Cysltr1 (cysteinyl leukotriene receptor 1) - Rat Genome Database

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Gene: Cysltr1 (cysteinyl leukotriene receptor 1) Rattus norvegicus
Analyze
Symbol: Cysltr1
Name: cysteinyl leukotriene receptor 1
RGD ID: 619796
Description: Enables leukotriene receptor activity. Involved in inflammatory response; positive regulation of angiogenesis; and positive regulation of vasoconstriction. Predicted to be active in plasma membrane. Used to study pulmonary hypertension. Biomarker of pulmonary fibrosis. Human ortholog(s) of this gene implicated in allergic disease; asthma; and rhinitis. Orthologous to human CYSLTR1 (cysteinyl leukotriene receptor 1); PARTICIPATES IN endothelin signaling pathway; calcium/calcium-mediated signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; ammonium chloride; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Cyslt1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2X71,661,415 - 71,690,158 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX71,663,821 - 71,690,121 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX73,181,064 - 73,182,083 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0X76,680,942 - 76,681,961 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0X74,236,459 - 74,237,478 (-)NCBIRnor_WKY
Rnor_6.0X77,671,028 - 77,700,491 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX77,674,150 - 77,700,269 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X77,868,476 - 77,895,363 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X94,802,078 - 94,803,097 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1X94,875,510 - 94,876,530 (-)NCBI
CeleraX72,975,213 - 72,976,232 (-)NCBICelera
Cytogenetic MapXq22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Cysteinyl leukotriene 1 receptor controls the severity of chronic pulmonary inflammation and fibrosis. Beller TC, etal., Proc Natl Acad Sci U S A. 2004 Mar 2;101(9):3047-52. Epub 2004 Feb 17.
2. Ribavirin and cysteinyl leukotriene-1 receptor blockade as treatment for severe bronchiolitis. Bonville CA, etal., Antiviral Res. 2006 Feb;69(2):53-9. Epub 2005 Nov 28.
3. Cysteinyl leukotriene 1 receptor expression in nasal polyps. Chao SS, etal., Ann Otol Rhinol Laryngol. 2006 May;115(5):394-7.
4. Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition Chen X, etal., Sichuan Da Xue Xue Bao Yi Xue Ban. 2003 Jul;34(3):555-8.
5. Leukotriene antagonism reduces the generation of endothelin-1 and interferon-gamma and inhibits eosinophilic airway inflammation. Finsnes F, etal., Respir Med 2002 Nov;96(11):901-6.
6. Role of cysteinyl leukotrienes in airway inflammation and responsiveness following RSV infection in BALB/c mice. Fullmer JJ, etal., Pediatr Allergy Immunol. 2005 Nov;16(7):593-601.
7. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
8. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
9. The cysteinyl-leukotriene type 1 receptor polymorphism 927T/C is associated with atopy severity but not with asthma. Hao L, etal., Clin Exp Allergy. 2006 Jun;36(6):735-41.
10. Reversal of allergen-induced airway remodeling by CysLT1 receptor blockade. Henderson WR Jr, etal., Am J Respir Crit Care Med. 2006 Apr 1;173(7):718-28. Epub 2005 Dec 30.
11. [Lung fibrosis induced by mechanical ventilation with different tidal volume in neonatal rats]. Huang JJ, etal., Zhongguo Dang Dai Er Ke Za Zhi. 2010 Oct;12(10):799-803.
12. Attenuation of hypoxic pulmonary vasoconstriction by endotoxemia requires 5-lipoxygenase in mice. Ichinose F, etal., Circ Res. 2001 Apr 27;88(8):832-8.
13. Cysteinyl leukotriene receptors are expressed by tonsillar T cells of children with obstructive sleep apnea. Kaditis AG, etal., Chest. 2008 Aug;134(2):324-31. Epub 2008 May 19.
14. Cysteinyl leukotriene receptor 1 promoter polymorphism is associated with aspirin-intolerant asthma in males. Kim SH, etal., Clin Exp Allergy. 2006 Apr;36(4):433-9.
15. Effect of 5-lipoxygenase blockade on blood pressure and acetylcholine-evoked endothelium-dependent contraction in aorta from spontaneously hypertensive rats. Lefebvre B, etal., J Hypertens. 2006 Jan;24(1):85-93.
16. Targeted gene disruption reveals the role of cysteinyl leukotriene 1 receptor in the enhanced vascular permeability of mice undergoing acute inflammatory responses. Maekawa A, etal., J Biol Chem 2002 Jun 7;277(23):20820-4. Epub 2002 Apr 3.
17. Study of cysteinyl leukotriene-1 receptor in rat renal ischemia-reperfusion injury. Matsuyama M, etal., Transplant Proc. 2008 Sep;40(7):2149-51.
18. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
19. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
20. A double-blind non-inferiority clinical study of montelukast, a cysteinyl leukotriene receptor 1 antagonist, compared with pranlukast in patients with seasonal allergic rhinitis. Okubo K and Baba K, Allergol Int. 2008 Dec;57(4):383-90. Epub 2008 Nov 1.
21. Cysteinyl leukotriene receptor 1 facilitates tumorigenesis in a mouse model of colitis-associated colon cancer. Osman J, etal., Oncotarget. 2017 May 23;8(21):34773-34786. doi: 10.18632/oncotarget.16718.
22. Expression of eicosanoid receptors subtypes and eosinophilic inflammation: implication on chronic rhinosinusitis. Perez-Novo CA, etal., Respir Res. 2006 May 12;7:75.
23. Inhibition of allergen-induced bronchoconstriction in hyperreactive rats as a model for testing 5-lipoxygenase inhibitors and leukotriene D4 receptor antagonists. Piechuta H, etal., Agents Actions. 1987 Oct;22(1-2):69-74.
24. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
25. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
26. An open audit of montelukast, a leukotriene receptor antagonist, in nasal polyposis associated with asthma. Ragab S, etal., Clin Exp Allergy. 2001 Sep;31(9):1385-91.
27. GOA pipeline RGD automated data pipeline
28. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
29. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
30. Comprehensive gene review and curation RGD comprehensive gene curation
31. The effects of montelukast on tissue inflammatory and bone marrow responses in murine experimental allergic rhinitis: interaction with interleukin-5 deficiency. Roa J, etal., Immunology. 2007 Nov;122(3):438-44. Epub 2007 Jul 11.
32. Effects of a cysteinyl leukotriene receptor antagonist on eosinophil recruitment in experimental allergic rhinitis. Saito H, etal., Immunology. 2004 Oct;113(2):246-52.
33. Analysis of 927T> C CYSLTRI and -444A > C LTC4S polymorphisms in patients with asthma. Sanz C, etal., J Investig Allergol Clin Immunol. 2006;16(6):331-7.
34. Anti-inflammatory effects of montelukast in mild cystic fibrosis. Schmitt-Grohe S, etal., Ann Allergy Asthma Immunol. 2002 Dec;89(6):599-605.
35. Chronic renal failure-induced multiple-organ injury in rats is alleviated by the selective CysLT1 receptor antagonist montelukast. Sener G, etal., Prostaglandins Other Lipid Mediat. 2007 Jun;83(4):257-67. Epub 2007 Jan 20.
36. Leukotriene B4 receptor type 2 protects against pneumolysin-dependent acute lung injury. Shigematsu M, etal., Sci Rep. 2016 Oct 5;6:34560. doi: 10.1038/srep34560.
37. Effects of 6 weeks of therapy with oral doses of ICI 204,219, a leukotriene D4 receptor antagonist, in subjects with bronchial asthma. ACCOLATE Asthma Trialists Group. Spector SL, etal., Am J Respir Crit Care Med. 1994 Sep;150(3):618-23.
38. Cysteinyl leukotrienes and leukotriene B mediate vasoconstriction to arginine vasopressin in rat basilar artery. Trandafir CC, etal., Clin Exp Pharmacol Physiol. 2005 Dec;32(12):1027-33.
39. The long-term effect of Helicobacter pylori eradication on COX-1/2, 5-LOX and leukotriene receptors in patients with a risk gastritis phenotype--a link to gastric carcinogenesis. Venerito M, etal., Cancer Lett. 2008 Nov 8;270(2):218-28. doi: 10.1016/j.canlet.2008.05.015. Epub 2008 Jun 20.
40. Cysteinyl leukotriene receptor antagonist MK-571 alters bronchoalveolar lavage fluid proteome in a mouse asthma model. Wong WS, etal., Eur J Pharmacol. 2007 Dec 1;575(1-3):134-41. Epub 2007 Jul 24.
41. Involvement of cysteinyl leukotriene receptors in angiogenesis in rat thoracic aortic rings. Xu L, etal., Pharmazie. 2010 Oct;65(10):750-4.
42. Expression of cysteinyl leukotriene receptor in brain tissues of rats with Streptococcus pneumoniae meningitis. Yu S, etal., Int J Clin Exp Pathol. 2019 Dec 1;12(12):4242-4252. eCollection 2019.
43. Sceptridium ternatum extract exerts antiasthmatic effects by regulating Th1/Th2 balance and the expression levels of leukotriene receptors in a mouse asthma model. Yuan Y, etal., J Ethnopharmacol. 2013 Oct 7;149(3):701-6. doi: 10.1016/j.jep.2013.07.032. Epub 2013 Aug 9.
44. Determination of structure and transcriptional regulation of CYSLTR1 and an association study with asthma and rhinitis. Zhang J, etal., Pediatr Allergy Immunol. 2006 Jun;17(4):242-9.
45. Localization and upregulation of cysteinyl leukotriene-1 receptor in asthmatic bronchial mucosa. Zhu J, etal., Am J Respir Cell Mol Biol. 2005 Dec;33(6):531-40. Epub 2005 Aug 25.
Additional References at PubMed
PMID:11226226   PMID:16002666   PMID:16650938   PMID:20574000   PMID:22230957   PMID:22499509   PMID:27909742  


Genomics

Comparative Map Data
Cysltr1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2X71,661,415 - 71,690,158 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX71,663,821 - 71,690,121 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX73,181,064 - 73,182,083 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0X76,680,942 - 76,681,961 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0X74,236,459 - 74,237,478 (-)NCBIRnor_WKY
Rnor_6.0X77,671,028 - 77,700,491 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX77,674,150 - 77,700,269 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X77,868,476 - 77,895,363 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X94,802,078 - 94,803,097 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1X94,875,510 - 94,876,530 (-)NCBI
CeleraX72,975,213 - 72,976,232 (-)NCBICelera
Cytogenetic MapXq22NCBI
CYSLTR1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X78,271,468 - 78,327,611 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 EnsemblX78,271,468 - 78,327,691 (-)EnsemblGRCh38hg38GRCh38
GRCh37X77,526,965 - 77,583,108 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X77,414,786 - 77,469,743 (-)NCBINCBI36Build 36hg18NCBI36
Build 34X77,334,275 - 77,389,232NCBI
CeleraX77,768,935 - 77,823,895 (-)NCBICelera
Cytogenetic MapXq21.1NCBI
HuRefX71,107,425 - 71,162,464 (-)NCBIHuRef
CHM1_1X77,421,213 - 77,476,168 (-)NCBICHM1_1
T2T-CHM13v2.0X76,708,793 - 76,764,940 (-)NCBIT2T-CHM13v2.0
Cysltr1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X105,617,952 - 105,647,329 (-)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX105,617,952 - 105,647,285 (-)EnsemblGRCm39 Ensembl
GRCm38X106,576,509 - 106,603,679 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX106,574,346 - 106,603,679 (-)EnsemblGRCm38mm10GRCm38
MGSCv37X103,771,856 - 103,798,801 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X102,779,236 - 102,806,181 (-)NCBIMGSCv36mm8
CeleraX93,425,096 - 93,451,782 (-)NCBICelera
Cytogenetic MapXDNCBI
Cysltr1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049555571,667,518 - 1,702,272 (-)NCBIChiLan1.0ChiLan1.0
CYSLTR1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1X77,523,188 - 77,579,350 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX77,524,455 - 77,525,468 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0X67,412,410 - 67,469,366 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
CYSLTR1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X60,462,290 - 60,513,155 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX60,463,526 - 60,464,548 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX51,475,377 - 51,526,196 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0X61,701,015 - 61,766,649 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX61,701,032 - 61,766,592 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X59,407,128 - 59,457,919 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X61,017,129 - 61,067,958 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X60,605,215 - 60,656,035 (-)NCBIUU_Cfam_GSD_1.0
Cysltr1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X54,157,074 - 54,184,386 (-)NCBIHiC_Itri_2
SpeTri2.0NW_004936547479,261 - 504,757 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CYSLTR1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX62,380,780 - 62,456,689 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X62,380,778 - 62,407,736 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X71,478,976 - 71,505,912 (-)NCBISscrofa10.2Sscrofa10.2susScr3
LOC103232241
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X67,218,777 - 67,300,655 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 EnsemblX67,220,048 - 67,221,061 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236680982,664 - 5,209 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cysltr1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248362,556,269 - 2,597,008 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Cysltr1
36 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:86
Count of miRNA genes:74
Interacting mature miRNAs:81
Transcripts:ENSRNOT00000042799
Prediction methods:Microtar, Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61430Cia18Collagen induced arthritis QTL 183.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)X14843113120568734Rat
1598837Memor13Memory QTL 133.2exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)X41052407146860749Rat
738035Stresp1Stress response QTL 14.960.000011stress-related behavior trait (VT:0010451)defensive burying - copingX41304447112935181Rat
61431Cia19Collagen induced arthritis QTL 194.4joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)X65612192120568734Rat

Markers in Region
PMC30125P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X71,665,566 - 71,665,787 (+)MAPPERmRatBN7.2
Rnor_6.0X77,675,174 - 77,675,394NCBIRnor6.0
Rnor_5.0X77,870,164 - 77,870,384UniSTSRnor5.0
RGSC_v3.4X94,802,903 - 94,803,123UniSTSRGSC3.4
CeleraX72,976,038 - 72,976,258UniSTS
Cytogenetic MapXq31UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 1
Low 3 15 21 6 19 6 8 9 8 21 25 11 8
Below cutoff 17 35 34 34 1 26 13 11

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000042799   ⟹   ENSRNOP00000040761
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX71,663,821 - 71,689,269 (-)Ensembl
Rnor_6.0 EnsemblX77,674,150 - 77,675,487 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000092418   ⟹   ENSRNOP00000075854
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX71,663,821 - 71,690,121 (-)Ensembl
Rnor_6.0 EnsemblX77,674,272 - 77,700,269 (-)Ensembl
RefSeq Acc Id: NM_053641   ⟹   NP_446093
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2X71,664,742 - 71,665,761 (-)NCBI
Rnor_6.0X77,674,349 - 77,675,368 (-)NCBI
Rnor_5.0X77,868,476 - 77,895,363 (-)NCBI
RGSC_v3.4X94,802,078 - 94,803,097 (-)RGD
CeleraX72,975,213 - 72,976,232 (-)RGD
Sequence:
RefSeq Acc Id: XM_006257158   ⟹   XP_006257220
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2X71,661,415 - 71,690,158 (-)NCBI
Rnor_6.0X77,671,028 - 77,700,491 (-)NCBI
Rnor_5.0X77,868,476 - 77,895,363 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_446093 (Get FASTA)   NCBI Sequence Viewer  
  XP_006257220 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein BAB60825 (Get FASTA)   NCBI Sequence Viewer  
  Q924T8 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_446093   ⟸   NM_053641
- UniProtKB: Q924T8 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006257220   ⟸   XM_006257158
- Peptide Label: isoform X1
- UniProtKB: Q924T8 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000075854   ⟸   ENSRNOT00000092418
RefSeq Acc Id: ENSRNOP00000040761   ⟸   ENSRNOT00000042799
Protein Domains
G_PROTEIN_RECEP_F1_2

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q924T8-F1-model_v2 AlphaFold Q924T8 1-339 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701911
Promoter ID:EPDNEW_R12428
Type:single initiation site
Name:Cysltr1_1
Description:cysteinyl leukotriene receptor 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0X77,700,297 - 77,700,357EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:619796 AgrOrtholog
BioCyc Gene G2FUF-1909 BioCyc
Ensembl Genes ENSRNOG00000037845 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000040761 UniProtKB/Swiss-Prot
  ENSRNOP00000075854 ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000042799 UniProtKB/Swiss-Prot
  ENSRNOT00000092418 ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro CLT1_recept UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyst_leuk_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:114099 UniProtKB/Swiss-Prot
NCBI Gene 114099 ENTREZGENE
Pfam 7tm_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB CYSLTR1 RGD
PhenoGen Cysltr1 PhenoGen
PRINTS CYSLT1RECPTR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CYSLTRECPTR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCRRHODOPSN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0U1RRX8_RAT UniProtKB/TrEMBL
  CLTR1_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-02-26 Cysltr1  cysteinyl leukotriene receptor 1  Cyslt1    Symbol updated 625702 APPROVED
2002-08-07 Cyslt1  cysteinyl leukotriene receptor 1      Symbol and Name status set to provisional 70820 PROVISIONAL