Egln3 (egl-9 family hypoxia-inducible factor 3)

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Gene: Egln3 (egl-9 family hypoxia-inducible factor 3) Rattus norvegicus

Analyze

Symbol:

Egln3

Name:

egl-9 family hypoxia-inducible factor 3

RGD ID:

71019

Description:

Predicted to enable ferrous iron binding activity and peptidyl-proline 4-dioxygenase activity. Involved in regulation of cell population proliferation. Predicted to be located in cytosol. Predicted to be active in cytoplasm and nucleus. Biomarker of acute kidney failure and myocardial infarction. Human ortholog(s) of this gene implicated in renal cell carcinoma. Orthologous to human EGLN3 (egl-9 family hypoxia inducible factor 3); PARTICIPATES IN hypoxia inducible factor pathway; vascular endothelial growth factor signaling pathway; renal cell carcinoma pathway; INTERACTS WITH (+)-schisandrin B; 1,2,4-trimethylbenzene; 1-naphthyl isothiocyanate.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

egl nine homolog 3; EGL nine homolog 3 (C. elegans); egl nine homolog 3, mitochondrial; factor-responsive smooth muscle protein; HIF-PH3; HIF-prolyl hydroxylase 3; HPH-3; hypoxia-inducible factor prolyl hydroxylase 3; PHD-3; PHD3; prolyl hydroxylase domain-containing protein 3; prolyl hydroxylase EGLN3; SM-20

RGD Orthologs

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	EGLN3 (egl-9 family hypoxia inducible factor 3)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Mus musculus (house mouse):	Egln3 (egl-9 family hypoxia-inducible factor 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Egln3 (egl-9 family hypoxia inducible factor 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	EGLN3 (egl-9 family hypoxia inducible factor 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	EGLN3 (egl-9 family hypoxia inducible factor 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Egln3 (egl-9 family hypoxia inducible factor 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	EGLN3 (egl-9 family hypoxia inducible factor 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Egln3 (egl-9 family hypoxia inducible factor 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	EGLN3 (egl-9 family hypoxia inducible factor 3)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Egln3 (egl-9 family hypoxia-inducible factor 3)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	egln3 (egl-9 family hypoxia-inducible factor 3)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	Hph	Alliance	DIOPT (Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Caenorhabditis elegans (roundworm):	egl-9	Alliance	DIOPT (Hieranoid\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	egln3	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|PANTHER\|PhylomeDB)

Allele / Splice:

Egln3^m1Mcwi

Genetic Models:

FHH-Egln3^m1Mcwi

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	6	71,650,297 - 71,675,766 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	6	71,650,297 - 71,675,766 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	6	72,071,359 - 72,096,960 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	6	72,378,007 - 72,403,609 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	6	71,817,527 - 71,843,127 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	6	75,050,329 - 75,075,795 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	6	75,050,329 - 75,075,795 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	6	84,592,894 - 84,618,360 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	6	74,451,038 - 74,476,506 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	6	74,454,165 - 74,479,632 (-)	NCBI
Celera	6	70,500,466 - 70,525,910 (-)	NCBI		Celera
Cytogenetic Map	6	q23	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

acute kidney failure (IEP)

Brain-Lung-Thyroid Syndrome (ISO)

clear cell renal cell carcinoma (ISO)

genetic disease (ISO)

Kidney Reperfusion Injury (IEP)

Liver Neoplasms (ISO)

myocardial infarction (IEP)

Pulmonary Hypertension, Hypoxia-Induced (IEP)

renal cell carcinoma (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(+)-schisandrin B (EXP)

(-)-alpha-phellandrene (ISO)

(1->4)-beta-D-glucan (ISO)

1,2,4-trimethylbenzene (EXP)

1,2-dimethylhydrazine (ISO)

1-naphthyl isothiocyanate (EXP)

17alpha-ethynylestradiol (EXP,ISO)

17beta-estradiol (EXP,ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

4,4'-sulfonyldiphenol (ISO)

4-hydroxyphenyl retinamide (ISO)

acetamide (EXP)

acrylamide (EXP,ISO)

aflatoxin B1 (EXP,ISO)

alendronic acid (EXP)

all-trans-retinoic acid (ISO)

alpha-phellandrene (ISO)

ammonium chloride (EXP)

amphetamine (EXP)

amphotericin B (ISO)

andrographolide (ISO)

arotinoid acid (ISO)

Azaspiracid (ISO)

Bardoxolone methyl (ISO)

benazepril (EXP)

benzo[a]pyrene (ISO)

beta-naphthoflavone (EXP)

bisphenol A (EXP,ISO)

bortezomib (ISO)

cantharidin (ISO)

carbon nanotube (ISO)

CHIR 99021 (ISO)

choline (ISO)

cisplatin (ISO)

cobalt atom (ISO)

cobalt dichloride (EXP,ISO)

copper atom (ISO)

copper(0) (ISO)

corticosterone (EXP)

cortisol (ISO)

cyclosporin A (ISO)

deguelin (ISO)

diazinon (EXP,ISO)

dieldrin (EXP)

diethyl maleate (ISO)

diethylstilbestrol (EXP,ISO)

dimethylselenide (ISO)

dinophysistoxin 1 (ISO)

dioxygen (EXP,ISO)

dorsomorphin (ISO)

doxorubicin (ISO)

endosulfan (EXP)

epoxiconazole (ISO)

fenthion (ISO)

flutamide (EXP)

folic acid (ISO)

gentamycin (EXP)

GW 4064 (ISO)

heparin (EXP)

hydrogen peroxide (ISO)

indole-3-methanol (EXP)

iron atom (EXP)

iron(0) (EXP)

ivermectin (ISO)

ketoconazole (EXP)

L-ascorbic acid (ISO)

L-ascorbic acid 2-phosphate (ISO)

L-methionine (ISO)

lead diacetate (ISO)

lipopolysaccharide (EXP)

manganese(II) chloride (EXP)

menadione (ISO)

methamphetamine (ISO)

methylmercury chloride (ISO)

N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal (ISO)

N-methyl-4-phenylpyridinium (ISO)

N-methyl-N-nitrosourea (ISO)

N-nitrosodiethylamine (EXP)

N1'-[2-[[5-[(dimethylamino)methyl]-2-furanyl]methylthio]ethyl]-N1-methyl-2-nitroethene-1,1-diamine (EXP)

nickel atom (ISO)

nickel dichloride (EXP,ISO)

okadaic acid (ISO)

organoselenium compound (ISO)

orphenadrine (EXP)

ozone (ISO)

paracetamol (ISO)

perfluorooctane-1-sulfonic acid (ISO)

perfluorooctanoic acid (EXP)

phenobarbital (ISO)

phenylephrine (EXP)

pirinixic acid (ISO)

potassium chromate (ISO)

potassium dichromate (ISO)

progesterone (EXP)

propiconazole (ISO)

quercetin (ISO)

raloxifene (EXP)

ranitidine (EXP)

reactive oxygen species (ISO)

rotenone (EXP)

SB 431542 (ISO)

succimer (ISO)

sunitinib (ISO)

Tesaglitazar (EXP)

testosterone (ISO)

tetrachloromethane (EXP,ISO)

theophylline (ISO)

thimerosal (ISO)

thioacetamide (EXP)

titanium dioxide (ISO)

trichloroethene (EXP)

trichostatin A (ISO)

triclosan (ISO)

triphenyl phosphate (EXP)

troglitazone (EXP)

Tungsten carbide (ISO)

urethane (ISO)

ursodeoxycholic acid (EXP)

valproic acid (ISO)

vorinostat (ISO)

XAV939 (ISO)

zinc atom (EXP)

zinc(0) (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

apoptotic process (ISO,ISS)

cellular response to hypoxia (IBA)

cellular response to leukemia inhibitory factor (ISO)

DNA damage response (IEA)

regulation of cell population proliferation (IMP,ISO)

regulation of neuron apoptotic process (ISO,ISS)

response to hypoxia (ISO)

Cellular Component

cytoplasm (IBA,ISO,ISS)

cytosol (ISO)

nucleus (IBA,ISO,ISS)

Molecular Function

2-oxoglutarate-dependent dioxygenase activity (ISO)

dioxygenase activity (IEA)

ferrous iron binding (IBA)

iron ion binding (IEA)

L-ascorbic acid binding (IEA)

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen (IEA)

peptidyl-proline 4-dioxygenase activity (IBA,ISO)

peptidyl-proline dioxygenase activity (ISO)

protein binding (IPI,ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

hypoxia inducible factor pathway (ISO)

renal cell carcinoma pathway (IEA)

vascular endothelial growth factor signaling pathway (ISS)

References

References - curated

#	Reference Title	Reference Citation
1.	Oxygen sensing in the hypoxic response pathway: regulation of the hypoxia-inducible transcription factor.	Bruick RK Genes Dev 2003 Nov 1;17(21):2614-23.
2.	Differential and reciprocal regulation between hypoxia-inducible factor-alpha subunits and their prolyl hydroxylases in pulmonary arteries of rat with hypoxia-induced hypertension.	Chen YR, etal., Acta Biochim Biophys Sin (Shanghai). 2006 Jun;38(6):423-34.
3.	Hypoxia up-regulates prolyl hydroxylase activity: a feedback mechanism that limits HIF-1 responses during reoxygenation.	D'Angelo G, etal., J Biol Chem 2003 Oct 3;278(40):38183-7.
4.	Beta-cell alpha-ketoglutarate hydroxylases may acutely participate in insulin secretion.	Fallon MJ and MacDonald MJ, Metabolism. 2008 Aug;57(8):1148-54.
5.	Prospective study assessing hypoxia-related proteins as markers for the outcome of treatment with sunitinib in advanced clear-cell renal cell carcinoma.	Garcia-Donas J, etal., Ann Oncol. 2013 Sep;24(9):2409-14. doi: 10.1093/annonc/mdt219. Epub 2013 Jun 20.
6.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
7.	Prolyl hydroxylase 3 interacts with Bcl-2 to regulate doxorubicin-induced apoptosis in H9c2 cells.	Liu Y, etal., Biochem Biophys Res Commun. 2010 Oct 15;401(2):231-7. doi: 10.1016/j.bbrc.2010.09.037. Epub 2010 Sep 16.
8.	HIF-1 and HIF-2 transcription factors--similar but not identical.	Loboda A, etal., Mol Cells. 2010 May;29(5):435-42. Epub 2010 Apr 12.
9.	Gene Data Set	MGD Curation, June 12, 2002
10.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
11.	PID Annotation Import Pipeline	Pipeline to import Pathway Interaction Database annotations from NCI into RGD
12.	GOA pipeline	RGD automated data pipeline
13.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
14.	HIF-prolyl hydroxylases in the rat kidney: physiologic expression patterns and regulation in acute kidney injury.	Schodel J, etal., Am J Pathol. 2009 May;174(5):1663-74. doi: 10.2353/ajpath.2009.080687. Epub 2009 Apr 6.
15.	Autoantibody against hypoxia-inducible factor prolyl hydroxylase-3 is a potential serological marker for renal cell carcinoma.	Tanaka T, etal., J Cancer Res Clin Oncol. 2011 May;137(5):789-94. doi: 10.1007/s00432-010-0940-6. Epub 2010 Jul 31.
16.	Identification of a novel growth factor-responsive gene in vascular smooth muscle cells.	Wax SD, etal., J Biol Chem 1994 Apr 29;269(17):13041-7.
17.	HIF prolyl hydroxylases in the rat; organ distribution and changes in expression following hypoxia and coronary artery ligation.	Willam C, etal., J Mol Cell Cardiol. 2006 Jul;41(1):68-77.
18.	Angiotensin II's antiproliferative effects mediated through AT2-receptors depend on down-regulation of SM-20.	Wolf G, etal., Lab Invest 2002 Oct;82(10):1305-17.

Additional References at PubMed

PMID:10386996	PMID:11060309	PMID:11595184	PMID:11598268	PMID:12615973	PMID:12675908	PMID:12788921	PMID:16407229	PMID:17129494	PMID:18332118	PMID:19420289	PMID:19584355
PMID:20439489	PMID:20978507	PMID:22286099	PMID:22905089	PMID:22948157	PMID:22955912	PMID:24030251	PMID:25633836	PMID:26108712	PMID:32123074

Genomics

Comparative Map Data

Egln3
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	6	71,650,297 - 71,675,766 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	6	71,650,297 - 71,675,766 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	6	72,071,359 - 72,096,960 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	6	72,378,007 - 72,403,609 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	6	71,817,527 - 71,843,127 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	6	75,050,329 - 75,075,795 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	6	75,050,329 - 75,075,795 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	6	84,592,894 - 84,618,360 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	6	74,451,038 - 74,476,506 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	6	74,454,165 - 74,479,632 (-)	NCBI
Celera	6	70,500,466 - 70,525,910 (-)	NCBI		Celera
Cytogenetic Map	6	q23	NCBI

EGLN3
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	14	33,924,227 - 33,951,074 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	14	33,924,227 - 34,462,774 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	14	34,393,433 - 34,420,280 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	14	33,463,172 - 33,490,035 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	14	33,463,172 - 33,490,037	NCBI
Celera	14	14,258,646 - 14,285,539 (-)	NCBI		Celera
Cytogenetic Map	14	q13.1	NCBI
HuRef	14	14,510,074 - 14,536,960 (-)	NCBI		HuRef
CHM1_1	14	34,391,710 - 34,418,579 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	14	28,121,430 - 28,148,293 (-)	NCBI		T2T-CHM13v2.0

Egln3
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	12	54,225,767 - 54,250,660 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	12	54,225,767 - 54,250,646 (-)	Ensembl		GRCm39 Ensembl
GRCm38	12	54,178,981 - 54,203,874 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	12	54,178,981 - 54,203,860 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	12	55,279,968 - 55,304,861 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	12	55,100,608 - 55,125,474 (-)	NCBI		MGSCv36	mm8
Celera	12	55,491,368 - 55,516,127 (-)	NCBI		Celera
Cytogenetic Map	12	C1	NCBI
cM Map	12	22.9	NCBI

Egln3
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955409	26,939,933 - 26,967,156 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955409	26,939,933 - 26,967,156 (+)	NCBI	ChiLan1.0	ChiLan1.0

EGLN3
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1	14	34,460,135 - 34,486,476 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	14	14,689,398 - 14,716,301 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	14	32,880,330 - 32,907,248 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	14	32,880,324 - 32,907,241 (-)	Ensembl	panpan1.1		panPan2

EGLN3
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	8	12,873,755 - 12,901,728 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	8	12,875,387 - 12,901,709 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	8	12,682,830 - 12,710,865 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	8	12,977,975 - 13,005,981 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	8	12,979,608 - 13,005,982 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	8	12,659,735 - 12,687,739 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	8	12,742,506 - 12,770,341 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	8	13,031,833 - 13,059,696 (-)	NCBI		UU_Cfam_GSD_1.0

Egln3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024408640	44,734,378 - 44,761,610 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936494	8,238,858 - 8,267,606 (-)	Ensembl	SpeTri2.0
SpeTri2.0	NW_004936494	8,240,272 - 8,267,487 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

EGLN3
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	7	65,805,522 - 65,833,529 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	7	65,805,513 - 65,833,536 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	7	70,667,662 - 70,695,671 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

Egln3
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624838	2,819,631 - 2,847,827 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624838	2,819,719 - 2,848,094 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Egln3
170 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	220
Count of miRNA genes:	145
Interacting mature miRNAs:	181
Transcripts:	ENSRNOT00000007219
Prediction methods:	Miranda, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
2301972	Bp325	Blood pressure QTL 325	4.8		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	6	1	72227641	Rat
4145119	Mcs25	Mammary carcinoma susceptibility QTL 25		0.0001	mammary gland integrity trait (VT:0010552)	ratio of deaths to total study population during a period of time (CMO:0001023)	6	10894415	110548006	Rat
1578665	Bss16	Bone structure and strength QTL 16	4.4		femur morphology trait (VT:0000559)	bone trabecular cross-sectional area (CMO:0002311)	6	11735669	72593685	Rat
1578668	Bmd14	Bone mineral density QTL 14	3.8		femur mineral mass (VT:0010011)	total volumetric bone mineral density (CMO:0001728)	6	11735669	72593685	Rat
1576309	Emca7	Estrogen-induced mammary cancer QTL 7	4		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	6	15107216	107351382	Rat
2293839	Kiddil2	Kidney dilation QTL 2	4.8		kidney pelvis morphology trait (VT:0004194)	hydronephrosis severity score (CMO:0001208)	6	20866422	81133036	Rat
2293841	Kiddil4	Kidney dilation QTL 4	4.4		kidney pelvis morphology trait (VT:0004194)	hydronephrosis severity score (CMO:0001208)	6	20866422	81133036	Rat
1331779	Rf38	Renal function QTL 38	2.876		kidney blood vessel physiology trait (VT:0100012)	absolute change in renal vascular resistance (CMO:0001900)	6	32074428	72227641	Rat
6893340	Cm77	Cardiac mass QTL 77	0.26	0.57	heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	6	33309549	81132889	Rat
1300143	Rf14	Renal function QTL 14	2.92		renal blood flow trait (VT:2000006)	absolute change in renal blood flow rate (CMO:0001168)	6	34434137	77102317	Rat
634307	Bp141	Blood pressure QTL 141	4		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	6	35230417	80230417	Rat
9590290	Uminl2	Urine mineral level QTL 2	3.96	0.001	urine mineral amount (VT:0015086)	urine electrolyte level (CMO:0000593)	6	38783989	83783989	Rat
9590306	Scort18	Serum corticosterone level QTL 18	2.88	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	6	38783989	83783989	Rat
9590140	Scort4	Serum corticosterone level QTL 4	14.49	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	6	38783989	83783989	Rat
634330	Pia16	Pristane induced arthritis QTL 16	3.9		joint integrity trait (VT:0010548)	arthritic paw count (CMO:0001460)	6	45790088	104200226	Rat
4889848	Pur25	Proteinuria QTL 25	14	0.003	urine total protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	6	56728562	90198260	Rat
6893332	Cm74	Cardiac mass QTL 74	0.4	0.64	heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	6	57730540	104085867	Rat
1558641	Cm47	Cardiac mass QTL 47	2.9	0.001	heart mass (VT:0007028)	heart wet weight (CMO:0000069)	6	57730540	104085867	Rat
70176	Mcsm1	Mammary carcinoma susceptibility modifier QTL 1			mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	6	58632962	103632962	Rat
12801471	Schws9	Schwannoma susceptibility QTL 9			nervous system integrity trait (VT:0010566)	percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)	6	61747639	106747639	Rat
731173	Uae22	Urinary albumin excretion QTL 22	10.1		urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	6	65531555	140994061	Rat
2290393	Uae37	Urinary albumin excretion QTL 37		0.0001	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	6	65531555	140994061	Rat
1641904	Alcrsp4	Alcohol response QTL 4			response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	6	67262953	112262953	Rat
1300075	Glom7	Glomerulus QTL 7	5.6	0.0000002	kidney glomerulus morphology trait (VT:0005325)	count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)	6	71201409	116201409	Rat

Markers in Region

RH142305

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	6	71,651,356 - 71,651,532 (+)	MAPPER	mRatBN7.2
Rnor_6.0	6	75,051,389 - 75,051,564	NCBI	Rnor6.0
Rnor_5.0	6	84,593,954 - 84,594,129	UniSTS	Rnor5.0
RGSC_v3.4	6	74,452,098 - 74,452,273	UniSTS	RGSC3.4
Celera	6	70,501,526 - 70,501,701	UniSTS
Cytogenetic Map	6	q23	UniSTS

RH135011

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	6	71,651,054 - 71,651,263 (+)	MAPPER	mRatBN7.2
Rnor_6.0	6	75,051,087 - 75,051,295	NCBI	Rnor6.0
Rnor_5.0	6	84,593,652 - 84,593,860	UniSTS	Rnor5.0
RGSC_v3.4	6	74,451,796 - 74,452,004	UniSTS	RGSC3.4
Celera	6	70,501,224 - 70,501,432	UniSTS
Cytogenetic Map	6	q23	UniSTS

Genetic Models

This gene Egln3 is modified in the following models/strains

FHH-Egln3^m1Mcwi

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium	3	41	16	10	6	10	6	9	35	16	13		6
Low		2	39	29	13	29	2	2	39	19	22	11	2
Below cutoff			2	2		2					6

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_019371	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JACYVU010000164	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	U06713	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSRNOT00000007219 ⟹ ENSRNOP00000007219

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	6	71,650,297 - 71,675,766 (-)	Ensembl
Rnor_6.0 Ensembl	6	75,050,329 - 75,075,795 (-)	Ensembl

RefSeq Acc Id:

NM_019371 ⟹ NP_062244

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	6	71,650,297 - 71,675,766 (-)	NCBI
Rnor_6.0	6	75,050,329 - 75,075,795 (-)	NCBI
Rnor_5.0	6	84,592,894 - 84,618,360 (-)	NCBI
RGSC_v3.4	6	74,451,038 - 74,476,506 (-)	RGD
Celera	6	70,500,466 - 70,525,910 (-)	RGD

Sequence:

show sequence

GGATCCAGGTTTTCAAGTTTGTTAGGGGATTTAATGCAAATCAATATGCAAACAGAGAGCATTG
TAAAAAAAAAAATCCAGTCCTTTCTCCGGTCACACACAGGTTAGCTAATGTGGAGCTCGCCCAG
ATGCTCTGCAGCACCAGCTCAAGGGGAAGGGCCAGGAGGAGGGCAGTCCCGGGGGCGGGACCAT
GACGTTGAGGTCAAGGCGGGGCTTCCTCTCGTTCCTCCCCGGGCTGCGGCCGCCGCGGCGGTGG
CTCCGCATCTCCAAAAGGGGCCCTCCGACTTCTCACTGGGCCAGTCCGGCGCTGGGTGGCAGAA
CTCTACACTACTCCTGCCGGTCTCAGAGCGGGACTCCCTTCTCTTCAGAGTTTCAAGCAACTTT
CCCCGCCTTTGCAGCTAAAGTGGCTCGGGGACCGTGGCTGCCGCAGGTGGTAGAGCCCCCGGCC
CGGCTCTCTGCATCTCCGCTGTGCGTTCGCTCTGGGCAAGCCCTCGGTGCGTGCACCCTGGGGG
TCCCCCGCCTCGGCTCTGTGAGCGAGATGCCTCTGGGACACATCATGAGGCTGGATCTGGAGAA
GATCGCCCTGGAGTACATCGTGCCCTGTCTGCACGAGGTCGGTTTCTGCTACCTGGACAACTTC
CTAGGCGAGGTGGTGGGCGACTGCGTACTGGAGCGAGTCAAGCAGCTGCATTACAACGGGGCCC
TGCGTGACGGCCAGCTGGCGGGGCCCCGCGCCGGCGTCTCCAAGCGGCACCTGCGAGGCGACCA
GATCACGTGGATCGGGGGCAACGAGGAGGGCTGCGAGGCCATCAACTTCCTCCTGTCCCTCATC
GACAGGCTGGTCCTGTACTGCGGGAGCCGCCTGGGCAAATACTATGTCAAGGAGCGGTCCAAGG
CGATGGTGGCTTGCTATCCAGGAAATGGAACAGGTTATGTTCGTCATGTGGACAACCCCAATGG
TGATGGCCGCTGTATCACCTGTATCTACTACCTGAATAAGAATTGGGACGCCAAGTTACATGGA
GGGGTCCTGCGGATATTTCCAGAAGGAAAATCATTTGTAGCAGACGTGGAGCCCATTTTTGATA
GACTCCTGTTCTCCTGGTCAGACCGCAGGAATCCACATGAAGTTCAGCCCTCCTATGCCACCAG
GTACGCCATGACTGTCTGGTACTTCGATGCTGAAGAAAGGGCAGAAGCCAAAAAGAAATTCAGG
AATCTAACTAGAAAAACTGAATCTGCTCTTGCTAAAGACTGACGGTGGTGTGAAGTCCGCTGGG
CGCATTCGTTTAGTGACAGTTCCTGAAATGTTAAGTGTCAAGATCCAAAGACTCTGTCCAATCC
CCTGCCTACCGCCTGCATCGTTTGGCTCCCTACCTTGTTTGTGGTACTTCGTGTTTTCTTGCTG
GGAATGCGTTGCCCTCCAGACACTCTCTTTGCCGGATGAACTCATTTGCTAACTCCAGAAACAC
CTGCAGACATCCTAGCTGGCCAGCGGTTTAACGGATAGATCTGGGAATGGATAGATATGGGAAT
GCAGCTGTTCAGCCCAGGATTGCCTCGTGTTCGCACTTTATGCATACTTCCTGGTCTGATAGGA
GGAGGTTTGCGAAGAAATAAACTGGTGACAGATGCCACAAAGAGGCACCCTTGAAACCCTAACA
GCAAGAAAGAGAAAGATCTGAACTATTTCCAGATGTTGTTAACCCGAGACTGGACGATTACGGA
CAACCTGATGACATTATCGCCTCTAGAAAGGGCTGCTGTCATAGCGATCGATTTATAAGTGTCC
CACGGTGGATGCTCCTTTTTCCTGGTCCTACAACCTGTTCTTTTTGAAGGTCATTGCTAAATTG
ATGCTCTCTTGTCGAAGACGACCCCAGCCTGTATGCTCCATTTTTACTTCTTACTTGGGGATCC
TAATTATCCAGAGAATAAAACTCACCAGGTAGTTTGGGTTGTTTTTTCTGGTACTGAAAATTTG
AAGTTAAATGAGAGGGACAGGAAGCGTCCTGGTAATTTAGCTTCTGCTAACTCTGTGGGAAGAG
CAAAGCCTAGCGGTATGCGATAACCATGCATACGGTGAGCAGTTCGAGAGGGAGATGTGGTTGG
AAGTGCAGACAGCCCCCTTTCATCATGTTCCCTTTAGCTGTTCTTCGTTCATGGCTAAGAACAG
CATGTTGTACTCTTAAAAGATATGGAAATAAAAAGACCTCAAAGCTATCGAGTTCTCCCACATT
GTCTGCTCTGCCAGCCTCGCTTTAGCCGTCTTGATCCTTGAGAGCAACTGGTTGGAAGTGCATC
CAGTGGTGTGGAATTTCCTAGAACTGTGGGAGGTTTCTCCTGCAGGATGCAGGTGCCGCTTCCC
CCAGAACTCTGTACGAAACACCCATTTTACGGAAGTTAGCCATCCTAGTTTTCGCTGCTACTTC
CCCATCTTTCGAACCTCTTTAATTTCCTTGTTAGAATCCCACAAGCAGCACAGACCCGAGAGTG
TTTTATTTCATCGTGTTCAGCCATGCAGACTTTCCAAGCAAAGAAGTTGATACTTCTTTCTTCT
TTCGGGAAAGTGTCCAGGAAGAACTGTCATTCCTCCCCCCATGGCTCTGTTTTGTTTTATTTCC
CACCTTCTAACTTACAACGTCATTTCCTTATTTATTATGTTTATTGTCTTGTAGCCTATGATGT
CTAGAGTGTTAAACACAACGAAGGCAGGGATTTGTACGTTTTTGATCCATGCAGCATGTTCCCA
GCACCTAAGCTAACATACAGTAAGCAACGGCTTACCAAACACATGTTCAATAAACTCAGTCTCC
TCTGTAAAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_062244	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAA19321	(Get FASTA)	NCBI Sequence Viewer
	Q62630	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_062244 ⟸ NM_019371

- UniProtKB:

G3V6N9 (UniProtKB/TrEMBL), A6HBJ8 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MTLRSRRGFLSFLPGLRPPRRWLRISKRGPPTSHWASPALGGRTLHYSCRSQSGTPFSSEFQAT
FPAFAAKVARGPWLPQVVEPPARLSASPLCVRSGQALGACTLGVPRLGSVSEMPLGHIMRLDLE
KIALEYIVPCLHEVGFCYLDNFLGEVVGDCVLERVKQLHYNGALRDGQLAGPRAGVSKRHLRGD
QITWIGGNEEGCEAINFLLSLIDRLVLYCGSRLGKYYVKERSKAMVACYPGNGTGYVRHVDNPN
GDGRCITCIYYLNKNWDAKLHGGVLRIFPEGKSFVADVEPIFDRLLFSWSDRRNPHEVQPSYAT
RYAMTVWYFDAEERAEAKKKFRNLTRKTESALAKD

hide sequence

RefSeq Acc Id:

ENSRNOP00000007219 ⟸ ENSRNOT00000007219

Protein Domains

Fe2OG dioxygenase

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q62630-F1-model_v2	AlphaFold	Q62630	1-239	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:71019	AgrOrtholog
BioCyc Gene	G2FUF-37555	BioCyc
BioCyc Pathway	PWY-7894 [procollagen hydroxylation and glycosylation]	BioCyc
Ensembl Genes	ENSRNOG00000005053	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein	ENSRNOP00000007219	ENTREZGENE
	ENSRNOP00000007219.2	UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000007219	ENTREZGENE
	ENSRNOT00000007219.3	UniProtKB/TrEMBL
Gene3D-CATH	q2cbj1_9rhob like domain	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro	Oxoglu/Fe-dep_dioxygenase	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Pro_4_hyd_alph	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Pro_4_hyd_alph_FE2OG_OXY	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:54702	UniProtKB/Swiss-Prot
NCBI Gene	54702	ENTREZGENE
PANTHER	EGL NINE HOMOLOG-RELATED	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PROLYL HYDROXYLASE EGLN3	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	2OG-FeII_Oxy_3	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Egln3	PhenoGen
PROSITE	FE2OG_OXY	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART	P4Hc	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	A6HBJ8	ENTREZGENE, UniProtKB/TrEMBL
	EGLN3_RAT	UniProtKB/Swiss-Prot
	G3V6N9	ENTREZGENE, UniProtKB/TrEMBL
	Q62630	ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2013-09-16	Egln3	egl-9 family hypoxia-inducible factor 3	Egln3	EGL nine homolog 3 (C. elegans)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2002-07-09	Egln3	EGL nine homolog 3 (C. elegans)			Symbol and Name updated to reflect Human and Mouse nomenclature	70877	APPROVED

RGD Curation Notes

Note Type	Note	Reference
gene_regulation	expression is down-regulated by angiotensin II induced AT2 receptor activity	728483

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

RGD Manual Annotations

Imported Annotations - KEGG (archival)

Imported Annotations - PID (archival)

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

RGD Manual Annotations

Imported Annotations - KEGG (archival)

Imported Annotations - PID (archival)