Gene: Egln3 (egl-9 family hypoxia-inducible factor 3) Rattus norvegicus
Symbol: Egln3
Name: egl-9 family hypoxia-inducible factor 3
Description: ENCODES a protein that exhibits oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors (ortholog); peptidyl-proline 4-dioxygenase activity (ortholog); peptidyl-proline dioxygenase activity (ortholog); INVOLVED IN regulation of cell proliferation; activation of cysteine-type endopeptidase activity involved in apoptotic process (ortholog); apoptotic process (ortholog); PARTICIPATES IN hypoxia inducible factor pathway; vascular endothelial growth factor signaling pathway; renal cell carcinoma pathway; ASSOCIATED WITH acute kidney failure; Kidney Reperfusion Injury; myocardial infarction; FOUND IN cytoplasm (ortholog); cytosol (ortholog); nucleus (ortholog); INTERACTS WITH 1,2,4-trimethylbenzene; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine
Type: protein-coding
Also known as: egl nine homolog 3; EGL nine homolog 3 (C. elegans); egl nine homolog 3, mitochondrial; factor-responsive smooth muscle protein; HIF-PH3; HIF-prolyl hydroxylase 3; HPH-3; hypoxia-inducible factor prolyl hydroxylase 3; PHD-3; PHD3; prolyl hydroxylase domain-containing protein 3; SM-20
Homo sapiens (human) : EGLN3 (egl-9 family hypoxia inducible factor 3)  HGNC  Alliance
Mus musculus (house mouse) : Egln3 (egl-9 family hypoxia-inducible factor 3)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Egln3 (egl-9 family hypoxia inducible factor 3)
Pan paniscus (bonobo/pygmy chimpanzee) : EGLN3 (egl-9 family hypoxia inducible factor 3)
Canis lupus familiaris (dog) : EGLN3 (egl-9 family hypoxia inducible factor 3)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Egln3 (egl-9 family hypoxia inducible factor 3)
more info ...
Allele / Splice: Egln3m1Mcwi  
Genetic Models: FHH-Egln3m1Mcwi
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.0675,050,329 - 75,075,795 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0684,592,894 - 84,618,360 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4674,451,038 - 74,476,506 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1674,454,165 - 74,479,632 (-)NCBI
Celera670,500,466 - 70,525,910 (-)NCBICelera
Cytogenetic Map6q23NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated
RGD Disease Portals


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
Genetic Models
miRNA Target Status


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 5.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Egln3
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 71019
Created: 2002-07-09
Species: Rattus norvegicus
Last Modified: 2018-08-08
Status: ACTIVE