Wnt3a (wingless-type MMTV integration site family, member 3A) - Rat Genome Database

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Gene: Wnt3a (wingless-type MMTV integration site family, member 3A) Mus musculus
Analyze
Symbol: Wnt3a
Name: wingless-type MMTV integration site family, member 3A
RGD ID: 1317607
MGI Page MGI
Description: Enables several functions, including identical protein binding activity; signaling receptor binding activity; and transcription coactivator activity. Involved in several processes, including Wnt signaling pathway; negative regulation of cell differentiation; and nervous system development. Acts upstream of or within several processes, including embryonic morphogenesis; nervous system development; and positive regulation of cell population proliferation. Located in cell surface and extracellular space. Is active in glutamatergic synapse. Is expressed in several structures, including alimentary system; central nervous system; embryo ectoderm; genitourinary system; and sensory organ. Orthologous to human WNT3A (Wnt family member 3A).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: vestigial tail; vt; wingless-related MMTV integration site 3A; Wnt-; Wnt-3a
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391159,138,859 - 59,181,579 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1159,138,859 - 59,181,578 (-)EnsemblGRCm39 Ensembl
GRCm381159,248,036 - 59,290,751 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1159,248,033 - 59,290,752 (-)EnsemblGRCm38mm10GRCm38
MGSCv371159,061,538 - 59,104,253 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361159,064,231 - 59,106,946 (-)NCBIMGSCv36mm8
Celera1164,013,041 - 64,056,135 (-)NCBICelera
Cytogenetic Map11B1.3NCBI
cM Map1137.17NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
3-isobutyl-1-methyl-7H-xanthine  (EXP)
3-methyladenine  (EXP)
4,4'-sulfonyldiphenol  (EXP)
5-aza-2'-deoxycytidine  (EXP)
5-methoxypsoralen  (EXP)
6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide  (EXP)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (EXP,ISO)
aphidicolin  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
atrazine  (ISO)
belinostat  (ISO)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
CHIR 99021  (ISO)
chloroprene  (EXP)
chlorpyrifos  (EXP)
chrysin 5,7-dimethyl ether  (ISO)
Cuprizon  (ISO)
cyfluthrin  (ISO)
cypermethrin  (ISO)
D-glucose  (ISO)
deguelin  (ISO)
dexamethasone  (EXP)
diazinon  (ISO)
dieldrin  (ISO)
diethylstilbestrol  (EXP)
dioxygen  (ISO)
doxorubicin  (ISO)
ethanol  (ISO)
ethylparaben  (ISO)
etoposide  (ISO)
fluoxetine  (EXP,ISO)
folic acid  (EXP)
fructose  (ISO)
glucose  (ISO)
glyphosate  (ISO)
griseofulvin  (EXP)
harmine  (EXP)
hexachlorophene  (ISO)
hydroxyurea  (EXP)
Icaritin  (EXP)
indole-3-methanol  (ISO)
L-ascorbic acid  (ISO)
lead diacetate  (EXP)
lead nitrate  (EXP)
lead(0)  (EXP)
lipopolysaccharide  (ISO)
melatonin  (ISO)
Morroniside  (ISO)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (ISO)
N-nitrosodiethylamine  (ISO)
nickel atom  (ISO)
niclosamide  (ISO)
Nor-9-carboxy-delta9-THC  (ISO)
paclitaxel  (ISO)
paraquat  (ISO)
pluronic P-123  (ISO)
Poloxamer  (ISO)
ramipril  (ISO)
resveratrol  (EXP)
SB 415286  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (EXP)
sodium fluoride  (EXP)
streptozocin  (EXP)
T-2 toxin  (EXP)
tadalafil  (EXP)
thioacetamide  (ISO)
thymoquinone  (ISO)
triptonide  (EXP)
uranium atom  (ISO)
valproic acid  (EXP)
XAV939  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
animal organ morphogenesis  (TAS)
anterior/posterior pattern specification  (IDA)
axis elongation involved in somitogenesis  (IGI)
axon guidance  (IDA)
axonogenesis  (IDA,IGI)
B cell proliferation  (IDA)
BMP signaling pathway  (ISO)
calcium ion transmembrane transport via low voltage-gated calcium channel  (IDA)
canonical Wnt signaling pathway  (IBA,IDA,IGI,IMP,ISO,NAS)
cardiac muscle cell fate commitment  (IGI,ISO)
cell fate commitment  (IBA)
cell population proliferation  (ISO)
cell proliferation in forebrain  (IDA)
cell proliferation in midbrain  (IDA)
cell-cell signaling  (TAS)
COP9 signalosome assembly  (IDA)
determination of left/right symmetry  (IMP)
dopaminergic neuron differentiation  (TAS)
dorsal/ventral neural tube patterning  (IMP)
extracellular matrix organization  (IDA)
fat cell differentiation  (IDA,IGI)
heart development  (ISO)
heart looping  (IMP)
hemopoiesis  (IDA)
hippocampus development  (IMP)
in utero embryonic development  (IMP)
inner ear morphogenesis  (IGI)
mammary gland development  (IDA)
mesoderm development  (IMP)
midbrain development  (IDA)
modulation of chemical synaptic transmission  (EXP,IDA,IMP)
myoblast differentiation  (IGI)
negative regulation of axon extension involved in axon guidance  (IDA)
negative regulation of dopaminergic neuron differentiation  (IDA)
negative regulation of fat cell differentiation  (IDA,IGI)
negative regulation of neurogenesis  (IDA)
negative regulation of neuron projection development  (IDA)
neurogenesis  (IDA)
neuron differentiation  (IBA)
non-canonical Wnt signaling pathway  (IDA)
osteoblast differentiation  (IGI)
paraxial mesodermal cell fate commitment  (IMP)
platelet activation  (IDA)
platelet aggregation  (IDA)
positive regulation of B cell proliferation  (IDA)
positive regulation of canonical Wnt signaling pathway  (IDA,ISO)
positive regulation of canonical Wnt signaling pathway involved in controlling type B pancreatic cell proliferation  (IDA)
positive regulation of cardiac muscle cell differentiation  (ISO)
positive regulation of cell population proliferation  (IDA)
positive regulation of cell-cell adhesion mediated by cadherin  (IDA)
positive regulation of collateral sprouting in absence of injury  (IDA)
positive regulation of cytokine production  (IDA)
positive regulation of dermatome development  (ISO)
positive regulation of DNA-templated transcription  (IDA)
positive regulation of gene expression  (ISO)
positive regulation of hepatocyte proliferation  (IDA)
positive regulation of mesodermal cell fate specification  (ISO)
positive regulation of neural precursor cell proliferation  (IDA)
positive regulation of peptidyl-serine phosphorylation  (ISO)
positive regulation of protein localization to plasma membrane  (IDA)
positive regulation of protein phosphorylation  (IDA,ISO)
positive regulation of receptor internalization  (ISO)
positive regulation of skeletal muscle tissue development  (IMP)
positive regulation of telomere maintenance via telomerase  (NAS)
positive regulation of transcription by RNA polymerase II  (IDA,IGI,ISO,NAS)
post-anal tail morphogenesis  (IMP)
protein localization  (IDA)
regulation of axonogenesis  (IGI)
regulation of cell differentiation  (IDA)
regulation of microtubule cytoskeleton organization  (IGI)
regulation of postsynapse to nucleus signaling pathway  (EXP,IDA)
regulation of presynapse assembly  (ISO)
regulation of RNA biosynthetic process  (IDA)
regulation of synapse organization  (ISO)
secondary palate development  (ISO)
signal transduction  (TAS)
skeletal muscle cell differentiation  (IGI)
somatic stem cell division  (IDA)
somitogenesis  (IMP)
spinal cord association neuron differentiation  (IDA,IGI)
transcription by RNA polymerase II  (IGI)
Wnt signaling pathway  (IGI)
Wnt signaling pathway involved in forebrain neuroblast division  (IMP)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal bone ossification  (IAGP)
abnormal caudal vertebrae morphology  (IAGP)
abnormal cerebral cortex morphology  (IAGP)
abnormal cervical axis morphology  (IAGP)
abnormal cervical vertebrae morphology  (IAGP)
abnormal cortical marginal zone morphology  (IAGP)
abnormal dermomyotome development  (IAGP)
abnormal dorsal-ventral axis patterning  (IAGP)
abnormal forebrain development  (IAGP)
abnormal gastrulation  (IAGP)
abnormal heart morphology  (IAGP)
abnormal intestine morphology  (IAGP)
abnormal melanoblast morphology  (IAGP)
abnormal mesoderm development  (IAGP)
abnormal metencephalon morphology  (IAGP)
abnormal midbrain development  (IAGP)
abnormal myotome development  (IAGP)
abnormal nervous system morphology  (IAGP)
abnormal neural crest cell morphology  (IAGP)
abnormal neural tube morphology  (IEA)
abnormal rostral-caudal axis patterning  (IAGP)
abnormal somite development  (IAGP)
abnormal spinal cord morphology  (IAGP)
abnormal suckling behavior  (IAGP)
abnormal tail bud morphology  (IEA)
abnormal tail morphology  (IEA)
abnormal tailgut morphology  (IEA)
abnormal thoracic vertebrae morphology  (IAGP)
abnormal thyroid cartilage morphology  (IAGP)
abnormal urination  (IAGP)
abnormal vertebrae morphology  (IAGP)
absent Cajal-Retzius cell  (IAGP)
absent choroid plexus  (IAGP)
absent hindlimb  (IAGP)
absent hyoid bone  (IAGP)
absent sacral vertebrae  (IAGP)
absent stapes  (IAGP)
absent tail  (IAGP)
absent tail bud  (IAGP)
caudal body truncation  (IAGP)
cervical vertebral transformation  (IAGP)
cleft palate  (IAGP)
decreased body length  (IAGP)
decreased Cajal-Retzius cell number  (IAGP)
decreased caudal vertebrae number  (IAGP)
decreased embryo size  (IAGP)
decreased lumbar vertebrae number  (IAGP)
decreased thoracic vertebrae number  (IAGP)
decreased ventral ectodermal ridge size  (IEA)
embryonic lethality during organogenesis, complete penetrance  (IAGP)
embryonic lethality during organogenesis, incomplete penetrance  (IAGP)
failure of somite differentiation  (IAGP)
hindlimb paralysis  (IAGP)
incomplete somite formation  (IAGP)
kinked neural tube  (IAGP)
kinked tail  (IAGP)
kyphosis  (IAGP)
lethality throughout fetal growth and development, incomplete penetrance  (IAGP)
lumbar vertebral transformation  (IAGP)
postnatal lethality  (IAGP)
premature death  (IAGP)
reduced female fertility  (IAGP)
sacral vertebral transformation  (IAGP)
short mandible  (IAGP)
sirenomelia  (IAGP)
small alisphenoid bone  (IAGP)
small basisphenoid bone  (IAGP)
small dorsal root ganglion  (IAGP)
small otic capsule  (IAGP)
small presphenoid bone  (IAGP)
small temporal bone squamous part  (IAGP)
spina bifida  (IAGP)
thoracic vertebral transformation  (IAGP)
truncated notochord  (IAGP)
ventricular septal defect  (IAGP)
vestigial tail  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. MGDs mouse GO annotations MGD data from the GO Consortium
2. MGD IEA MGD IEA
3. Wnt10a is involved in AER formation during chick limb development. Narita T, etal., Dev Dyn. 2005 Jun;233(2):282-7.
4. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
5. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
6. Mouse MP Annotation Import Pipeline RGD automated import pipeline
7. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
9. The Wnt Homepage Roel Nusse - Howard Hughes Medical Institute and the Department of Developmental Biology at Stanford University, California, USA
10. Transformation by Wnt family proteins correlates with regulation of beta-catenin. Shimizu H, etal., Cell Growth Differ. 1997 Dec;8(12):1349-58.
11. Alternative wnt signaling is initiated by distinct receptors. van Amerongen R, etal., Sci Signal. 2008 Sep 2;1(35):re9.
12. Differential transformation of mammary epithelial cells by Wnt genes. Wong GT, etal., Mol Cell Biol. 1994 Sep;14(9):6278-86.
13. Effects of postnatal thyroid hormone deficiency on neurogenesis in the juvenile and adult rat. Zhang L, etal., Neurobiol Dis. 2009 Feb 19.
Additional References at PubMed
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PMID:8887323   PMID:8951061   PMID:9006071   PMID:9070329   PMID:9070927   PMID:9126297   PMID:9160667   PMID:9334279   PMID:9353119   PMID:9356179   PMID:9490412   PMID:9529344  
PMID:9584130   PMID:9799734   PMID:9811581   PMID:9882496   PMID:9889131   PMID:9891778   PMID:10049592   PMID:10090727   PMID:10409711   PMID:10473117   PMID:10498273   PMID:10516314  
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PMID:19920076   PMID:19924825   PMID:19929441   PMID:19961844   PMID:20093360   PMID:20093472   PMID:20171206   PMID:20179324   PMID:20194509   PMID:20211162   PMID:20371816   PMID:20399290  
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PMID:21319221   PMID:21331042   PMID:21368052   PMID:21368122   PMID:21411632   PMID:21422228   PMID:21467208   PMID:21486944   PMID:21539518   PMID:21539826   PMID:21554246   PMID:21559415  
PMID:21599637   PMID:21606194   PMID:21611174   PMID:21623369   PMID:21652632   PMID:21677750   PMID:21685894   PMID:21731673   PMID:21743455   PMID:21750544   PMID:21752936   PMID:21768372  
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PMID:23307637   PMID:23376422   PMID:23395374   PMID:23400998   PMID:23436999   PMID:23447624   PMID:23454273   PMID:23469192   PMID:23520113   PMID:23534675   PMID:23613470   PMID:23623748  
PMID:23649620   PMID:23671110   PMID:23677472   PMID:23740243   PMID:23754280   PMID:23763947   PMID:23791946   PMID:23827310   PMID:23863479   PMID:23884445   PMID:23931996   PMID:24006258  
PMID:24080158   PMID:24101523   PMID:24114209   PMID:24151333   PMID:24246780   PMID:24318810   PMID:24318811   PMID:24340027   PMID:24371086   PMID:24394376   PMID:24403153   PMID:24444608  
PMID:24475213   PMID:24548083   PMID:24569166   PMID:24586192   PMID:24643512   PMID:24798332   PMID:24801048   PMID:24815018   PMID:24832538   PMID:24841207   PMID:24841652   PMID:24859004  
PMID:24867947   PMID:24885675   PMID:24922070   PMID:24952961   PMID:24995796   PMID:25002511   PMID:25038457   PMID:25053429   PMID:25071457   PMID:25084050   PMID:25147340   PMID:25152336  
PMID:25182747   PMID:25253849   PMID:25336178   PMID:25371364   PMID:25691658   PMID:25753732   PMID:25809880   PMID:25813538   PMID:25854560   PMID:25922526   PMID:25926459   PMID:26006230  
PMID:26038536   PMID:26085341   PMID:26189772   PMID:26266404   PMID:26371318   PMID:26377473   PMID:26387718   PMID:26414873   PMID:26443994   PMID:26671461   PMID:26740630   PMID:26744331  
PMID:26846714   PMID:26902720   PMID:26956881   PMID:27030109   PMID:27048518   PMID:27127101   PMID:27129247   PMID:27144312   PMID:27150625   PMID:27178193   PMID:27217206   PMID:27341073  
PMID:27362799   PMID:27369076   PMID:27411055   PMID:27450807   PMID:27453501   PMID:27510977   PMID:27544306   PMID:27557659   PMID:27633082   PMID:27649680   PMID:27770010   PMID:27871306  
PMID:27894818   PMID:28009284   PMID:28009287   PMID:28031177   PMID:28069946   PMID:28087565   PMID:28087631   PMID:28093227   PMID:28188179   PMID:28219675   PMID:28320874   PMID:28331224  
PMID:28637318   PMID:28710407   PMID:28729440   PMID:28808228   PMID:28813421   PMID:28834739   PMID:29176883   PMID:29184203   PMID:29199847   PMID:29229772   PMID:29394901   PMID:29420689  
PMID:29636380   PMID:29740905   PMID:29806907   PMID:29891676   PMID:29937280   PMID:30061166   PMID:30084950   PMID:30139740   PMID:30189017   PMID:30220568   PMID:30228991   PMID:30256721  
PMID:30347193   PMID:30459452   PMID:30485816   PMID:30548789   PMID:30550847   PMID:30559277   PMID:30622240   PMID:30651295   PMID:30664649   PMID:30692221   PMID:30879996   PMID:30894540  
PMID:30940800   PMID:30953627   PMID:31036956   PMID:31119171   PMID:31147591   PMID:31167144   PMID:31222549   PMID:31235634   PMID:31257105   PMID:31308417   PMID:31647919   PMID:31727925  
PMID:31729356   PMID:31845732   PMID:31884387   PMID:31891351   PMID:32012381   PMID:32098078   PMID:32156757   PMID:32253237   PMID:32597756   PMID:32616667   PMID:32703236   PMID:32755451  
PMID:32822074   PMID:32855167   PMID:32969478   PMID:32994168   PMID:33060832   PMID:33141892   PMID:33153107   PMID:33246067   PMID:33283877   PMID:33324648   PMID:33393905   PMID:33932339  
PMID:33947861   PMID:34025953   PMID:34028355   PMID:34107237   PMID:34157307   PMID:34170322   PMID:34197726   PMID:34256037   PMID:34321664   PMID:34321999   PMID:34446717   PMID:34642323  
PMID:34679163   PMID:34910127   PMID:35110543   PMID:35514355   PMID:35831952   PMID:35939138   PMID:36067402   PMID:36196585   PMID:36263009   PMID:36305473   PMID:36685938   PMID:37024462  
PMID:37037887   PMID:37321213   PMID:37390294   PMID:37633271   PMID:37838801   PMID:37871667   PMID:37878207  


Genomics

Comparative Map Data
Wnt3a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391159,138,859 - 59,181,579 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1159,138,859 - 59,181,578 (-)EnsemblGRCm39 Ensembl
GRCm381159,248,036 - 59,290,751 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1159,248,033 - 59,290,752 (-)EnsemblGRCm38mm10GRCm38
MGSCv371159,061,538 - 59,104,253 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361159,064,231 - 59,106,946 (-)NCBIMGSCv36mm8
Celera1164,013,041 - 64,056,135 (-)NCBICelera
Cytogenetic Map11B1.3NCBI
cM Map1137.17NCBI
WNT3A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381228,006,998 - 228,061,271 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1228,006,998 - 228,061,271 (+)EnsemblGRCh38hg38GRCh38
GRCh371228,194,699 - 228,248,972 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361226,261,375 - 226,315,584 (+)NCBINCBI36Build 36hg18NCBI36
Build 341224,501,486 - 224,555,696NCBI
Celera1201,384,988 - 201,439,196 (+)NCBICelera
Cytogenetic Map1q42.13NCBI
HuRef1198,726,487 - 198,764,776 (+)NCBIHuRef
CHM1_11229,467,104 - 229,521,343 (+)NCBICHM1_1
T2T-CHM13v2.01227,196,039 - 227,250,282 (+)NCBIT2T-CHM13v2.0
Wnt3a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81044,533,734 - 44,577,919 (-)NCBIGRCr8
mRatBN7.21044,034,174 - 44,078,366 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1044,034,194 - 44,078,324 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1048,728,066 - 48,767,462 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01048,218,422 - 48,257,821 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01043,722,025 - 43,761,422 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01045,598,898 - 45,643,151 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1045,598,912 - 45,638,035 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01045,354,369 - 45,398,647 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41045,553,682 - 45,594,983 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11045,567,304 - 45,609,958 (-)NCBI
Celera1043,297,443 - 43,336,315 (-)NCBICelera
Cytogenetic Map10q22NCBI
Wnt3a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955581350,889 - 382,541 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955581351,375 - 382,541 (-)NCBIChiLan1.0ChiLan1.0
WNT3A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2121,545,397 - 21,599,319 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1121,483,628 - 21,537,552 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01203,409,294 - 203,463,214 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11208,628,706 - 208,674,469 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1208,628,706 - 208,674,469 (+)Ensemblpanpan1.1panPan2
WNT3A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.114864,393 - 899,698 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl14863,424 - 896,412 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha14241,282 - 287,493 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.014584,578 - 630,800 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl14583,618 - 631,058 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.114775,380 - 821,576 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.014556,162 - 602,358 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.014542,112 - 590,168 (-)NCBIUU_Cfam_GSD_1.0
Wnt3a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721387,809,460 - 87,851,090 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936864150,732 - 192,423 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936864150,742 - 179,205 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
WNT3A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl251,153,970 - 51,202,176 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1251,153,978 - 51,203,678 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2253,908,485 - 53,958,148 (-)NCBISscrofa10.2Sscrofa10.2susScr3
WNT3A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1251,664,316 - 1,675,006 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl251,666,053 - 1,719,881 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660551,547,656 - 1,601,952 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Wnt3a
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624937816,759 - 845,458 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624937816,752 - 845,866 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Wnt3a
1342 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:686
Count of miRNA genes:416
Interacting mature miRNAs:492
Transcripts:ENSMUST00000010044
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
27226798Scvln18_msacral vertebrae length 2, 16 week (mouse)11325000060690826Mouse
26884446Sklq10_mskull length QTL 10, 10 week (mouse)11325000062890826Mouse
26884453Sklq16_mskull length QTL 16, 16 week (mouse)11325000072690826Mouse
13208559Wght10_mweight 10 (mouse)11395000088890826Mouse
13208558Lgth12_mbody length 12 (mouse)11395000094890826Mouse
1300905Scc6_mcolon tumor susceptibility 6 (mouse)Not determined11688027789019734Mouse
27226738Metcl11_mmetatarsal-calcaneal length 11, 10 week (mouse)11885000061390826Mouse
26884401Huml4_mhumerus length 4, 10 week (mouse)111155000068490826Mouse
27226762Feml21_mfemur length 21, 16 week (mouse)111175000065990826Mouse
1357640Orq2_movulation rate QTL 2 (mouse)Not determined111226863768500330Mouse
4141127W3q4_mweight 3 weeks QTL 4 (mouse)Not determined1226863768500330Mouse
4141470Egq4_mearly growth QTL 4 (mouse)Not determined1226863768500330Mouse
4142109W10q2_mweight 10 weeks QTL 2 (mouse)Not determined1226863768500330Mouse
4141582Lgaq1_mlate growth adjusted QTL 1 (mouse)Not determined1226863768500330Mouse
4142308W6q3_mweight 6 weeks QTL 3 (mouse)Not determined111226863768500330Mouse
4142216Lgq1_mlate growth QTL 1 (mouse)Not determined1226863768500330Mouse
4141966Tailq1_mtail length QTL 1 (mouse)Not determined1226863768500330Mouse
1357851Scfq3_msubcutaneous fat pad weight QTL 3 (mouse)Not determined111226863768500330Mouse
1357720Kidpq1_mkidney weight percentage QTL 1 (mouse)Not determined111226863768500330Mouse
1357437Epfq4_mepididymal fat pad weight QTL 4 (mouse)Not determined111226863768500330Mouse
1559002Lmrq4_mLeishmania major resistance QTL 4 (mouse)Not determined111226863769684947Mouse
39128214Lwq20_mliver weight QTL 20 (mouse)1112268637118022724Mouse
1558945Orgwq8_morgan weight QTL 8 (mouse)Not determined111705617567078411Mouse
10053687Eae6_msusceptibility to experimental allergic encephalomyelitis 6 (mouse)Not determined111778196668500330Mouse
4141894Nidd6k_mNidd6 on KK-A (mouse)Not determined1912420496897826Mouse
10412246Dfs2_mdental fluorosis suseptibility 2 (mouse)Not determined112180736495881231Mouse
10044006Hbnr13_mHeligmosomoides bakeri nematode resistance 13 (mouse)Not determined112577262659772741Mouse
1357844Si5lq5_mserum IGFBP-5 level QTL 5 (mouse)Not determined112816587362165976Mouse
13524848Ppiq7_mprepulse inhibition QTL 7 (mouse)112856914762569147Mouse
1301426Desp2_mdespair 2 (mouse)Not determined112870858162708700Mouse
11522752Cocia18_mcocaine-induced activity, QTL 18 (mouse)113100820965008209Mouse
11059563Lmr31_mleishmaniasis resistance 31 (mouse)113210057766100694Mouse
1357782Char8_mP. chabaudi malaria resistance QTL 8 (mouse)Not determined113557861669684987Mouse
13208569Bmiq10_mbody mass index QTL 10 (mouse)113589082784890826Mouse
1301328Mol4_mmodifier of LPS-response 4 (mouse)Not determined113628257783481356Mouse
1301788Lbw8_mlupus NZB x NZW 8 (mouse)Not determined113650328770509492Mouse
1301896Tria1_mT-cell receptor induced activation 1 (mouse)Not determined113661356570613855Mouse
4141853Skmw17_mskeletal muscle weight 17 (mouse)Not determined113708094171081064Mouse
4142475Ity2a_mimmunity to S. typhimurium 2a (mouse)Not determined113776858060402716Mouse
10766457Nwa3_mNew Zealand White autoimmunity 3 (mouse)113801611572016209Mouse
11532698Sluc36a_msusceptibility to lung cancer 36a (mouse)114225661776256730Mouse
11532699Sluc36b_msusceptibility to lung cancer 36b (mouse)114225661776256730Mouse
4142300Ctrq3_mC. trachomatis resistance QTL 3 (mouse)Not determined114463003876854757Mouse
4141367Inf1_macute ozone induced inflammation (mouse)Not determined44630038113058009Mouse
1302021Nidd1n_mnon-insulin-dependent diabetes mellitus 1 in NSY (mouse)Not determined114516587379978324Mouse
1357878Mastr_mmodifier of astrocytoma (mouse)Not determined114570858189818733Mouse
1300765Bbaa4_mB.burgdorferi-associated arthritis 4 (mouse)Not determined114618516780185262Mouse
1301988Bmd11_mbone mineral density 11 (mouse)Not determined114631940780319522Mouse
1301830Ssta4_msusceptibility to Salmonella typhimurium antigens 4 (mouse)Not determined115007819184078411Mouse
13524840Ppiq9a_mprepulse inhibition QTL 9a (mouse)115249438586494385Mouse
1300774Pgia7_mproteoglycan induced arthritis 7 (mouse)Not determined115339058887390737Mouse
4141084Spqq1_msperm quality QTL 1 (mouse)Not determined5406567063319522Mouse
1302186Blmpf2_mbleomycin-induced pulmonary fibrosis 2 (mouse)Not determined115406567067078411Mouse
4142148Ckdbp2_mchronic kidney disease blood pressure locus 2 (mouse)Not determined115408094165103841Mouse
4141830Pregq1_mpregnancy QTL 1 (mouse)Not determined115412675283733652Mouse
4141875Etax9_methanol induced ataxia 9 (mouse)Not determined5528498572209927Mouse
4142121Tmc1m2_mTmc1 modifier 2 (mouse)Not determined1156864027114157957Mouse
1300664Etohcta9_methanol conditioned taste aversion 9 (mouse)Not determined115775466091754758Mouse
13513917Heal54_mwound healing/ regeneration 54 (mouse)115787291759879610Mouse
10053682Eae45_mexperimental allergic encephalomyelitis susceptibility 45 (mouse)Not determined115849055574754758Mouse
1300924Ity2_mimmunity to S. typhimurium 2 (mouse)Not determined15850803087695238Mouse
4141982Skts-fp2_mskin tumor susceptibility in FVB and PWK 2 (mouse)Not determined5871926685066529Mouse

Markers in Region
Wnt3a  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381159,249,104 - 59,249,647UniSTSGRCm38
MGSCv371159,062,606 - 59,063,149UniSTSGRCm37
Celera1164,014,105 - 64,014,648UniSTS
Cytogenetic Map11B1.3UniSTS
cM Map1132.0UniSTS
PMC26484P1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381159,249,229 - 59,249,541UniSTSGRCm38
MGSCv371159,062,731 - 59,063,043UniSTSGRCm37
Celera1164,014,230 - 64,014,542UniSTS
Cytogenetic Map11B1.3UniSTS
Wnt3a  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381159,248,150 - 59,248,988UniSTSGRCm38
MGSCv371159,061,652 - 59,062,490UniSTSGRCm37
Celera1164,013,151 - 64,013,989UniSTS
Cytogenetic Map11B1.3UniSTS
Wnt3a  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381159,248,657 - 59,248,975UniSTSGRCm38
MGSCv371159,062,159 - 59,062,477UniSTSGRCm37
Celera1164,013,658 - 64,013,976UniSTS
Cytogenetic Map11B1.3UniSTS
Wnt3a  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381159,248,554 - 59,249,087UniSTSGRCm38
MGSCv371159,062,056 - 59,062,589UniSTSGRCm37
Celera1164,013,555 - 64,014,088UniSTS
Cytogenetic Map11B1.3UniSTS
Wnt3a  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map11B1.3UniSTS
Wnt3a  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map11B1.3UniSTS
Wnt3a  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381159,248,150 - 59,248,376UniSTSGRCm38
MGSCv371159,061,652 - 59,061,878UniSTSGRCm37
Celera1164,013,151 - 64,013,377UniSTS
Cytogenetic Map11B1.3UniSTS
cM Map1132.0UniSTS
Wnt3a  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381159,248,827 - 59,248,988UniSTSGRCm38
MGSCv371159,062,329 - 59,062,490UniSTSGRCm37
Celera1164,013,828 - 64,013,989UniSTS
Cytogenetic Map11B1.3UniSTS
Wnt3a  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map11B1.3UniSTS
Wnt3a  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map11B1.3UniSTS
Wnt3a  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map11B1.3UniSTS


Expression


Sequence


RefSeq Acc Id: ENSMUST00000010044   ⟹   ENSMUSP00000010044
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1159,138,859 - 59,181,578 (-)Ensembl
GRCm38.p6 Ensembl1159,248,033 - 59,290,752 (-)Ensembl
RefSeq Acc Id: NM_009522   ⟹   NP_033548
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391159,138,859 - 59,181,579 (-)NCBI
GRCm381159,248,036 - 59,290,751 (-)ENTREZGENE
MGSCv371159,061,538 - 59,104,253 (-)RGD
Celera1164,013,041 - 64,056,135 (-)RGD
cM Map11 ENTREZGENE
Sequence:
Protein Sequences
Protein RefSeqs NP_033548 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein CAA40173 (Get FASTA)   NCBI Sequence Viewer  
  CAI38662 (Get FASTA)   NCBI Sequence Viewer  
  EDL07662 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000010044
  ENSMUSP00000010044.8
GenBank Protein P27467 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_033548   ⟸   NM_009522
- Peptide Label: precursor
- UniProtKB: P27467 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000010044   ⟸   ENSMUST00000010044

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P27467-F1-model_v2 AlphaFold P27467 1-352 view protein structure

Promoters
RGD ID:8674820
Promoter ID:EPDNEW_M15434
Type:initiation region
Name:Wnt3a_1
Description:Mus musculus wingless-type MMTV integration site family, member3A , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381159,290,753 - 59,290,813EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:98956 AgrOrtholog
Ensembl Genes ENSMUSG00000009900 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000010044 ENTREZGENE
  ENSMUST00000010044.8 UniProtKB/Swiss-Prot
Gene3D-CATH 3.30.2460.20 UniProtKB/Swiss-Prot
InterPro Wnt UniProtKB/Swiss-Prot
  Wnt3 UniProtKB/Swiss-Prot
  Wnt_C UniProtKB/Swiss-Prot
  Wnt_CS UniProtKB/Swiss-Prot
KEGG Report mmu:22416 UniProtKB/Swiss-Prot
MGD MGI:98956 ENTREZGENE
NCBI Gene 22416 ENTREZGENE
PANTHER PROTEIN WNT-3A UniProtKB/Swiss-Prot
  PTHR12027 UniProtKB/Swiss-Prot
Pfam wnt UniProtKB/Swiss-Prot
PhenoGen Wnt3a PhenoGen
PRINTS WNT3PROTEIN UniProtKB/Swiss-Prot
  WNTPROTEIN UniProtKB/Swiss-Prot
PROSITE WNT1 UniProtKB/Swiss-Prot
SMART WNT1 UniProtKB/Swiss-Prot
UniProt P27467 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2014-07-01 Wnt3a  wingless-type MMTV integration site family, member 3A    wingless-related MMTV integration site 3A  Symbol and/or name change 5135510 APPROVED