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Gene: Ephx2 (epoxide hydrolase 2) Rattus norvegicus
Symbol: Ephx2
Name: epoxide hydrolase 2
Description: Exhibits epoxide hydrolase activity; magnesium ion binding activity; and phosphatase activity. Involved in several processes, including linoleic acid metabolic process; prostaglandin production involved in inflammatory response; and sensory perception of pain. Localizes to cytosol and peroxisome. Used to study cerebral infarction; hypertension; and pulmonary hypertension. Human ortholog(s) of this gene implicated in coronary artery disease; familial hypercholesterolemia; and hypertension. Orthologous to human EPHX2 (epoxide hydrolase 2); PARTICIPATES IN acetylsalicylic acid pharmacodynamics pathway; antipyrine drug pathway; arachidonic acid metabolic pathway; INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; 3,3',4,4',5-pentachlorobiphenyl.
Type: protein-coding
Also known as: bifunctional epoxide hydrolase 2; CEH; cytosolic epoxide hydrolase; epoxide hydratase; epoxide hydrolase 2, cytoplasmic; SEH; soluble epoxide hydrolase
Homo sapiens (human) : EPHX2 (epoxide hydrolase 2)  HGNC  Alliance
Mus musculus (house mouse) : Ephx2 (epoxide hydrolase 2, cytoplasmic)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ephx2 (epoxide hydrolase 2)
Pan paniscus (bonobo/pygmy chimpanzee) : EPHX2 (epoxide hydrolase 2)
Canis lupus familiaris (dog) : EPHX2 (epoxide hydrolase 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Ephx2 (epoxide hydrolase 2)
Sus scrofa (pig) : EPHX2 (epoxide hydrolase 2)
Chlorocebus sabaeus (African green monkey) : EPHX2 (epoxide hydrolase 2)
Heterocephalus glaber (naked mole-rat) : Ephx2 (epoxide hydrolase 2)
more info ...
Allele / Splice: Ephx2em2Mcwi  
Genetic Models: SD-Ephx2em2Mcwi
Is Marker For: Strains:   SHR  
QTLs:   Strs7  
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.01542,757,241 - 42,794,211 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1542,757,235 - 42,794,279 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01548,799,823 - 48,836,848 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41545,497,660 - 45,556,101 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11545,513,439 - 45,571,881 (-)NCBI
Celera1539,961,087 - 40,000,936 (-)NCBICelera
Cytogenetic Map15p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
Related Rat Strains
Genetic Models
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Ephx2
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 620732
Created: 2002-08-06
Species: Rattus norvegicus
Last Modified: 2020-06-09
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.