2312666Insul16Insulin level QTL 160.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)16155018763210301Rat
2312669Stl23Serum triglyceride level QTL 230.01blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)16155018763210301Rat
2301406Kidm39Kidney mass QTL 390.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)16329668817464293Rat
2302380Slep6Serum leptin concentration QTL 63.36blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)16133160624Rat
634355Rends4Renal damage susceptibility QTL 40.05kidney blood vessel morphology trait (VT:0000530)organ lesion measurement (CMO:0000677)16127556253Rat
1600369Hcas8Hepatocarcinoma susceptibility QTL 8liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)16124228366Rat
1600378Arunc4Aerobic running capacity QTL 40.03exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)16109005486162972Rat
1300133Rf24Renal function QTL 243.64blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)16413635523105837Rat
1354625Despr7Despair related QTL 73.160.016locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)16172829746728297Rat
2306902Bp339Blood pressure QTL 3390.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16413635545905331Rat
2293343Glom16Glomerulus QTL 167.4kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)16155018749247447Rat
61338Bp23Blood pressure QTL 234.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16501380250013802Rat
61372Bp40Blood pressure QTL 402.2blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)16509870419398181Rat
61405Niddm6Non-insulin dependent diabetes mellitus QTL 63.660.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)16501380252144919Rat
6903319Bw114Body weight QTL 1142.70.0037body mass (VT:0001259)body weight (CMO:0000012)1624459345244593Rat
9590151Scort8Serum corticosterone level QTL 88.450.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)16131816439Rat
7411664Foco30Food consumption QTL 30110.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)16134074146340741Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:806
Count of miRNA genes:283
Interacting mature miRNAs:341
Transcripts:ENSRNOT00000013788, ENSRNOT00000074601
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 57 41 19 41 8 11 74 35 41 11 8
Low
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000083446   ⟹   ENSRNOP00000075032
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1610,662,021 - 10,695,557 (+)Ensembl
RefSeq Acc Id: NM_012570   ⟹   NP_036702
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2169,640,312 - 9,673,961 (+)NCBI
Rnor_6.01610,661,911 - 10,695,557 (+)NCBI
Rnor_5.0168,980,352 - 9,014,005 (+)NCBI
RGSC_v3.4169,965,718 - 9,999,254 (+)RGD
Celera165,542,860 - 5,576,454 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017599992   ⟹   XP_017455481
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01610,661,486 - 10,695,557 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_036702   ⟸   NM_012570
- Peptide Label: precursor
- UniProtKB: P10860 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_017455481   ⟸   XM_017599992
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSRNOP00000075032   ⟸   ENSRNOT00000083446

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699956
Promoter ID:EPDNEW_R10480
Type:multiple initiation site
Name:Glud1_1
Description:glutamate dehydrogenase 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01610,662,013 - 10,662,073EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2708 AgrOrtholog
Ensembl Genes ENSRNOG00000057367 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSRNOP00000075032 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000083446 ENTREZGENE, UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7107138 IMAGE-MGC_LOAD
InterPro Glu/Leu/Phe/Val_DH UniProtKB/Swiss-Prot
  Glu/Leu/Phe/Val_DH_AS UniProtKB/Swiss-Prot
  Glu/Leu/Phe/Val_DH_C UniProtKB/Swiss-Prot
  Glu/Leu/Phe/Val_DH_dimer_dom UniProtKB/Swiss-Prot
  NAD(P)-bd_dom_sf UniProtKB/Swiss-Prot
  NAD_bind_Glu_DH UniProtKB/Swiss-Prot
KEGG Report rno:24399 UniProtKB/Swiss-Prot
MGC_CLONE MGC:93608 IMAGE-MGC_LOAD
NCBI Gene 24399 ENTREZGENE
Pfam ELFV_dehydrog UniProtKB/Swiss-Prot
  ELFV_dehydrog_N UniProtKB/Swiss-Prot
PhenoGen Glud1 PhenoGen
PRINTS GLFDHDRGNASE UniProtKB/Swiss-Prot
PROSITE GLFV_DEHYDROGENASE UniProtKB/Swiss-Prot
SMART ELFV_dehydrog UniProtKB/Swiss-Prot
Superfamily-SCOP SSF51735 UniProtKB/Swiss-Prot
TIGR TC216839
UniProt DHE3_RAT UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary Q66HI8 UniProtKB/Swiss-Prot
  Q6LC16 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-11-06 Glud1  glutamate dehydrogenase 1    Glutamate dehydrogenase  Name updated 625702 APPROVED
2002-06-10 Glud1  Glutamate dehydrogenase      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_transcript contains 13 exons and spans approximately 34 kb pairs 632876
gene_transcript promoter contains binding sites of the transcription factors Sp1 and Zif268 632876