Wnt3a (Wnt family member 3A) - Rat Genome Database

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Pathways
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Gene: Wnt3a (Wnt family member 3A) Heterocephalus glaber
Analyze
Symbol: Wnt3a
Name: Wnt family member 3A
RGD ID: 18908030
Description: ENCODES a protein that exhibits co-receptor binding (ortholog); identical protein binding (ortholog); protein domain specific binding (ortholog); INVOLVED IN anterior/posterior pattern specification (ortholog); axis elongation involved in somitogenesis (ortholog); axon guidance (ortholog); PARTICIPATES IN Wnt signaling pathway; Wnt signaling, canonical pathway; ASSOCIATED WITH Experimental Mammary Neoplasms (ortholog); gastrointestinal stromal tumor (ortholog); genetic disease (ortholog); FOUND IN cell surface (ortholog); glutamatergic synapse (ortholog); synapse (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: protein Wnt-3a
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624937816,759 - 845,458 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624937816,752 - 845,866 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
anterior/posterior pattern specification  (ISO)
axis elongation involved in somitogenesis  (ISO)
axon guidance  (ISO)
axonogenesis  (ISO)
B cell proliferation  (ISO)
calcium ion transmembrane transport via low voltage-gated calcium channel  (ISO)
canonical Wnt signaling pathway  (IEA,ISO)
cardiac muscle cell fate commitment  (ISO)
cell fate commitment  (IEA)
cell population proliferation  (ISO)
cell proliferation in forebrain  (ISO)
cell proliferation in midbrain  (ISO)
COP9 signalosome assembly  (ISO)
determination of left/right symmetry  (ISO)
dorsal/ventral neural tube patterning  (ISO)
extracellular matrix organization  (ISO)
fat cell differentiation  (ISO)
heart development  (ISO)
heart looping  (ISO)
hemopoiesis  (ISO)
hippocampus development  (ISO)
in utero embryonic development  (ISO)
inner ear morphogenesis  (ISO)
mammary gland development  (ISO)
mesoderm development  (ISO)
midbrain development  (ISO)
modulation of chemical synaptic transmission  (ISO)
myoblast differentiation  (ISO)
negative regulation of axon extension involved in axon guidance  (ISO)
negative regulation of dopaminergic neuron differentiation  (ISO)
negative regulation of fat cell differentiation  (ISO)
negative regulation of neurogenesis  (ISO)
negative regulation of neuron projection development  (ISO)
neurogenesis  (ISO)
neuron differentiation  (IEA)
non-canonical Wnt signaling pathway  (ISO)
osteoblast differentiation  (ISO)
paraxial mesodermal cell fate commitment  (ISO)
platelet activation  (ISO)
platelet aggregation  (ISO)
positive regulation of B cell proliferation  (ISO)
positive regulation of canonical Wnt signaling pathway  (ISO)
positive regulation of cardiac muscle cell differentiation  (ISO)
positive regulation of cell population proliferation  (ISO)
positive regulation of cell-cell adhesion mediated by cadherin  (ISO)
positive regulation of collateral sprouting in absence of injury  (ISO)
positive regulation of cytokine production  (ISO)
positive regulation of dermatome development  (ISO)
positive regulation of DNA-templated transcription  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of hepatocyte proliferation  (ISO)
positive regulation of mesodermal cell fate specification  (ISO)
positive regulation of neural precursor cell proliferation  (ISO)
positive regulation of peptidyl-serine phosphorylation  (ISO)
positive regulation of protein localization to plasma membrane  (ISO)
positive regulation of protein phosphorylation  (ISO)
positive regulation of receptor internalization  (ISO)
positive regulation of skeletal muscle tissue development  (ISO)
positive regulation of transcription by RNA polymerase II  (ISO)
post-anal tail morphogenesis  (ISO)
protein localization  (ISO)
regulation of axonogenesis  (ISO)
regulation of cell differentiation  (ISO)
regulation of gene expression  (IEA)
regulation of microtubule cytoskeleton organization  (ISO)
regulation of postsynapse to nucleus signaling pathway  (ISO)
regulation of presynapse assembly  (ISO)
regulation of RNA biosynthetic process  (ISO)
regulation of synapse organization  (ISO)
secondary palate development  (ISO)
skeletal muscle cell differentiation  (ISO)
somatic stem cell division  (ISO)
somitogenesis  (ISO)
spinal cord association neuron differentiation  (ISO)
transcription by RNA polymerase II  (ISO)
Wnt signaling pathway  (IEA)
Wnt signaling pathway involved in forebrain neuroblast division  (ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Wnt3a
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624937816,759 - 845,458 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624937816,752 - 845,866 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
WNT3A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381228,006,998 - 228,061,271 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1228,006,998 - 228,061,271 (+)EnsemblGRCh38hg38GRCh38
GRCh371228,194,699 - 228,248,972 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361226,261,375 - 226,315,584 (+)NCBINCBI36Build 36hg18NCBI36
Build 341224,501,486 - 224,555,696NCBI
Celera1201,384,988 - 201,439,196 (+)NCBICelera
Cytogenetic Map1q42.13NCBI
HuRef1198,726,487 - 198,764,776 (+)NCBIHuRef
CHM1_11229,467,104 - 229,521,343 (+)NCBICHM1_1
T2T-CHM13v2.01227,196,039 - 227,250,282 (+)NCBIT2T-CHM13v2.0
Wnt3a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391159,138,859 - 59,181,579 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1159,138,859 - 59,181,578 (-)EnsemblGRCm39 Ensembl
GRCm381159,248,036 - 59,290,751 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1159,248,033 - 59,290,752 (-)EnsemblGRCm38mm10GRCm38
MGSCv371159,061,538 - 59,104,253 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361159,064,231 - 59,106,946 (-)NCBIMGSCv36mm8
Celera1164,013,041 - 64,056,135 (-)NCBICelera
Cytogenetic Map11B1.3NCBI
cM Map1137.17NCBI
Wnt3a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81044,533,734 - 44,577,919 (-)NCBIGRCr8
mRatBN7.21044,034,174 - 44,078,366 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1044,034,194 - 44,078,324 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1048,728,066 - 48,767,462 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01048,218,422 - 48,257,821 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01043,722,025 - 43,761,422 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01045,598,898 - 45,643,151 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1045,598,912 - 45,638,035 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01045,354,369 - 45,398,647 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41045,553,682 - 45,594,983 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11045,567,304 - 45,609,958 (-)NCBI
Celera1043,297,443 - 43,336,315 (-)NCBICelera
Cytogenetic Map10q22NCBI
Wnt3a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955581350,889 - 382,541 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955581351,375 - 382,541 (-)NCBIChiLan1.0ChiLan1.0
WNT3A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2121,545,397 - 21,599,319 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1121,483,628 - 21,537,552 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01203,409,294 - 203,463,214 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11208,628,706 - 208,674,469 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1208,628,706 - 208,674,469 (+)Ensemblpanpan1.1panPan2
WNT3A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.114864,393 - 899,698 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl14863,424 - 896,412 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha14241,282 - 287,493 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.014584,578 - 630,800 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl14583,618 - 631,058 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.114775,380 - 821,576 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.014556,162 - 602,358 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.014542,112 - 590,168 (-)NCBIUU_Cfam_GSD_1.0
Wnt3a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721387,809,460 - 87,851,090 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936864150,732 - 192,423 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936864150,742 - 179,205 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
WNT3A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl251,153,970 - 51,202,176 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1251,153,978 - 51,203,678 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2253,908,485 - 53,958,148 (-)NCBISscrofa10.2Sscrofa10.2susScr3
WNT3A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1251,664,316 - 1,675,006 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl251,666,053 - 1,719,881 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660551,547,656 - 1,601,952 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSHGLT00000002024   ⟹   ENSHGLP00000001978
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_004624937816,759 - 845,458 (+)Ensembl
RefSeq Acc Id: XM_004874714   ⟹   XP_004874771
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_004624937816,752 - 845,866 (+)NCBI
Protein Sequences
Protein RefSeqs XP_004874771 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSHGLP00000001978
Reference Protein Sequences
RefSeq Acc Id: XP_004874771   ⟸   XM_004874714
- UniProtKB: G5C9A0 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSHGLP00000001978   ⟸   ENSHGLT00000002024


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000001502 Ensembl, ENTREZGENE
Ensembl Transcript ENSHGLT00000002024 ENTREZGENE
InterPro Wnt UniProtKB/TrEMBL
  Wnt3 UniProtKB/TrEMBL
  Wnt_CS UniProtKB/TrEMBL
NCBI Gene Wnt3a ENTREZGENE
PANTHER PROTEIN WNT-3A UniProtKB/TrEMBL
  WNT RELATED UniProtKB/TrEMBL
Pfam wnt UniProtKB/TrEMBL
PRINTS WNT3PROTEIN UniProtKB/TrEMBL
  WNTPROTEIN UniProtKB/TrEMBL
PROSITE WNT1 UniProtKB/TrEMBL
SMART WNT1 UniProtKB/TrEMBL
UniProt G5C9A0 ENTREZGENE, UniProtKB/TrEMBL