WNT3A (Wnt family member 3A) - Rat Genome Database

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Gene: WNT3A (Wnt family member 3A) Canis lupus familiaris
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Symbol: WNT3A
Name: Wnt family member 3A
RGD ID: 12300969
Description: ENCODES a protein that exhibits co-receptor binding (ortholog); protein domain specific binding (ortholog); receptor ligand activity (ortholog); INVOLVED IN anterior/posterior pattern specification (ortholog); axis elongation involved in somitogenesis (ortholog); axon guidance (ortholog); PARTICIPATES IN Wnt signaling pathway; Wnt signaling, canonical pathway; ASSOCIATED WITH gastrointestinal stromal tumor (ortholog); hypothyroidism (ortholog); Mammary Neoplasms, Experimental (ortholog); FOUND IN cell surface (ortholog); extracellular space (ortholog); glutamatergic synapse (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: protein Wnt-3a
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.114864,393 - 899,698 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl14863,424 - 896,412 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha14241,282 - 287,493 (+)NCBI
ROS_Cfam_1.014584,578 - 630,800 (-)NCBI
ROS_Cfam_1.0 Ensembl14583,618 - 631,058 (-)Ensembl
UMICH_Zoey_3.114775,380 - 821,576 (-)NCBI
UNSW_CanFamBas_1.014556,162 - 602,358 (-)NCBI
UU_Cfam_GSD_1.014542,112 - 590,168 (-)NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
anterior/posterior pattern specification  (ISO)
axis elongation involved in somitogenesis  (ISO)
axon guidance  (ISO)
axonogenesis  (ISO)
calcium ion transmembrane transport via low voltage-gated calcium channel  (ISO)
canonical Wnt signaling pathway  (IBA,IEA,ISO)
canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment  (ISO)
cardiac muscle cell fate commitment  (ISO)
cell fate commitment  (IBA)
cell population proliferation  (ISO)
cell proliferation in forebrain  (ISO)
cell proliferation in midbrain  (ISO)
cellular protein localization  (ISO)
COP9 signalosome assembly  (ISO)
determination of left/right symmetry  (ISO)
dorsal/ventral neural tube patterning  (ISO)
extracellular matrix organization  (ISO)
heart looping  (ISO)
hemopoiesis  (ISO)
hippocampus development  (ISO)
in utero embryonic development  (ISO)
inner ear morphogenesis  (ISO)
mammary gland development  (ISO)
mesoderm development  (ISO)
midbrain development  (ISO)
modulation of chemical synaptic transmission  (ISO)
negative regulation of axon extension involved in axon guidance  (ISO)
negative regulation of dopaminergic neuron differentiation  (ISO)
negative regulation of fat cell differentiation  (ISO)
negative regulation of heart induction by canonical Wnt signaling pathway  (ISO)
negative regulation of neurogenesis  (ISO)
negative regulation of neuron death  (ISO)
negative regulation of neuron projection development  (ISO)
neurogenesis  (ISO)
neuron differentiation  (IBA)
osteoblast differentiation  (ISO)
paraxial mesodermal cell fate commitment  (ISO)
platelet activation  (ISO)
platelet aggregation  (ISO)
positive regulation of B cell proliferation  (ISO)
positive regulation of canonical Wnt signaling pathway  (ISO)
positive regulation of canonical Wnt signaling pathway involved in controlling type B pancreatic cell proliferation  (ISO)
positive regulation of cardiac muscle cell differentiation  (ISO)
positive regulation of cell population proliferation  (ISO)
positive regulation of cell-cell adhesion mediated by cadherin  (ISO)
positive regulation of collateral sprouting in absence of injury  (ISO)
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process  (ISO)
positive regulation of cytokine production  (ISO)
positive regulation of dermatome development  (ISO)
positive regulation of DNA-binding transcription factor activity  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of hepatocyte proliferation  (ISO)
positive regulation of mesodermal cell fate specification  (ISO)
positive regulation of neural precursor cell proliferation  (ISO)
positive regulation of peptidyl-serine phosphorylation  (ISO)
positive regulation of protein binding  (ISO)
positive regulation of protein kinase activity  (ISO)
positive regulation of protein localization to plasma membrane  (ISO)
positive regulation of protein phosphorylation  (ISO)
positive regulation of protein tyrosine kinase activity  (ISO)
positive regulation of receptor internalization  (ISO)
positive regulation of skeletal muscle tissue development  (ISO)
positive regulation of transcription by RNA polymerase II  (ISO)
positive regulation of transcription, DNA-templated  (ISO)
post-anal tail morphogenesis  (ISO)
postsynapse to nucleus signaling pathway  (ISO)
regulation of axonogenesis  (ISO)
regulation of cell differentiation  (ISO)
regulation of gene expression  (IEA)
regulation of microtubule cytoskeleton organization  (ISO)
regulation of presynapse assembly  (ISO)
regulation of RNA biosynthetic process  (ISO)
regulation of synapse organization  (ISO)
secondary palate development  (ISO)
skeletal muscle cell differentiation  (ISO)
somatic stem cell division  (ISO)
somitogenesis  (ISO)
spinal cord association neuron differentiation  (ISO)
Wnt signaling pathway  (IEA)
Wnt signaling pathway involved in forebrain neuroblast division  (ISO)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:20693288   PMID:27782880  


Genomics

Comparative Map Data
WNT3A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.114864,393 - 899,698 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl14863,424 - 896,412 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha14241,282 - 287,493 (+)NCBI
ROS_Cfam_1.014584,578 - 630,800 (-)NCBI
ROS_Cfam_1.0 Ensembl14583,618 - 631,058 (-)Ensembl
UMICH_Zoey_3.114775,380 - 821,576 (-)NCBI
UNSW_CanFamBas_1.014556,162 - 602,358 (-)NCBI
UU_Cfam_GSD_1.014542,112 - 590,168 (-)NCBI
WNT3A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1228,006,998 - 228,061,271 (+)EnsemblGRCh38hg38GRCh38
GRCh381228,006,998 - 228,067,113 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371228,194,699 - 228,248,972 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361226,261,375 - 226,315,584 (+)NCBINCBI36hg18NCBI36
Build 341224,501,486 - 224,555,696NCBI
Celera1201,384,988 - 201,439,196 (+)NCBI
Cytogenetic Map1q42.13NCBI
HuRef1198,726,487 - 198,764,776 (+)NCBIHuRef
CHM1_11229,467,104 - 229,521,343 (+)NCBICHM1_1
Wnt3a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391159,138,862 - 59,181,577 (-)NCBIGRCm39mm39
GRCm39 Ensembl1159,138,859 - 59,181,578 (-)Ensembl
GRCm381159,248,036 - 59,290,751 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1159,248,033 - 59,290,752 (-)EnsemblGRCm38mm10GRCm38
MGSCv371159,061,538 - 59,104,253 (-)NCBIGRCm37mm9NCBIm37
MGSCv361159,064,231 - 59,106,946 (-)NCBImm8
Celera1164,013,041 - 64,056,135 (-)NCBICelera
Cytogenetic Map11B1.3NCBI
cM Map1137.17NCBI
Wnt3a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21044,034,174 - 44,078,463 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl1044,034,194 - 44,078,324 (-)Ensembl
Rnor_6.01045,598,898 - 45,643,151 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1045,598,912 - 45,638,035 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01045,354,369 - 45,398,647 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41045,553,682 - 45,594,983 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11045,567,304 - 45,609,958 (-)NCBI
Celera1043,297,443 - 43,336,315 (-)NCBICelera
Cytogenetic Map10q22NCBI
Wnt3a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955581350,889 - 382,541 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955581351,375 - 382,541 (-)NCBIChiLan1.0ChiLan1.0
WNT3A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11208,628,706 - 208,674,469 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1208,628,706 - 208,674,469 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01203,409,294 - 203,463,214 (+)NCBIMhudiblu_PPA_v0panPan3
Wnt3a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721387,809,460 - 87,851,090 (-)NCBI
SpeTri2.0NW_004936864150,742 - 179,205 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
WNT3A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl251,154,086 - 51,202,176 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1251,153,978 - 51,203,678 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2253,908,485 - 53,958,148 (-)NCBISscrofa10.2Sscrofa10.2susScr3
WNT3A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1251,664,316 - 1,675,006 (-)NCBIChlSab1.1chlSab2
ChlSab1.1251,664,316 - 1,675,006 (-)NCBIChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660551,547,656 - 1,601,952 (-)NCBIVero_WHO_p1.0
Wnt3a
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624937816,752 - 845,866 (+)NCBIHetGla_female_1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system integumental system nervous system reproductive system respiratory system
High
Medium 2
Low 6 3
Below cutoff 1 1 4 1 6 6

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000001825   ⟹   ENSCAFP00000001681
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl14863,424 - 896,412 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845014001   ⟹   ENSCAFP00845010849
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl14583,618 - 631,058 (-)Ensembl
RefSeq Acc Id: XM_038442861   ⟹   XP_038298789
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha14241,282 - 287,493 (+)NCBI
RefSeq Acc Id: XM_038495268   ⟹   XP_038351196
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.114775,380 - 821,576 (-)NCBI
RefSeq Acc Id: XM_038556358   ⟹   XP_038412286
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.014542,112 - 590,168 (-)NCBI
RefSeq Acc Id: XM_038620285   ⟹   XP_038476213
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.014556,162 - 602,358 (-)NCBI
RefSeq Acc Id: XM_038685962   ⟹   XP_038541890
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.014584,578 - 630,800 (-)NCBI
Reference Sequences
RefSeq Acc Id: ENSCAFP00000001681   ⟸   ENSCAFT00000001825
RefSeq Acc Id: XP_038351196   ⟸   XM_038495268
RefSeq Acc Id: XP_038476213   ⟸   XM_038620285
RefSeq Acc Id: XP_038541890   ⟸   XM_038685962
RefSeq Acc Id: XP_038298789   ⟸   XM_038442861
RefSeq Acc Id: XP_038412286   ⟸   XM_038556358
RefSeq Acc Id: ENSCAFP00845010849   ⟸   ENSCAFT00845014001


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000001179 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00845007960 Ensembl, ENTREZGENE
Ensembl Protein ENSCAFP00000001681 UniProtKB/TrEMBL
  ENSCAFP00845010849 ENTREZGENE
Ensembl Transcript ENSCAFT00000001825 UniProtKB/TrEMBL
  ENSCAFT00845014001 ENTREZGENE
Gene3D-CATH 3.30.2460.20 UniProtKB/TrEMBL
InterPro Wnt UniProtKB/TrEMBL
  Wnt3 UniProtKB/TrEMBL
  Wnt_C UniProtKB/TrEMBL
  Wnt_CS UniProtKB/TrEMBL
NCBI Gene WNT3A ENTREZGENE
PANTHER PTHR12027 UniProtKB/TrEMBL
Pfam wnt UniProtKB/TrEMBL
PRINTS WNT3PROTEIN UniProtKB/TrEMBL
  WNTPROTEIN UniProtKB/TrEMBL
PROSITE WNT1 UniProtKB/TrEMBL
SMART WNT1 UniProtKB/TrEMBL
UniProt L7N052_CANLF UniProtKB/TrEMBL
VGNC ID VGNC:54800 ENTREZGENE