Gene: Cysltr1 (cysteinyl leukotriene receptor 1) Rattus norvegicus
Analyze
Symbol:
Cysltr1
Name:
cysteinyl leukotriene receptor 1
RGD ID:
619796
Description:
Exhibits leukotriene receptor activity. Involved in inflammatory response; positive regulation of angiogenesis; and positive regulation of vasoconstriction. Predicted to localize to integral component of plasma membrane. Used to study pulmonary hypertension. Biomarker of pulmonary fibrosis. Human ortholog(s) of this gene implicated in allergic hypersensitivity disease; asthma; and rhinitis. Orthologous to human CYSLTR1 (cysteinyl leukotriene receptor 1); PARTICIPATES IN endothelin signaling pathway; calcium/calcium-mediated signaling pathway; INTERACTS WITH ammonium chloride; bisphenol A; glycine betaine.
Type:
protein-coding
RefSeq Status:
PROVISIONAL
Also known as:
Cyslt1
Orthologs:
Species
Gene symbol and name
Data Source
Assertion derived from
less info ...
Orthologs 1
Homo sapiens (human):
CYSLTR1 (cysteinyl leukotriene receptor 1) HGNC
EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):
Cysltr1 (cysteinyl leukotriene receptor 1) HGNC
Treefam, EggNOG, OrthoMCL, NCBI, OMA, HomoloGene, Inparanoid, Panther, PhylomeDB, OrthoDB, Ensembl
Chinchilla lanigera (long-tailed chinchilla):
Cysltr1 (cysteinyl leukotriene receptor 1) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):
CYSLTR1 (cysteinyl leukotriene receptor 1) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Canis lupus familiaris (dog):
CYSLTR1 (cysteinyl leukotriene receptor 1) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):
Cysltr1 (cysteinyl leukotriene receptor 1) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Sus scrofa (pig):
CYSLTR1 (cysteinyl leukotriene receptor 1) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Chlorocebus sabaeus (African green monkey):
CYSLTR1 (cysteinyl leukotriene receptor 1) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):
Cysltr1 (cysteinyl leukotriene receptor 1) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Alliance orthologs 3
Homo sapiens (human):
CYSLTR1 (cysteinyl leukotriene receptor 1)
Alliance
DIOPT (Ensembl Compara|HGNC|Hieranoid|InParanoid|OMA|OrthoFinder|OrthoInspector|PANTHER|PhylomeDB|TreeFam)
Mus musculus (house mouse):
Cysltr1 (cysteinyl leukotriene receptor 1)
Alliance
DIOPT (Ensembl Compara|Hieranoid|InParanoid|OMA|OrthoFinder|OrthoInspector|PANTHER|PhylomeDB|TreeFam)
Danio rerio (zebrafish):
cysltr1 (cysteinyl leukotriene receptor 1)
Alliance
DIOPT (Ensembl Compara|Hieranoid|InParanoid|OMA|OrthoFinder|OrthoInspector|PANTHER|PhylomeDB)
Latest Assembly:
Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl Rnor_6.0 X 77,671,028 - 77,700,491 (-) NCBI Rnor6.0 Rnor_6.0 rn6 Rnor6.0 Rnor_6.0 Ensembl X 77,674,150 - 77,700,269 (-) Ensembl Rnor6.0 rn6 Rnor6.0 Rnor_5.0 X 77,868,476 - 77,895,363 (-) NCBI Rnor5.0 Rnor_5.0 rn5 Rnor5.0 RGSC_v3.4 X 94,802,078 - 94,803,097 (-) NCBI RGSC3.4 rn4 RGSC3.4 RGSC_v3.1 X 94,875,510 - 94,876,530 (-) NCBI Celera X 72,975,213 - 72,976,232 (-) NCBI Celera Cytogenetic Map X q22 NCBI
JBrowse:
View Region in Genome Browser (JBrowse)
Model
Imported Annotations - ClinVar
autistic disorder ISO RGD:732524 8554872 ClinVar Annotator: match by term: Autistic disorder of childhood onset ClinVar PMID:21681106 , PMID:30208311 prostate cancer ISO RGD:732524 8554872 ClinVar Annotator: match by term: Prostate cancer ClinVar PMID:23265383 syndromic X-linked intellectual disability Lubs type ISO RGD:732524 8554872 ClinVar Annotator: match by term: MECP2 duplication syndrome ClinVar PMID:25741868
Imported Annotations - CTD
Aspirin-Induced Asthma ISO RGD:732524 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:16502481 more ... drug allergy ISO RGD:732524 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:16630147 Fractures, Closed ISO RGD:732524 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:19544365
17beta-estradiol increases expression ISO RGD:732525 6480464 Estradiol results in increased expression of CYSLTR1 mRNA CTD PMID:19484750 2,3,7,8-tetrachlorodibenzodioxine increases expression ISO RGD:732525 6480464 Tetrachlorodibenzodioxin results in increased expression of CYSLTR1 mRNA CTD PMID:19933214 4-hydroxynon-2-enal decreases expression ISO RGD:732525 6480464 4-hydroxy-2-nonenal results in decreased expression of CYSLTR1 mRNA CTD PMID:19191707 acetylsalicylic acid increases expression ISO RGD:732524 6480464 Aspirin results in increased expression of CYSLTR1 mRNA CTD PMID:17641958 acetylsalicylic acid multiple interactions ISO RGD:732524 6480464 Aspirin inhibits the reaction [IL4 results in increased expression of CYSLTR1 mRNA] CTD PMID:19767084 acetylsalicylic acid affects response to substance ISO RGD:732524 6480464 CYSLTR1 gene SNP affects the susceptibility to Aspirin, CYSLTR1 SNP affects the susceptibility to Aspirin CTD PMID:16630147 more ... ammonium chloride affects expression EXP 6480464 Ammonium Chloride affects the expression of CYSLTR1 mRNA CTD PMID:16483693 asbestos decreases expression ISO RGD:732524 6480464 Asbestos results in decreased expression of CYSLTR1 mRNA CTD PMID:22398240 bisphenol A decreases expression EXP 6480464 bisphenol A results in decreased expression of CYSLTR1 mRNA CTD PMID:25181051 calcium atom multiple interactions ISO RGD:732524 6480464 [CP 199330 binds to and results in decreased activity of CYSLTR1 protein] which affects the abundance of Calcium more ... CTD PMID:10391245 more ... calcium atom multiple interactions ISO RGD:732525 6480464 [Leukotriene D4 binds to and results in increased activity of CYSLTR1 protein] which results in increased abundance of Calcium CTD PMID:11705452 , PMID:15792791 calcium(0) multiple interactions ISO RGD:732524 6480464 [CP 199330 binds to and results in decreased activity of CYSLTR1 protein] which affects the abundance of Calcium more ... CTD PMID:10391245 more ... calcium(0) multiple interactions ISO RGD:732525 6480464 [Leukotriene D4 binds to and results in increased activity of CYSLTR1 protein] which results in increased abundance of Calcium CTD PMID:11705452 , PMID:15792791 carbon nanotube increases expression ISO RGD:732525 6480464 Nanotubes, Carbon analog results in increased expression of CYSLTR1 mRNA, Nanotubes, Carbon results in increased expression of CYSLTR1 mRNA CTD PMID:25554681 chloroprene decreases expression ISO RGD:732525 6480464 Chloroprene results in decreased expression of CYSLTR1 mRNA CTD PMID:23125180 choline multiple interactions ISO RGD:732525 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of CYSLTR1 mRNA CTD PMID:20938992 dibutyl phthalate increases expression ISO RGD:732525 6480464 Dibutyl Phthalate results in increased expression of CYSLTR1 mRNA CTD PMID:17361019 dioxygen increases expression ISO RGD:732525 6480464 Oxygen deficiency results in increased expression of CYSLTR1 mRNA CTD PMID:20880076 ethyl methanesulfonate decreases expression ISO RGD:732524 6480464 Ethyl Methanesulfonate results in decreased expression of CYSLTR1 mRNA CTD PMID:23649840 folic acid multiple interactions ISO RGD:732525 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of CYSLTR1 mRNA CTD PMID:20938992 formaldehyde decreases expression ISO RGD:732524 6480464 Formaldehyde results in decreased expression of CYSLTR1 mRNA CTD PMID:23649840 glycine betaine increases expression EXP 6480464 Betaine results in increased expression of CYSLTR1 mRNA CTD PMID:26391144 GW 4064 decreases expression ISO RGD:732525 6480464 GW 4064 results in decreased expression of CYSLTR1 mRNA CTD PMID:26655953 hydrogen peroxide decreases expression ISO RGD:732524 6480464 Hydrogen Peroxide results in decreased expression of CYSLTR1 mRNA CTD PMID:18951874 isoprenaline increases expression ISO RGD:732525 6480464 Isoproterenol results in increased expression of CYSLTR1 mRNA CTD PMID:20003209 ketorolac multiple interactions ISO RGD:732524 6480464 Ketorolac inhibits the reaction [IL4 results in increased expression of CYSLTR1 mRNA] CTD PMID:19767084 L-methionine multiple interactions ISO RGD:732525 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of CYSLTR1 mRNA CTD PMID:20938992 leukotriene B4 multiple interactions ISO RGD:732525 6480464 [LY 171883 binds to and results in decreased activity of CYSLTR1 protein] which results in decreased abundance of Leukotriene B4 CTD PMID:8014878 leukotriene C4 multiple interactions ISO RGD:732524 6480464 [Leukotriene C4 binds to and results in increased activity of CYSLTR1 protein] which results in increased abundance of Calcium more ... CTD PMID:10391245 more ... leukotriene C4 affects binding ISO RGD:732524 6480464 Leukotriene C4 binds to CYSLTR1 protein CTD PMID:10825389 more ... leukotriene C4 multiple interactions ISO RGD:732525 6480464 CYSLTR1 protein binds to and affects the susceptibility to Leukotriene C4, Leukotriene C4 inhibits the reaction [Leukotriene D4 binds to CYSLTR1 protein] CTD PMID:11705452 , PMID:11932261 leukotriene D4 multiple interactions ISO RGD:732524 6480464 [Leukotriene D4 binds to and results in increased activity of CYSLTR1 protein] which results in increased abundance of Calcium more ... CTD PMID:10391245 more ... leukotriene D4 affects binding ISO RGD:732524 6480464 Leukotriene D4 binds to CYSLTR1 protein CTD PMID:10825389 more ... leukotriene D4 multiple interactions ISO RGD:732525 6480464 [Leukotriene D4 binds to and results in increased activity of CYSLTR1 protein] which results in increased abundance of Calcium more ... CTD PMID:11705452 more ... leukotriene D4 increases activity ISO RGD:732524 6480464 Leukotriene D4 results in increased activity of CYSLTR1 protein CTD PMID:18704935 leukotriene D4 increases response to substance ISO RGD:732524 6480464 CYSLTR1 protein results in increased susceptibility to Leukotriene D4 CTD PMID:9647482 leukotriene E4 affects binding ISO RGD:732524 6480464 Leukotriene E4 binds to CYSLTR1 protein CTD PMID:8384568 leukotriene E4 multiple interactions ISO RGD:732524 6480464 [Leukotriene E4 binds to and results in increased activity of CYSLTR1 protein] which results in increased abundance of Calcium more ... CTD PMID:10462554 more ... leukotriene E4 multiple interactions ISO RGD:732525 6480464 Leukotriene E4 inhibits the reaction [Leukotriene D4 binds to CYSLTR1 protein] CTD PMID:11705452 methyl methanesulfonate decreases expression ISO RGD:732524 6480464 Methyl Methanesulfonate results in decreased expression of CYSLTR1 mRNA CTD PMID:23649840 MK 571 multiple interactions ISO RGD:732524 6480464 alpha-pentyl-3-(2-quinolinylmethoxy)benzenemethanol inhibits the reaction [verlukast binds to and results in decreased activity of CYSLTR1 protein] more ... CTD PMID:10391245 more ... MK 571 multiple interactions ISO RGD:732525 6480464 verlukast binds to and results in decreased activity of CYSLTR1 protein, verlukast inhibits the reaction [Leukotriene D4 binds to CYSLTR1 protein] CTD PMID:11705452 montelukast multiple interactions ISO RGD:732524 6480464 alpha-pentyl-3-(2-quinolinylmethoxy)benzenemethanol inhibits the reaction [montelukast binds to and results in decreased activity of CYSLTR1 protein] more ... CTD PMID:10391245 more ... montelukast multiple interactions EXP 6480464 montelukast inhibits the reaction [Rotenone results in increased expression of CYSLTR1 mRNA] CTD PMID:30222980 montelukast multiple interactions ISO RGD:732525 6480464 montelukast inhibits the reaction [Streptozocin results in increased expression of CYSLTR1 mRNA], montelukast inhibits the reaction [Streptozocin results in increased expression of CYSLTR1 protein] CTD PMID:27702591 montelukast decreases expression ISO RGD:732525 6480464 montelukast results in decreased expression of CYSLTR1 mRNA CTD PMID:19544365 rotenone multiple interactions EXP 6480464 montelukast inhibits the reaction [Rotenone results in increased expression of CYSLTR1 mRNA] CTD PMID:30222980 rotenone increases expression EXP 6480464 Rotenone results in increased expression of CYSLTR1 mRNA CTD PMID:30222980 silicon dioxide decreases expression ISO RGD:732525 6480464 Silicon Dioxide results in decreased expression of CYSLTR1 mRNA CTD PMID:19073995 streptozocin multiple interactions ISO RGD:732525 6480464 montelukast inhibits the reaction [Streptozocin results in increased expression of CYSLTR1 mRNA], montelukast inhibits the reaction [Streptozocin results in increased expression of CYSLTR1 protein] CTD PMID:27702591 streptozocin increases expression ISO RGD:732525 6480464 Streptozocin results in increased expression of CYSLTR1 mRNA, Streptozocin results in increased expression of CYSLTR1 protein CTD PMID:27702591 theophylline decreases expression ISO RGD:732524 6480464 Theophylline results in decreased expression of CYSLTR1 mRNA CTD PMID:18951874 tomelukast multiple interactions ISO RGD:732524 6480464 LY 171883 binds to and results in increased activity of CYSLTR1 protein, LY 171883 inhibits the reaction [Leukotriene D4 binds to and results in increased activity of CYSLTR1 protein] CTD PMID:14718577 tomelukast multiple interactions ISO RGD:732525 6480464 [LY 171883 binds to and results in decreased activity of CYSLTR1 protein] which results in decreased abundance of Leukotriene B4, LY 171883 binds to and results in decreased activity of CYSLTR1 protein CTD PMID:8014878 UDP multiple interactions ISO RGD:732524 6480464 [Uridine Diphosphate binds to and results in increased activity of CYSLTR1 protein] which results in increased abundance of Calcium more ... CTD PMID:20083671 valproic acid decreases expression ISO RGD:732525 6480464 Valproic Acid results in decreased expression of CYSLTR1 mRNA CTD PMID:21427059 vincristine decreases expression ISO RGD:732524 6480464 Vincristine results in decreased expression of CYSLTR1 mRNA CTD PMID:23649840 zafirlukast multiple interactions ISO RGD:732524 6480464 [zafirlukast binds to and results in decreased activity of CYSLTR1 protein] which affects the abundance of Calcium more ... CTD PMID:10391245 more ... zafirlukast affects binding ISO RGD:732524 6480464 zafirlukast binds to CYSLTR1 protein CTD PMID:10825389 zafirlukast multiple interactions ISO RGD:732525 6480464 zafirlukast binds to and results in decreased activity of CYSLTR1 protein, zafirlukast inhibits the reaction [Leukotriene D4 binds to CYSLTR1 protein] CTD PMID:11705452
Biological Process calcium ion transport ISO RGD:732525 1624291 (MGI:MGI:3589305, PMID:16002666) RGD MGI:MGI:3589305 , PMID:16002666 calcium ion transport IEA UniProtKB:Q99JA4 , ensembl:ENSMUSP000001091081600115 GO_REF:0000107 Ensembl GO_REF:0000107 cell surface receptor signaling pathway ISO RGD:732525 1624291 (MGI:MGI:1931614, PMID:11226226) RGD MGI:MGI:1931614 , PMID:11226226 cell surface receptor signaling pathway IEA UniProtKB:Q99JA4 , ensembl:ENSMUSP000001091081600115 GO_REF:0000107 Ensembl GO_REF:0000107 chemotaxis ISO RGD:732525 1624291 (MGI:MGI:3589305, PMID:16002666) RGD MGI:MGI:3589305 , PMID:16002666 chemotaxis IEA UniProtKB:Q99JA4 , ensembl:ENSMUSP000001091081600115 GO_REF:0000107 Ensembl GO_REF:0000107 inflammatory response IDA 634736 RGD inflammatory response to antigenic stimulus ISO RGD:732525 1624291 MGI:MGI:2182326 (MGI:MGI:4819040 , PMID:20574000) RGD MGI:MGI:4819040 , PMID:20574000 inflammatory response to antigenic stimulus IEA UniProtKB:Q99JA4 , ensembl:ENSMUSP000001091081600115 GO_REF:0000107 Ensembl GO_REF:0000107 leukotriene signaling pathway IEA GO:0004974 1600115 GO_REF:0000108 GOC GO_REF:0000108 leukotriene signaling pathway IEA GO:0001631 1600115 GO_REF:0000108 GOC GO_REF:0000108 neuropeptide signaling pathway IBA FB:FBgn0036278 more ... 13792537 PMID:21873635 GO_Central positive regulation of angiogenesis IMP 5144005 RGD positive regulation of vasoconstriction IMP 2316238 ; 1626151 RGD Cellular Component cellular_component ND 1598407 02/2010: no relevant rat data RGD integral component of plasma membrane ISO RGD:732525 1624291 (MGI:MGI:1931614, PMID:11226226) RGD MGI:MGI:1931614 , PMID:11226226 integral component of plasma membrane IBA FB:FBgn0036278 more ... 13792537 PMID:21873635 GO_Central integral component of plasma membrane IEA UniProtKB:Q99JA4 , ensembl:ENSMUSP000001091081600115 GO_REF:0000107 Ensembl GO_REF:0000107 Molecular Function cysteinyl leukotriene receptor activity IBA MGI:MGI:1917336 , PANTHER:PTN000660397 13792537 PMID:21873635 GO_Central G protein-coupled peptide receptor activity IBA FB:FBgn0039595 more ... 13792537 PMID:21873635 GO_Central leukotriene receptor activity IDA 634736 RGD leukotriene receptor activity IEA UniProtKB:Q99JA4 , ensembl:ENSMUSP000001091081600115 GO_REF:0000107 Ensembl GO_REF:0000107 leukotriene receptor activity ISO RGD:732525 1624291 (MGI:MGI:1931614, PMID:11226226) RGD MGI:MGI:1931614 , PMID:11226226 protein binding ISO RGD:732525 1624291 UniProtKB:Q6NS65 (MGI:MGI:3851858 , PMID:19561298) RGD MGI:MGI:3851858 , PMID:19561298 protein binding ISO RGD:732524 1624291 UniProtKB:Q9NS75 (PMID:21203429) RGD PMID:21203429
Gene-Chemical Interaction Annotations
