Ephx2 (epoxide hydrolase 2) - Rat Genome Database

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Gene: Ephx2 (epoxide hydrolase 2) Rattus norvegicus
Symbol: Ephx2
Name: epoxide hydrolase 2
RGD ID: 620732
Description: Enables epoxide hydrolase activity; magnesium ion binding activity; and phosphatase activity. Involved in several processes, including linoleic acid metabolic process; prostaglandin production involved in inflammatory response; and response to 3-methylcholanthrene. Located in peroxisome. Used to study cerebral infarction; hypertension; and pulmonary hypertension. Biomarker of hypertrophic cardiomyopathy. Human ortholog(s) of this gene implicated in coronary artery disease; familial hypercholesterolemia; and hypertension. Orthologous to human EPHX2 (epoxide hydrolase 2); PARTICIPATES IN acetylsalicylic acid pharmacodynamics pathway; antipyrine drug pathway; arachidonic acid metabolic pathway; INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; 3,3',4,4',5-pentachlorobiphenyl.
Type: protein-coding
Previously known as: bifunctional epoxide hydrolase 2; CEH; cytosolic epoxide hydrolase; epoxide hydratase; epoxide hydrolase 2, cytoplasmic; SEH; soluble epoxide hydrolase
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: Ephx2em2Mcwi  
Genetic Models: SD-Ephx2em2Mcwi
Is Marker For: Strains:   SHR  
QTLs:   Strs7  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
GRCr81544,465,447 - 44,503,157 (-)NCBIGRCr8
mRatBN7.21540,289,901 - 40,327,632 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1540,289,902 - 40,327,615 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1542,154,869 - 42,194,845 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01543,305,067 - 43,345,042 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01541,750,237 - 41,787,912 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01542,757,241 - 42,794,211 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1542,757,235 - 42,794,279 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01548,799,823 - 48,836,848 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41545,497,660 - 45,556,101 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11545,513,439 - 45,571,881 (-)NCBI
Celera1539,961,087 - 40,000,936 (-)NCBICelera
Cytogenetic Map15p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(2,4,5-trichlorophenoxy)acetic acid  (ISO)
(5Z,8Z,11Z,13E)-15-HETE  (ISO)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (ISO)
14,15-EET  (ISO)
16-alpha,17-Epoxypregn-4-ene-3,20-dione  (ISO)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrabromodibenzodioxine  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-D  (ISO)
2,6-dichloroindophenol  (ISO)
2-(4-chloro-2-methylphenoxy)propanoic acid  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,3',4,4'-tetrachlorobiphenyl  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3-[3-(tert-butylsulfanyl)-1-(4-chlorobenzyl)-5-(propan-2-yl)-1H-indol-2-yl]-2,2-dimethylpropanoic acid  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methylcholanthrene  (EXP,ISO)
4,4'-diaminodiphenylmethane  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5,6-EET  (ISO)
5,6alpha-epoxy-5alpha-cholestan-3beta-ol  (ISO)
6-propyl-2-thiouracil  (EXP)
8,9-EET  (ISO)
acetylsalicylic acid  (ISO)
acrylamide  (ISO)
aflatoxin B1  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
amphibole asbestos  (ISO)
arachidonic acid  (ISO)
arsenite ion  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
aspartame  (ISO)
benzil  (ISO)
benzo[a]pyrene  (EXP,ISO)
bexarotene  (EXP)
bezafibrate  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
butylated hydroxyanisole  (ISO)
cadmium dichloride  (EXP,ISO)
calcium atom  (EXP)
calcium(0)  (EXP)
captan  (ISO)
carbamazepine  (EXP)
carbonyl cyanide p-trifluoromethoxyphenylhydrazone  (ISO)
cerium trichloride  (ISO)
CGP 52608  (ISO)
CGS-21680  (ISO)
chlordecone  (ISO)
chlorobenzene  (ISO)
chlorohydrocarbon  (ISO)
chlorpyrifos  (ISO)
ciguatoxin CTX1B  (ISO)
cisplatin  (ISO)
clofibrate  (EXP,ISO)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) sulfate  (ISO)
corn oil  (EXP)
cyclosporin A  (ISO)
cyfluthrin  (ISO)
cylindrospermopsin  (ISO)
cyproconazole  (ISO)
decabromodiphenyl ether  (EXP,ISO)
dexamethasone  (EXP,ISO)
diarsenic trioxide  (ISO)
dieldrin  (ISO)
dihydroxyacetone  (ISO)
dinophysistoxin 1  (ISO)
dioxygen  (EXP)
diuron  (EXP)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
ebselen  (ISO)
edaravone  (ISO)
elemental selenium  (ISO)
endosulfan  (EXP)
epoxiconazole  (ISO)
ethanol  (EXP)
felbamate  (EXP)
fenofibrate  (EXP,ISO)
fenvalerate  (EXP)
flavonoids  (EXP)
flutamide  (EXP)
folic acid  (ISO)
folpet  (ISO)
fulvestrant  (ISO)
furan  (ISO)
gemfibrozil  (ISO)
genistein  (ISO)
gentamycin  (EXP)
glycyrrhizinic acid  (EXP)
glyphosate  (EXP,ISO)
GW 7647  (ISO)
Heliotrine  (ISO)
Heptachlor epoxide  (ISO)
hexachlorobenzene  (EXP)
hydrogen peroxide  (ISO)
icosanoid  (ISO)
indirubin-3'-monoxime  (ISO)
indometacin  (EXP)
kojic acid  (EXP)
L-ascorbic acid  (ISO)
L-ethionine  (ISO)
lanosterol  (ISO)
lead diacetate  (EXP)
leflunomide  (ISO)
limonin  (ISO)
linsidomine  (EXP)
lipopolysaccharide  (ISO)
mecoprop  (ISO)
mercury dichloride  (ISO)
methapyrilene  (EXP)
methimazole  (EXP)
methylmercury chloride  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
monosodium L-glutamate  (ISO)
morphine  (ISO)
Muraglitazar  (EXP)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-ethyl-5'-carboxamidoadenosine  (ISO)
N-nitrosodiethylamine  (EXP)
N-Nitrosopyrrolidine  (ISO)
naphthalene  (ISO)
nickel atom  (ISO)
nomilin  (ISO)
O-methyleugenol  (ISO)
oxycodone  (EXP)
ozone  (EXP,ISO)
p-chloromercuribenzoic acid  (ISO)
paclitaxel  (EXP)
paracetamol  (EXP,ISO)
paraquat  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (EXP,ISO)
phenobarbital  (EXP,ISO)
phenylephrine  (EXP)
phenylmercury acetate  (ISO)
phenytoin  (EXP)
pirinixic acid  (EXP,ISO)
pravastatin  (EXP,ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
propiconazole  (ISO)
prostaglandin D2  (ISO)
prostaglandin E2  (ISO)
quercetin  (EXP,ISO)
resveratrol  (ISO)
rotenone  (EXP)
SB 431542  (ISO)
selenium atom  (ISO)
senecionine  (ISO)
Senkirkine  (ISO)
silicon dioxide  (EXP,ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP,ISO)
sodium fluoride  (ISO)
stilbene oxide  (ISO)
streptozocin  (EXP,ISO)
sulfadimethoxine  (EXP)
sulforaphane  (ISO)
tert-butyl hydroperoxide  (ISO)
Tesaglitazar  (EXP)
tetrachloromethane  (EXP,ISO)
tetracycline  (ISO)
titanium dioxide  (ISO)
trichloroethene  (EXP,ISO)
Tridiphane  (ISO)
trimellitic anhydride  (ISO)
triptonide  (ISO)
troglitazone  (EXP,ISO)
urea  (ISO)
urethane  (ISO)
valproic acid  (EXP,ISO)
vinclozolin  (EXP)
zaragozic acid A  (EXP,ISO)
zinc pyrithione  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytosol  (IEA,ISO)
peroxisome  (IBA,IDA,IEA,ISO,TAS)

Molecular Function


References - curated
# Reference Title Reference Citation
1. 3-methylcholanthrene and benzo(a)pyrene modulate cardiac cytochrome P450 gene expression and arachidonic acid metabolism in male Sprague Dawley rats. Aboutabl ME, etal., Br J Pharmacol. 2009 Dec;158(7):1808-19. doi: 10.1111/j.1476-5381.2009.00461.x.
2. An impaired peroxisomal targeting sequence leading to an unusual bicompartmental distribution of cytosolic epoxide hydrolase. Arand M, etal., FEBS Lett 1991 Dec 2;294(1-2):19-22.
3. Asp333, Asp495, and His523 form the catalytic triad of rat soluble epoxide hydrolase. Arand M, etal., J Biol Chem. 1996 Feb 23;271(8):4223-9.
4. Altered soluble epoxide hydrolase gene expression and function and vascular disease risk in the stroke-prone spontaneously hypertensive rat. Corenblum MJ, etal., Hypertension. 2008 Feb;51(2):567-73. Epub 2007 Dec 17.
5. Mammalian soluble epoxide hydrolase is identical to liver hepoxilin hydrolase. Cronin A, etal., J Lipid Res. 2011 Apr;52(4):712-9. doi: 10.1194/jlr.M009639. Epub 2011 Jan 7.
6. The N-terminal domain of mammalian soluble epoxide hydrolase is a phosphatase. Cronin A, etal., Proc Natl Acad Sci U S A. 2003 Feb 18;100(4):1552-7. Epub 2003 Feb 6.
7. An epoxide hydrolase inhibitor, 12-(3-adamantan-1-yl-ureido)dodecanoic acid (AUDA), reduces ischemic cerebral infarct size in stroke-prone spontaneously hypertensive rats. Dorrance AM, etal., J Cardiovasc Pharmacol. 2005 Dec;46(6):842-8.
8. Soluble epoxide hydrolase in rat inflammatory cells is indistinguishable from soluble epoxide hydrolase in rat liver. Draper AJ and Hammock BD, Toxicol Sci. 1999 Jul;50(1):30-5.
9. Deletion of soluble epoxide hydrolase gene improves renal endothelial function and reduces renal inflammation and injury in streptozotocin-induced type 1 diabetes. Elmarakby AA, etal., Am J Physiol Regul Integr Comp Physiol. 2011 Nov;301(5):R1307-17. Epub 2011 Aug 10.
10. Genetic polymorphisms of microsomal and soluble epoxide hydrolase and the risk of Parkinson's disease. Farin FM, etal., Pharmacogenetics. 2001 Nov;11(8):703-8.
11. Homozygosity for the EPHX2 K55R polymorphism increases the long-term risk of ischemic stroke in men: a study in Swedes. Fava C, etal., Pharmacogenet Genomics. 2010 Feb;20(2):94-103.
12. Polymorphism of the soluble epoxide hydrolase is associated with coronary artery calcification in African-American subjects: The Coronary Artery Risk Development in Young Adults (CARDIA) study. Fornage M, etal., Circulation. 2004 Jan 27;109(3):335-9. Epub 2004 Jan 19.
13. The soluble epoxide hydrolase gene harbors sequence variation associated with susceptibility to and protection from incident ischemic stroke. Fornage M, etal., Hum Mol Genet. 2005 Oct 1;14(19):2829-37. Epub 2005 Aug 22.
14. Polymorphism in soluble epoxide hydrolase and blood pressure in spontaneously hypertensive rats. Fornage M, etal., Hypertension 2002 Oct;40(4):485-90.
15. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
16. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
17. Genetic variation in soluble epoxide hydrolase (EPHX2) is associated with an increased risk of ischemic stroke in white Europeans. Gschwendtner A, etal., Stroke. 2008 May;39(5):1593-6. Epub 2008 Mar 6.
18. Combined genealogical, mapping, and expression approaches to identify spontaneously hypertensive rat hypertension candidate genes. Hinojos CA, etal., Hypertension 2005 Apr;45(4):698-704. Epub 2005 Feb 14.
19. Immunocytochemical analysis of soluble epoxide hydrolase and catalase in mouse and rat hepatocytes demonstrates a peroxisomal localization before and after clofibrate treatment. Hollinshead M and Meijer J, Eur J Cell Biol. 1988 Aug;46(3):394-402.
20. Inhibition of soluble epoxide hydrolase improves the impaired pressure-natriuresis relationship and attenuates the development of hypertension and hypertension-associated end-organ damage in Cyp1a1-Ren-2 transgenic rats. Honetschlagerova Z, etal., J Hypertens. 2011 Aug;29(8):1590-601.
21. Soluble epoxide hydrolase gene deletion reduces survival after cardiac arrest and cardiopulmonary resuscitation. Hutchens MP, etal., Resuscitation. 2008 Jan;76(1):89-94. Epub 2007 Aug 28.
22. Soluble epoxide hydrolase inhibition lowers arterial blood pressure in angiotensin II hypertension. Imig JD, etal., Hypertension 2002 Feb;39(2 Pt 2):690-4.
23. An orally active epoxide hydrolase inhibitor lowers blood pressure and provides renal protection in salt-sensitive hypertension. Imig JD, etal., Hypertension. 2005 Oct;46(4):975-81. Epub 2005 Sep 12.
24. Inhibition of soluble epoxide hydrolase reduces LPS-induced thermal hyperalgesia and mechanical allodynia in a rat model of inflammatory pain. Inceoglu B, etal., Life Sci. 2006 Nov 10;79(24):2311-9. Epub 2006 Aug 2.
25. Pharmacological inhibition of soluble epoxide hydrolase ameliorates diet-induced metabolic syndrome in rats. Iyer A, etal., Exp Diabetes Res. 2012;2012:758614. Epub 2011 Oct 10.
26. In vivo optical imaging of revascularization after brain trauma in mice. Jia Y, etal., Microvasc Res. 2011 Jan;81(1):73-80. Epub 2010 Nov 12.
27. Inhibition of the soluble epoxide hydrolase promotes albuminuria in mice with progressive renal disease. Jung O, etal., PLoS One. 2010 Aug 4;5(8):e11979.
28. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
29. Isolation and characterization of a cDNA encoding rat liver cytosolic epoxide hydrolase and its functional expression in Escherichia coli. Knehr M, etal., J Biol Chem 1993 Aug 15;268(23):17623-7.
30. Genetic variation in soluble epoxide hydrolase (EPHX2) and risk of coronary heart disease: The Atherosclerosis Risk in Communities (ARIC) study. Lee CR, etal., Hum Mol Genet. 2006 May 15;15(10):1640-9. Epub 2006 Apr 4.
31. Beneficial effects of soluble epoxide hydrolase inhibitors in myocardial infarction model: Insight gained using metabolomic approaches. Li N, etal., J Mol Cell Cardiol. 2009 Dec;47(6):835-45. Epub 2009 Aug 28.
32. Pharmacokinetic optimization of four soluble epoxide hydrolase inhibitors for use in a murine model of inflammation. Liu JY, etal., Br J Pharmacol. 2009 Jan;156(2):284-96. Epub 2009 Jan 13.
33. Soluble epoxide hydrolase gene deletion attenuates renal injury and inflammation with DOCA-salt hypertension. Manhiani M, etal., Am J Physiol Renal Physiol. 2009 Sep;297(3):F740-8. Epub 2009 Jun 24.
34. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
35. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
36. Difference of gene expression profiles in spontaneous hypertensive rats and Wistar-Kyoto rats from two sources. Okuda T, etal., Biochem Biophys Res Commun 2002 Aug 23;296(3):537.
37. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
38. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
39. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
40. Alleviation of lung injury by glycyrrhizic acid in benzo(a)pyrene exposed rats: Probable role of soluble epoxide hydrolase and thioredoxin reductase. Qamar W, etal., Toxicology. 2012 Jan 27;291(1-3):25-31. Epub 2011 Oct 25.
41. Soluble epoxide hydrolase deficiency attenuates neointima formation in the femoral cuff model of hyperlipidemic mice. Revermann M, etal., Arterioscler Thromb Vasc Biol. 2010 May;30(5):909-14. Epub 2010 Mar 11.
42. Inhibition of the soluble epoxide hydrolase attenuates monocrotaline-induced pulmonary hypertension in rats. Revermann M, etal., J Hypertens. 2009 Feb;27(2):322-31.
43. GOA pipeline RGD automated data pipeline
44. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
45. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
46. Attenuation of tobacco smoke-induced lung inflammation by treatment with a soluble epoxide hydrolase inhibitor. Smith KR, etal., Proc Natl Acad Sci U S A. 2005 Feb 8;102(6):2186-91. Epub 2005 Jan 31.
47. The gap junctional intercellular communication is no prerequisite for the stabilization of xenobiotic metabolizing enzyme activities in primary rat liver parenchymal cells in vitro. Traiser M, etal., In Vitro Cell Dev Biol Anim. 1995 Apr;31(4):266-73.
48. Sequence variation in the soluble epoxide hydrolase gene and subclinical coronary atherosclerosis: interaction with cigarette smoking. Wei Q, etal., Atherosclerosis. 2007 Jan;190(1):26-34. Epub 2006 Mar 20.
49. Role of soluble epoxide hydrolase in the sex-specific vascular response to cerebral ischemia. Zhang W, etal., J Cereb Blood Flow Metab. 2009 Aug;29(8):1475-81. Epub 2009 May 27.
Additional References at PubMed
PMID:8342951   PMID:10862610   PMID:12477932   PMID:12574510   PMID:15096040   PMID:15196990   PMID:16314446   PMID:17495027   PMID:18443590   PMID:18513744   PMID:18974052   PMID:19056867  
PMID:19126686   PMID:20035028   PMID:20178365   PMID:21078594   PMID:21164107   PMID:21266668   PMID:22178827   PMID:22217705   PMID:22387545   PMID:22798687   PMID:22865388   PMID:23376485  
PMID:23533145   PMID:25509856   PMID:25659109   PMID:28296232   PMID:28863368   PMID:29196978   PMID:29751149   PMID:30610956   PMID:30950936   PMID:32767848   PMID:36585106   PMID:36669577  


Comparative Map Data
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
GRCr81544,465,447 - 44,503,157 (-)NCBIGRCr8
mRatBN7.21540,289,901 - 40,327,632 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1540,289,902 - 40,327,615 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1542,154,869 - 42,194,845 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01543,305,067 - 43,345,042 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01541,750,237 - 41,787,912 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01542,757,241 - 42,794,211 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1542,757,235 - 42,794,279 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01548,799,823 - 48,836,848 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41545,497,660 - 45,556,101 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11545,513,439 - 45,571,881 (-)NCBI
Celera1539,961,087 - 40,000,936 (-)NCBICelera
Cytogenetic Map15p12NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38827,491,143 - 27,548,626 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl827,490,781 - 27,545,564 (+)EnsemblGRCh38hg38GRCh38
GRCh37827,348,660 - 27,403,081 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36827,404,562 - 27,458,403 (+)NCBINCBI36Build 36hg18NCBI36
Build 34827,404,561 - 27,458,403NCBI
Celera826,308,750 - 26,362,585 (+)NCBICelera
Cytogenetic Map8p21.2-p21.1NCBI
HuRef825,893,566 - 25,947,482 (+)NCBIHuRef
CHM1_1827,550,382 - 27,604,304 (+)NCBICHM1_1
T2T-CHM13v2.0827,768,490 - 27,825,967 (+)NCBIT2T-CHM13v2.0
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm391466,321,821 - 66,361,971 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1466,321,823 - 66,361,949 (-)EnsemblGRCm39 Ensembl
GRCm381466,084,372 - 66,124,522 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1466,084,374 - 66,124,500 (-)EnsemblGRCm38mm10GRCm38
MGSCv371466,703,214 - 66,743,337 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361465,038,487 - 65,078,610 (-)NCBIMGSCv36mm8
Celera1463,832,362 - 63,872,496 (-)NCBICelera
Cytogenetic Map14D1NCBI
cM Map1434.36NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_00495540349,999,563 - 50,041,572 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540349,999,563 - 50,038,800 (+)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
NHGRI_mPanPan1-v2746,021,291 - 46,079,005 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1821,735,517 - 21,793,206 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0826,761,090 - 26,818,436 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1823,964,094 - 24,017,749 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl823,964,094 - 24,017,749 (+)Ensemblpanpan1.1panPan2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.12530,045,040 - 30,107,110 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2530,045,291 - 30,107,110 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2530,631,771 - 30,693,869 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02530,235,290 - 30,297,630 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2530,232,724 - 30,297,642 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12530,165,721 - 30,227,963 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02530,046,546 - 30,108,832 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02530,212,901 - 30,275,213 (-)NCBIUU_Cfam_GSD_1.0
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_0244049438,193,232 - 8,235,694 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936675350,342 - 392,551 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936675350,357 - 392,919 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl1411,216,978 - 11,293,410 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11411,217,125 - 11,293,018 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21412,397,646 - 12,473,595 (+)NCBISscrofa10.2Sscrofa10.2susScr3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.1825,603,668 - 25,659,232 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl825,603,735 - 25,659,345 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605216,482,843 - 16,540,761 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla_female_1.0 EnsemblNW_00462475822,221,314 - 22,254,813 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475822,216,462 - 22,252,467 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Variants in Ephx2
344 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:230
Count of miRNA genes:155
Interacting mature miRNAs:173
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
731170Pur3Proteinuria QTL 32.30.0005urine protein amount (VT:0005160)urine protein excretion rate (CMO:0000759)15141686771Rat
1641887Alcrsp14Alcohol response QTL 14response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)15142356671Rat
2298549Neuinf12Neuroinflammation QTL 123.5nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)15155302115Rat
10401805Kidm51Kidney mass QTL 51kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1530632945306329Rat
738017Hcas7Hepatocarcinoma susceptibility QTL 72.91liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)15226636846921453Rat
1582251Gluco24Glucose level QTL 243.20.0008blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)15553075650530756Rat
631273Lecl2Lens clarity QTL 20.001lens clarity trait (VT:0001304)age of onset/diagnosis of cataract (CMO:0001584)151059608955596089Rat
2300167Bmd63Bone mineral density QTL 635.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)151111114256111142Rat
2300173Bmd62Bone mineral density QTL 6212.80.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)151111114256111142Rat
2293688Bss29Bone structure and strength QTL 295.310.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)151111114256111142Rat
2317750Glom26Glomerulus QTL 264.3urine protein amount (VT:0005160)urine protein level (CMO:0000591)151249614165205939Rat
61424Scl1Serum cholesterol level QTL 17.70.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)151672552880672115Rat
1331729Rf42Renal function QTL 423.071kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)151736289773690657Rat
2324620Coatc3Coat color QTL 3coat/hair pigmentation trait (VT:0010463)pigmented coat/hair area to total coat/hair area ratio (CMO:0001810)151985656646187442Rat
10054130Srcrt8Stress Responsive Cort QTL 82.180.0085blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)152211793367117933Rat
1578646Bmd18Bone mineral density QTL 185.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)152280624098288169Rat
1578647Bmd17Bone mineral density QTL 174femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)152280624098288169Rat
1578660Bss19Bone structure and strength QTL 194.3femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)152280624098288169Rat
1582214Stl21Serum triglyceride level QTL 213.10.022blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)152803066582262678Rat
1582227Gluco30Glucose level QTL 303.60.0003blood glucose amount (VT:0000188)absolute change in blood glucose level area under curve (CMO:0002034)152803066582262678Rat
1582228Epfw3Epididymal fat weight QTL 34.10.0002epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)152803066582262678Rat
1582242Gluco28Glucose level QTL 283.30.0008blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)152803066582262678Rat
1582244Bw79Body weight QTL 7940.0002epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)152803066582262678Rat
2293691Bmd37Bone mineral density QTL 376.60.0001femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)153361105871477291Rat
2293686Bmd36Bone mineral density QTL 367.40.0001femur strength trait (VT:0010010)femoral neck ultimate force (CMO:0001703)153361105871477291Rat
1598828Glom14Glomerulus QTL 142.5kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)153405413979054139Rat
7411725Strs7Sensitivity to stroke QTL 73.8cerebrum integrity trait (VT:0010549)percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)154028990149308583Rat

Markers in Region
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21540,310,640 - 40,310,754 (+)MAPPERmRatBN7.2
Rnor_6.01542,777,221 - 42,777,333NCBIRnor6.0
Rnor_5.01548,816,756 - 48,816,868UniSTSRnor5.0
RGSC_v3.41545,539,132 - 45,539,245RGDRGSC3.4
RGSC_v3.41545,539,133 - 45,539,245UniSTSRGSC3.4
RGSC_v3.11545,554,912 - 45,555,025RGD
Celera1539,983,968 - 39,984,080UniSTS
FHH x ACI Map1547.39RGD
FHH x ACI Map1547.39UniSTS
Cytogenetic Map15p12UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21540,290,169 - 40,290,504 (+)MAPPERmRatBN7.2
Rnor_6.01542,757,510 - 42,757,844NCBIRnor6.0
Rnor_5.01548,836,245 - 48,836,579UniSTSRnor5.0
RGSC_v3.41545,497,892 - 45,498,226UniSTSRGSC3.4
Celera1539,961,319 - 39,961,653UniSTS
Cytogenetic Map15p12UniSTS

Related Rat Strains
The following Strains have been annotated to Ephx2

Genetic Models
This gene Ephx2 is modified in the following models/strains:


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
Medium 3 31 50 41 3 41 3 18 33 29 11
Low 12 7 16 8 8 56 2 12 8
Below cutoff


RefSeq Acc Id: ENSRNOT00000023385   ⟹   ENSRNOP00000023385
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1540,289,902 - 40,327,615 (-)Ensembl
Rnor_6.0 Ensembl1542,757,235 - 42,794,279 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000098285   ⟹   ENSRNOP00000086024
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1540,289,902 - 40,327,615 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000101008   ⟹   ENSRNOP00000089032
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1540,289,902 - 40,327,615 (-)Ensembl
RefSeq Acc Id: NM_022936   ⟹   NP_075225
Rat AssemblyChrPosition (strand)Source
GRCr81544,465,484 - 44,503,155 (-)NCBI
mRatBN7.21540,289,938 - 40,327,610 (-)NCBI
Rnor_6.01542,757,278 - 42,794,189 (-)NCBI
Rnor_5.01548,799,823 - 48,836,848 (+)NCBI
RGSC_v3.41545,497,660 - 45,556,101 (-)RGD
Celera1539,961,087 - 40,000,936 (-)RGD
RefSeq Acc Id: XM_006252147   ⟹   XP_006252209
Rat AssemblyChrPosition (strand)Source
GRCr81544,465,447 - 44,503,157 (-)NCBI
mRatBN7.21540,289,901 - 40,327,632 (-)NCBI
Rnor_6.01542,757,241 - 42,794,211 (-)NCBI
Rnor_5.01548,799,823 - 48,836,848 (+)NCBI
RefSeq Acc Id: NP_075225   ⟸   NM_022936
- UniProtKB: P80299 (UniProtKB/Swiss-Prot),   A0A9K3Y813 (UniProtKB/TrEMBL),   D4A6V6 (UniProtKB/TrEMBL),   Q5RKK3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006252209   ⟸   XM_006252147
- Peptide Label: isoform X1
- UniProtKB: A6K6L7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000023385   ⟸   ENSRNOT00000023385
RefSeq Acc Id: ENSRNOP00000086024   ⟸   ENSRNOT00000098285
RefSeq Acc Id: ENSRNOP00000089032   ⟸   ENSRNOT00000101008
Protein Domains
AB hydrolase-1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P80299-F1-model_v2 AlphaFold P80299 1-554 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13699755
Promoter ID:EPDNEW_R10278
Type:initiation region
Description:epoxide hydrolase 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Rat AssemblyChrPosition (strand)Source
Rnor_6.01542,794,211 - 42,794,271EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620732 AgrOrtholog
BioCyc Gene G2FUF-13332 BioCyc
Ensembl Genes ENSRNOG00000017286 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOG00055006699 UniProtKB/Swiss-Prot
  ENSRNOG00060010710 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000023385 ENTREZGENE
  ENSRNOT00000023385.8 UniProtKB/TrEMBL
  ENSRNOT00000098285.1 UniProtKB/TrEMBL
  ENSRNOT00000101008.1 UniProtKB/TrEMBL
  ENSRNOT00055010957 UniProtKB/Swiss-Prot
  ENSRNOT00055010964 UniProtKB/Swiss-Prot
  ENSRNOT00060018220 UniProtKB/Swiss-Prot
  ENSRNOT00060018225 UniProtKB/Swiss-Prot
Gene3D-CATH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro AB_hydrolase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  AB_hydrolase_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Epox_hydrolase-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HAD-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HAD-SF_hydro_IA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HAD-SF_ppase_IA/epoxid_hydro_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HAD_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PGP-like_dom2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:65030 UniProtKB/Swiss-Prot
Pfam Abhydrolase_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Hydrolase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Ephx2 PhenoGen
RatGTEx ENSRNOG00000017286 RatGTEx
  ENSRNOG00055006699 RatGTEx
  ENSRNOG00060010710 RatGTEx
Superfamily-SCOP SSF53474 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF56784 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I6A4C3_RAT UniProtKB/TrEMBL
UniProt Secondary D4A6V6 UniProtKB/TrEMBL

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-01-27 Ephx2  epoxide hydrolase 2  Ephx2  epoxide hydrolase 2, cytoplasmic  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-02-26 Ephx2  epoxide hydrolase 2, cytoplasmic    cytosolic epoxide hydrolase  Name updated 625702 APPROVED
2002-08-07 Ephx2  cytosolic epoxide hydrolase      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization contains a non-ideal peroxisomal targeting sequence, Ser-Lys-Ile, which results in dual localization to the cytosol and to peroxisomes 728863
gene_disease increased cytosolic epoxide hydrolase gene expression and high protein levels may lead to overactive conversion of EETs which may cause hypertension 625710
gene_expression expressed in abundance in renal cortex of kidney 625710
gene_expression expression is decreased 5.2 and 2.0 fold in SHR compared with WKY rats 1357414
gene_function converts epoxyeicosatrienoic acids [EETs] into corresponding diols 625710
gene_mutations_overexpression targeted disruption results in reduction of blood pressure 625710
gene_other displays sequence polymorphism and is differentially expressed among inbred strains, including the Japanese SHR/Hos, SHR/Izm, SHR/Ncrj, HRSP/Izm, WKY/Hos, WKY/Izm, and WKY/Ncrj strains 625539
gene_process may be involved in the regulation of blood pressure 625539
gene_transcript two alleles of Ephx2, differing by 4 single nucleotide polymorphisms 3 of which results in nonsynonymous amino acid substitutions 625710