Egln3 (egl-9 family hypoxia inducible factor 3)

Gene: Egln3 (egl-9 family hypoxia inducible factor 3) Chinchilla lanigera

Analyze

Symbol:

Egln3

Name:

egl-9 family hypoxia inducible factor 3

RGD ID:

8843732

Description:

ENCODES a protein that exhibits 2-oxoglutarate-dependent dioxygenase activity (ortholog); peptidyl-proline 4-dioxygenase activity (ortholog); peptidyl-proline dioxygenase activity (ortholog); INVOLVED IN apoptotic process (ortholog); cellular response to leukemia inhibitory factor (ortholog); regulation of cell population proliferation (ortholog); PARTICIPATES IN hypoxia inducible factor pathway; vascular endothelial growth factor signaling pathway; ASSOCIATED WITH acute kidney failure (ortholog); Brain-Lung-Thyroid Syndrome (ortholog); clear cell renal cell carcinoma (ortholog); FOUND IN cytoplasm (ortholog); cytosol (ortholog); nucleus (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

egl nine homolog 3; egl-9 family hypoxia-inducible factor 3

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

ChiLan1.0 - Chinchilla ChiLan1.0 Assembly

Position:

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955409	26,939,933 - 26,967,156 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955409	26,939,933 - 26,967,156 (+)	NCBI	ChiLan1.0	ChiLan1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

acute kidney failure (ISO)

Brain-Lung-Thyroid Syndrome (ISO)

clear cell renal cell carcinoma (ISO)

genetic disease (ISO)

Kidney Reperfusion Injury (ISO)

Liver Neoplasms (ISO)

myocardial infarction (ISO)

Pulmonary Hypertension, Hypoxia-Induced (ISO)

renal cell carcinoma (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

apoptotic process (ISO)

cellular response to leukemia inhibitory factor (ISO)

regulation of cell population proliferation (ISO)

regulation of neuron apoptotic process (ISO)

response to hypoxia (ISO)

Cellular Component

cytoplasm (ISO)

cytosol (ISO)

nucleus (ISO)

Molecular Function

2-oxoglutarate-dependent dioxygenase activity (ISO)

peptidyl-proline 4-dioxygenase activity (ISO)

peptidyl-proline dioxygenase activity (ISO)

protein binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

hypoxia inducible factor pathway (ISO)

vascular endothelial growth factor signaling pathway (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Transitive Annotation Pipeline	Automated assignment of GO, PW and RDO ISO annotations across species

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

Egln3
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955409	26,939,933 - 26,967,156 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955409	26,939,933 - 26,967,156 (+)	NCBI	ChiLan1.0	ChiLan1.0

EGLN3
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	14	33,924,227 - 33,951,074 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	14	33,924,227 - 34,462,774 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	14	34,393,433 - 34,420,280 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	14	33,463,172 - 33,490,035 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	14	33,463,172 - 33,490,037	NCBI
Celera	14	14,258,646 - 14,285,539 (-)	NCBI		Celera
Cytogenetic Map	14	q13.1	NCBI
HuRef	14	14,510,074 - 14,536,960 (-)	NCBI		HuRef
CHM1_1	14	34,391,710 - 34,418,579 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	14	28,121,430 - 28,148,293 (-)	NCBI		T2T-CHM13v2.0

Egln3
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	12	54,225,767 - 54,250,660 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	12	54,225,767 - 54,250,646 (-)	Ensembl		GRCm39 Ensembl
GRCm38	12	54,178,981 - 54,203,874 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	12	54,178,981 - 54,203,860 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	12	55,279,968 - 55,304,861 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	12	55,100,608 - 55,125,474 (-)	NCBI		MGSCv36	mm8
Celera	12	55,491,368 - 55,516,127 (-)	NCBI		Celera
Cytogenetic Map	12	C1	NCBI
cM Map	12	22.9	NCBI

Egln3
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	6	77,385,549 - 77,411,015 (-)	NCBI		GRCr8
mRatBN7.2	6	71,650,297 - 71,675,766 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	6	71,650,297 - 71,675,766 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	6	72,071,359 - 72,096,960 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	6	72,378,007 - 72,403,609 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	6	71,817,527 - 71,843,127 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	6	75,050,329 - 75,075,795 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	6	75,050,329 - 75,075,795 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	6	84,592,894 - 84,618,360 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	6	74,451,038 - 74,476,506 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	6	74,454,165 - 74,479,632 (-)	NCBI
Celera	6	70,500,466 - 70,525,910 (-)	NCBI		Celera
Cytogenetic Map	6	q23	NCBI

EGLN3
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	15	35,243,634 - 35,269,614 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	14	34,460,135 - 34,486,476 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	14	14,689,398 - 14,716,301 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	14	32,880,330 - 32,907,248 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	14	32,880,324 - 32,907,241 (-)	Ensembl	panpan1.1		panPan2

EGLN3
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	8	12,873,755 - 12,901,728 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	8	12,875,387 - 12,901,709 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	8	12,682,830 - 12,710,865 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	8	12,977,975 - 13,005,981 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	8	12,979,608 - 13,005,982 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	8	12,659,735 - 12,687,739 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	8	12,742,506 - 12,770,341 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	8	13,031,833 - 13,059,696 (-)	NCBI		UU_Cfam_GSD_1.0

Egln3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024408640	44,734,378 - 44,761,610 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936494	8,238,858 - 8,267,606 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936494	8,240,272 - 8,267,487 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

EGLN3
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	7	65,805,522 - 65,833,529 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	7	65,805,513 - 65,833,536 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	7	70,667,662 - 70,695,671 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

Egln3
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624838	2,819,631 - 2,847,827 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624838	2,819,719 - 2,848,094 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005376943	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AGCD01010203	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GBCQ01004650	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSCLAT00000015756 ⟹ ENSCLAP00000015594

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0 Ensembl	NW_004955409	26,939,933 - 26,967,156 (+)	Ensembl

RefSeq Acc Id:

XM_005376943 ⟹ XP_005377000

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0	NW_004955409	26,939,933 - 26,967,156 (+)	NCBI

Sequence:

show sequence

TCGGACTCCTCACTGGGCCAGTCCGGCGCTGGGTGCCGGAGCCCCGCGCAACTCCCGCGGCTCC
CTCACCGGGGATCCCTTCTCCCCAGAGTTTGCGAGCAACTTTCCCCTCCGTCCGCGGCGCTGCG
GTGGCTCGGAGACCGTGGCCGCCGCAGGTTGCTCCGCTCCCCGAACCTCGGCTCGGCGCTCGCG
TAGGTCGCTTCCTCTCCGGCTGCACCCTGGGGGTCCCCGACCTCGAGGCTGAGGGCGAGATGCC
TCTGGGACACATCATGAGGCTGGATCTGGAGAAAATCGCCCTGGAGTACATCGTGCCTTGTCTG
CACGAGATCGGCTTCTGCTACCTGGACAACTTCCTGGGCGAGGTGGTGGGCGACTGCGTCCTGG
AGCGCGTGAAACAGCTGCATTACAACGGGGTCCTGCGCGACGGCCAGCTGGCCGGGCCGCGTGC
TGGCGTCTCCAAGCGGCACCTGCGAGGCGACCAGATCACGTGGATCGGGGGCAACGAGGAGGGC
TGCGAGGCCATCAGCTTCCTCTTGTCTCTCATCGACCGGCTGGTCCTGTACTGCGGGAGCCGGC
TGGGCAAATACTACGTCAAGGAGAGGTCCAAGGCAATGGTGGCCTGCTACCCAGGAAATGGAGC
AGGTTATGTTCGCCATGTGGACAACCCCAATGGTGACGGCCGCTGCATCACCTGCATCTACTAT
CTGAACAAGAACTGGGATGCCAAGTTGCATGGTGGAGTCCTGCGGATATTTCCAGAAGGGAAGT
CATTCATTGCAGATGTGGAGCCCATTTTTGACAGACTGTTGTTCTTCTGGTCAGATCGCAGGAA
CCCACATGAAGTGCAGCCTTCCTATGCAACCAGGTATGCCATGACTGTTTGGTACTTTGATGCT
GAAGAAAGGGCGGAAGCCAAGAAGAAATTTAGGAATTTAACTAGGAAAACTGAATCTGCCCTCA
CTGAAGACTGAATGTGCTCTGAAATCCGCTGGCCTCCTTCATTTTGGTATCAGCTGAATTCTCC
GTAAGAGTTGAGATCCAAAGATGGCCTCTTCAGTGACCATAGGTTATTCCCTACTGCTCGCATC
ATTTGCATCCCTGTCTTGTGTGTGGTACTTCTTGTTTTCTTGCCAGGACCGCATTGACCTCCAG
ACACTCTCTTTGCCAGACATGAACTCACTTGATAACTCCAGAAATGCCTGCAGACATCCTCGCT
GGTCAGCGGTTTAAGGATAGATTTGGTGATGTTGGCTATCAAAGCAAGAGCCTGGGAGCGCAGA
AGTGAATCTTACTTGCACTTTATGTATTCTTCCTGATTTGAAAGGAGGAGGTTTGCAAAGAAAA
GCAAAAATTGGTGACAGAGGCATCATCGAAGCCTGAACAGTAGAAAACTGAAATTTTTGTCATC
TGAACAATTTCCAGATGTTGTTAATCCTGGGCTGTTGGGGTTTCTGGAGAATTACCACAACCTA
ATGACATGATTACCTCCAGCAAGGGCTGCTGTCAGAGTGATCAAGTTGTAAGTGTCCCATGGGG
TGGACACTCCTTTTTCCCTTCCCACCACCACTTGGACTTTCAGCCTCAGCCCTGTTTTGCTGAA
AATGATTTTCTAATTGAGGATGACACCACCACTTATTCTTTATGTTCACTTTTTCCTGGGAGAC
TCTAATTACTCCGAGGCTAAAACTAGATATTAGTTGTTTTGGTTGCTTTGTTGGAATTCGAATT
TAAATCAAAGGACAGGAAACTACCTGATAGTTTAGCATCAGGCGCCAGTGACAGTGTGGAAAAA
TCCAGGTGTGCTGATATGCAATAAAAGAGCGTACCATGAAAGATTGAGAGGGAAGATGGAAGTT
GTAAATGCGGGTTTTCCCATTTTTTTCAGTATTCCTTTTTAACGAGCTCACCTTTCCTTAACAT
CAACAACAACAAAATAGGGTGCTATGTTTTAAAAAGGAAATGGAAATAAAAAAAATTATCAAAG
TTG

hide sequence

Protein Sequences


Protein RefSeqs	XP_005377000	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCLAP00000015594
	ENSCLAP00000015594.1

RefSeq Acc Id:

XP_005377000 ⟸ XM_005376943

- UniProtKB:

A0A8C2VL76 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MPLGHIMRLDLEKIALEYIVPCLHEIGFCYLDNFLGEVVGDCVLERVKQLHYNGVLRDGQLAGP
RAGVSKRHLRGDQITWIGGNEEGCEAISFLLSLIDRLVLYCGSRLGKYYVKERSKAMVACYPGN
GAGYVRHVDNPNGDGRCITCIYYLNKNWDAKLHGGVLRIFPEGKSFIADVEPIFDRLLFFWSDR
RNPHEVQPSYATRYAMTVWYFDAEERAEAKKKFRNLTRKTESALTED

hide sequence

RefSeq Acc Id:

ENSCLAP00000015594 ⟸ ENSCLAT00000015756

Protein Domains

Fe2OG dioxygenase

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCLAG00000010720	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCLAT00000015756	ENTREZGENE
	ENSCLAT00000015756.1	UniProtKB/TrEMBL
Gene3D-CATH	q2cbj1_9rhob like domain	UniProtKB/TrEMBL
InterPro	Oxoglu/Fe-dep_dioxygenase	UniProtKB/TrEMBL
	Pro_4_hyd_alph	UniProtKB/TrEMBL
	Pro_4_hyd_alph_FE2OG_OXY	UniProtKB/TrEMBL
NCBI Gene	Egln3	ENTREZGENE
PANTHER	EGL NINE HOMOLOG-RELATED	UniProtKB/TrEMBL
	PROLYL HYDROXYLASE EGLN3	UniProtKB/TrEMBL
Pfam	2OG-FeII_Oxy_3	UniProtKB/TrEMBL
PROSITE	FE2OG_OXY	UniProtKB/TrEMBL
SMART	P4Hc	UniProtKB/TrEMBL
UniProt	A0A8C2VL76	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-08-03	Egln3	egl-9 family hypoxia inducible factor 3		egl-9 family hypoxia-inducible factor 3	Symbol and/or name change	5135510	APPROVED
2015-08-25	Egln3	egl-9 family hypoxia-inducible factor 3		egl nine homolog 3 (C. elegans)	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

RGD Manual Annotations

Imported Annotations - PID (archival)

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

RGD Manual Annotations

Imported Annotations - PID (archival)