WNT3A (Wnt family member 3A) - Rat Genome Database

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Gene: WNT3A (Wnt family member 3A) Sus scrofa
Analyze
Symbol: WNT3A
Name: Wnt family member 3A
RGD ID: 14100121
Description: ENCODES a protein that exhibits co-receptor binding (inferred); cytokine activity (inferred); frizzled binding (inferred); INVOLVED IN anterior/posterior pattern specification (ortholog); axis elongation involved in somitogenesis (ortholog); axon guidance (ortholog); PARTICIPATES IN Wnt signaling pathway; Wnt signaling, canonical pathway; ASSOCIATED WITH Experimental Mammary Neoplasms (ortholog); gastrointestinal stromal tumor (ortholog); genetic disease (ortholog); FOUND IN glutamatergic synapse (ortholog); synapse (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: protein Wnt-3a; wingless-type MMTV integration site family, member 3A
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl251,153,970 - 51,202,176 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1251,153,978 - 51,203,678 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2253,908,485 - 53,958,148 (-)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
anterior/posterior pattern specification  (IEA,ISO)
axis elongation involved in somitogenesis  (IEA,ISO)
axon guidance  (IEA,ISO)
axonogenesis  (IEA,ISO)
B cell proliferation  (IEA,ISO)
calcium ion transmembrane transport via low voltage-gated calcium channel  (IEA)
canonical Wnt signaling pathway  (IBA,IEA,ISO)
cardiac muscle cell fate commitment  (IEA,ISO)
cell fate commitment  (IBA,IEA)
cell population proliferation  (IEA)
cell proliferation in forebrain  (IEA)
cell proliferation in midbrain  (IEA)
COP9 signalosome assembly  (IEA)
determination of left/right symmetry  (IEA,ISO)
dorsal/ventral neural tube patterning  (IEA,ISO)
extracellular matrix organization  (IEA,ISO)
fat cell differentiation  (IEA,ISO)
heart development  (IEA)
heart looping  (IEA,ISO)
hemopoiesis  (IEA,ISO)
hippocampus development  (IEA,ISO)
in utero embryonic development  (IEA,ISO)
inner ear morphogenesis  (IEA,ISO)
mammary gland development  (IEA,ISO)
mesoderm development  (IEA,ISO)
midbrain development  (IEA)
modulation of chemical synaptic transmission  (IEA)
myoblast differentiation  (IEA,ISO)
negative regulation of axon extension involved in axon guidance  (IEA,ISO)
negative regulation of dopaminergic neuron differentiation  (IEA)
negative regulation of fat cell differentiation  (IEA,ISO)
negative regulation of neurogenesis  (IEA)
negative regulation of neuron projection development  (IEA)
neurogenesis  (IEA)
neuron differentiation  (IBA,IEA)
non-canonical Wnt signaling pathway  (IEA)
osteoblast differentiation  (IEA,ISO)
paraxial mesodermal cell fate commitment  (IEA,ISO)
platelet activation  (IEA,ISO)
platelet aggregation  (IEA,ISO)
positive regulation of B cell proliferation  (IEA,ISO)
positive regulation of canonical Wnt signaling pathway  (IEA,ISO)
positive regulation of canonical Wnt signaling pathway involved in controlling type B pancreatic cell proliferation  (IEA)
positive regulation of cardiac muscle cell differentiation  (IEA,ISO)
positive regulation of cell population proliferation  (IEA,ISO)
positive regulation of cell-cell adhesion mediated by cadherin  (IEA,ISO)
positive regulation of collateral sprouting in absence of injury  (IEA,ISO)
positive regulation of cytokine production  (IEA,ISO)
positive regulation of dermatome development  (IEA)
positive regulation of DNA-templated transcription  (IEA,ISO)
positive regulation of gene expression  (IEA)
positive regulation of hepatocyte proliferation  (IEA,ISO)
positive regulation of mesodermal cell fate specification  (IEA)
positive regulation of neural precursor cell proliferation  (IEA,ISO)
positive regulation of peptidyl-serine phosphorylation  (IEA)
positive regulation of protein localization to plasma membrane  (IEA)
positive regulation of protein phosphorylation  (IEA)
positive regulation of receptor internalization  (IEA)
positive regulation of skeletal muscle tissue development  (IEA)
positive regulation of transcription by RNA polymerase II  (IEA,ISO)
post-anal tail morphogenesis  (IEA,ISO)
protein localization  (IEA,ISO)
regulation of axonogenesis  (IEA,ISO)
regulation of cell differentiation  (IEA,ISO)
regulation of gene expression  (IEA)
regulation of microtubule cytoskeleton organization  (IEA,ISO)
regulation of postsynapse to nucleus signaling pathway  (IEA)
regulation of presynapse assembly  (IEA)
regulation of RNA biosynthetic process  (IEA,ISO)
regulation of synapse organization  (IEA)
secondary palate development  (IEA)
skeletal muscle cell differentiation  (IEA,ISO)
somatic stem cell division  (IEA,ISO)
somitogenesis  (IEA,ISO)
spinal cord association neuron differentiation  (IEA,ISO)
transcription by RNA polymerase II  (IEA,ISO)
Wnt signaling pathway  (IEA)
Wnt signaling pathway involved in forebrain neuroblast division  (IEA,ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:18584948   PMID:21536751   PMID:22301074   PMID:22889676   PMID:30032202  


Genomics

Comparative Map Data
WNT3A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl251,153,970 - 51,202,176 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1251,153,978 - 51,203,678 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2253,908,485 - 53,958,148 (-)NCBISscrofa10.2Sscrofa10.2susScr3
WNT3A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381228,006,998 - 228,061,271 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1228,006,998 - 228,061,271 (+)EnsemblGRCh38hg38GRCh38
GRCh371228,194,699 - 228,248,972 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361226,261,375 - 226,315,584 (+)NCBINCBI36Build 36hg18NCBI36
Build 341224,501,486 - 224,555,696NCBI
Celera1201,384,988 - 201,439,196 (+)NCBICelera
Cytogenetic Map1q42.13NCBI
HuRef1198,726,487 - 198,764,776 (+)NCBIHuRef
CHM1_11229,467,104 - 229,521,343 (+)NCBICHM1_1
T2T-CHM13v2.01227,196,039 - 227,250,282 (+)NCBIT2T-CHM13v2.0
Wnt3a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391159,138,859 - 59,181,579 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1159,138,859 - 59,181,578 (-)EnsemblGRCm39 Ensembl
GRCm381159,248,036 - 59,290,751 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1159,248,033 - 59,290,752 (-)EnsemblGRCm38mm10GRCm38
MGSCv371159,061,538 - 59,104,253 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361159,064,231 - 59,106,946 (-)NCBIMGSCv36mm8
Celera1164,013,041 - 64,056,135 (-)NCBICelera
Cytogenetic Map11B1.3NCBI
cM Map1137.17NCBI
Wnt3a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81044,533,734 - 44,577,919 (-)NCBIGRCr8
mRatBN7.21044,034,174 - 44,078,366 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1044,034,194 - 44,078,324 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1048,728,066 - 48,767,462 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01048,218,422 - 48,257,821 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01043,722,025 - 43,761,422 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01045,598,898 - 45,643,151 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1045,598,912 - 45,638,035 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01045,354,369 - 45,398,647 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41045,553,682 - 45,594,983 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11045,567,304 - 45,609,958 (-)NCBI
Celera1043,297,443 - 43,336,315 (-)NCBICelera
Cytogenetic Map10q22NCBI
Wnt3a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955581350,889 - 382,541 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955581351,375 - 382,541 (-)NCBIChiLan1.0ChiLan1.0
WNT3A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2121,545,397 - 21,599,319 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1121,483,628 - 21,537,552 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01203,409,294 - 203,463,214 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11208,628,706 - 208,674,469 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1208,628,706 - 208,674,469 (+)Ensemblpanpan1.1panPan2
WNT3A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.114864,393 - 899,698 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl14863,424 - 896,412 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha14241,282 - 287,493 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.014584,578 - 630,800 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl14583,618 - 631,058 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.114775,380 - 821,576 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.014556,162 - 602,358 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.014542,112 - 590,168 (-)NCBIUU_Cfam_GSD_1.0
Wnt3a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721387,809,460 - 87,851,090 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936864150,732 - 192,423 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936864150,742 - 179,205 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
WNT3A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1251,664,316 - 1,675,006 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl251,666,053 - 1,719,881 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660551,547,656 - 1,601,952 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Wnt3a
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624937816,759 - 845,458 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624937816,752 - 845,866 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in WNT3A
614 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

hemolymphoid system reproductive system respiratory system
High
Medium
Low 1
Below cutoff 1 1

Sequence


RefSeq Acc Id: ENSSSCT00000031062   ⟹   ENSSSCP00000021525
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl251,153,970 - 51,202,176 (+)Ensembl
RefSeq Acc Id: XM_003123621   ⟹   XP_003123669
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1251,153,978 - 51,203,678 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021083340   ⟹   XP_020938999
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1251,154,150 - 51,203,678 (+)NCBI
Sequence:
RefSeq Acc Id: XP_003123669   ⟸   XM_003123621
- Peptide Label: isoform X1
- UniProtKB: I3LBV3 (UniProtKB/TrEMBL),   A0A480RFN3 (UniProtKB/TrEMBL),   A0A8D0T7B7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020938999   ⟸   XM_021083340
- Peptide Label: isoform X2
- UniProtKB: A0A8D0T7B7 (UniProtKB/TrEMBL),   I3LBV3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000021525   ⟸   ENSSSCT00000031062


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000029870 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00015064272 UniProtKB/TrEMBL
  ENSSSCG00025068757 UniProtKB/TrEMBL
  ENSSSCG00030056223 UniProtKB/TrEMBL
  ENSSSCG00040072427 UniProtKB/TrEMBL
  ENSSSCG00045033566 UniProtKB/TrEMBL
  ENSSSCG00050059080 UniProtKB/TrEMBL
  ENSSSCG00055017996 UniProtKB/TrEMBL
  ENSSSCG00060008184 UniProtKB/TrEMBL
  ENSSSCG00065044417 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000031062 ENTREZGENE
  ENSSSCT00000031062.4 UniProtKB/TrEMBL
  ENSSSCT00015085969.1 UniProtKB/TrEMBL
  ENSSSCT00025094457.1 UniProtKB/TrEMBL
  ENSSSCT00030078325.1 UniProtKB/TrEMBL
  ENSSSCT00040099728.1 UniProtKB/TrEMBL
  ENSSSCT00045057412.1 UniProtKB/TrEMBL
  ENSSSCT00050080509.1 UniProtKB/TrEMBL
  ENSSSCT00055035292.1 UniProtKB/TrEMBL
  ENSSSCT00060010449.1 UniProtKB/TrEMBL
  ENSSSCT00065060741.1 UniProtKB/TrEMBL
Gene3D-CATH 3.30.2460.20 UniProtKB/TrEMBL
InterPro Wnt UniProtKB/TrEMBL
  Wnt3 UniProtKB/TrEMBL
  Wnt_C UniProtKB/TrEMBL
  Wnt_CS UniProtKB/TrEMBL
KEGG Report ssc:100514950 UniProtKB/TrEMBL
NCBI Gene WNT3A ENTREZGENE
PANTHER PROTEIN WNT-3A UniProtKB/TrEMBL
  PTHR12027 UniProtKB/TrEMBL
Pfam wnt UniProtKB/TrEMBL
PRINTS WNT3PROTEIN UniProtKB/TrEMBL
  WNTPROTEIN UniProtKB/TrEMBL
PROSITE WNT1 UniProtKB/TrEMBL
SMART WNT1 UniProtKB/TrEMBL
UniProt A0A480RFN3 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D0T7B7 ENTREZGENE, UniProtKB/TrEMBL
  I3LBV3 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:94971 ENTREZGENE