Gene: Egln3 (egl-9 family hypoxia-inducible factor 3) Rattus norvegicus
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Symbol: Egln3
Name: egl-9 family hypoxia-inducible factor 3
Description: ENCODES a protein that exhibits 2-oxoglutarate-dependent dioxygenase activity (ortholog); peptidyl-proline 4-dioxygenase activity (ortholog); peptidyl-proline dioxygenase activity (ortholog); INVOLVED IN regulation of cell population proliferation; activation of cysteine-type endopeptidase activity involved in apoptotic process (ortholog); apoptotic process (ortholog); PARTICIPATES IN hypoxia inducible factor pathway; vascular endothelial growth factor signaling pathway; renal cell carcinoma pathway; ASSOCIATED WITH acute kidney failure; Kidney Reperfusion Injury; myocardial infarction; FOUND IN cytoplasm (ortholog); cytosol (ortholog); nucleus (ortholog); INTERACTS WITH 1,2,4-trimethylbenzene; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine
AGR Description: Predicted to have peptidyl-proline 4-dioxygenase activity; involved in regulation of cell population proliferation; predicted to localize to the cytosol and nucleus; biomarker of acute kidney failure and myocardial infarction; orthologous to human EGLN3 (egl-9 family hypoxia inducible factor 3).
Merged Description: Predicted to have peptidyl-proline 4-dioxygenase activity; involved in regulation of cell population proliferation; predicted to localize to the cytosol and nucleus; biomarker of acute kidney failure and myocardial infarction; orthologous to human EGLN3 (egl-9 family hypoxia inducible factor 3); PARTICIPATES IN hypoxia inducible factor pathway; vascular endothelial growth factor signaling pathway; renal cell carcinoma pathway; INTERACTS WITH 1,2,4-trimethylbenzene; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: egl nine homolog 3; EGL nine homolog 3 (C. elegans); egl nine homolog 3, mitochondrial; factor-responsive smooth muscle protein; HIF-PH3; HIF-prolyl hydroxylase 3; HPH-3; hypoxia-inducible factor prolyl hydroxylase 3; PHD-3; PHD3; prolyl hydroxylase domain-containing protein 3; SM-20
Orthologs:
Homo sapiens (human) : EGLN3 (egl-9 family hypoxia inducible factor 3)  HGNC  Alliance
Mus musculus (house mouse) : Egln3 (egl-9 family hypoxia-inducible factor 3)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Egln3 (egl-9 family hypoxia inducible factor 3)
Pan paniscus (bonobo/pygmy chimpanzee) : EGLN3 (egl-9 family hypoxia inducible factor 3)
Canis lupus familiaris (dog) : EGLN3 (egl-9 family hypoxia inducible factor 3)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Egln3 (egl-9 family hypoxia inducible factor 3)
Sus scrofa (pig) : EGLN3 (egl-9 family hypoxia inducible factor 3)
more info ...
Allele / Splice: Egln3m1Mcwi  
Genetic Models: FHH-Egln3m1Mcwi
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0675,050,329 - 75,075,795 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0684,592,894 - 84,618,360 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4674,451,038 - 74,476,506 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1674,454,165 - 74,479,632 (-)NCBI
Celera670,500,466 - 70,525,910 (-)NCBICelera
Cytogenetic Map6q23NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
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References - curated
References - uncurated
RGD Disease Portals

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
Genetic Models
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome

Strain Variation

Strain Sequence Variants (Rnor 5.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Egln3
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 71019
Created: 2002-07-09
Species: Rattus norvegicus
Last Modified: 2019-04-12
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.