Wnt3a (Wnt family member 3A) - Rat Genome Database

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Gene: Wnt3a (Wnt family member 3A) Rattus norvegicus
Analyze
Symbol: Wnt3a
Name: Wnt family member 3A
RGD ID: 1308057
Description: Predicted to enable several functions, including co-receptor binding activity; identical protein binding activity; and signaling receptor binding activity. Predicted to be involved in several processes, including negative regulation of cell differentiation; nervous system development; and positive regulation of protein phosphorylation. Predicted to act upstream of or within several processes, including nervous system development; positive regulation of cell population proliferation; and positive regulation of macromolecule metabolic process. Predicted to be located in cell surface. Predicted to be part of Wnt-Frizzled-LRP5/6 complex. Predicted to be active in extracellular space and glutamatergic synapse. Biomarker of hypothyroidism. Orthologous to human WNT3A (Wnt family member 3A); PARTICIPATES IN Wnt signaling pathway; Wnt signaling, canonical pathway; basal cell carcinoma pathway; INTERACTS WITH 2,2',4,4',5,5'-hexachlorobiphenyl; aldehydo-D-glucose; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: protein Wnt-3a; wingless-related MMTV integration site 3A; wingless-type MMTV integration site family, member 3A
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21044,034,174 - 44,078,463 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1044,034,194 - 44,078,324 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1048,728,066 - 48,767,462 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01048,218,422 - 48,257,821 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01043,722,025 - 43,761,422 (-)NCBIRnor_WKY
Rnor_6.01045,598,898 - 45,643,151 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1045,598,912 - 45,638,035 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01045,354,369 - 45,398,647 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41045,553,682 - 45,594,983 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11045,567,304 - 45,609,958 (-)NCBI
Celera1043,297,443 - 43,336,315 (-)NCBICelera
Cytogenetic Map10q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-methoxypsoralen  (ISO)
6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide  (ISO)
aldehydo-D-glucose  (EXP)
all-trans-retinoic acid  (ISO)
aphidicolin  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
belinostat  (ISO)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
CHIR 99021  (ISO)
chloroprene  (ISO)
chlorpyrifos  (ISO)
chrysin 5,7-dimethyl ether  (EXP)
Cuprizon  (EXP)
cyfluthrin  (ISO)
cypermethrin  (ISO)
D-glucose  (EXP)
deguelin  (ISO)
dexamethasone  (ISO)
diazinon  (EXP)
dieldrin  (EXP)
diethylstilbestrol  (ISO)
dioxygen  (ISO)
ethanol  (ISO)
etoposide  (ISO)
fluoxetine  (EXP,ISO)
folic acid  (ISO)
glucose  (EXP)
glyphosate  (ISO)
griseofulvin  (ISO)
harmine  (ISO)
hexachlorophene  (ISO)
hydroxyurea  (ISO)
indole-3-methanol  (EXP)
L-ascorbic acid  (ISO)
lead nitrate  (ISO)
lead(0)  (ISO)
lead(2+)  (ISO)
lipopolysaccharide  (ISO)
Matrine  (ISO)
Morroniside  (EXP)
N-nitrosodiethylamine  (EXP)
nickel atom  (EXP)
niclosamide  (EXP,ISO)
Nor-9-carboxy-delta9-THC  (ISO)
paclitaxel  (ISO)
paraquat  (EXP)
pluronic P-123  (EXP)
Poloxamer  (EXP)
resveratrol  (ISO)
SB 415286  (EXP)
SB 431542  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
streptozocin  (ISO)
tadalafil  (ISO)
thioacetamide  (EXP)
thymoquinone  (ISO)
triptonide  (ISO)
uranium atom  (EXP)
valproic acid  (ISO)
XAV939  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
anterior/posterior pattern specification  (ISO)
axis elongation involved in somitogenesis  (ISO)
axon guidance  (ISO)
axonogenesis  (ISO)
B cell proliferation  (ISO)
biological_process  (ND)
calcium ion transmembrane transport via low voltage-gated calcium channel  (ISO)
canonical Wnt signaling pathway  (IBA,ISO)
canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment  (ISO)
cardiac muscle cell fate commitment  (ISO)
cell fate commitment  (IBA)
cell population proliferation  (ISO)
cell proliferation in forebrain  (ISO)
cell proliferation in midbrain  (ISO)
COP9 signalosome assembly  (ISO)
determination of left/right symmetry  (ISO)
dorsal/ventral neural tube patterning  (ISO)
extracellular matrix organization  (ISO)
fat cell differentiation  (ISO)
heart looping  (ISO)
hemopoiesis  (ISO)
hippocampus development  (ISO)
in utero embryonic development  (ISO)
inner ear morphogenesis  (ISO)
mammary gland development  (ISO)
mesoderm development  (ISO)
midbrain development  (ISO)
modulation of chemical synaptic transmission  (ISO)
myoblast differentiation  (ISO)
negative regulation of axon extension involved in axon guidance  (ISO)
negative regulation of dopaminergic neuron differentiation  (ISO)
negative regulation of fat cell differentiation  (ISO)
negative regulation of heart induction by canonical Wnt signaling pathway  (ISO)
negative regulation of neurogenesis  (ISO)
negative regulation of neuron death  (ISO)
negative regulation of neuron projection development  (ISO)
neurogenesis  (ISO)
neuron differentiation  (IBA)
osteoblast differentiation  (ISO)
paraxial mesodermal cell fate commitment  (ISO)
platelet activation  (ISO)
platelet aggregation  (ISO)
positive regulation of B cell proliferation  (ISO)
positive regulation of canonical Wnt signaling pathway  (ISO)
positive regulation of canonical Wnt signaling pathway involved in controlling type B pancreatic cell proliferation  (ISO)
positive regulation of cardiac muscle cell differentiation  (ISO)
positive regulation of cell population proliferation  (ISO)
positive regulation of cell-cell adhesion mediated by cadherin  (ISO)
positive regulation of collateral sprouting in absence of injury  (ISO)
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process  (ISO)
positive regulation of cytokine production  (ISO)
positive regulation of dermatome development  (ISO)
positive regulation of DNA-binding transcription factor activity  (ISO)
positive regulation of DNA-templated transcription  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of hepatocyte proliferation  (ISO)
positive regulation of mesodermal cell fate specification  (ISO)
positive regulation of neural precursor cell proliferation  (ISO)
positive regulation of peptidyl-serine phosphorylation  (ISO)
positive regulation of protein binding  (ISO)
positive regulation of protein kinase activity  (ISO)
positive regulation of protein localization to plasma membrane  (ISO)
positive regulation of protein phosphorylation  (ISO)
positive regulation of protein tyrosine kinase activity  (ISO)
positive regulation of receptor internalization  (ISO)
positive regulation of skeletal muscle tissue development  (ISO)
positive regulation of transcription by RNA polymerase II  (ISO)
post-anal tail morphogenesis  (ISO)
postsynapse to nucleus signaling pathway  (ISO)
protein localization  (ISO)
regulation of axonogenesis  (ISO)
regulation of cell differentiation  (ISO)
regulation of microtubule cytoskeleton organization  (ISO)
regulation of postsynapse to nucleus signaling pathway  (ISO)
regulation of presynapse assembly  (ISO)
regulation of RNA biosynthetic process  (ISO)
regulation of synapse organization  (ISO)
secondary palate development  (ISO)
skeletal muscle cell differentiation  (ISO)
somatic stem cell division  (ISO)
somitogenesis  (ISO)
spinal cord association neuron differentiation  (ISO)
transcription by RNA polymerase II  (ISO)
Wnt signaling pathway  (ISO)
Wnt signaling pathway involved in forebrain neuroblast division  (ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Differential regulation of midbrain dopaminergic neuron development by Wnt-1, Wnt-3a, and Wnt-5a. Castelo-Branco G, etal., Proc Natl Acad Sci U S A 2003 Oct 28;100(22):12747-52. Epub 2003 Oct 13.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. Wnt10a is involved in AER formation during chick limb development. Narita T, etal., Dev Dyn. 2005 Jun;233(2):282-7.
6. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
7. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
8. GOA pipeline RGD automated data pipeline
9. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
11. Comprehensive gene review and curation RGD comprehensive gene curation
12. The Wnt Homepage Roel Nusse - Howard Hughes Medical Institute and the Department of Developmental Biology at Stanford University, California, USA
13. Transformation by Wnt family proteins correlates with regulation of beta-catenin. Shimizu H, etal., Cell Growth Differ. 1997 Dec;8(12):1349-58.
14. Alternative wnt signaling is initiated by distinct receptors. van Amerongen R, etal., Sci Signal. 2008 Sep 2;1(35):re9.
15. Differential transformation of mammary epithelial cells by Wnt genes. Wong GT, etal., Mol Cell Biol. 1994 Sep;14(9):6278-86.
16. Effects of postnatal thyroid hormone deficiency on neurogenesis in the juvenile and adult rat. Zhang L, etal., Neurobiol Dis. 2009 Feb 19.
Additional References at PubMed
PMID:4819561   PMID:8167409   PMID:8299937   PMID:9126297   PMID:9356179   PMID:10409711   PMID:10557084   PMID:10631167   PMID:10654605   PMID:10893270   PMID:10933391   PMID:11029008  
PMID:11856745   PMID:11877374   PMID:12121999   PMID:12610652   PMID:12636920   PMID:12717450   PMID:12843296   PMID:12897152   PMID:15143170   PMID:15148409   PMID:15265686   PMID:15342465  
PMID:15454084   PMID:15579909   PMID:15796911   PMID:15961523   PMID:16115200   PMID:16291790   PMID:16501258   PMID:16543246   PMID:16581771   PMID:16602827   PMID:16890161   PMID:17027228  
PMID:17244647   PMID:17251350   PMID:17360443   PMID:17462603   PMID:17569865   PMID:17606995   PMID:17888405   PMID:17943183   PMID:17976063   PMID:17994217   PMID:18155657   PMID:18347988  
PMID:18413325   PMID:18521822   PMID:18555765   PMID:18606138   PMID:18716223   PMID:18929644   PMID:18941195   PMID:18986540   PMID:19001364   PMID:19001373   PMID:19075000   PMID:19101069  
PMID:19109969   PMID:19497282   PMID:19690384   PMID:19699733   PMID:19701191   PMID:19736317   PMID:19883499   PMID:19896444   PMID:19901330   PMID:19910923   PMID:19920076   PMID:19961844  
PMID:20093360   PMID:20137080   PMID:20371816   PMID:20404321   PMID:20412773   PMID:20501703   PMID:20559569   PMID:20723538   PMID:21189423   PMID:21238590   PMID:21249402   PMID:21539518  
PMID:21554246   PMID:21567076   PMID:21599637   PMID:21602191   PMID:21668888   PMID:22665494   PMID:22723415   PMID:22899650   PMID:23396967   PMID:23677472   PMID:23740243   PMID:23797875  
PMID:24080158   PMID:24254835   PMID:24307102   PMID:24922070   PMID:26024594   PMID:26209081   PMID:26218875   PMID:26687115   PMID:26902720   PMID:27484039   PMID:28260053   PMID:28347817  
PMID:28733458   PMID:30927382   PMID:31178968   PMID:32098078   PMID:32164275   PMID:32818702   PMID:33236141   PMID:33243628   PMID:34399774  


Genomics

Comparative Map Data
Wnt3a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21044,034,174 - 44,078,463 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1044,034,194 - 44,078,324 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1048,728,066 - 48,767,462 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01048,218,422 - 48,257,821 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01043,722,025 - 43,761,422 (-)NCBIRnor_WKY
Rnor_6.01045,598,898 - 45,643,151 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1045,598,912 - 45,638,035 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01045,354,369 - 45,398,647 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41045,553,682 - 45,594,983 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11045,567,304 - 45,609,958 (-)NCBI
Celera1043,297,443 - 43,336,315 (-)NCBICelera
Cytogenetic Map10q22NCBI
WNT3A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381228,006,998 - 228,061,271 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1228,006,998 - 228,061,271 (+)EnsemblGRCh38hg38GRCh38
GRCh371228,194,699 - 228,248,972 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361226,261,375 - 226,315,584 (+)NCBINCBI36Build 36hg18NCBI36
Build 341224,501,486 - 224,555,696NCBI
Celera1201,384,988 - 201,439,196 (+)NCBICelera
Cytogenetic Map1q42.13NCBI
HuRef1198,726,487 - 198,764,776 (+)NCBIHuRef
CHM1_11229,467,104 - 229,521,343 (+)NCBICHM1_1
T2T-CHM13v2.01227,196,039 - 227,250,282 (+)NCBIT2T-CHM13v2.0
Wnt3a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391159,138,862 - 59,181,577 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1159,138,859 - 59,181,578 (-)EnsemblGRCm39 Ensembl
GRCm381159,248,036 - 59,290,751 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1159,248,033 - 59,290,752 (-)EnsemblGRCm38mm10GRCm38
MGSCv371159,061,538 - 59,104,253 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361159,064,231 - 59,106,946 (-)NCBIMGSCv36mm8
Celera1164,013,041 - 64,056,135 (-)NCBICelera
Cytogenetic Map11B1.3NCBI
cM Map1137.17NCBI
Wnt3a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955581350,889 - 382,541 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955581351,375 - 382,541 (-)NCBIChiLan1.0ChiLan1.0
WNT3A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11208,628,706 - 208,674,469 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1208,628,706 - 208,674,469 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01203,409,294 - 203,463,214 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
WNT3A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.114864,393 - 899,698 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl14863,424 - 896,412 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha14241,282 - 287,493 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.014584,578 - 630,800 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl14583,618 - 631,058 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.114775,380 - 821,576 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.014556,162 - 602,358 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.014542,112 - 590,168 (-)NCBIUU_Cfam_GSD_1.0
Wnt3a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721387,809,460 - 87,851,090 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936864150,732 - 192,423 (-)EnsemblSpeTri2.0
SpeTri2.0NW_004936864150,742 - 179,205 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
WNT3A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl251,153,970 - 51,202,176 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1251,153,978 - 51,203,678 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2253,908,485 - 53,958,148 (-)NCBISscrofa10.2Sscrofa10.2susScr3
WNT3A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1251,664,316 - 1,675,006 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl251,666,053 - 1,719,881 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660551,547,656 - 1,601,952 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Wnt3a
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624937816,759 - 845,458 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624937816,752 - 845,866 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Wnt3a
181 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:128
Count of miRNA genes:82
Interacting mature miRNAs:91
Transcripts:ENSRNOT00000064505
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70223Bp57Blood pressure QTL 575arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)10180676123Rat
10401803Kidm50Kidney mass QTL 50kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1041834445418344Rat
631554Bp133Blood pressure QTL 1330.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1074336463851208Rat
2313064Bmd71Bone mineral density QTL 710.90.0001tibia mineral mass (VT:1000283)cortical volumetric bone mineral density (CMO:0001730)10538701450387014Rat
2313066Bss63Bone structure and strength QTL 631.40.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)10538701450387014Rat
2313081Bss64Bone structure and strength QTL 641.30.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)10538701450387014Rat
2313095Bss62Bone structure and strength QTL 621.50.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)10538701450387014Rat
2313104Bss61Bone structure and strength QTL 610.90.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)10538701450387014Rat
2298544Neuinf9Neuroinflammation QTL 94.6nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)10580199062146030Rat
8662860Vetf10Vascular elastic tissue fragility QTL 10artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)10615418273453136Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10635789696121100Rat
1578761Stresp21Stress response QTL 213.3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)10637574651375746Rat
2303118Mamtr7Mammary tumor resistance QTL 70.003mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)109658275104670812Rat
9590310Scort19Serum corticosterone level QTL 196.30.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)101147401056474010Rat
9590268Scort13Serum corticosterone level QTL 133.260.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)101147401056474010Rat
9589136Insul27Insulin level QTL 2710.460.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)101147401056474010Rat
2301967Cm73Cardiac mass QTL 734.55heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)101448701189062041Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014487011104060283Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014487011107057807Rat
1354587Kidm21Kidney mass QTL 213.3kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)101502851360430477Rat
631564Apr3Acute phase response QTL 33.9blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)101527595560275955Rat
6893350Bw99Body weight QTL 990.870.16body mass (VT:0001259)body weight (CMO:0000012)11590666560906665Rat
6893352Bw100Body weight QTL 1000.330.6body mass (VT:0001259)body weight (CMO:0000012)11590666560906665Rat
631532Cm50Cardiac mass QTL 506.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)101790711351786432Rat
1598852Anxrr19Anxiety related response QTL 195.07body movement coordination trait (VT:0005424)number of rearing movements in an experimental apparatus (CMO:0001752)101816784163167841Rat
2313055Bw96Body weight QTL 963.60.0001body mass (VT:0001259)body weight (CMO:0000012)101960648364606483Rat
2313087Bmd80Bone mineral density QTL 803.20.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)101960648364606483Rat
1554317Bmd4Bone mineral density QTL 49.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)101981604299406971Rat
1581497Esta1Estrogen-induced thymic atrophy QTL 1thymus mass (VT:0004954)thymus wet weight (CMO:0000855)102132980561345413Rat
724556Pur2Proteinuria QTL 25.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)102242750090627625Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
70224Eae3Experimental allergic encephalomyelitis QTL 34.1nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)102652195761345413Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102652195798003205Rat
631542Bp82Blood pressure QTL 826.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102652195798952741Rat
2300171Bmd58Bone mineral density QTL 584.90.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)102694462871944628Rat
10402859Bp381Blood pressure QTL 3810.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102760646872606468Rat
2292441Bp308Blood pressure QTL 308arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102760646872606468Rat
724527Bp148Blood pressure QTL 1480.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102845313673453136Rat
1600371Mcs21Mammary carcinoma susceptibility QTL 213mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)102887565052200160Rat
1331762Rf40Renal function QTL 403.873kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)102929950464155584Rat
1331791Cm31Cardiac mass QTL 313.84606heart mass (VT:0007028)heart wet weight (CMO:0000069)1029299504107211142Rat
631557Bp136Blood pressure QTL 1360.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)103063205375632053Rat
1576311Pia26Pristane induced arthritis QTL 26joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)103122402675632053Rat
1578779Tcas10Tongue tumor susceptibility QTL 103.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)103129743976297439Rat
1576319Cia29Collagen induced arthritis QTL 29joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)103397392178973921Rat
61332Eau3Experimental allergic uveoretinitis QTL 30.004uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)103449055945579777Rat
1354614Hpcl1Hepatic cholesterol level QTL 13.3liver cholesterol amount (VT:0010498)liver cholesterol level (CMO:0001597)103539226751793994Rat
1358897Stresp6Stress response QTL 64.170.022blood norepinephrine amount (VT:0005663)plasma norepinephrine level (CMO:0001010)103539226764155584Rat
61441Btemp1Thermal response to stress QTL 14body temperature trait (VT:0005535)core body temperature (CMO:0001036)103539245763642539Rat
2317042Aia20Adjuvant induced arthritis QTL 203.38joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)103756507982565079Rat
2317043Aia7Adjuvant induced arthritis QTL 73.82joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)103756507982565079Rat
1576308Schws1Schwannoma susceptibility QTL 10.0041nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)1040035094102359817Rat
631269Cia22Collagen induced arthritis QTL 228.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040035094104060283Rat
631270Cia23Collagen induced arthritis QTL 233.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040035094104060283Rat
631552Vetf2Vascular elastic tissue fragility QTL 24.50.0002aorta elastic tissue integrity trait (VT:0010556)artery internal elastic lamina non-tumorous lesion count (CMO:0001913)104114263386142633Rat
61463Bp12Blood pressure QTL 126.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104133325886333258Rat
8552805Bw145Body weight QTL 1452.2body mass (VT:0001259)change in body weight to body weight ratio (CMO:0002216)104194452678307017Rat
1298078Stresp5Stress response QTL 52.990.00025blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1042045676104670812Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)14232313287323132Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)14232313287323132Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)14232313287323132Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)14232313287323132Rat
70198BpQTLcluster9Blood pressure QTL cluster 92.94arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)104232313287323132Rat
6893342Cm78Cardiac mass QTL 780.10.88heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)104287676679813922Rat

Markers in Region
BF390303  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21044,046,551 - 44,046,701 (+)MAPPERmRatBN7.2
Rnor_6.01045,611,268 - 45,611,417NCBIRnor6.0
Rnor_5.01045,366,740 - 45,366,889UniSTSRnor5.0
RGSC_v3.41045,564,488 - 45,564,637UniSTSRGSC3.4
Celera1043,309,811 - 43,309,960UniSTS
RH 3.4 Map10488.69UniSTS
Cytogenetic Map10q22UniSTS
Wnt3a  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21044,034,686 - 44,035,203 (+)MAPPERmRatBN7.2
Rnor_6.01045,599,405 - 45,599,921NCBIRnor6.0
Rnor_5.01045,354,876 - 45,355,392UniSTSRnor5.0
RGSC_v3.41045,552,624 - 45,553,140UniSTSRGSC3.4
Celera1043,297,947 - 43,298,463UniSTS
Cytogenetic Map10q22UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

nervous system reproductive system respiratory system
High
Medium 4 11
Low 33 9
Below cutoff 6 11

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000064505   ⟹   ENSRNOP00000063833
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1044,034,194 - 44,073,325 (-)Ensembl
Rnor_6.0 Ensembl1045,598,912 - 45,638,035 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000098693   ⟹   ENSRNOP00000092428
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1044,034,194 - 44,078,324 (-)Ensembl
RefSeq Acc Id: NM_001107005   ⟹   NP_001100475
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21044,034,183 - 44,073,325 (-)NCBI
Rnor_6.01045,598,901 - 45,638,035 (-)NCBI
Rnor_5.01045,354,369 - 45,398,647 (-)NCBI
Celera1043,297,443 - 43,336,315 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006246487   ⟹   XP_006246549
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21044,034,174 - 44,078,463 (-)NCBI
Rnor_6.01045,598,898 - 45,643,151 (-)NCBI
Rnor_5.01045,354,369 - 45,398,647 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039085949   ⟹   XP_038941877
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21044,034,174 - 44,077,702 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001100475 (Get FASTA)   NCBI Sequence Viewer  
  NP_001401278 (Get FASTA)   NCBI Sequence Viewer  
  XP_006246549 (Get FASTA)   NCBI Sequence Viewer  
  XP_038941877 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDM04606 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001100475   ⟸   NM_001107005
- Sequence:
RefSeq Acc Id: XP_006246549   ⟸   XM_006246487
- Peptide Label: isoform X1
- UniProtKB: A0A8I6ADM6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000063833   ⟸   ENSRNOT00000064505
RefSeq Acc Id: XP_038941877   ⟸   XM_039085949
- Peptide Label: isoform X2
RefSeq Acc Id: ENSRNOP00000092428   ⟸   ENSRNOT00000098693

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F1M077-F1-model_v2 AlphaFold F1M077 1-359 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1308057 AgrOrtholog
BioCyc Gene G2FUF-24905 BioCyc
Ensembl Genes ENSRNOG00000003039 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000063833.3 UniProtKB/TrEMBL
  ENSRNOP00000092428 ENTREZGENE
  ENSRNOP00000092428.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000064505.4 UniProtKB/TrEMBL
  ENSRNOT00000098693 ENTREZGENE
  ENSRNOT00000098693.1 UniProtKB/TrEMBL
Gene3D-CATH 3.30.2460.20 UniProtKB/TrEMBL
InterPro Wnt UniProtKB/TrEMBL
  Wnt3 UniProtKB/TrEMBL
  Wnt_C UniProtKB/TrEMBL
  Wnt_grthfactor_CS UniProtKB/TrEMBL
KEGG Report rno:303181 UniProtKB/TrEMBL
NCBI Gene 303181 ENTREZGENE
PANTHER Wnt UniProtKB/TrEMBL
Pfam wnt UniProtKB/TrEMBL
PhenoGen Wnt3a PhenoGen
PRINTS WNT3PROTEIN UniProtKB/TrEMBL
  WNTPROTEIN UniProtKB/TrEMBL
PROSITE WNT1 UniProtKB/TrEMBL
SMART WNT1 UniProtKB/TrEMBL
UniProt A0A8I6ADM6 ENTREZGENE, UniProtKB/TrEMBL
  F1M077_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-03-29 Wnt3a  Wnt family member 3A  Wnt3a  wingless-type MMTV integration site family, member 3A  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-11-14 Wnt3a  wingless-type MMTV integration site family, member 3A  Wnt3a  wingless-related MMTV integration site 3A   Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Wnt3a  wingless-related MMTV integration site 3A   Wnt3a_predicted  wingless-related MMTV integration site 3A (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Wnt3a_predicted  wingless-related MMTV integration site 3A (predicted)      Symbol and Name status set to approved 70820 APPROVED