Egln3 (egl-9 family hypoxia-inducible factor 3) - Rat Genome Database

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Gene: Egln3 (egl-9 family hypoxia-inducible factor 3) Rattus norvegicus
Analyze
Symbol: Egln3
Name: egl-9 family hypoxia-inducible factor 3
RGD ID: 71019
Description: Predicted to enable ferrous iron binding activity and peptidyl-proline 4-dioxygenase activity. Involved in regulation of cell population proliferation. Predicted to be located in cytosol. Predicted to be active in cytoplasm and nucleus. Biomarker of acute kidney failure and myocardial infarction. Human ortholog(s) of this gene implicated in renal cell carcinoma. Orthologous to human EGLN3 (egl-9 family hypoxia inducible factor 3); PARTICIPATES IN hypoxia inducible factor pathway; vascular endothelial growth factor signaling pathway; renal cell carcinoma pathway; INTERACTS WITH (+)-schisandrin B; 1,2,4-trimethylbenzene; 1-naphthyl isothiocyanate.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: egl nine homolog 3; EGL nine homolog 3 (C. elegans); egl nine homolog 3, mitochondrial; factor-responsive smooth muscle protein; HIF-PH3; HIF-prolyl hydroxylase 3; HPH-3; hypoxia-inducible factor prolyl hydroxylase 3; PHD-3; PHD3; prolyl hydroxylase domain-containing protein 3; prolyl hydroxylase EGLN3; SM-20
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: Egln3m1Mcwi  
Genetic Models: FHH-Egln3m1Mcwi
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8677,385,549 - 77,411,015 (-)NCBIGRCr8
mRatBN7.2671,650,297 - 71,675,766 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl671,650,297 - 71,675,766 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx672,071,359 - 72,096,960 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0672,378,007 - 72,403,609 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0671,817,527 - 71,843,127 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0675,050,329 - 75,075,795 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl675,050,329 - 75,075,795 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0684,592,894 - 84,618,360 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4674,451,038 - 74,476,506 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1674,454,165 - 74,479,632 (-)NCBI
Celera670,500,466 - 70,525,910 (-)NCBICelera
Cytogenetic Map6q23NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(-)-alpha-phellandrene  (ISO)
(1->4)-beta-D-glucan  (ISO)
1,2,4-trimethylbenzene  (EXP)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
acetamide  (EXP)
acrylamide  (EXP,ISO)
aflatoxin B1  (EXP,ISO)
alendronic acid  (EXP)
all-trans-retinoic acid  (ISO)
alpha-phellandrene  (ISO)
aluminium atom  (ISO)
aluminium(0)  (ISO)
ammonium chloride  (EXP)
amphetamine  (EXP)
amphotericin B  (ISO)
andrographolide  (ISO)
arotinoid acid  (ISO)
Azaspiracid  (ISO)
Bardoxolone methyl  (ISO)
benazepril  (EXP)
benzo[a]pyrene  (ISO)
beta-naphthoflavone  (EXP)
bisphenol A  (EXP,ISO)
bortezomib  (ISO)
cantharidin  (ISO)
carbon nanotube  (ISO)
CHIR 99021  (ISO)
choline  (ISO)
cisplatin  (ISO)
cobalt atom  (ISO)
cobalt dichloride  (EXP,ISO)
copper atom  (ISO)
copper(0)  (ISO)
corticosterone  (EXP)
cortisol  (ISO)
cyclosporin A  (ISO)
deguelin  (ISO)
diallyl trisulfide  (EXP)
diazinon  (EXP,ISO)
Dibutyl phosphate  (ISO)
dieldrin  (EXP)
diethyl maleate  (ISO)
diethylstilbestrol  (EXP,ISO)
dimethylselenide  (ISO)
dinophysistoxin 1  (ISO)
dioxygen  (EXP,ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
epoxiconazole  (ISO)
fenthion  (ISO)
flutamide  (EXP)
folic acid  (ISO)
gentamycin  (EXP)
GW 4064  (ISO)
heparin  (EXP)
hydrogen peroxide  (ISO)
indole-3-methanol  (EXP)
iron atom  (EXP)
iron dichloride  (ISO)
iron(0)  (EXP)
ivermectin  (ISO)
ketoconazole  (EXP)
L-ascorbic acid  (ISO)
L-ascorbic acid 2-phosphate  (ISO)
L-methionine  (ISO)
lead diacetate  (ISO)
lipopolysaccharide  (EXP)
manganese(II) chloride  (EXP)
menadione  (ISO)
methamphetamine  (ISO)
methylmercury chloride  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-methyl-N-nitrosourea  (ISO)
N-nitrosodiethylamine  (EXP)
N1'-[2-[[5-[(dimethylamino)methyl]-2-furanyl]methylthio]ethyl]-N1-methyl-2-nitroethene-1,1-diamine  (EXP)
nickel atom  (ISO)
nickel dichloride  (EXP,ISO)
okadaic acid  (ISO)
organoselenium compound  (ISO)
orphenadrine  (EXP)
ozone  (ISO)
paracetamol  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP)
phenobarbital  (ISO)
phenylephrine  (EXP)
pirinixic acid  (ISO)
potassium chromate  (ISO)
potassium dichromate  (ISO)
progesterone  (EXP)
propiconazole  (ISO)
quercetin  (ISO)
raloxifene  (EXP)
ranitidine  (EXP)
reactive oxygen species  (ISO)
rotenone  (EXP)
SB 431542  (ISO)
succimer  (ISO)
sunitinib  (ISO)
Tesaglitazar  (EXP)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
theophylline  (ISO)
thimerosal  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
triclosan  (ISO)
triphenyl phosphate  (EXP,ISO)
troglitazone  (EXP)
Tungsten carbide  (ISO)
urethane  (ISO)
ursodeoxycholic acid  (EXP)
valproic acid  (ISO)
vorinostat  (ISO)
XAV939  (ISO)
zinc atom  (EXP)
zinc(0)  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IBA,ISO,ISS)
cytosol  (ISO)
nucleus  (IBA,ISO,ISS)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Oxygen sensing in the hypoxic response pathway: regulation of the hypoxia-inducible transcription factor. Bruick RK Genes Dev 2003 Nov 1;17(21):2614-23.
2. Differential and reciprocal regulation between hypoxia-inducible factor-alpha subunits and their prolyl hydroxylases in pulmonary arteries of rat with hypoxia-induced hypertension. Chen YR, etal., Acta Biochim Biophys Sin (Shanghai). 2006 Jun;38(6):423-34.
3. Hypoxia up-regulates prolyl hydroxylase activity: a feedback mechanism that limits HIF-1 responses during reoxygenation. D'Angelo G, etal., J Biol Chem 2003 Oct 3;278(40):38183-7.
4. Beta-cell alpha-ketoglutarate hydroxylases may acutely participate in insulin secretion. Fallon MJ and MacDonald MJ, Metabolism. 2008 Aug;57(8):1148-54.
5. Prospective study assessing hypoxia-related proteins as markers for the outcome of treatment with sunitinib in advanced clear-cell renal cell carcinoma. Garcia-Donas J, etal., Ann Oncol. 2013 Sep;24(9):2409-14. doi: 10.1093/annonc/mdt219. Epub 2013 Jun 20.
6. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
7. Prolyl hydroxylase 3 interacts with Bcl-2 to regulate doxorubicin-induced apoptosis in H9c2 cells. Liu Y, etal., Biochem Biophys Res Commun. 2010 Oct 15;401(2):231-7. doi: 10.1016/j.bbrc.2010.09.037. Epub 2010 Sep 16.
8. HIF-1 and HIF-2 transcription factors--similar but not identical. Loboda A, etal., Mol Cells. 2010 May;29(5):435-42. Epub 2010 Apr 12.
9. Gene Data Set MGD Curation, June 12, 2002
10. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
11. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
12. GOA pipeline RGD automated data pipeline
13. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
14. HIF-prolyl hydroxylases in the rat kidney: physiologic expression patterns and regulation in acute kidney injury. Schodel J, etal., Am J Pathol. 2009 May;174(5):1663-74. doi: 10.2353/ajpath.2009.080687. Epub 2009 Apr 6.
15. Autoantibody against hypoxia-inducible factor prolyl hydroxylase-3 is a potential serological marker for renal cell carcinoma. Tanaka T, etal., J Cancer Res Clin Oncol. 2011 May;137(5):789-94. doi: 10.1007/s00432-010-0940-6. Epub 2010 Jul 31.
16. Identification of a novel growth factor-responsive gene in vascular smooth muscle cells. Wax SD, etal., J Biol Chem 1994 Apr 29;269(17):13041-7.
17. HIF prolyl hydroxylases in the rat; organ distribution and changes in expression following hypoxia and coronary artery ligation. Willam C, etal., J Mol Cell Cardiol. 2006 Jul;41(1):68-77.
18. Angiotensin II's antiproliferative effects mediated through AT2-receptors depend on down-regulation of SM-20. Wolf G, etal., Lab Invest 2002 Oct;82(10):1305-17.
Additional References at PubMed
PMID:10386996   PMID:11060309   PMID:11595184   PMID:11598268   PMID:12615973   PMID:12675908   PMID:12788921   PMID:16407229   PMID:17129494   PMID:18332118   PMID:19420289   PMID:19584355  
PMID:20439489   PMID:20978507   PMID:22286099   PMID:22905089   PMID:22948157   PMID:22955912   PMID:24030251   PMID:25633836   PMID:26108712   PMID:32123074  


Genomics

Comparative Map Data
Egln3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8677,385,549 - 77,411,015 (-)NCBIGRCr8
mRatBN7.2671,650,297 - 71,675,766 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl671,650,297 - 71,675,766 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx672,071,359 - 72,096,960 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0672,378,007 - 72,403,609 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0671,817,527 - 71,843,127 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0675,050,329 - 75,075,795 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl675,050,329 - 75,075,795 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0684,592,894 - 84,618,360 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4674,451,038 - 74,476,506 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1674,454,165 - 74,479,632 (-)NCBI
Celera670,500,466 - 70,525,910 (-)NCBICelera
Cytogenetic Map6q23NCBI
EGLN3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381433,924,227 - 33,951,074 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1433,924,227 - 34,462,774 (-)EnsemblGRCh38hg38GRCh38
GRCh371434,393,433 - 34,420,280 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361433,463,172 - 33,490,035 (-)NCBINCBI36Build 36hg18NCBI36
Build 341433,463,172 - 33,490,037NCBI
Celera1414,258,646 - 14,285,539 (-)NCBICelera
Cytogenetic Map14q13.1NCBI
HuRef1414,510,074 - 14,536,960 (-)NCBIHuRef
CHM1_11434,391,710 - 34,418,579 (-)NCBICHM1_1
T2T-CHM13v2.01428,121,430 - 28,148,293 (-)NCBIT2T-CHM13v2.0
Egln3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391254,225,767 - 54,250,660 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1254,225,767 - 54,250,646 (-)EnsemblGRCm39 Ensembl
GRCm381254,178,981 - 54,203,874 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1254,178,981 - 54,203,860 (-)EnsemblGRCm38mm10GRCm38
MGSCv371255,279,968 - 55,304,861 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361255,100,608 - 55,125,474 (-)NCBIMGSCv36mm8
Celera1255,491,368 - 55,516,127 (-)NCBICelera
Cytogenetic Map12C1NCBI
cM Map1222.9NCBI
Egln3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540926,939,933 - 26,967,156 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540926,939,933 - 26,967,156 (+)NCBIChiLan1.0ChiLan1.0
EGLN3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21535,243,634 - 35,269,614 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11434,460,135 - 34,486,476 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01414,689,398 - 14,716,301 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11432,880,330 - 32,907,248 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1432,880,324 - 32,907,241 (-)Ensemblpanpan1.1panPan2
EGLN3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1812,873,755 - 12,901,728 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl812,875,387 - 12,901,709 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha812,682,830 - 12,710,865 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0812,977,975 - 13,005,981 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl812,979,608 - 13,005,982 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1812,659,735 - 12,687,739 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0812,742,506 - 12,770,341 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0813,031,833 - 13,059,696 (-)NCBIUU_Cfam_GSD_1.0
Egln3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864044,734,378 - 44,761,610 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364948,238,858 - 8,267,606 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364948,240,272 - 8,267,487 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
EGLN3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl765,805,522 - 65,833,529 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1765,805,513 - 65,833,536 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2770,667,662 - 70,695,671 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Egln3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248382,819,631 - 2,847,827 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248382,819,719 - 2,848,094 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Egln3
205 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:220
Count of miRNA genes:145
Interacting mature miRNAs:181
Transcripts:ENSRNOT00000007219
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4145119Mcs25Mammary carcinoma susceptibility QTL 250.0001mammary gland integrity trait (VT:0010552)ratio of deaths to total study population during a period of time (CMO:0001023)610894415110548006Rat
9590290Uminl2Urine mineral level QTL 23.960.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)63878398983783989Rat
70176Mcsm1Mammary carcinoma susceptibility modifier QTL 1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)658632962103632962Rat
1558641Cm47Cardiac mass QTL 472.90.001heart mass (VT:0007028)heart wet weight (CMO:0000069)657730540104085867Rat
1641904Alcrsp4Alcohol response QTL 4response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)667262953112262953Rat
634307Bp141Blood pressure QTL 1414arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)63523041780230417Rat
2293839Kiddil2Kidney dilation QTL 24.8kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)62086642281133036Rat
1576309Emca7Estrogen-induced mammary cancer QTL 74mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)615107216107351382Rat
9590140Scort4Serum corticosterone level QTL 414.490.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)63878398983783989Rat
731173Uae22Urinary albumin excretion QTL 2210.1urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)665531555140994061Rat
9590306Scort18Serum corticosterone level QTL 182.880.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)63878398983783989Rat
1578665Bss16Bone structure and strength QTL 164.4femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)61173566972593685Rat
2293841Kiddil4Kidney dilation QTL 44.4kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)62086642281133036Rat
4889848Pur25Proteinuria QTL 25140.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)65672856290198260Rat
634330Pia16Pristane induced arthritis QTL 163.9joint integrity trait (VT:0010548)arthritic paw count (CMO:0001460)645790088104200226Rat
1578668Bmd14Bone mineral density QTL 143.8femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)61173566972593685Rat
6893340Cm77Cardiac mass QTL 770.260.57heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)63330954981132889Rat
2301972Bp325Blood pressure QTL 3254.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)6172227641Rat
1331779Rf38Renal function QTL 382.876kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)63207442872227641Rat
1300075Glom7Glomerulus QTL 75.60.0000002kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)671201409116201409Rat
2290393Uae37Urinary albumin excretion QTL 370.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)665531555140994061Rat
1300143Rf14Renal function QTL 142.92renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)63443413777102317Rat
12801471Schws9Schwannoma susceptibility QTL 9nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)661747639106747639Rat
6893332Cm74Cardiac mass QTL 740.40.64heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)657730540104085867Rat

Markers in Region
RH142305  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2671,651,356 - 71,651,532 (+)MAPPERmRatBN7.2
Rnor_6.0675,051,389 - 75,051,564NCBIRnor6.0
Rnor_5.0684,593,954 - 84,594,129UniSTSRnor5.0
RGSC_v3.4674,452,098 - 74,452,273UniSTSRGSC3.4
Celera670,501,526 - 70,501,701UniSTS
Cytogenetic Map6q23UniSTS
RH135011  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2671,651,054 - 71,651,263 (+)MAPPERmRatBN7.2
Rnor_6.0675,051,087 - 75,051,295NCBIRnor6.0
Rnor_5.0684,593,652 - 84,593,860UniSTSRnor5.0
RGSC_v3.4674,451,796 - 74,452,004UniSTSRGSC3.4
Celera670,501,224 - 70,501,432UniSTS
Cytogenetic Map6q23UniSTS


Genetic Models
This gene Egln3 is modified in the following models/strains:
FHH-Egln3m1Mcwi    


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 41 16 10 6 10 6 9 35 16 13 6
Low 2 39 29 13 29 2 2 39 19 22 11 2
Below cutoff 2 2 2 6

Sequence


Ensembl Acc Id: ENSRNOT00000007219   ⟹   ENSRNOP00000007219
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl671,650,297 - 71,675,766 (-)Ensembl
Rnor_6.0 Ensembl675,050,329 - 75,075,795 (-)Ensembl
RefSeq Acc Id: NM_019371   ⟹   NP_062244
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8677,385,549 - 77,411,015 (-)NCBI
mRatBN7.2671,650,297 - 71,675,766 (-)NCBI
Rnor_6.0675,050,329 - 75,075,795 (-)NCBI
Rnor_5.0684,592,894 - 84,618,360 (-)NCBI
RGSC_v3.4674,451,038 - 74,476,506 (-)RGD
Celera670,500,466 - 70,525,910 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_062244 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA19321 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000007219.2
GenBank Protein Q62630 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_062244   ⟸   NM_019371
- UniProtKB: G3V6N9 (UniProtKB/TrEMBL),   A6HBJ8 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000007219   ⟸   ENSRNOT00000007219
Protein Domains
Fe2OG dioxygenase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q62630-F1-model_v2 AlphaFold Q62630 1-239 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:71019 AgrOrtholog
BioCyc Gene G2FUF-37555 BioCyc
BioCyc Pathway PWY-7894 [procollagen hydroxylation and glycosylation] BioCyc
BioCyc Pathway Image PWY-7894 BioCyc
Ensembl Genes ENSRNOG00000005053 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000007219.3 UniProtKB/TrEMBL
Gene3D-CATH q2cbj1_9rhob like domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Oxoglu/Fe-dep_dioxygenase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pro_4_hyd_alph UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pro_4_hyd_alph_FE2OG_OXY UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:54702 UniProtKB/Swiss-Prot
NCBI Gene 54702 ENTREZGENE
PANTHER EGL NINE HOMOLOG-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROLYL HYDROXYLASE EGLN3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam 2OG-FeII_Oxy_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Egln3 PhenoGen
PROSITE FE2OG_OXY UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000005053 RatGTEx
SMART P4Hc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A6HBJ8 ENTREZGENE, UniProtKB/TrEMBL
  EGLN3_RAT UniProtKB/Swiss-Prot
  G3V6N9 ENTREZGENE, UniProtKB/TrEMBL
  Q62630 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-09-16 Egln3  egl-9 family hypoxia-inducible factor 3  Egln3  EGL nine homolog 3 (C. elegans)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-07-09 Egln3  EGL nine homolog 3 (C. elegans)      Symbol and Name updated to reflect Human and Mouse nomenclature 70877 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_regulation expression is down-regulated by angiotensin II induced AT2 receptor activity 728483