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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 71019
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Egln3
Name: egl-9 family hypoxia-inducible factor 3
Acc ID: CHEBI:16469
Term: 17beta-estradiol
Definition: The 17beta-isomer of estradiol.
Chemical ID: MESH:D004958
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Egln3affects expressionEXP 6480464CTDEstradiol affects the expression of EGLN3 mRNAPMID:32145629
Egln3decreases expressionISOEGLN3 (Homo sapiens)6480464CTDEstradiol results in decreased expression of EGLN3 mRNAPMID:20106945 PMID:21632981 PMID:24758408
Egln3increases expressionISOEGLN3 (Homo sapiens)6480464CTDEstradiol results in increased expression of EGLN3 mRNAPMID:19619570
Egln3increases expressionISOEgln3 (Mus musculus)6480464CTDEstradiol results in increased expression of EGLN3 mRNAPMID:19484750
Egln3multiple interactionsISOEGLN3 (Homo sapiens)6480464CTD[Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of EGLN3 mRNA; [Estradiol co-treated with TGFB1 protein] results in decreased expression of EGLN3 mRNA; EGF protein inhibits the reaction [Estradiol results in decreased expression of EGLN3 mRNA]PMID:19619570 PMID:24758408 PMID:30165855
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