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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:L-gamma-glutamyl-L-cysteine
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Accession:CHEBI:17515 term browser browse the term
Definition:A molecular entity formed when L-cysteine amino group binds to the gamma-carbonyl of L-glutamic acid.
Synonyms:related_synonym: 5-L-Glutamyl-L-cysteine;   Formula=C8H14N2O5S;   Glu(-Cys);   InChI=1S/C8H14N2O5S/c9-4(7(12)13)1-2-6(11)10-5(3-16)8(14)15/h4-5,16H,1-3,9H2,(H,10,11)(H,12,13)(H,14,15)/t4-,5-/m0/s1;   InChIKey=RITKHVBHSGLULN-WHFBIAKZSA-N;   L-gamma-Glutamylcysteine;   SMILES=N[C@@H](CCC(=O)N[C@@H](CS)C(O)=O)C(O)=O;   gamma-Glu-Cys;   gamma-Glutamylcysteine;   gammaGluCys
 alt_id: CHEBI:10566;   CHEBI:10570;   CHEBI:12400;   CHEBI:12404;   CHEBI:24185;   CHEBI:24194;   CHEBI:39975
 xref: CAS:636-58-8;   DrugBank:DB03408;   HMDB:HMDB0001049;   KEGG:C00669;   KNApSAcK:C00007507
 xref_mesh: MESH:C017341
 xref: MetaCyc:L-GAMMA-GLUTAMYLCYSTEINE;   PMID:11409324;   Reaxys:1729154;   Wikipedia:Gamma-Glutamylcysteine
 cyclic_relationship: is_conjugate_acid_of CHEBI:58173


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L-gamma-glutamyl-L-cysteine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gclc glutamate-cysteine ligase, catalytic subunit multiple interactions
increases chemical synthesis
EXP Buthionine Sulfoximine inhibits the reaction [GCLC protein results in increased chemical synthesis of gamma-glutamylcysteine]; Cysteine promotes the reaction [GCLC protein results in increased chemical synthesis of gamma-glutamylcysteine]; Excitatory Amino Acid Agents promotes the reaction [GCLC protein results in increased chemical synthesis of gamma-glutamylcysteine] CTD PMID:15115889 NCBI chr 8:85,059,051...85,097,471
Ensembl chr 8:85,059,051...85,097,468
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Path 1
Term Annotations click to browse term
  CHEBI ontology 19767
    role 19714
      biological role 19714
        biochemical role 19303
          ferroptosis inducer 0
            L-glutamic acid 10203
              L-gamma-glutamyl-L-cysteine 1
                DON-10-gamma-glutamylcysteine 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19767
    subatomic particle 19766
      composite particle 19766
        hadron 19766
          baryon 19766
            nucleon 19766
              atomic nucleus 19766
                atom 19766
                  main group element atom 19657
                    p-block element atom 19657
                      carbon group element atom 19573
                        carbon atom 19563
                          organic molecular entity 19563
                            organic group 18599
                              organic divalent group 18590
                                organodiyl group 18590
                                  carbonyl group 18505
                                    carbonyl compound 18505
                                      carboxylic acid 18156
                                        carboacyl group 17415
                                          univalent carboacyl group 17415
                                            carbamoyl group 17212
                                              carboxamide 17212
                                                peptide 9418
                                                  oligopeptide 1251
                                                    dipeptide 373
                                                      glutamyl-L-amino acid 1
                                                        gamma-glutamylcysteine 1
                                                          L-gamma-glutamyl-L-cysteine 1
                                                            DON-10-gamma-glutamylcysteine 0
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